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    SBP1 Sbp1p [ Saccharomyces cerevisiae S288C ]

    Gene ID: 856351, updated on 9-Jun-2024

    Summary

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    Gene symbol
    SBP1
    Gene description
    Sbp1p
    Primary source
    FungiDB:YHL034C
    Locus tag
    YHL034C
    See related
    SGD:S000001026; AllianceGenome:SGD:S000001026; VEuPathDB:YHL034C
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Saccharomyces cerevisiae S288C (strain: S288C)
    Lineage
    Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes; Saccharomycetales; Saccharomycetaceae; Saccharomyces
    Also known as
    SSB1; SSBR1
    Summary
    Enables eukaryotic initiation factor 4G binding activity and mRNA binding activity. Involved in negative regulation of translation in response to stress. Located in P-body; cytoplasmic stress granule; and nucleolus. [provided by Alliance of Genome Resources, Apr 2022]
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    Genomic context

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    See SBP1 in Genome Data Viewer
    Location:
    chromosome: VIII
    Exon count:
    1
    Sequence:
    Chromosome: VIII; NC_001140.6 (33193..34077, complement)

    Chromosome VIII - NC_001140.6Genomic Context describing neighboring genes Neighboring gene Mup3p Neighboring gene putative ATP-binding cassette multidrug transporter VMR1 Neighboring gene ribosomal 60S subunit protein L8A Neighboring gene glycerol kinase

    Genomic regions, transcripts, and products

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    Genomic Sequence:
    NC_001140.6

    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. RNase treatment of yeast and mammalian cell extracts affects in vitro substrate methylation by type I protein arginine N-methyltransferases. Frankel A, et al. Biochem Biophys Res Commun, 1999 Jun 7. PMID 10362520
    2. Isolation of the gene encoding yeast single-stranded nucleic acid binding protein 1. Jong AY, et al. Proc Natl Acad Sci U S A, 1986 Feb. PMID 3513165, Free PMC Article
    3. Saccharomyces cerevisiae SSB1 protein and its relationship to nucleolar RNA-binding proteins. Jong AY, et al. Mol Cell Biol, 1987 Aug. PMID 2823109, Free PMC Article
    4. Purification of ribonucleoproteins by a novel approach: isolation of the SSB1 ribonucleoprotein from yeast and demonstration that it has no role in mRNA splicing. Cusick ME. Biochim Biophys Acta, 1992 Dec 29. PMID 1482680
    5. Low complexity RGG-motif sequence is required for Processing body (P-body) disassembly. Roy R, et al. Nat Commun, 2022 Apr 19. PMID 35440550, Free PMC Article

    See all (103) citations in PubMed

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?
    1. Sbp1 regulates transcript-specific mRNA translation in an RGG-dependent manner.
      Title: Sbp1 modulates the translation of Pab1 mRNA in a poly(A)- and RGG-dependent manner.
    2. These results identify Sbp1p as a new protein that functions in the transition of mRNAs from translation to an mRNP complex destined for decapping.
      Title: Sbp1p affects translational repression and decapping in Saccharomyces cerevisiae.
    3. Ssb either stimulates refolding into nonprion conformation or targets misfolded proteins for degradation.
      Title: Hsp70 chaperones as modulators of prion life cycle: novel effects of Ssa and Ssb on the Saccharomyces cerevisiae prion [PSI+].
    Submit: New GeneRIF Correction

    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Homology

    Gene Ontology Provided by SGD

    Function Evidence Code Pubs
    enables RNA binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables eukaryotic initiation factor 4G binding IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    enables mRNA binding HDA PubMed 
    enables mRNA binding IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables mRNA binding IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    Process Evidence Code Pubs
    involved_in negative regulation of translation IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    involved_in negative regulation of translation in response to stress IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    acts_upstream_of_or_within stress granule disassembly IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    Component Evidence Code Pubs
    located_in P-body IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    located_in P-body IEA
    Inferred from Electronic Annotation
    more info
    		  
    is_active_in cytoplasm IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    located_in cytoplasm IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    located_in cytoplasm IEA
    Inferred from Electronic Annotation
    more info
    		  
    located_in cytoplasmic stress granule HDA PubMed 
    located_in cytoplasmic stress granule IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    located_in cytoplasmic stress granule IEA
    Inferred from Electronic Annotation
    more info
    		  
    located_in nucleolus IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    located_in nucleolus IEA
    Inferred from Electronic Annotation
    more info
    		  
    is_active_in nucleus IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    located_in nucleus IEA
    Inferred from Electronic Annotation
    more info
    		  
    part_of ribonucleoprotein complex IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  

    General protein information

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    Preferred Names
    Sbp1p
    NP_011829.1
    • Protein involved in translation repression and P-body disassembly; binds to mRNAs under glucose starvation stress, most often in the 5' UTR; found associated with small nucleolar RNAs snR10 and snR11; binds eIF4G; HMT1-dependent arginine monomethylation important for stress granule localization during glucose starvation and for eIF4G binding; contains an RGG motif; found in cytoplasmic P bodies and stress granules; SBP1 has a paralog, RNP1, that arose from the whole genome duplication

    NCBI Reference Sequences (RefSeq)

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    Genome Annotation

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference assembly

    Genomic

    1. NC_001140.6 Reference assembly

      Range
      33193..34077 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_001179114.1 → NP_011829.1  TPA: Sbp1p [Saccharomyces cerevisiae S288C]

      See identical proteins and their annotated locations for NP_011829.1

      Status: REVIEWED

      UniProtKB/Swiss-Prot
      D3DKT4, P10080
      UniProtKB/TrEMBL
      A0A8H4FB66, A6ZSL6, B3LS85, C7GRT8, C8ZA29, G2WF31, N1P1L0
      Conserved Domains (2) summary
      smart00360
      Location:187 → 269
      RRM; RNA recognition motif
      pfam00076
      Location:39 → 113
      RRM_1; RNA recognition motif. (a.k.a. RRM, RBD, or RNP domain)
    Nucleotide Protein
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    P10080.2

    Gene LinkOut

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