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    GLC8 Glc8p [ Saccharomyces cerevisiae S288C ]

    Gene ID: 855359, updated on 18-Sep-2024

    Summary

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    Official Symbol
    GLC8
    Official Full Name
    Glc8p
    Primary source
    SGD:S000004928
    Locus tag
    YMR311C
    See related
    AllianceGenome:SGD:S000004928; FungiDB:YMR311C; VEuPathDB:YMR311C
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Saccharomyces cerevisiae S288C (strain: S288C)
    Lineage
    Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes; Saccharomycetales; Saccharomycetaceae; Saccharomyces
    Summary
    Enables enzyme activator activity. Involved in chromosome segregation. Located in cytoplasm and nucleus. Orthologous to several human genes including PPP1R2C (PPP1R2C family member C); PPP1R2 (protein phosphatase 1 regulatory inhibitor subunit 2); and PPP1R2P1 (protein phosphatase 1 regulatory inhibitor subunit 2 pseudogene 1). [provided by Alliance of Genome Resources, Apr 2022]
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    Genomic context

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    See GLC8 in Genome Data Viewer
    Location:
    chromosome: XIII
    Exon count:
    1
    Sequence:
    Chromosome: XIII; NC_001145.3 (896914..897603, complement)

    Chromosome XIII - NC_001145.3Genomic Context describing neighboring genes Neighboring gene translation initiation factor eIF3 core subunit c Neighboring gene putative methyltransferase Neighboring gene Elongator subunit ELP6 Neighboring gene bifunctional triglyceride lipase/lysophosphatidylethanolamine acyltransferase

    Genomic regions, transcripts, and products

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    Genomic Sequence:
    NC_001145.3

    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. Inhibitor-1 interaction domain that mediates the inhibition of protein phosphatase-1. Connor JH, et al. J Biol Chem, 1998 Oct 16. PMID 9765309
    2. Regulation of chromosome segregation by Glc8p, a structural homolog of mammalian inhibitor 2 that functions as both an activator and an inhibitor of yeast protein phosphatase 1. Tung HY, et al. Mol Cell Biol, 1995 Nov. PMID 7565759, Free PMC Article
    3. Phosphorylation and functions of inhibitor-2 family of proteins. Li M, et al. Biochemistry, 2007 Mar 6. PMID 17286390
    4. Sli15 associates with the ipl1 protein kinase to promote proper chromosome segregation in Saccharomyces cerevisiae. Kim JH, et al. J Cell Biol, 1999 Jun 28. PMID 10385519, Free PMC Article
    5. Glc8 is a glucose-repressible activator of Glc7 protein phosphatase-1. Nigavekar SS, et al. Arch Biochem Biophys, 2002 Aug 1. PMID 12127071

    See all (45) citations in PubMed

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?
    1. Data suggest that the Cdc48(Shp1) complex controls Glc7 activity by regulating its interaction with Glc8 and possibly further regulatory subunits.
      Title: The budding yeast Cdc48(Shp1) complex promotes cell cycle progression by positive regulation of protein phosphatase 1 (Glc7).
    Submit: New GeneRIF Correction

    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Homology

    Gene Ontology Provided by SGD

    Function Evidence Code Pubs
    enables enzyme activator activity IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    enables protein phosphatase inhibitor activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables protein phosphatase inhibitor activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    Process Evidence Code Pubs
    involved_in chromosome segregation IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in glycogen biosynthetic process TAS
    Traceable Author Statement
    more info
    		 PubMed 
    involved_in glycogen metabolic process IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in intracellular signal transduction IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in regulation of signal transduction IEA
    Inferred from Electronic Annotation
    more info
    		  
    Component Evidence Code Pubs
    located_in cytoplasm HDA PubMed 
    located_in nucleus HDA PubMed 

    General protein information

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    Preferred Names
    Glc8p
    NP_014042.1
    • Regulatory subunit of protein phosphatase 1 (Glc7p); involved in glycogen metabolism and chromosome segregation; proposed to regulate Glc7p activity via conformational alteration; ortholog of the mammalian protein phosphatase inhibitor 2; protein abundance increases in response to DNA replication stress

    NCBI Reference Sequences (RefSeq)

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    Genome Annotation

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference assembly

    Genomic

    1. NC_001145.3 Reference assembly

      Range
      896914..897603 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_001182822.1 → NP_014042.1  TPA: Glc8p [Saccharomyces cerevisiae S288C]

      See identical proteins and their annotated locations for NP_014042.1

      Status: REVIEWED

      UniProtKB/Swiss-Prot
      D6W0D8, P41818
      UniProtKB/TrEMBL
      A6ZN28, B3LMJ9, B5VQ77, C7GPV2, C8ZFI2, G2WL20, N1NZ84
      Conserved Domains (1) summary
      pfam04979
      Location:91 → 201
      IPP-2; Protein phosphatase inhibitor 2 (IPP-2)
    Nucleotide Protein
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    P41818.1

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