Pgbd5 piggyBac transposable element derived 5 [Mus musculus (house mouse)] - Gene

Summary

Official Symbol: Pgbd5provided by MGI
Official Full Name: piggyBac transposable element derived 5provided by MGI
Primary source: MGI:MGI:2429955
See related: Ensembl:ENSMUSG00000050751 AllianceGenome:MGI:2429955
Gene type: protein coding
RefSeq status: VALIDATED
Organism: Mus musculus
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as: 2900019M05Rik
Summary: The piggyBac family of proteins, found in diverse animals, are transposases related to the transposase of the canonical piggyBac transposon from the moth, Trichoplusia ni. This family also includes genes in several genomes that appear to have been derived from the piggyBac transposons. This gene belongs to the subfamily of piggyBac transposable element derived (PGBD) genes. The PGBD proteins appear to be novel, with no obvious relationship to other transposases, or other known protein families. The exact function of this gene is not known. [provided by RefSeq, Jul 2008]
Expression: Biased expression in cortex adult (RPKM 40.9), frontal lobe adult (RPKM 35.4) and 11 other tissues See more
Orthologs: human all
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Genomic context

Location:: 8 E2; 8 72.65 cM

Exon count:: 8

Annotation release	Status	Assembly	Chr	Location
RS_2024_02	current	GRCm39 (GCF_000001635.27)	8	NC_000074.7 (125095788..125161230, complement)
108.20200622	previous assembly	GRCm38.p6 (GCF_000001635.26)	8	NC_000074.6 (124369049..124433936, complement)

Chromosome 8 - NC_000074.7 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Genomic Sequence:

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Expression

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See details

Project title: Mouse ENCODE transcriptome data Mouse ENCODE transcriptome data
Description: RNA profiling data sets generated by the Mouse ENCODE project.
BioProject: PRJNA66167
Publication: PMID 25409824
Analysis date: n/a

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Knockdown of PGBD5 inhibits the malignant progression of glioma through upregulation of the PPAR pathway.
Title: Knockdown of PGBD5 inhibits the malignant progression of glioma through upregulation of the PPAR pathway.
Childhood cancer mutagenesis caused by transposase-derived PGBD5.
Title: Childhood cancer mutagenesis caused by transposase-derived PGBD5.

Submit: New GeneRIF Correction

Variation

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Alleles

Alleles of this type are documented at Mouse Genome Informatics (MGI)

Endonuclease-mediated (3) 1 citation
Targeted (3) 1 citation

General gene information

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Markers

UniSTS:25220 (e-PCR)
- UniSTS:25220

AI854313 (e-PCR)
- UniSTS:179846

Gene Ontology Provided by MGI

Function	Evidence Code	Pubs
enables endonuclease activity	IEA Inferred from Electronic Annotation more info
enables transposase activity	IBA Inferred from Biological aspect of Ancestor more info
enables transposase activity	ISO Inferred from Sequence Orthology more info
enables transposase activity	ISS Inferred from Sequence or Structural Similarity more info

Process	Evidence Code	Pubs
involved_in non-replicative DNA transposition	IBA Inferred from Biological aspect of Ancestor more info
involved_in non-replicative DNA transposition	ISO Inferred from Sequence Orthology more info
involved_in non-replicative DNA transposition	ISS Inferred from Sequence or Structural Similarity more info

Component	Evidence Code	Pubs
located_in nucleoplasm	IEA Inferred from Electronic Annotation more info
located_in nucleoplasm	ISO Inferred from Sequence Orthology more info
is_active_in nucleus	IBA Inferred from Biological aspect of Ancestor more info
located_in nucleus	IDA Inferred from Direct Assay more info	PubMed

General protein information

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Preferred Names: piggyBac transposable element-derived protein 5

Names: piggyBac transposase 5

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

NM_171824.3 → NP_741958.2 piggyBac transposable element-derived protein 5

Status: VALIDATED

Source sequence(s)

AC114005, AC126930

Consensus CDS

CCDS22770.1

UniProtKB/Swiss-Prot

D3YZI9, D3Z077, E9PUA8, Q52KE6

Related

ENSMUSP00000120984.2, ENSMUST00000140012.8

RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm39 C57BL/6J

Genomic

NC_000074.7 Reference GRCm39 C57BL/6J

Range

125095788..125161230 complement

Download

GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

XM_030243379.2 → XP_030099239.1 piggyBac transposable element-derived protein 5 isoform X1

UniProtKB/TrEMBL

A0A510C1L5

Related

ENSMUSP00000133560.2, ENSMUST00000172566.8

Conserved Domains (1) summary

pfam13843
Location:20 → 386

DDE_Tnp_1_7; Transposase IS4