Micu2 mitochondrial calcium uptake 2 [Mus musculus (house mouse)] - Gene

Summary

Official Symbol: Micu2provided by MGI
Official Full Name: mitochondrial calcium uptake 2provided by MGI
Primary source: MGI:MGI:1915764
See related: Ensembl:ENSMUSG00000021973 AllianceGenome:MGI:1915764
Gene type: protein coding
RefSeq status: VALIDATED
Organism: Mus musculus
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as: Efha1; Smhs2; 1110008L20Rik; 4833427E09Rik
Summary: Enables calcium ion binding activity and protein heterodimerization activity. Involved in mitochondrial calcium ion transmembrane transport and positive regulation of mitochondrial calcium ion concentration. Located in mitochondrion. Part of calcium channel complex. Orthologous to human MICU2 (mitochondrial calcium uptake 2). [provided by Alliance of Genome Resources, Nov 2024]
Expression: Ubiquitous expression in bladder adult (RPKM 13.6), CNS E11.5 (RPKM 13.1) and 28 other tissues See more
Orthologs: human all
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Genomic context

Location:: 14 C3; 14 30.51 cM

Exon count:: 13

Annotation release	Status	Assembly	Chr	Location
RS_2024_02	current	GRCm39 (GCF_000001635.27)	14	NC_000080.7 (58153718..58236716, complement)
108.20200622	previous assembly	GRCm38.p6 (GCF_000001635.26)	14	NC_000080.6 (57916280..57999296, complement)

Chromosome 14 - NC_000080.7 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Genomic Sequence:

Go to nucleotide: Graphics FASTA GenBank

Expression

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See details

Project title: Mouse ENCODE transcriptome data Mouse ENCODE transcriptome data
Description: RNA profiling data sets generated by the Mouse ENCODE project.
BioProject: PRJNA66167
Publication: PMID 25409824
Analysis date: n/a

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

MICU1 and MICU2 control mitochondrial calcium signaling in the mammalian heart.
Title: MICU1 and MICU2 control mitochondrial calcium signaling in the mammalian heart.
Mitochondrial clearance of calcium facilitated by MICU2 controls insulin secretion.
Title: Mitochondrial clearance of calcium facilitated by MICU2 controls insulin secretion.
s. We propose that in the MICU1-MICU2 oligomeric complex the C-terminal helices of both proteins form a central semiautonomous assembly which contributes to the gating mechanism of the uniporter.
Title: Crystal structure of MICU2 and comparison with MICU1 reveal insights into the uniporter gating mechanism.
Micu2 role in regulating angiotensin II-mediated hypertensive responses that are critical in protecting the abdominal aorta from injury.
Title: Cardiovascular homeostasis dependence on MICU2, a regulatory subunit of the mitochondrial calcium uniporter.
a possible role for tissue-specific stoichiometry between the Ca(2+)-sensing regulators (MICUs) and pore unit (MCU) of the uniporter, was investigated.
Title: Tissue-Specific Mitochondrial Decoding of Cytoplasmic Ca(2+) Signals Is Controlled by the Stoichiometry of MICU1/2 and MCU.

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Variation

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Alleles

Alleles of this type are documented at Mouse Genome Informatics (MGI)

Gene trapped (1)
Targeted (1)

Interactions

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Products	Interactant	Other Gene	Complex	Source	Pubs	Description

General gene information

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Markers

D14Mit154 (e-PCR), detects polymorphism
- UniSTS:127264

AU041871 (e-PCR)
- UniSTS:160396

NoName (e-PCR)
- UniSTS:237197

Gene Ontology Provided by MGI

Function	Evidence Code	Pubs
enables calcium ion binding	IBA Inferred from Biological aspect of Ancestor more info
enables calcium ion binding	IMP Inferred from Mutant Phenotype more info	PubMed
enables calcium ion binding	ISO Inferred from Sequence Orthology more info
enables calcium ion sensor activity	ISO Inferred from Sequence Orthology more info
enables calcium ion sensor activity	ISS Inferred from Sequence or Structural Similarity more info
enables protein binding	IPI Inferred from Physical Interaction more info	PubMed
enables protein heterodimerization activity	IPI Inferred from Physical Interaction more info	PubMed
enables protein heterodimerization activity	ISO Inferred from Sequence Orthology more info

Process	Evidence Code	Pubs
involved_in calcium import into the mitochondrion	IBA Inferred from Biological aspect of Ancestor more info
involved_in calcium import into the mitochondrion	ISO Inferred from Sequence Orthology more info
involved_in calcium import into the mitochondrion	ISS Inferred from Sequence or Structural Similarity more info
involved_in cellular response to calcium ion	IEA Inferred from Electronic Annotation more info
involved_in mitochondrial calcium ion homeostasis	IBA Inferred from Biological aspect of Ancestor more info
involved_in mitochondrial calcium ion homeostasis	ISO Inferred from Sequence Orthology more info
involved_in mitochondrial calcium ion transmembrane transport	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in mitochondrial calcium ion transmembrane transport	ISO Inferred from Sequence Orthology more info
involved_in negative regulation of mitochondrial calcium ion concentration	ISO Inferred from Sequence Orthology more info
involved_in negative regulation of mitochondrial calcium ion concentration	ISS Inferred from Sequence or Structural Similarity more info
involved_in positive regulation of mitochondrial calcium ion concentration	IMP Inferred from Mutant Phenotype more info	PubMed

Component	Evidence Code	Pubs
part_of calcium channel complex	IDA Inferred from Direct Assay more info	PubMed
is_active_in mitochondrial inner membrane	ISO Inferred from Sequence Orthology more info
located_in mitochondrial inner membrane	ISO Inferred from Sequence Orthology more info
located_in mitochondrial inner membrane	ISS Inferred from Sequence or Structural Similarity more info
located_in mitochondrial intermembrane space	ISO Inferred from Sequence Orthology more info
located_in mitochondrial intermembrane space	ISS Inferred from Sequence or Structural Similarity more info
located_in mitochondrion	HDA more info	PubMed
located_in mitochondrion	IMP Inferred from Mutant Phenotype more info	PubMed
part_of uniplex complex	IBA Inferred from Biological aspect of Ancestor more info
part_of uniplex complex	ISO Inferred from Sequence Orthology more info
part_of uniplex complex	ISS Inferred from Sequence or Structural Similarity more info

General protein information

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Preferred Names: calcium uptake protein 2, mitochondrial

Names: EF hand domain family A1; EF-hand domain-containing family member A1

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

NM_001418535.1 → NP_001405464.1 calcium uptake protein 2, mitochondrial isoform 2

Status: VALIDATED

Source sequence(s)

AC125399
NM_001418536.1 → NP_001405465.1 calcium uptake protein 2, mitochondrial isoform 3

Status: VALIDATED

Source sequence(s)

AC125399
NM_028643.4 → NP_082919.1 calcium uptake protein 2, mitochondrial isoform 1

See identical proteins and their annotated locations for NP_082919.1

Status: VALIDATED

Source sequence(s)

AC125399

Consensus CDS

CCDS27163.1

UniProtKB/Swiss-Prot

Q3TJU4, Q8CD10, Q8K0K2, Q9CUR8

Related

ENSMUSP00000022543.9, ENSMUST00000022543.10

Conserved Domains (1) summary

pfam13833
Location:345 → 391

EF-hand_8; EF-hand domain pair