Cd74 CD74 antigen (invariant polypeptide of major histocompatibility complex, class II antigen-associated) [Mus musculus (house mouse)] - Gene

Summary

Official Symbol: Cd74provided by MGI
Official Full Name: CD74 antigen (invariant polypeptide of major histocompatibility complex, class II antigen-associated)provided by MGI
Primary source: MGI:MGI:96534
See related: Ensembl:ENSMUSG00000024610 AllianceGenome:MGI:96534
Gene type: protein coding
RefSeq status: VALIDATED
Organism: Mus musculus
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as: Ii; CLIP; DHLAG; HLADG; Ia-GAMMA
Summary: Enables MHC class II protein binding activity; cytokine receptor activity; and nitric-oxide synthase binding activity. Contributes to cytokine binding activity. Involved in several processes, including macrophage migration inhibitory factor signaling pathway; positive regulation of cytokine production; and regulation of signal transduction. Acts upstream of or within several processes, including antigen processing and presentation of exogenous peptide antigen via MHC class II; regulation of T cell differentiation; and thymic T cell selection. Located in several cellular components, including external side of plasma membrane; lysosome; and multivesicular body. Part of MHC class II protein complex; NOS2-CD74 complex; and macrophage migration inhibitory factor receptor complex. Is expressed in lower jaw; lower jaw incisor; lower jaw molar; and thymus primordium. Orthologous to human CD74 (CD74 molecule). [provided by Alliance of Genome Resources, Oct 2024]
Expression: Biased expression in spleen adult (RPKM 2800.7), large intestine adult (RPKM 1812.1) and 12 other tissues See more
Orthologs: human all
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Genomic context

Location:: 18 E1; 18 34.41 cM

Exon count:: 9

Annotation release	Status	Assembly	Chr	Location
RS_2024_02	current	GRCm39 (GCF_000001635.27)	18	NC_000084.7 (60936921..60945724)
108.20200622	previous assembly	GRCm38.p6 (GCF_000001635.26)	18	NC_000084.6 (60803849..60812652)

Chromosome 18 - NC_000084.7 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Go to reference sequence details

Genomic Sequence:

Go to nucleotide: Graphics FASTA GenBank

Expression

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See details

Project title: Mouse ENCODE transcriptome data Mouse ENCODE transcriptome data
Description: RNA profiling data sets generated by the Mouse ENCODE project.
BioProject: PRJNA66167
Publication: PMID 25409824
Analysis date: n/a

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Macrophage migration inhibitory factor mediates skin aging via CD74: Insights from single-cell and bulk RNA sequencing data.
Title: Macrophage migration inhibitory factor mediates skin aging via CD74: Insights from single-cell and bulk RNA sequencing data.
CD74 supports accumulation and function of regulatory T cells in tumors.
Title: CD74 supports accumulation and function of regulatory T cells in tumors.
Blocking the MIF-CD74 axis augments radiotherapy efficacy for brain metastasis in NSCLC via synergistically promoting microglia M1 polarization.
Title: Blocking the MIF-CD74 axis augments radiotherapy efficacy for brain metastasis in NSCLC via synergistically promoting microglia M1 polarization.
CD74 deficiency reduces trophoblast invasion and proliferation mediated by SIRT1 in preeclampsia.
Title: CD74 deficiency reduces trophoblast invasion and proliferation mediated by SIRT1 in preeclampsia.
Tumor Necrosis Factor alpha-Dependent Lung Inflammation Promotes the Progression of Lung Adenocarcinoma Originating From Alveolar Type II Cells by Upregulating MIF-CD74.
Title: Tumor Necrosis Factor α-Dependent Lung Inflammation Promotes the Progression of Lung Adenocarcinoma Originating From Alveolar Type II Cells by Upregulating MIF-CD74.
Decreased expression of surfactant Protein-C and CD74 in alveolar epithelial cells during influenza virus A(H1N1)pdm09 and H3N2 infection.
Title: Decreased expression of surfactant Protein-C and CD74 in alveolar epithelial cells during influenza virus A(H1N1)pdm09 and H3N2 infection.
Soluble cluster of differentiation 74 regulates lung inflammation through the nuclear factor-kappaB signaling pathway.
Title: Soluble cluster of differentiation 74 regulates lung inflammation through the nuclear factor-κB signaling pathway.
CD74 is a regulator of hematopoietic stem cell maintenance.
Title: CD74 is a regulator of hematopoietic stem cell maintenance.
alpha-Hemolysin suppresses osteogenesis by inducing lipid rafts accumulation in bone marrow stromal cells.
Title: α-Hemolysin suppresses osteogenesis by inducing lipid rafts accumulation in bone marrow stromal cells.
CD74 Signaling Links Inflammation to Intestinal Epithelial Cell Regeneration and Promotes Mucosal Healing.
Title: CD74 Signaling Links Inflammation to Intestinal Epithelial Cell Regeneration and Promotes Mucosal Healing.

Submit: New GeneRIF Correction See all GeneRIFs (69)

Variation

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Alleles

Alleles of this type are documented at Mouse Genome Informatics (MGI)

Endonuclease-mediated (12) 1 citation
Targeted (6) 1 citation

Interactions

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Products	Interactant	Other Gene	Complex	Source	Pubs	Description

General gene information

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Markers

D18Mit77 (e-PCR), detects polymorphism
- UniSTS:128292

D18Mit78 (e-PCR), detects polymorphism
- UniSTS:128293

Ii (e-PCR), detects polymorphism
- UniSTS:143531

PMC154349P1 (e-PCR)
- UniSTS:271308

Gene Ontology Provided by MGI

Function	Evidence Code	Pubs
enables CD4 receptor binding	IEA Inferred from Electronic Annotation more info
enables CD4 receptor binding	ISO Inferred from Sequence Orthology more info
enables MHC class II protein binding	IBA Inferred from Biological aspect of Ancestor more info
enables MHC class II protein binding	IPI Inferred from Physical Interaction more info	PubMed
enables MHC class II protein binding, via antigen binding groove	IEA Inferred from Electronic Annotation more info
enables MHC class II protein binding, via antigen binding groove	ISO Inferred from Sequence Orthology more info
enables MHC class II protein complex binding	ISO Inferred from Sequence Orthology more info
enables amyloid-beta binding	IEA Inferred from Electronic Annotation more info
enables amyloid-beta binding	ISO Inferred from Sequence Orthology more info
contributes_to cytokine binding	IDA Inferred from Direct Assay more info	PubMed
enables cytokine binding	ISO Inferred from Sequence Orthology more info
enables cytokine receptor activity	IBA Inferred from Biological aspect of Ancestor more info
enables cytokine receptor activity	IMP Inferred from Mutant Phenotype more info	PubMed
enables cytokine receptor activity	ISO Inferred from Sequence Orthology more info
enables macrophage migration inhibitory factor binding	IBA Inferred from Biological aspect of Ancestor more info
enables macrophage migration inhibitory factor binding	IEA Inferred from Electronic Annotation more info
enables macrophage migration inhibitory factor binding	ISO Inferred from Sequence Orthology more info
enables nitric-oxide synthase binding	IPI Inferred from Physical Interaction more info	PubMed
enables protein binding	IPI Inferred from Physical Interaction more info	PubMed
enables protein folding chaperone	IEA Inferred from Electronic Annotation more info
enables protein folding chaperone	ISO Inferred from Sequence Orthology more info

Process	Evidence Code	Pubs
involved_in T cell activation involved in immune response	IBA Inferred from Biological aspect of Ancestor more info
involved_in antigen processing and presentation	IBA Inferred from Biological aspect of Ancestor more info
acts_upstream_of_or_within antigen processing and presentation	IDA Inferred from Direct Assay more info	PubMed
acts_upstream_of_or_within antigen processing and presentation	IMP Inferred from Mutant Phenotype more info	PubMed
acts_upstream_of_or_within antigen processing and presentation of exogenous peptide antigen via MHC class II	IMP Inferred from Mutant Phenotype more info	PubMed
acts_upstream_of_or_within chaperone cofactor-dependent protein refolding	IDA Inferred from Direct Assay more info	PubMed
acts_upstream_of_or_within chaperone cofactor-dependent protein refolding	IMP Inferred from Mutant Phenotype more info	PubMed
acts_upstream_of_or_within defense response	IMP Inferred from Mutant Phenotype more info	PubMed
acts_upstream_of_or_within immunoglobulin mediated immune response	IMP Inferred from Mutant Phenotype more info	PubMed
acts_upstream_of_or_within intracellular protein transport	IDA Inferred from Direct Assay more info	PubMed
acts_upstream_of_or_within intracellular protein transport	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in macrophage migration inhibitory factor signaling pathway	IDA Inferred from Direct Assay more info	PubMed
involved_in negative regulation of DNA damage response, signal transduction by p53 class mediator	IBA Inferred from Biological aspect of Ancestor more info
involved_in negative regulation of DNA damage response, signal transduction by p53 class mediator	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in negative regulation of DNA damage response, signal transduction by p53 class mediator	ISO Inferred from Sequence Orthology more info
acts_upstream_of_or_within negative regulation of T cell differentiation	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in negative regulation of apoptotic process	ISO Inferred from Sequence Orthology more info
involved_in negative regulation of apoptotic process	ISS Inferred from Sequence or Structural Similarity more info
involved_in negative regulation of cell migration	IEA Inferred from Electronic Annotation more info
involved_in negative regulation of cell migration	ISO Inferred from Sequence Orthology more info
involved_in negative regulation of intrinsic apoptotic signaling pathway in response to DNA damage by p53 class mediator	IBA Inferred from Biological aspect of Ancestor more info
involved_in negative regulation of intrinsic apoptotic signaling pathway in response to DNA damage by p53 class mediator	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in negative regulation of intrinsic apoptotic signaling pathway in response to DNA damage by p53 class mediator	ISO Inferred from Sequence Orthology more info
involved_in negative regulation of mature B cell apoptotic process	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in negative regulation of peptide secretion	IEA Inferred from Electronic Annotation more info
involved_in negative regulation of peptide secretion	ISO Inferred from Sequence Orthology more info
involved_in negative regulation of viral entry into host cell	ISO Inferred from Sequence Orthology more info
acts_upstream_of_or_within negative thymic T cell selection	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in positive regulation of B cell proliferation	IEA Inferred from Electronic Annotation more info
involved_in positive regulation of B cell proliferation	ISO Inferred from Sequence Orthology more info
involved_in positive regulation of DNA-templated transcription	IEA Inferred from Electronic Annotation more info
involved_in positive regulation of DNA-templated transcription	ISO Inferred from Sequence Orthology more info
involved_in positive regulation of ERK1 and ERK2 cascade	IBA Inferred from Biological aspect of Ancestor more info
involved_in positive regulation of ERK1 and ERK2 cascade	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in positive regulation of ERK1 and ERK2 cascade	ISO Inferred from Sequence Orthology more info
involved_in positive regulation of MAPK cascade	ISO Inferred from Sequence Orthology more info
acts_upstream_of_or_within positive regulation of T cell differentiation	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in positive regulation of adaptive immune response	NAS Non-traceable Author Statement more info	PubMed
involved_in positive regulation of canonical NF-kappaB signal transduction	IEA Inferred from Electronic Annotation more info
involved_in positive regulation of canonical NF-kappaB signal transduction	ISO Inferred from Sequence Orthology more info
involved_in positive regulation of chemokine (C-X-C motif) ligand 2 production	IDA Inferred from Direct Assay more info	PubMed
involved_in positive regulation of chemokine production	ISO Inferred from Sequence Orthology more info
involved_in positive regulation of cytokine-mediated signaling pathway	IBA Inferred from Biological aspect of Ancestor more info
involved_in positive regulation of cytokine-mediated signaling pathway	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in positive regulation of cytokine-mediated signaling pathway	ISO Inferred from Sequence Orthology more info
involved_in positive regulation of dendritic cell antigen processing and presentation	IDA Inferred from Direct Assay more info	PubMed
involved_in positive regulation of fibroblast proliferation	IEA Inferred from Electronic Annotation more info
involved_in positive regulation of fibroblast proliferation	ISO Inferred from Sequence Orthology more info
involved_in positive regulation of gene expression	ISO Inferred from Sequence Orthology more info
involved_in positive regulation of innate immune response	IC Inferred by Curator more info	PubMed
involved_in positive regulation of interleukin-6 production	IEA Inferred from Electronic Annotation more info
involved_in positive regulation of interleukin-6 production	ISO Inferred from Sequence Orthology more info
involved_in positive regulation of interleukin-8 production	IEA Inferred from Electronic Annotation more info
involved_in positive regulation of interleukin-8 production	ISO Inferred from Sequence Orthology more info
involved_in positive regulation of kinase activity	IEA Inferred from Electronic Annotation more info
involved_in positive regulation of kinase activity	ISO Inferred from Sequence Orthology more info
involved_in positive regulation of macrophage cytokine production	IBA Inferred from Biological aspect of Ancestor more info
involved_in positive regulation of macrophage cytokine production	IDA Inferred from Direct Assay more info	PubMed
involved_in positive regulation of macrophage migration inhibitory factor signaling pathway	IEA Inferred from Electronic Annotation more info
involved_in positive regulation of macrophage migration inhibitory factor signaling pathway	ISO Inferred from Sequence Orthology more info
involved_in positive regulation of monocyte differentiation	IEA Inferred from Electronic Annotation more info
involved_in positive regulation of monocyte differentiation	ISO Inferred from Sequence Orthology more info
involved_in positive regulation of neutrophil chemotaxis	IDA Inferred from Direct Assay more info	PubMed
involved_in positive regulation of peptidyl-tyrosine phosphorylation	ISO Inferred from Sequence Orthology more info
involved_in positive regulation of prostaglandin biosynthetic process	IEA Inferred from Electronic Annotation more info
involved_in positive regulation of prostaglandin biosynthetic process	ISO Inferred from Sequence Orthology more info
involved_in positive regulation of protein phosphorylation	IEA Inferred from Electronic Annotation more info
involved_in positive regulation of protein phosphorylation	ISO Inferred from Sequence Orthology more info
involved_in positive regulation of type 2 immune response	IBA Inferred from Biological aspect of Ancestor more info
involved_in positive regulation of type 2 immune response	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in positive regulation of viral entry into host cell	IEA Inferred from Electronic Annotation more info
involved_in positive regulation of viral entry into host cell	ISO Inferred from Sequence Orthology more info
acts_upstream_of_or_within positive thymic T cell selection	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in prostaglandin biosynthetic process	ISO Inferred from Sequence Orthology more info
involved_in prostaglandin biosynthetic process	ISS Inferred from Sequence or Structural Similarity more info
involved_in protein stabilization	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in protein trimerization	IEA Inferred from Electronic Annotation more info
acts_upstream_of_or_within protein-containing complex assembly	IDA Inferred from Direct Assay more info	PubMed
involved_in response to type II interferon	IDA Inferred from Direct Assay more info	PubMed
involved_in response to type II interferon	ISO Inferred from Sequence Orthology more info

Component	Evidence Code	Pubs
located_in Golgi apparatus	IDA Inferred from Direct Assay more info	PubMed
part_of MHC class II protein complex	IDA Inferred from Direct Assay more info	PubMed
part_of NOS2-CD74 complex	IDA Inferred from Direct Assay more info	PubMed
is_active_in cell surface	IBA Inferred from Biological aspect of Ancestor more info
located_in cell surface	ISO Inferred from Sequence Orthology more info
is_active_in cytoplasm	IBA Inferred from Biological aspect of Ancestor more info
located_in cytoplasm	ISO Inferred from Sequence Orthology more info
located_in endoplasmic reticulum	IDA Inferred from Direct Assay more info	PubMed
located_in endoplasmic reticulum membrane	IEA Inferred from Electronic Annotation more info
located_in external side of plasma membrane	IDA Inferred from Direct Assay more info	PubMed
located_in extracellular region	IEA Inferred from Electronic Annotation more info
located_in extracellular space	IDA Inferred from Direct Assay more info	PubMed
located_in late endosome	IDA Inferred from Direct Assay more info	PubMed
located_in lysosome	IDA Inferred from Direct Assay more info	PubMed
part_of macrophage migration inhibitory factor receptor complex	IDA Inferred from Direct Assay more info	PubMed
part_of macrophage migration inhibitory factor receptor complex	ISO Inferred from Sequence Orthology more info
located_in membrane	ISO Inferred from Sequence Orthology more info
located_in multivesicular body	IDA Inferred from Direct Assay more info	PubMed
located_in nucleus	IEA Inferred from Electronic Annotation more info
located_in nucleus	ISO Inferred from Sequence Orthology more info
located_in plasma membrane	IDA Inferred from Direct Assay more info	PubMed
located_in plasma membrane	IMP Inferred from Mutant Phenotype more info	PubMed
located_in plasma membrane	ISO Inferred from Sequence Orthology more info
located_in plasma membrane	TAS Traceable Author Statement more info	PubMed
part_of protein-containing complex	ISO Inferred from Sequence Orthology more info
located_in vacuole	ISO Inferred from Sequence Orthology more info

General protein information

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Preferred Names: H-2 class II histocompatibility antigen gamma chain

Names: HLA-DR-GAMMA; Ia-associated invariant chain; MHC class II-associated invariant chain; class II-associated invariant chain peptide; dinucleotide microsatellite; histocompatibility: class II antigens, gamma chain of; ia antigen-associated invariant chain; ii chain; invariant polypeptide of major histocompatibility complex, class II antigen-associated

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

NM_001042605.1 → NP_001036070.1 H-2 class II histocompatibility antigen gamma chain isoform 1

See identical proteins and their annotated locations for NP_001036070.1

Status: VALIDATED

Source sequence(s)

AK002232, AW123644, BG148172

Consensus CDS

CCDS37835.1

UniProtKB/Swiss-Prot

O19452, P04441

UniProtKB/TrEMBL

Q3U4Q8

Related

ENSMUSP00000095171.3, ENSMUST00000097563.9

Conserved Domains (3) summary

cd00191
Location:195 → 254

TY; Thyroglobulin type I repeats.; The N-terminal region of human thyroglobulin contains 11 type-1 repeats TY repeats are proposed to be inhibitors of cysteine proteases

pfam08831
Location:119 → 184

MHCassoc_trimer; Class II MHC-associated invariant chain trimerization domain

pfam09307
Location:1 → 111

MHC2-interact; CLIP, MHC2 interacting
NM_010545.3 → NP_034675.1 H-2 class II histocompatibility antigen gamma chain isoform 2

See identical proteins and their annotated locations for NP_034675.1

Status: VALIDATED

Source sequence(s)

AK002232, AW123644

Consensus CDS

CCDS50299.1

UniProtKB/TrEMBL

Q545Y5

Related

ENSMUSP00000057836.9, ENSMUST00000050487.16

Conserved Domains (2) summary

pfam08831
Location:119 → 184

MHCassoc_trimer; Class II MHC-associated invariant chain trimerization domain

pfam09307
Location:1 → 111

MHC2-interact; CLIP, MHC2 interacting