B4galt3 UDP-Gal:betaGlcNAc beta 1,4-galactosyltransferase, polypeptide 3 [Mus musculus (house mouse)] - Gene

Summary

Official Symbol: B4galt3provided by MGI
Official Full Name: UDP-Gal:betaGlcNAc beta 1,4-galactosyltransferase, polypeptide 3provided by MGI
Primary source: MGI:MGI:1928767
See related: Ensembl:ENSMUSG00000052423 AllianceGenome:MGI:1928767
Gene type: protein coding
RefSeq status: VALIDATED
Organism: Mus musculus
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as: ESTM6; ESTM26; 9530061M23Rik
Summary: Predicted to enable galactosyltransferase activity. Predicted to be involved in galactosylceramide biosynthetic process and glycosylation. Predicted to be located in cytosol. Predicted to be active in Golgi apparatus. Is expressed in several structures, including alimentary system; eye; genitourinary system; nervous system; and respiratory system. Orthologous to human B4GALT3 (beta-1,4-galactosyltransferase 3). [provided by Alliance of Genome Resources, Oct 2024]
Expression: Ubiquitous expression in duodenum adult (RPKM 38.6), ovary adult (RPKM 29.1) and 28 other tissues See more
Orthologs: human all
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Genomic context

Location:: 1 H3; 1 79.29 cM

Exon count:: 8

Annotation release	Status	Assembly	Chr	Location
RS_2024_02	current	GRCm39 (GCF_000001635.27)	1	NC_000067.7 (171097898..171104468)
108.20200622	previous assembly	GRCm38.p6 (GCF_000001635.26)	1	NC_000067.6 (171270328..171276895)

Chromosome 1 - NC_000067.7 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Genomic Sequence:

Go to nucleotide: Graphics FASTA GenBank

Expression

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See details

Project title: Mouse ENCODE transcriptome data Mouse ENCODE transcriptome data
Description: RNA profiling data sets generated by the Mouse ENCODE project.
BioProject: PRJNA66167
Publication: PMID 25409824
Analysis date: n/a

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Beta-1,4-galactosyltransferase-3 deficiency suppresses the growth of immunogenic tumors in mice.
Title: Beta-1,4-galactosyltransferase-3 deficiency suppresses the growth of immunogenic tumors in mice.

Submit: New GeneRIF Correction

Variation

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Alleles

Alleles of this type are documented at Mouse Genome Informatics (MGI)

Endonuclease-mediated (3)

General gene information

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Markers

AW125175 (e-PCR)
- UniSTS:178515

RH128542 (e-PCR)
- UniSTS:211850

AA104562 (e-PCR), detects polymorphism
- UniSTS:143012

RH125138 (e-PCR)
- UniSTS:161960

RH64578 (e-PCR)
- UniSTS:32953

Gene Ontology Provided by MGI

Function	Evidence Code	Pubs
enables N-acetyllactosamine synthase activity	IEA Inferred from Electronic Annotation more info
enables beta-N-acetylglucosaminylglycopeptide beta-1,4-galactosyltransferase activity	IEA Inferred from Electronic Annotation more info
enables galactosyltransferase activity	IBA Inferred from Biological aspect of Ancestor more info
enables galactosyltransferase activity	ISO Inferred from Sequence Orthology more info
enables metal ion binding	IEA Inferred from Electronic Annotation more info

Process	Evidence Code	Pubs
involved_in carbohydrate metabolic process	IEA Inferred from Electronic Annotation more info
involved_in galactosylceramide biosynthetic process	IBA Inferred from Biological aspect of Ancestor more info
involved_in galactosylceramide biosynthetic process	IEA Inferred from Electronic Annotation more info
involved_in galactosylceramide biosynthetic process	ISO Inferred from Sequence Orthology more info
involved_in glycosylation	IBA Inferred from Biological aspect of Ancestor more info
involved_in protein glycosylation	IEA Inferred from Electronic Annotation more info

Component	Evidence Code	Pubs
is_active_in Golgi apparatus	IBA Inferred from Biological aspect of Ancestor more info
located_in Golgi apparatus	ISO Inferred from Sequence Orthology more info
located_in Golgi cisterna membrane	IEA Inferred from Electronic Annotation more info
located_in cytosol	IEA Inferred from Electronic Annotation more info
located_in cytosol	ISO Inferred from Sequence Orthology more info

General protein information

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Preferred Names: beta-1,4-galactosyltransferase 3

Names: N-acetyllactosamine synthase; UDP-Gal:beta-GlcNAc beta-1,4-galactosyltransferase 3; UDP-Gal:betaGlcNAc beta 1,4-galactosyltransferase, polypeptide 3; beta-1,4-galactosyltransferase III; beta4GalT-III; expressed sequence tag mouse EST 6; UDP-galactose:beta-N-acetylglucosamine beta-1,4-galactosyltransferase 3; b4Gal-T3; beta-1,4-GalTase 3; beta-1,4-galactosyltransferase III; beta-N-acetylglucosaminyl-glycolipid beta-1,4-galactosyltransferase; beta-N-acetylglucosaminylglycopeptide beta-1,4-galactosyltransferase; beta4Gal-T3; beta4GalT-III; nal synthase; neolactotriaosylceramide beta-1,4-galactosyltransferase

NP_065604.2

EC 2.4.1.275

EC 2.4.1.38

EC 2.4.1.90

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

NM_001433474.1 → NP_001420403.1 beta-1,4-galactosyltransferase 3

Status: VALIDATED

Source sequence(s)

AC087229
NM_020579.3 → NP_065604.2 beta-1,4-galactosyltransferase 3

See identical proteins and their annotated locations for NP_065604.2

Status: VALIDATED

Source sequence(s)

AC087229

Consensus CDS

CCDS15486.1

UniProtKB/Swiss-Prot

Q91YY2, Q9QY13

UniProtKB/TrEMBL

Q3U260

Related

ENSMUSP00000066353.4, ENSMUST00000064272.10

Conserved Domains (1) summary

cd00899
Location:124 → 343

b4GalT; Beta-4-Galactosyltransferase is involved in the formation of the poly-N-acetyllactosamine core structures present in glycoproteins and glycosphingolipids