Syt7 synaptotagmin VII [Mus musculus (house mouse)] - Gene

Summary

Official Symbol: Syt7provided by MGI
Official Full Name: synaptotagmin VIIprovided by MGI
Primary source: MGI:MGI:1859545
See related: Ensembl:ENSMUSG00000024743 AllianceGenome:MGI:1859545
Gene type: protein coding
RefSeq status: VALIDATED
Organism: Mus musculus
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as: B230112P13Rik
Summary: Enables SNARE binding activity; calmodulin binding activity; and phospholipid binding activity. Involved in several processes, including calcium ion regulated lysosome exocytosis; regulation of secretion by cell; and synaptic vesicle cycle. Acts upstream of or within plasma membrane repair. Located in several cellular components, including cytoplasmic vesicle; neuronal cell body; and presynaptic membrane. Is active in GABA-ergic synapse and glutamatergic synapse. Is expressed in several structures, including alimentary system; genitourinary system; nervous system; respiratory system; and sensory organ. Orthologous to human SYT7 (synaptotagmin 7). [provided by Alliance of Genome Resources, Oct 2024]
Expression: Biased expression in cortex adult (RPKM 37.8), frontal lobe adult (RPKM 34.9) and 13 other tissues See more
Orthologs: human all
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Genomic context

Location:: 19 A; 19 6.58 cM

Exon count:: 15

Annotation release	Status	Assembly	Chr	Location
RS_2024_02	current	GRCm39 (GCF_000001635.27)	19	NC_000085.7 (10366142..10430545)
108.20200622	previous assembly	GRCm38.p6 (GCF_000001635.26)	19	NC_000085.6 (10388802..10453181)

Chromosome 19 - NC_000085.7 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Go to reference sequence details

Genomic Sequence:

Go to nucleotide: Graphics FASTA GenBank

Expression

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See details

Project title: Mouse ENCODE transcriptome data Mouse ENCODE transcriptome data
Description: RNA profiling data sets generated by the Mouse ENCODE project.
BioProject: PRJNA66167
Publication: PMID 25409824
Analysis date: n/a

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Region-Related Differences in Short-Term Synaptic Plasticity and Synaptotagmin-7 in the Male and Female Hippocampus of a Rat Model of Fragile X Syndrome.
Title: Region-Related Differences in Short-Term Synaptic Plasticity and Synaptotagmin-7 in the Male and Female Hippocampus of a Rat Model of Fragile X Syndrome.
Double-strand-break repair protein rad21 homolog/Synaptotagmin-7 alleviates Alzheimer's disease in mice by promoting M2 polarization of microglia.
Title: Double-strand-break repair protein rad21 homolog/Synaptotagmin-7 alleviates Alzheimer's disease in mice by promoting M2 polarization of microglia.
Synaptotagmin 7 docks synaptic vesicles to support facilitation and Doc2alpha-triggered asynchronous release.
Title: Synaptotagmin 7 docks synaptic vesicles to support facilitation and Doc2α-triggered asynchronous release.
Synaptotagmin-7 Counteracts Short-Term Depression during Phasic Dopamine Release.
Title: Synaptotagmin-7 Counteracts Short-Term Depression during Phasic Dopamine Release.
Synaptotagmin 7 Sculpts Short-Term Plasticity at a High Probability Synapse.
Title: Synaptotagmin 7 Sculpts Short-Term Plasticity at a High Probability Synapse.
miR-93 and synaptotagmin-7: two novel players in the regulation of autophagy during cardiac hypertrophy.
Title: miR-93 and synaptotagmin-7: two novel players in the regulation of autophagy during cardiac hypertrophy.
Synaptotagmin-7 mediates cardiac hypertrophy by targeting autophagy.
Title: Synaptotagmin-7 mediates cardiac hypertrophy by targeting autophagy.
Excessive iron inhibits insulin secretion via perturbing transcriptional regulation of SYT7 by OGG1.
Title: Excessive iron inhibits insulin secretion via perturbing transcriptional regulation of SYT7 by OGG1.
Synaptotagmins 1 and 7 Play Complementary Roles in Somatodendritic Dopamine Release.
Title: Synaptotagmins 1 and 7 Play Complementary Roles in Somatodendritic Dopamine Release.
Effects and Mechanisms of Synaptotagmin-7 in the Hippocampus on Cognitive Impairment in Aging Mice.
Title: Effects and Mechanisms of Synaptotagmin-7 in the Hippocampus on Cognitive Impairment in Aging Mice.

Submit: New GeneRIF Correction See all GeneRIFs (51)

Variation

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Alleles

Alleles of this type are documented at Mouse Genome Informatics (MGI)

Endonuclease-mediated (7) 1 citation
Targeted (6) 1 citation

Interactions

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Products	Interactant	Other Gene	Complex	Source	Pubs	Description

General gene information

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Markers

NoName (e-PCR)
- UniSTS:489540

Syt7 (e-PCR), detects polymorphism
- UniSTS:507266

AI851541 (e-PCR)
- UniSTS:166125

Gene Ontology Provided by MGI

Function	Evidence Code	Pubs
enables SNARE binding	IBA Inferred from Biological aspect of Ancestor more info
enables SNARE binding	IDA Inferred from Direct Assay more info	PubMed
enables calcium ion binding	ISO Inferred from Sequence Orthology more info
enables calcium ion sensor activity	IBA Inferred from Biological aspect of Ancestor more info
enables calcium-dependent phospholipid binding	IBA Inferred from Biological aspect of Ancestor more info
enables calcium-dependent phospholipid binding	IDA Inferred from Direct Assay more info	PubMed
enables calcium-dependent phospholipid binding	ISO Inferred from Sequence Orthology more info
enables calmodulin binding	IDA Inferred from Direct Assay more info	PubMed
enables clathrin binding	ISO Inferred from Sequence Orthology more info
enables metal ion binding	IEA Inferred from Electronic Annotation more info
enables phosphatidylinositol-4,5-bisphosphate binding	IDA Inferred from Direct Assay more info	PubMed
enables phosphatidylserine binding	IDA Inferred from Direct Assay more info	PubMed
enables protein binding	IPI Inferred from Physical Interaction more info	PubMed
enables syntaxin binding	ISO Inferred from Sequence Orthology more info

Process	Evidence Code	Pubs
involved_in calcium ion regulated lysosome exocytosis	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in calcium ion regulated lysosome exocytosis	ISO Inferred from Sequence Orthology more info
involved_in calcium ion regulated lysosome exocytosis	ISS Inferred from Sequence or Structural Similarity more info
involved_in calcium ion-regulated exocytosis of neurotransmitter	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in calcium-dependent activation of synaptic vesicle fusion	IBA Inferred from Biological aspect of Ancestor more info
involved_in calcium-dependent activation of synaptic vesicle fusion	IDA Inferred from Direct Assay more info	PubMed
involved_in calcium-dependent activation of synaptic vesicle fusion	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in calcium-ion regulated exocytosis	ISO Inferred from Sequence Orthology more info
involved_in phagocytosis	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in phagosome-lysosome fusion	IMP Inferred from Mutant Phenotype more info	PubMed
acts_upstream_of_or_within plasma membrane repair	IDA Inferred from Direct Assay more info	PubMed
involved_in plasma membrane repair	ISO Inferred from Sequence Orthology more info
involved_in positive regulation of calcium ion-dependent exocytosis	ISO Inferred from Sequence Orthology more info
involved_in regulation of bone remodeling	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in regulation of calcium ion-dependent exocytosis	IBA Inferred from Biological aspect of Ancestor more info
involved_in regulation of calcium ion-dependent exocytosis	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in regulation of calcium ion-dependent exocytosis	ISO Inferred from Sequence Orthology more info
involved_in regulation of dopamine secretion	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in regulation of glucagon secretion	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in regulation of insulin secretion	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in regulation of insulin secretion	ISO Inferred from Sequence Orthology more info
involved_in regulation of phagocytosis	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in regulation of synaptic vesicle endocytosis	ISO Inferred from Sequence Orthology more info
involved_in short-term synaptic potentiation	IDA Inferred from Direct Assay more info	PubMed
involved_in short-term synaptic potentiation	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in synaptic vesicle recycling	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in vesicle fusion	IBA Inferred from Biological aspect of Ancestor more info
involved_in vesicle-mediated cholesterol transport	IDA Inferred from Direct Assay more info	PubMed
involved_in vesicle-mediated transport	IBA Inferred from Biological aspect of Ancestor more info

Component	Evidence Code	Pubs
is_active_in GABA-ergic synapse	IDA Inferred from Direct Assay more info	PubMed
is_active_in GABA-ergic synapse	IMP Inferred from Mutant Phenotype more info	PubMed
is_active_in axon	IBA Inferred from Biological aspect of Ancestor more info
located_in axon terminus	IDA Inferred from Direct Assay more info	PubMed
located_in cytosol	IEA Inferred from Electronic Annotation more info
located_in dendrite	IDA Inferred from Direct Assay more info	PubMed
located_in dense core granule	ISO Inferred from Sequence Orthology more info
located_in early phagosome	IDA Inferred from Direct Assay more info	PubMed
is_active_in glutamatergic synapse	IDA Inferred from Direct Assay more info	PubMed
is_active_in glutamatergic synapse	IMP Inferred from Mutant Phenotype more info	PubMed
is_active_in hippocampal mossy fiber to CA3 synapse	ISO Inferred from Sequence Orthology more info
located_in lysosomal membrane	IEA Inferred from Electronic Annotation more info
located_in lysosome	IDA Inferred from Direct Assay more info	PubMed
located_in lysosome	ISO Inferred from Sequence Orthology more info
located_in neuronal cell body	IDA Inferred from Direct Assay more info	PubMed
located_in peroxisomal membrane	IEA Inferred from Electronic Annotation more info
located_in peroxisome	IDA Inferred from Direct Assay more info	PubMed
located_in phagocytic vesicle membrane	IEA Inferred from Electronic Annotation more info
is_active_in plasma membrane	IBA Inferred from Biological aspect of Ancestor more info
located_in presynaptic membrane	IDA Inferred from Direct Assay more info	PubMed
is_active_in presynaptic membrane	ISO Inferred from Sequence Orthology more info
is_active_in synapse	IBA Inferred from Biological aspect of Ancestor more info
is_active_in synaptic vesicle	IBA Inferred from Biological aspect of Ancestor more info
located_in synaptic vesicle	IMP Inferred from Mutant Phenotype more info	PubMed
located_in synaptic vesicle membrane	IEA Inferred from Electronic Annotation more info

General protein information

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Preferred Names: synaptotagmin-7

Names: sytVII

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

NM_001373944.1 → NP_001360873.1 synaptotagmin-7 isoform 4

Status: VALIDATED

Source sequence(s)

AC124169

Consensus CDS

CCDS89341.1

UniProtKB/TrEMBL

A0A2C9F2C1

Related

ENSMUSP00000076234.5, ENSMUST00000076968.11

Conserved Domains (2) summary

cd08386
Location:343 → 467

C2A_Synaptotagmin-7; C2A domain first repeat present in Synaptotagmin 7

cd08405
Location:475 → 610

C2B_Synaptotagmin-7; C2 domain second repeat present in Synaptotagmin 7
NM_018801.3 → NP_061271.1 synaptotagmin-7 isoform alpha

See identical proteins and their annotated locations for NP_061271.1

Status: VALIDATED

Source sequence(s)

AC124169

Consensus CDS

CCDS29575.1

UniProtKB/Swiss-Prot

A4QPF1, E9PZA8, Q0D2K7, Q8CF95, Q8CF96, Q9R0N7

UniProtKB/TrEMBL

A0A494B9N4

Related

ENSMUSP00000073560.5, ENSMUST00000073899.6

Conserved Domains (2) summary

cd08386
Location:135 → 259

C2A_Synaptotagmin-7; C2A domain first repeat present in Synaptotagmin 7

cd08405
Location:267 → 402

C2B_Synaptotagmin-7; C2 domain second repeat present in Synaptotagmin 7
NM_173067.3 → NP_775090.1 synaptotagmin-7 isoform beta

See identical proteins and their annotated locations for NP_775090.1

Status: VALIDATED

Source sequence(s)

AC124169

Consensus CDS

CCDS29576.1

UniProtKB/TrEMBL

A0A494B9N4

Related

ENSMUSP00000153482.2, ENSMUST00000223586.2

Conserved Domains (2) summary

cd08386
Location:179 → 303

C2A_Synaptotagmin-7; C2A domain first repeat present in Synaptotagmin 7

cd08405
Location:311 → 446

C2B_Synaptotagmin-7; C2 domain second repeat present in Synaptotagmin 7
NM_173068.2 → NP_775091.2 synaptotagmin-7 isoform gamma

Status: VALIDATED

Source sequence(s)

AC124169

Consensus CDS

CCDS50388.1

UniProtKB/Swiss-Prot

Q9R0N7

Related

ENSMUSP00000153132.3, ENSMUST00000224135.3

Conserved Domains (2) summary

cd08386
Location:299 → 423

C2A_Synaptotagmin-7; C2A domain first repeat present in Synaptotagmin 7

cd08405
Location:431 → 566

C2B_Synaptotagmin-7; C2 domain second repeat present in Synaptotagmin 7

RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm39 C57BL/6J

Genomic

NC_000085.7 Reference GRCm39 C57BL/6J

Range

10366142..10430545

Download

GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

XM_006527204.5 → XP_006527267.1 synaptotagmin-7 isoform X2

UniProtKB/TrEMBL

A0A498WGM0

Related

ENSMUSP00000127973.3, ENSMUST00000169121.9

Conserved Domains (3) summary

cd08386
Location:419 → 543

C2A_Synaptotagmin-7; C2A domain first repeat present in Synaptotagmin 7

cd08405
Location:551 → 686

C2B_Synaptotagmin-7; C2 domain second repeat present in Synaptotagmin 7

PHA03307
Location:106 → 311

PHA03307; transcriptional regulator ICP4; Provisional
XM_030250995.2 → XP_030106855.1 synaptotagmin-7 isoform X5

UniProtKB/TrEMBL

A0A494B991, A0A494BB44

Related

ENSMUSP00000158359.2, ENSMUST00000235784.2

Conserved Domains (3) summary

cd08386
Location:375 → 499

C2A_Synaptotagmin-7; C2A domain first repeat present in Synaptotagmin 7

cd08405
Location:507 → 642

C2B_Synaptotagmin-7; C2 domain second repeat present in Synaptotagmin 7

PHA03307
Location:100 → 267

PHA03307; transcriptional regulator ICP4; Provisional
XM_030250997.2 → XP_030106857.1 synaptotagmin-7 isoform X9

Conserved Domains (2) summary

cd08386
Location:242 → 366

C2A_Synaptotagmin-7; C2A domain first repeat present in Synaptotagmin 7

cd08405
Location:374 → 509

C2B_Synaptotagmin-7; C2 domain second repeat present in Synaptotagmin 7
XM_030250994.1 → XP_030106854.1 synaptotagmin-7 isoform X1

Conserved Domains (3) summary

cd08386
Location:451 → 575

C2A_Synaptotagmin-7; C2A domain first repeat present in Synaptotagmin 7

cd08405
Location:583 → 718

C2B_Synaptotagmin-7; C2 domain second repeat present in Synaptotagmin 7

PHA03307
Location:138 → 343

PHA03307; transcriptional regulator ICP4; Provisional
XM_036161637.1 → XP_036017530.1 synaptotagmin-7 isoform X4

Conserved Domains (2) summary

cd08386
Location:375 → 499

C2A_Synaptotagmin-7; C2A domain first repeat present in Synaptotagmin 7

cd08405
Location:507 → 642

C2B_Synaptotagmin-7; C2 domain second repeat present in Synaptotagmin 7
XM_017318255.1 → XP_017173744.1 synaptotagmin-7 isoform X10

UniProtKB/TrEMBL

A0A494B9N4

Conserved Domains (2) summary

cd08386
Location:211 → 335

C2A_Synaptotagmin-7; C2A domain first repeat present in Synaptotagmin 7

cd08405
Location:343 → 478

C2B_Synaptotagmin-7; C2 domain second repeat present in Synaptotagmin 7
XM_017318252.1 → XP_017173741.1 synaptotagmin-7 isoform X3

Conserved Domains (2) summary

cd08386
Location:407 → 531

C2A_Synaptotagmin-7; C2A domain first repeat present in Synaptotagmin 7

cd08405
Location:539 → 674

C2B_Synaptotagmin-7; C2 domain second repeat present in Synaptotagmin 7
XM_017318253.1 → XP_017173742.1 synaptotagmin-7 isoform X7

Conserved Domains (2) summary

cd08386
Location:331 → 455

C2A_Synaptotagmin-7; C2A domain first repeat present in Synaptotagmin 7

cd08405
Location:463 → 598

C2B_Synaptotagmin-7; C2 domain second repeat present in Synaptotagmin 7
XM_017318257.1 → XP_017173746.1 synaptotagmin-7 isoform X11

UniProtKB/TrEMBL

A0A494B9N4

Conserved Domains (2) summary

cd08386
Location:167 → 291

C2A_Synaptotagmin-7; C2A domain first repeat present in Synaptotagmin 7

cd08405
Location:299 → 434

C2B_Synaptotagmin-7; C2 domain second repeat present in Synaptotagmin 7
XM_036161638.1 → XP_036017531.1 synaptotagmin-7 isoform X6

Conserved Domains (3) summary

cd08386
Location:366 → 490

C2A_Synaptotagmin-7; C2A domain first repeat present in Synaptotagmin 7

cd08405
Location:498 → 633

C2B_Synaptotagmin-7; C2 domain second repeat present in Synaptotagmin 7

PHA03307
Location:91 → 258

PHA03307; transcriptional regulator ICP4; Provisional
XM_030250996.2 → XP_030106856.1 synaptotagmin-7 isoform X8

Conserved Domains (2) summary

cd08386
Location:300 → 424

C2A_Synaptotagmin-7; C2A domain first repeat present in Synaptotagmin 7

cd08405
Location:432 → 567

C2B_Synaptotagmin-7; C2 domain second repeat present in Synaptotagmin 7