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    Trpv5 transient receptor potential cation channel, subfamily V, member 5 [ Mus musculus (house mouse) ]

    Gene ID: 194352, updated on 2-Nov-2024

    Summary

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    Official Symbol
    Trpv5provided by MGI
    Official Full Name
    transient receptor potential cation channel, subfamily V, member 5provided by MGI
    Primary source
    MGI:MGI:2429764
    See related
    Ensembl:ENSMUSG00000036899 AllianceGenome:MGI:2429764
    Gene type
    protein coding
    RefSeq status
    PROVISIONAL
    Organism
    Mus musculus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
    Also known as
    CAT2; ECAC1; D630033B11
    Summary
    Enables calcium channel activity. Involved in calcium ion homeostasis; calcium ion transmembrane transport; and regulation of urine volume. Located in apical plasma membrane. Part of calcium channel complex. Is expressed in central nervous system; metanephros; and sensory organ. Orthologous to human TRPV5 (transient receptor potential cation channel subfamily V member 5). [provided by Alliance of Genome Resources, Nov 2024]
    Expression
    Biased expression in kidney adult (RPKM 1.9), placenta adult (RPKM 0.2) and 2 other tissues See more
    Orthologs
    human all
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    Genomic context

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    See Trpv5 in Genome Data Viewer
    Location:
    6 B2.1; 6 19.83 cM
    Exon count:
    16
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCm39 (GCF_000001635.27) 6 NC_000072.7 (41628595..41658158, complement)
    108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 6 NC_000072.6 (41651661..41681224, complement)

    Chromosome 6 - NC_000072.7Genomic Context describing neighboring genes Neighboring gene Eph receptor B6 Neighboring gene predicted gene, 38795 Neighboring gene transient receptor potential cation channel, subfamily V, member 6 Neighboring gene predicted gene, 34642 Neighboring gene LLLL and CFNLAS motif containing 1 Neighboring gene Kell blood group

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: Mouse ENCODE transcriptome data Mouse ENCODE transcriptome data
    • Description: RNA profiling data sets generated by the Mouse ENCODE project.
    • BioProject: PRJNA66167
    • Publication: PMID 25409824
    • Analysis date: n/a

    Bibliography

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    Related articles in PubMed

    1. Bone resorption inhibitor alendronate normalizes the reduced bone thickness of TRPV5(-/-) mice. Nijenhuis T, et al. J Bone Miner Res, 2008 Nov. PMID 18597625
    2. Regulation of the epithelial calcium channel TRPV5 by extracellular factors. Topala CN, et al. Curr Opin Nephrol Hypertens, 2007 Jul. PMID 17565273
    3. Calcitonin-stimulated renal Ca2+ reabsorption occurs independently of TRPV5. Hsu YJ, et al. Nephrol Dial Transplant, 2010 May. PMID 19965988
    4. Hypervitaminosis D mediates compensatory Ca2+ hyperabsorption in TRPV5 knockout mice. Renkema KY, et al. J Am Soc Nephrol, 2005 Nov. PMID 16148038
    5. The TRPV5 promoter as a tool for generation of transgenic mouse models. Hofmeister MV, et al. Adv Exp Med Biol, 2011. PMID 21290301

    See all (63) citations in PubMed

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?
    1. NF-kappaB plays an important role in the transcriptional activation of estrogen-ERalpha stimulated TRPV5 expression to inhibit bone resorption and osteoclastogenesis.
      Title: Regulation of TRPV5 transcription and expression by E2/ERα signalling contributes to inhibition of osteoclastogenesis.
    2. This study found that TRPV5 and TRPV6 are involved in calcium transport in the placenta and bone, and therefore play a role in calcium homeostasis during embryonic and fetal development.
      Title: TRPV5 and TRPV6 are expressed in placenta and bone tissues during pregnancy in mice.
    3. life-long challenge of Ca2+ homeostasis present in Trpv5-/- mice causes accelerated bone aging and a low cortical and trabecular bone mass phenotype
      Title: Lifelong challenge of calcium homeostasis in male mice lacking TRPV5 leads to changes in bone and calcium metabolism.
    4. beta-gal is present in the pro-urine from where it is thought to stimulate TRPV5 activity.
      Title: Urinary β-galactosidase stimulates Ca2+ transport by stabilizing TRPV5 at the plasma membrane.
    5. A novel primary cell model with TRPV5-dependent Ca(2+) transport characteristics was successfully established.
      Title: Coordinated regulation of TRPV5-mediated Ca²⁺ transport in primary distal convolution cultures.
    6. Phosphorylation of beta1-AR by PKA stimulates active Ca(2+)influx through TRPV5.
      Title: β1-Adrenergic receptor signaling activates the epithelial calcium channel, transient receptor potential vanilloid type 5 (TRPV5), via the protein kinase A pathway.
    7. The expression of TRPV5 channel is regulated by estrogen via estrogen receptor in osteoblasts.
      Title: Estrogen inhibits RANKL-induced osteoclastic differentiation by increasing the expression of TRPV5 channel.
    8. Uromodulin upregulates TRPV5 by decreasing caveolin-1 dependent endocytosis of TRPV5.
      Title: Uromodulin upregulates TRPV5 by impairing caveolin-mediated endocytosis.
    9. In colitis in mice, tumor necrosis factor and interferon-gamma reduced expression of Klotho, which otherwise would protect TRPV5 from hypersialylation and cytokine-induced TRPV5 endocytosis, UBR4-dependent ubiquitination, degradation, and Ca(2+) wasting.
      Title: Post-translational loss of renal TRPV5 calcium channel expression, Ca(2+) wasting, and bone loss in experimental colitis.
    10. The TRPV5 S682P mutant is a functionally significant factor in autosomal dominant hypercalciuria.
      Title: Autosomal dominant hypercalciuria in a mouse model due to a mutation of the epithelial calcium channel, TRPV5.
    Submit: New GeneRIF Correction See all GeneRIFs (24)

    Variation

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    Alleles

    Alleles of this type are documented at Mouse Genome Informatics  (MGI)

    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Markers

    Homology

    Clone Names

    • MGC129346, MGC129347

    Gene Ontology Provided by MGI

    Function Evidence Code Pubs
    enables calcium channel activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables calcium channel activity IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    enables calcium channel activity IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    enables calcium channel activity ISO
    Inferred from Sequence Orthology
    more info
    		  
    enables calmodulin binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables metal ion binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables protein binding IPI
    Inferred from Physical Interaction
    more info
    		 PubMed 
    Process Evidence Code Pubs
    involved_in calcium ion homeostasis IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in calcium ion import across plasma membrane IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in calcium ion import across plasma membrane ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in calcium ion import across plasma membrane ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  
    involved_in calcium ion transmembrane transport IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in calcium ion transmembrane transport ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in calcium ion transport IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    involved_in calcium ion transport into cytosol IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in calcium ion transport into cytosol ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in intracellular calcium ion homeostasis NAS
    Non-traceable Author Statement
    more info
    		 PubMed 
    involved_in protein homotetramerization ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  
    involved_in regulation of urine volume IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    Component Evidence Code Pubs
    located_in apical plasma membrane IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    located_in apical plasma membrane ISO
    Inferred from Sequence Orthology
    more info
    		  
    part_of calcium channel complex IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    is_active_in plasma membrane IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    located_in plasma membrane ISO
    Inferred from Sequence Orthology
    more info
    		  
    located_in plasma membrane ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  

    General protein information

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    Preferred Names
    transient receptor potential cation channel subfamily V member 5
    Names
    OTRPC3
    calcium transport protein 2
    epithelial calcium channel 1
    osm-9-like TRP channel 3

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001007572.2 → NP_001007573.1  transient receptor potential cation channel subfamily V member 5

      See identical proteins and their annotated locations for NP_001007573.1

      Status: PROVISIONAL

      Source sequence(s)
      BC110555
      Consensus CDS
      CCDS20053.1
      UniProtKB/Swiss-Prot
      P69744, Q2TB50
      UniProtKB/TrEMBL
      A0A0A6YW69
      Related
      ENSMUSP00000031901.6, ENSMUST00000031901.11
      Conserved Domains (2) summary
      TIGR00870
      Location:5 → 701
      trp; transient-receptor-potential calcium channel protein
      sd00045
      Location:111 → 154
      ANK; ANK repeat [structural motif]

    RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCm39 C57BL/6J

    Genomic

    1. NC_000072.7 Reference GRCm39 C57BL/6J

      Range
      41628595..41658158 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_017321464.2 → XP_017176953.1  transient receptor potential cation channel subfamily V member 5 isoform X2

      UniProtKB/TrEMBL
      A0A0A6YW69
      Conserved Domains (2) summary
      TIGR00870
      Location:5 → 655
      trp; transient-receptor-potential calcium channel protein
      sd00045
      Location:73 → 101
      ANK; ANK repeat [structural motif]

    2. XM_017321463.2 → XP_017176952.1  transient receptor potential cation channel subfamily V member 5 isoform X1

      UniProtKB/Swiss-Prot
      P69744, Q2TB50
      UniProtKB/TrEMBL
      A0A0A6YW69
      Conserved Domains (2) summary
      TIGR00870
      Location:5 → 701
      trp; transient-receptor-potential calcium channel protein
      sd00045
      Location:111 → 154
      ANK; ANK repeat [structural motif]

    3. XM_006505770.4 → XP_006505833.1  transient receptor potential cation channel subfamily V member 5 isoform X3

      UniProtKB/TrEMBL
      A0A0A6YW69
      Conserved Domains (2) summary
      TIGR00870
      Location:15 → 650
      trp; transient-receptor-potential calcium channel protein
      sd00045
      Location:60 → 103
      ANK; ANK repeat [structural motif]

    4. XM_006505771.2 → XP_006505834.1  transient receptor potential cation channel subfamily V member 5 isoform X4

      UniProtKB/TrEMBL
      A0A0A6YW69
      Conserved Domains (2) summary
      TIGR00870
      Location:1 → 582
      trp; transient-receptor-potential calcium channel protein
      sd00045
      Location:37 → 68
      ANK; ANK repeat [structural motif]
    Nucleotide Protein Strain
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    P69744.2 GenPept UniProtKB/Swiss-Prot:P69744

    Gene LinkOut

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