GPR87 G protein-coupled receptor 87 [Homo sapiens (human)] - Gene

Summary

Official Symbol: GPR87provided by HGNC
Official Full Name: G protein-coupled receptor 87provided by HGNC
Primary source: HGNC:HGNC:4538
See related: Ensembl:ENSG00000138271 MIM:606379; AllianceGenome:HGNC:4538
Gene type: protein coding
RefSeq status: VALIDATED
Organism: Homo sapiens
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Also known as: GPR95; FKSG78; KPG_002
Summary: This gene encodes a G protein-coupled receptor and is located in a cluster of G protein-couple receptor genes on chromosome 3. The encoded protein has been shown to be overexpressed in lung squamous cell carcinoma (PMID:18057535) and regulated by p53 (PMID:19602589). [provided by RefSeq, Nov 2011]
Expression: Biased expression in skin (RPKM 16.8), esophagus (RPKM 16.5) and 4 other tissues See more
Orthologs: mouse all
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Genomic context

Location:: 3q25.1

Exon count:: 3

Annotation release	Status	Assembly	Chr	Location
RS_2024_08	current	GRCh38.p14 (GCF_000001405.40)	3	NC_000003.12 (151294086..151316820, complement)
RS_2024_08	current	T2T-CHM13v2.0 (GCF_009914755.1)	3	NC_060927.1 (154045086..154067827, complement)
RS_2024_09	previous assembly	GRCh37.p13 (GCF_000001405.25)	3	NC_000003.11 (151011874..151034608, complement)

Chromosome 3 - NC_000003.12 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Genomic Sequence:

Go to nucleotide: Graphics FASTA GenBank

Expression

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See details

Project title: HPA RNA-seq normal tissues HPA RNA-seq normal tissues
Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
BioProject: PRJEB4337
Publication: PMID 24309898
Analysis date: Wed Apr 4 07:08:55 2018

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Single-cell RNA sequencing identifies G-protein coupled receptor 87 as a basal cell marker expressed in distal honeycomb cysts in idiopathic pulmonary fibrosis.
Title: Single-cell RNA sequencing identifies G-protein coupled receptor 87 as a basal cell marker expressed in distal honeycomb cysts in idiopathic pulmonary fibrosis.
Engineering of siRNA loaded PLGA Nano-Particles for highly efficient silencing of GPR87 gene as a target for pancreatic cancer treatment.
Title: Engineering of siRNA loaded PLGA Nano-Particles for highly efficient silencing of GPR87 gene as a target for pancreatic cancer treatment.
the basal activity of GPR87 was investigated.
Title: Signaling via G proteins mediates tumorigenic effects of GPR87.
we reported that GPR87 expression was significantly upregulated in pancreatic cancer, and higher GPR87 correlated with shorter overall survival of patients with pancreatic cancer.
Title: Overexpression of G protein-coupled receptor GPR87 promotes pancreatic cancer aggressiveness and activates NF-κB signaling pathway.
knockdown of GPR87 led to a p53-dependent signal transduction and caused apoptosis in the bladder cancer cells.
Title: G Protein-Coupled Receptor 87 (GPR87) Promotes Cell Proliferation in Human Bladder Cancer Cells.
This study aimed to clarify the role of GPR87 in urothelial carcinoma of the bladder.
Title: Expression and role of GPR87 in urothelial carcinoma of the bladder.
GPR87 promotes the growth and metastasis of CD133(+) cancer stem-like cells, and our findings may reveal new targets for HCC prevention or therapy
Title: G protein-coupled receptor 87 (GPR87) promotes the growth and metastasis of CD133⁺ cancer stem-like cells in hepatocellular carcinoma.
GPR87 knockdown sensitized cancer cells to DNA damage-induced growth suppression via enhanced p53 stabilization and activation.
Title: The G protein-coupled receptor 87 is necessary for p53-dependent cell survival in response to genotoxic stress.
Human GPR87 mRNA transcript was preferentially overexpressed in squamous cell carcinomas. Up-regulation of both, transcript and protein, was detected in samples of SCC of the lung, cervix, skin and head and neck (pharynx, larynx and epiglottis).
Title: hGPR87 contributes to viability of human tumor cells.
Results suggest that the GPR87 is a LPA receptor which evolved from a common ancestor of P2Y receptors.
Title: The orphan GPCR GPR87 was deorphanized and shown to be a lysophosphatidic acid receptor.

Submit: New GeneRIF Correction See all GeneRIFs (11)

Phenotypes

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Find tests for this gene in the NIH Genetic Testing Registry (GTR)

Review eQTL and phenotype association data in this region using PheGenI

Variation

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See variants in ClinVar

See studies and variants in dbVar

See Variation Viewer (GRCh37.p13)

See Variation Viewer (GRCh38)

Interactions

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Products	Interactant	Other Gene	Complex	Source	Pubs	Description

General gene information

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Markers

SHGC-13689 (e-PCR)
- UniSTS:18695

SHGC-151126 (e-PCR)
- UniSTS:173346

G54363 (e-PCR)
- UniSTS:146784

D3S1594 (e-PCR)
- UniSTS:39039

D3S1279 (e-PCR), detects polymorphism
- UniSTS:36810

D3S1279 (e-PCR), detects polymorphism
- UniSTS:24538

Gene Ontology Provided by GOA

Function	Evidence Code	Pubs
enables G protein-coupled purinergic nucleotide receptor activity	IBA Inferred from Biological aspect of Ancestor more info

Process	Evidence Code	Pubs
involved_in G protein-coupled purinergic nucleotide receptor signaling pathway	IEA Inferred from Electronic Annotation more info
involved_in G protein-coupled receptor signaling pathway	IBA Inferred from Biological aspect of Ancestor more info
involved_in biological_process	ND No biological Data available more info
involved_in negative regulation of adenylate cyclase activity	IEA Inferred from Electronic Annotation more info

Component	Evidence Code	Pubs
located_in plasma membrane	IEA Inferred from Electronic Annotation more info

General protein information

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Preferred Names: G-protein coupled receptor 87

Names: G-protein coupled receptor 95; orphan GPCR 87

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

NM_023915.4 → NP_076404.3 G-protein coupled receptor 87

See identical proteins and their annotated locations for NP_076404.3

Status: VALIDATED

Source sequence(s)

AF345566, BC117565, BP226924

Consensus CDS

CCDS3157.1

UniProtKB/Swiss-Prot

Q5KU35, Q96JZ8, Q9BXC2, Q9BY21

Related

ENSP00000260843.4, ENST00000260843.5

Conserved Domains (1) summary

cd15969
Location:43 → 325

7tmA_GPR87; G protein-coupled receptor 87, member of the class A family of seven-transmembrane G protein-coupled receptors