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    OYE3 NADPH dehydrogenase [ Saccharomyces cerevisiae S288C ]

    Gene ID: 855932, updated on 18-Sep-2024

    Summary

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    Official Symbol
    OYE3
    Official Full Name
    NADPH dehydrogenase
    Primary source
    SGD:S000006092
    Locus tag
    YPL171C
    See related
    AllianceGenome:SGD:S000006092; FungiDB:YPL171C; VEuPathDB:YPL171C
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Saccharomyces cerevisiae S288C (strain: S288C)
    Lineage
    Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes; Saccharomycetales; Saccharomycetaceae; Saccharomyces
    Also known as
    ZRG6
    Summary
    Enables NADPH dehydrogenase activity. Involved in apoptotic process. [provided by Alliance of Genome Resources, Apr 2022]
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    Genomic context

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    See OYE3 in Genome Data Viewer
    Location:
    chromosome: XVI
    Exon count:
    1
    Sequence:
    Chromosome: XVI; NC_001148.4 (226169..227371, complement)

    Chromosome XVI - NC_001148.4Genomic Context describing neighboring genes Neighboring gene mitochondrial 54S ribosomal protein YmL40 Neighboring gene protoheme IX farnesyltransferase Neighboring gene Dap1p Neighboring gene Mex67p

    Genomic regions, transcripts, and products

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    Genomic Sequence:
    NC_001148.4

    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. Engineering of Yeast Old Yellow Enzyme OYE3 Enables Its Capability Discriminating of (E)-Citral and (Z)-Citral. Wang T, et al. Molecules, 2021 Aug 20. PMID 34443627, Free PMC Article
    2. Enhanced transformation of TNT by Arabidopsis plants expressing an old yellow enzyme. Zhu B, et al. PLoS One, 2012. PMID 22808068, Free PMC Article
    3. Candida albicans estrogen-binding protein gene encodes an oxidoreductase that is inhibited by estradiol. Madani ND, et al. Proc Natl Acad Sci U S A, 1994 Feb 1. PMID 8302868, Free PMC Article
    4. Kinetic studies of the old yellow enzyme. I. The reaction mechanism of the enzyme with reduced nicotinamide adenine dinucleotide. Honma T, et al. Biochim Biophys Acta, 1977 Sep 15. PMID 196654
    5. Engineering the biocatalytic selectivity of iridoid production in Saccharomyces cerevisiae. Billingsley JM, et al. Metab Eng, 2017 Nov. PMID 28939278, Free PMC Article

    See all (48) citations in PubMed

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?
    1. Ectopic expression of an Old Yellow Enzyme (OYE3) gene from Saccharomyces cerevisiae increases the tolerance and phytoremediation of 2-nitroaniline in rice.
      Title: Ectopic expression of an Old Yellow Enzyme (OYE3) gene from Saccharomyces cerevisiae increases the tolerance and phytoremediation of 2-nitroaniline in rice.
    2. OYE proteins are firmly placed in the signaling network connecting ROS generation, PCD modulation, and cytoskeletal dynamics in yeast.
      Title: Old yellow enzymes, highly homologous FMN oxidoreductases with modulating roles in oxidative stress and programmed cell death in yeast.
    Submit: New GeneRIF Correction

    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Homology

    Gene Ontology Provided by SGD

    Function Evidence Code Pubs
    enables FMN binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables NADPH dehydrogenase activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables NADPH dehydrogenase activity IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    enables NADPH dehydrogenase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables oxidoreductase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    Process Evidence Code Pubs
    involved_in apoptotic process IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    Component Evidence Code Pubs
    is_active_in cellular_component ND
    No biological Data available
    more info
    		  

    General protein information

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    Preferred Names
    NADPH dehydrogenase
    NP_015154.1
    • Conserved NADPH oxidoreductase containing flavin mononucleotide (FMN); homologous to Oye2p with different ligand binding and catalytic properties; has potential roles in oxidative stress response and programmed cell death

    NCBI Reference Sequences (RefSeq)

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    Genome Annotation

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference assembly

    Genomic

    1. NC_001148.4 Reference assembly

      Range
      226169..227371 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_001183985.1 → NP_015154.1  TPA: NADPH dehydrogenase [Saccharomyces cerevisiae S288C]

      See identical proteins and their annotated locations for NP_015154.1

      Status: REVIEWED

      UniProtKB/Swiss-Prot
      D6W3J7, E9P937, P41816
      UniProtKB/TrEMBL
      A6ZW82, B3LKQ7, B5VT01, C7GJC2, C8ZIK7, N1P1D3
      Conserved Domains (1) summary
      cd02933
      Location:16 → 372
      OYE_like_FMN; Old yellow enzyme (OYE)-like FMN binding domain. OYE was the first flavin-dependent enzyme identified, however its true physiological role remains elusive to this day. Each monomer of OYE contains FMN as a non-covalently bound cofactor, uses NADPH as a ...
    Nucleotide Protein
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    P41816.2

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