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    PPQ1 protein-serine/threonine phosphatase [ Saccharomyces cerevisiae S288C ]

    Gene ID: 855923, updated on 17-May-2024

    Summary

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    Gene symbol
    PPQ1
    Gene description
    protein-serine/threonine phosphatase
    Primary source
    FungiDB:YPL179W
    Locus tag
    YPL179W
    See related
    SGD:S000006100; AllianceGenome:SGD:S000006100; VEuPathDB:YPL179W
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Saccharomyces cerevisiae S288C (strain: S288C)
    Lineage
    Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes; Saccharomycetales; Saccharomycetaceae; Saccharomyces
    Also known as
    SAL6
    Summary
    Enables phosphoprotein phosphatase activity. Involved in negative regulation of pheromone-dependent signal transduction involved in conjugation with cellular fusion and protein dephosphorylation. Located in cytoplasm. [provided by Alliance of Genome Resources, Apr 2022]
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    Genomic context

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    See PPQ1 in Genome Data Viewer
    Location:
    chromosome: XVI
    Exon count:
    1
    Sequence:
    Chromosome: XVI; NC_001148.4 (208157..209806)

    Chromosome XVI - NC_001148.4Genomic Context describing neighboring genes Neighboring gene Cti6p Neighboring gene Tco89p Neighboring gene tRNA-Glu Neighboring gene nuclear cap-binding protein subunit CBC2

    Genomic regions, transcripts, and products

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    Genomic Sequence:
    NC_001148.4

    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. Large-scale functional analysis of the roles of phosphorylation in yeast metabolic pathways. Schulz JC, et al. Sci Signal, 2014 Nov 25. PMID 25429078
    2. Identification of a novel Ser/Thr protein phosphatase Ppq1 as a negative regulator of mating MAP kinase pathway in Saccharomyces cerevisiae. Shim E, et al. Biochem Biophys Res Commun, 2014 Jan 3. PMID 24309106
    3. PPQ, a novel protein phosphatase containing a Ser + Asn-rich amino-terminal domain, is involved in the regulation of protein synthesis. Chen MX, et al. Eur J Biochem, 1993 Dec 1. PMID 8269960
    4. The yeast translational allosuppressor, SAL6: a new member of the PP1-like phosphatase family with a long serine-rich N-terminal extension. Vincent A, et al. Genetics, 1994 Nov. PMID 7851758, Free PMC Article
    5. Allosuppressors that enhance the efficiency of omnipotent suppressors in Saccharomyces cerevisiae. Song JM, et al. Genetics, 1987 Mar. PMID 3552876, Free PMC Article

    See all (45) citations in PubMed

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?
    1. these data suggest that Ppq1 functions as a negative regulator of mating MAPK pathway by dephosphorylating target pathway protein(s) and plays a key role in the control of the background signaling noise.
      Title: Identification of a novel Ser/Thr protein phosphatase Ppq1 as a negative regulator of mating MAP kinase pathway in Saccharomyces cerevisiae.
    Submit: New GeneRIF Correction

    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Homology

    Gene Ontology Provided by SGD

    Function Evidence Code Pubs
    enables metal ion binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables myosin phosphatase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables phosphoprotein phosphatase activity IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    enables phosphoprotein phosphatase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables protein serine/threonine phosphatase activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables protein serine/threonine phosphatase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    Process Evidence Code Pubs
    involved_in chromosome segregation IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in negative regulation of pheromone-dependent signal transduction involved in conjugation with cellular fusion IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in regulation of mitotic cell cycle IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    Component Evidence Code Pubs
    located_in cytoplasm HDA PubMed 
    is_active_in cytoplasm IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    is_active_in nucleus IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  

    General protein information

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    Preferred Names
    protein-serine/threonine phosphatase
    NP_015146.1
    • Protein phosphatase that regulates the mating response; negatively regulates the MAP kinase signaling cascade during mating; member of the serine/threonine phosphatase PP1 family

    NCBI Reference Sequences (RefSeq)

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    Genome Annotation

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference assembly

    Genomic

    1. NC_001148.4 Reference assembly

      Range
      208157..209806
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_001183993.1 → NP_015146.1  TPA: protein-serine/threonine phosphatase [Saccharomyces cerevisiae S288C]

      See identical proteins and their annotated locations for NP_015146.1

      Status: REVIEWED

      UniProtKB/Swiss-Prot
      D6W3I9, P32945
      UniProtKB/TrEMBL
      A0A6A5Q5J3, A6ZW74, B3LKP9, B5VSZ3, C7GJC8, C8ZIJ9, G2WP03, N1NWP3
      Conserved Domains (1) summary
      cd07414
      Location:239 → 535
      MPP_PP1_PPKL; PP1, PPKL (PP1 and kelch-like) enzymes, and related proteins, metallophosphatase domain
    Nucleotide Protein
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    P32945.1

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