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    SLC39A11 solute carrier family 39 member 11 [ Homo sapiens (human) ]

    Gene ID: 201266, updated on 2-Nov-2024

    Summary

    Official Symbol
    SLC39A11provided by HGNC
    Official Full Name
    solute carrier family 39 member 11provided by HGNC
    Primary source
    HGNC:HGNC:14463
    See related
    Ensembl:ENSG00000133195 MIM:616508; AllianceGenome:HGNC:14463
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Homo sapiens
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
    Also known as
    ZIP11; ZIP-11; C17orf26
    Summary
    Predicted to enable copper ion transmembrane transporter activity and zinc ion transmembrane transporter activity. Predicted to be involved in zinc ion transmembrane transport. Predicted to be located in Golgi apparatus; nucleus; and plasma membrane. Predicted to be active in membrane. [provided by Alliance of Genome Resources, Nov 2024]
    Expression
    Ubiquitous expression in thyroid (RPKM 5.6), stomach (RPKM 5.0) and 25 other tissues See more
    Orthologs
    NEW
    Try the new Gene table
    Try the new Transcript table

    Genomic context

    See SLC39A11 in Genome Data Viewer
    Location:
    17q24.3-q25.1
    Exon count:
    19
    Annotation release Status Assembly Chr Location
    RS_2024_08 current GRCh38.p14 (GCF_000001405.40) 17 NC_000017.11 (72645949..73092688, complement)
    RS_2024_08 current T2T-CHM13v2.0 (GCF_009914755.1) 17 NC_060941.1 (73518976..73981577, complement)
    RS_2024_09 previous assembly GRCh37.p13 (GCF_000001405.25) 17 NC_000017.10 (70642088..71088827, complement)

    Chromosome 17 - NC_000017.11Genomic Context describing neighboring genes Neighboring gene long intergenic non-protein coding RNA 511 Neighboring gene uncharacterized LOC107985005 Neighboring gene uncharacterized LOC105371887 Neighboring gene NANOG-H3K4me1 hESC enhancer GRCh37_chr17:70662937-70663580 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr17:70663581-70664223 Neighboring gene H3K27ac hESC enhancer GRCh37_chr17:70682597-70683097 Neighboring gene RN7SK pseudogene 180 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr17:70715406-70716084 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr17:70716085-70716762 Neighboring gene ReSE screen-validated silencer GRCh37_chr17:70717445-70717660 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 8917 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 12682 Neighboring gene Sharpr-MPRA regulatory region 3582 Neighboring gene NANOG-H3K27ac-H3K4me1 hESC enhancer GRCh37_chr17:70738945-70739482 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr17:70739483-70740019 Neighboring gene small Cajal body-specific RNA 24 Neighboring gene Sharpr-MPRA regulatory region 3335 Neighboring gene BRD4-independent group 4 enhancer GRCh37_chr17:70943638-70944837 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr17:70947920-70948848 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr17:70948849-70949777 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr17:70949987-70950548 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr17:70950549-70951109 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr17:70974043-70974543 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 8918 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 12683 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 12684 Neighboring gene Sharpr-MPRA regulatory region 7306 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr17:71085784-71086284 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr17:71086285-71086785 Neighboring gene ReSE screen-validated silencer GRCh37_chr17:71087756-71087987 Neighboring gene autophagy related 12 pseudogene 1 Neighboring gene OCT4-NANOG hESC enhancer GRCh37_chr17:71128061-71128610 Neighboring gene MPRA-validated peak2987 silencer Neighboring gene ATAC-STARR-seq lymphoblastoid active region 12685 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 12686 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 12687 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 12688 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 8920 Neighboring gene OCT4-NANOG hESC enhancer GRCh37_chr17:71166424-71167002 Neighboring gene RNA polymerase III subunit K pseudogene 2 Neighboring gene somatostatin receptor 2

    Genomic regions, transcripts, and products

    Expression

    • Project title: HPA RNA-seq normal tissues HPA RNA-seq normal tissues
    • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
    • BioProject: PRJEB4337
    • Publication: PMID 24309898
    • Analysis date: Wed Apr 4 07:08:55 2018

    Bibliography

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?

    Phenotypes

    EBI GWAS Catalog

    Description
    Common variants in left/right asymmetry genes and pathways are associated with relative hand skill.
    EBI GWAS Catalog
    Gene-environment interactions and obesity traits among postmenopausal African-American and Hispanic women in the Women's Health Initiative SHARe Study.
    EBI GWAS Catalog
    Genome-wide association analyses suggest NELL1 influences adverse metabolic response to HCTZ in African Americans.
    EBI GWAS Catalog
    Genome-wide association for abdominal subcutaneous and visceral adipose reveals a novel locus for visceral fat in women.
    EBI GWAS Catalog
    Genome-wide association study of liver enzymes in korean children.
    EBI GWAS Catalog
    Genome-wide association study of serum selenium concentrations.
    EBI GWAS Catalog
    Genome-wide association study of smoking behaviours among Bangladeshi adults.
    EBI GWAS Catalog
    Host-microbe interactions have shaped the genetic architecture of inflammatory bowel disease.
    EBI GWAS Catalog
    Reduced expression of the Kinesin-Associated Protein 3 (KIFAP3) gene increases survival in sporadic amyotrophic lateral sclerosis.
    EBI GWAS Catalog

    Pathways from PubChem

    Interactions

    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

    Markers

    Gene Ontology Provided by GOA

    Function Evidence Code Pubs
    enables copper ion transmembrane transporter activity ISS
    Inferred from Sequence or Structural Similarity
    more info
     
    enables zinc ion transmembrane transporter activity IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    enables zinc ion transmembrane transporter activity ISS
    Inferred from Sequence or Structural Similarity
    more info
     
    Process Evidence Code Pubs
    involved_in copper ion transmembrane transport IEA
    Inferred from Electronic Annotation
    more info
     
    involved_in zinc ion import across plasma membrane IEA
    Inferred from Electronic Annotation
    more info
     
    involved_in zinc ion transmembrane transport IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    Component Evidence Code Pubs
    located_in Golgi apparatus ISS
    Inferred from Sequence or Structural Similarity
    more info
     
    located_in cytoplasm ISS
    Inferred from Sequence or Structural Similarity
    more info
     
    is_active_in membrane IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    located_in nucleus ISS
    Inferred from Sequence or Structural Similarity
    more info
     
    located_in plasma membrane ISS
    Inferred from Sequence or Structural Similarity
    more info
     

    General protein information

    Preferred Names
    zinc transporter ZIP11
    Names
    ZRT/IRT-like protein 11
    Zrt- and Irt-like protein 11
    solute carrier family 39 (metal ion transporter), member 11
    zinc transporter 11

    NCBI Reference Sequences (RefSeq)

    NEW Try the new Transcript table

    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001159770.2NP_001153242.1  zinc transporter ZIP11 isoform 1

      See identical proteins and their annotated locations for NP_001153242.1

      Status: VALIDATED

      Description
      Transcript Variant: This variant (1) differs in the 5' UTR and uses an alternate in-frame splice site in the coding region, compared to variant 3. The encoded isoform (1) is longer, compared to isoform 2. Variants 1 and 4 encode the same isoform (1).
      Source sequence(s)
      AC025198, AC080037, AK095227, BU686998, DA380043
      Consensus CDS
      CCDS54160.1
      UniProtKB/Swiss-Prot
      B2R8H7, Q8N1S5, Q8WZ81
      Related
      ENSP00000445829.2, ENST00000542342.6
      Conserved Domains (1) summary
      COG0428
      Location:6342
      ZupT; Zinc transporter ZupT [Inorganic ion transport and metabolism]
    2. NM_001352691.2NP_001339620.1  zinc transporter ZIP11 isoform 2

      Status: VALIDATED

      Description
      Transcript Variant: This variant (3) represents the longest transcript but encodes the shorter isoform (2). Variants 2, 3, and 5 encode the same isoform (2).
      Source sequence(s)
      AC011120, AC025198, AC080037
      Consensus CDS
      CCDS11690.1
      Conserved Domains (1) summary
      COG0428
      Location:6335
      ZupT; Zinc transporter ZupT [Inorganic ion transport and metabolism]
    3. NM_001352692.2NP_001339621.1  zinc transporter ZIP11 isoform 1

      Status: VALIDATED

      Description
      Transcript Variant: This variant (4) differs in the 5' UTR and uses an alternate in-frame splice site in the coding region, compared to variant 3. The encoded isoform (1) is longer, compared to isoform 2. Variants 1 and 4 encode the same isoform (1).
      Source sequence(s)
      AC011120, AC025198, AC080037
      Consensus CDS
      CCDS54160.1
      UniProtKB/Swiss-Prot
      B2R8H7, Q8N1S5, Q8WZ81
      Conserved Domains (1) summary
      COG0428
      Location:6342
      ZupT; Zinc transporter ZupT [Inorganic ion transport and metabolism]
    4. NM_001352693.2NP_001339622.1  zinc transporter ZIP11 isoform 2

      Status: VALIDATED

      Description
      Transcript Variant: This variant (5) differs in the 5' UTR, compared to variant 3. Variants 2, 3, and 5 encode the same isoform (2).
      Source sequence(s)
      AC011120, AC025198, AC080037
      Consensus CDS
      CCDS11690.1
      Conserved Domains (1) summary
      COG0428
      Location:6335
      ZupT; Zinc transporter ZupT [Inorganic ion transport and metabolism]
    5. NM_139177.4NP_631916.2  zinc transporter ZIP11 isoform 2

      See identical proteins and their annotated locations for NP_631916.2

      Status: VALIDATED

      Description
      Transcript Variant: This variant (2) differs in the 5' UTR, compared to variant 3. Variants 2, 3, and 5 encode the same isoform (2).
      Source sequence(s)
      AC025198, BC035631
      Consensus CDS
      CCDS11690.1
      UniProtKB/Swiss-Prot
      Q8N1S5
      Related
      ENSP00000255559.3, ENST00000255559.8
      Conserved Domains (1) summary
      COG0428
      Location:6335
      ZupT; Zinc transporter ZupT [Inorganic ion transport and metabolism]

    RefSeqs of Annotated Genomes: GCF_000001405.40-RS_2024_08

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCh38.p14 Primary Assembly

    Genomic

    1. NC_000017.11 Reference GRCh38.p14 Primary Assembly

      Range
      72645949..73092688 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_017024335.2XP_016879824.1  zinc transporter ZIP11 isoform X8

    2. XM_006721757.3XP_006721820.1  zinc transporter ZIP11 isoform X6

      Conserved Domains (1) summary
      COG0428
      Location:6285
      ZupT; Zinc transporter ZupT [Inorganic ion transport and metabolism]
    3. XM_017024330.2XP_016879819.1  zinc transporter ZIP11 isoform X2

      UniProtKB/Swiss-Prot
      Q8N1S5
      Conserved Domains (1) summary
      COG0428
      Location:6335
      ZupT; Zinc transporter ZupT [Inorganic ion transport and metabolism]
    4. XM_006721755.3XP_006721818.1  zinc transporter ZIP11 isoform X1

      See identical proteins and their annotated locations for XP_006721818.1

      UniProtKB/Swiss-Prot
      B2R8H7, Q8N1S5, Q8WZ81
      Conserved Domains (1) summary
      COG0428
      Location:6342
      ZupT; Zinc transporter ZupT [Inorganic ion transport and metabolism]
    5. XM_047435571.1XP_047291527.1  zinc transporter ZIP11 isoform X8

    6. XM_017024334.3XP_016879823.1  zinc transporter ZIP11 isoform X6

      Conserved Domains (1) summary
      COG0428
      Location:6285
      ZupT; Zinc transporter ZupT [Inorganic ion transport and metabolism]
    7. XM_011524493.2XP_011522795.1  zinc transporter ZIP11 isoform X1

      See identical proteins and their annotated locations for XP_011522795.1

      UniProtKB/Swiss-Prot
      B2R8H7, Q8N1S5, Q8WZ81
      Conserved Domains (1) summary
      COG0428
      Location:6342
      ZupT; Zinc transporter ZupT [Inorganic ion transport and metabolism]
    8. XM_011524494.2XP_011522796.1  zinc transporter ZIP11 isoform X1

      See identical proteins and their annotated locations for XP_011522796.1

      UniProtKB/Swiss-Prot
      B2R8H7, Q8N1S5, Q8WZ81
      Conserved Domains (1) summary
      COG0428
      Location:6342
      ZupT; Zinc transporter ZupT [Inorganic ion transport and metabolism]
    9. XM_017024332.1XP_016879821.1  zinc transporter ZIP11 isoform X2

      UniProtKB/Swiss-Prot
      Q8N1S5
      Conserved Domains (1) summary
      COG0428
      Location:6335
      ZupT; Zinc transporter ZupT [Inorganic ion transport and metabolism]
    10. XM_017024333.2XP_016879822.1  zinc transporter ZIP11 isoform X4

    11. XM_011524495.4XP_011522797.1  zinc transporter ZIP11 isoform X7

      Conserved Domains (1) summary
      COG0428
      Location:6218
      ZupT; Zinc transporter ZupT [Inorganic ion transport and metabolism]
    12. XM_017024342.2XP_016879831.1  zinc transporter ZIP11 isoform X14

      UniProtKB/TrEMBL
      J3KRX2
    13. XM_006721759.2XP_006721822.1  zinc transporter ZIP11 isoform X12

      UniProtKB/TrEMBL
      J3KRX2
      Conserved Domains (1) summary
      cl00437
      Location:6218
      Zip; ZIP Zinc transporter
    14. XM_047435575.1XP_047291531.1  zinc transporter ZIP11 isoform X12

    15. XM_047435577.1XP_047291533.1  zinc transporter ZIP11 isoform X14

      Related
      ENSP00000462200.1, ENST00000580557.5
    16. XM_047435578.1XP_047291534.1  zinc transporter ZIP11 isoform X15

    17. XM_047435568.1XP_047291524.1  zinc transporter ZIP11 isoform X5

    18. XM_006721756.4XP_006721819.1  zinc transporter ZIP11 isoform X3

      Conserved Domains (1) summary
      cl00437
      Location:6218
      Zip; ZIP Zinc transporter
    19. XM_047435569.1XP_047291525.1  zinc transporter ZIP11 isoform X5

    20. XM_047435565.1XP_047291521.1  zinc transporter ZIP11 isoform X3

    21. XM_047435570.1XP_047291526.1  zinc transporter ZIP11 isoform X5

    22. XM_047435566.1XP_047291522.1  zinc transporter ZIP11 isoform X3

    23. XM_011524498.4XP_011522800.1  zinc transporter ZIP11 isoform X16

      UniProtKB/TrEMBL
      J3KRX2
      Related
      ENSP00000464525.1, ENST00000579732.5
      Conserved Domains (1) summary
      cl00437
      Location:6102
      Zip; ZIP Zinc transporter
    24. XM_011524496.3XP_011522798.1  zinc transporter ZIP11 isoform X9

      Conserved Domains (1) summary
      cl00437
      Location:6102
      Zip; ZIP Zinc transporter
    25. XM_047435572.1XP_047291528.1  zinc transporter ZIP11 isoform X10

    26. XM_017024340.3XP_016879829.1  zinc transporter ZIP11 isoform X13

      UniProtKB/TrEMBL
      J3KRX2
    27. XM_006721758.5XP_006721821.1  zinc transporter ZIP11 isoform X11

      UniProtKB/TrEMBL
      J3KRX2
      Conserved Domains (1) summary
      cl00437
      Location:6102
      Zip; ZIP Zinc transporter
    28. XM_047435576.1XP_047291532.1  zinc transporter ZIP11 isoform X13

    29. XM_017024341.3XP_016879830.1  zinc transporter ZIP11 isoform X13

      UniProtKB/TrEMBL
      J3KRX2
    30. XM_047435574.1XP_047291530.1  zinc transporter ZIP11 isoform X11

    Alternate T2T-CHM13v2.0

    Genomic

    1. NC_060941.1 Alternate T2T-CHM13v2.0

      Range
      73518976..73981577 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_054315384.1XP_054171359.1  zinc transporter ZIP11 isoform X8

    2. XM_054315382.1XP_054171357.1  zinc transporter ZIP11 isoform X6

    3. XM_054315373.1XP_054171348.1  zinc transporter ZIP11 isoform X2

    4. XM_054315370.1XP_054171345.1  zinc transporter ZIP11 isoform X1

    5. XM_054315385.1XP_054171360.1  zinc transporter ZIP11 isoform X8

    6. XM_054315383.1XP_054171358.1  zinc transporter ZIP11 isoform X6

    7. XM_054315371.1XP_054171346.1  zinc transporter ZIP11 isoform X1

    8. XM_054315372.1XP_054171347.1  zinc transporter ZIP11 isoform X1

    9. XM_054315374.1XP_054171349.1  zinc transporter ZIP11 isoform X2

    10. XM_054315378.1XP_054171353.1  zinc transporter ZIP11 isoform X4

    11. XM_054315388.1XP_054171363.1  zinc transporter ZIP11 isoform X17

    12. XM_054315396.1XP_054171371.1  zinc transporter ZIP11 isoform X14

    13. XM_054315391.1XP_054171366.1  zinc transporter ZIP11 isoform X12

    14. XM_054315392.1XP_054171367.1  zinc transporter ZIP11 isoform X12

    15. XM_054315397.1XP_054171372.1  zinc transporter ZIP11 isoform X14

    16. XM_054315398.1XP_054171373.1  zinc transporter ZIP11 isoform X15

    17. XM_054315379.1XP_054171354.1  zinc transporter ZIP11 isoform X5

    18. XM_054315375.1XP_054171350.1  zinc transporter ZIP11 isoform X3

    19. XM_054315380.1XP_054171355.1  zinc transporter ZIP11 isoform X5

    20. XM_054315376.1XP_054171351.1  zinc transporter ZIP11 isoform X3

    21. XM_054315381.1XP_054171356.1  zinc transporter ZIP11 isoform X5

    22. XM_054315377.1XP_054171352.1  zinc transporter ZIP11 isoform X3

    23. XM_054315399.1XP_054171374.1  zinc transporter ZIP11 isoform X16

    24. XM_054315387.1XP_054171362.1  zinc transporter ZIP11 isoform X10

    25. XM_054315386.1XP_054171361.1  zinc transporter ZIP11 isoform X9

    26. XM_054315393.1XP_054171368.1  zinc transporter ZIP11 isoform X13

    27. XM_054315389.1XP_054171364.1  zinc transporter ZIP11 isoform X11

    28. XM_054315395.1XP_054171370.1  zinc transporter ZIP11 isoform X13

    29. XM_054315394.1XP_054171369.1  zinc transporter ZIP11 isoform X13

    30. XM_054315390.1XP_054171365.1  zinc transporter ZIP11 isoform X11