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    CT45A1 cancer/testis antigen family 45 member A1 [ Homo sapiens (human) ]

    Gene ID: 541466, updated on 28-Oct-2024

    Summary

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    Official Symbol
    CT45A1provided by HGNC
    Official Full Name
    cancer/testis antigen family 45 member A1provided by HGNC
    Primary source
    HGNC:HGNC:33267
    See related
    Ensembl:ENSG00000268940 MIM:300648; AllianceGenome:HGNC:33267
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Homo sapiens
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
    Also known as
    CT45; CT45-1; CT45.1
    Expression
    Restricted expression toward testis (RPKM 10.8) See more
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    Genomic context

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    See CT45A1 in Genome Data Viewer
    Location:
    Xq26.3
    Exon count:
    7
    Annotation release Status Assembly Chr Location
    RS_2024_08 current GRCh38.p14 (GCF_000001405.40) X NC_000023.11 (135708398..135723228)
    RS_2024_08 current T2T-CHM13v2.0 (GCF_009914755.1) X NC_060947.1 (134058013..134066160)
    RS_2024_09 previous assembly GRCh37.p13 (GCF_000001405.25) X NC_000023.10 (134847372..134856990)

    Chromosome X - NC_000023.11Genomic Context describing neighboring genes Neighboring gene sarcoma antigen 3, pseudogene Neighboring gene sarcoma antigen 2, pseudogene Neighboring gene ATAC-STARR-seq lymphoblastoid active region 29985 Neighboring gene MGAT2 pseudogene 1 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 29986 Neighboring gene MGAT2 pseudogene 2

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: HPA RNA-seq normal tissues HPA RNA-seq normal tissues
    • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
    • BioProject: PRJEB4337
    • Publication: PMID 24309898
    • Analysis date: Wed Apr 4 07:08:55 2018

    Bibliography

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    Related articles in PubMed

    1. Cancer/testis-45A1 promotes cervical cancer cell tumorigenesis and drug resistance by activating oncogenic SRC and downstream signaling pathways. Meng M, et al. Cell Oncol (Dordr), 2024 Apr. PMID 37924456, Free PMC Article
    2. CT45A1 siRNA silencing suppresses the proliferation, metastasis and invasion of lung cancer cells by downregulating the ERK/CREB signaling pathway. Tang F, et al. Mol Med Rep, 2017 Nov. PMID 28901509, Free PMC Article
    3. DNA hypomethylation-mediated activation of Cancer/Testis Antigen 45 (CT45) genes is associated with disease progression and reduced survival in epithelial ovarian cancer. Zhang W, et al. Epigenetics, 2015. PMID 26098711, Free PMC Article
    4. CT45A1 acts as a new proto-oncogene to trigger tumorigenesis and cancer metastasis. Shang B, et al. Cell Death Dis, 2014 Jun 5. PMID 24901056, Free PMC Article
    5. Expression of cancer testis antigen CT45 in classical Hodgkin lymphoma and other B-cell lymphomas. Chen YT, et al. Proc Natl Acad Sci U S A, 2010 Feb 16. PMID 20133697, Free PMC Article

    See all (16) citations in PubMed

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?
    1. Cancer/testis-45A1 promotes cervical cancer cell tumorigenesis and drug resistance by activating oncogenic SRC and downstream signaling pathways.
      Title: Cancer/testis-45A1 promotes cervical cancer cell tumorigenesis and drug resistance by activating oncogenic SRC and downstream signaling pathways.
    2. YBX2 and cancer testis antigen 45 contribute to stemness, chemoresistance and a high degree of malignancy in human endometrial cancer.
      Title: YBX2 and cancer testis antigen 45 contribute to stemness, chemoresistance and a high degree of malignancy in human endometrial cancer.
    3. Uev1A promotes breast cancer cell migration by up-regulating CT45A expression via the AKT pathway.
      Title: Uev1A promotes breast cancer cell migration by up-regulating CT45A expression via the AKT pathway.
    4. CT45A1 promotes the metastasis of osteosarcoma cells in vitro and in vivo through beta-catenin.
      Title: CT45A1 promotes the metastasis of osteosarcoma cells in vitro and in vivo through β-catenin.
    5. Following CT45A1 silencing, the expressions of Bcl2, survivin, MMP2, MMP9, pERK1/2 and pCREB were downregulated and the expression of Bax was upregulated.
      Title: CT45A1 siRNA silencing suppresses the proliferation, metastasis and invasion of lung cancer cells by downregulating the ERK/CREB signaling pathway.
    6. These data verify CT45 expression and promoter hypomethylation as possible prognostic biomarkers, and suggest CT45 as an immunological or therapeutic target in Epithelial ovarian cancer
      Title: DNA hypomethylation-mediated activation of Cancer/Testis Antigen 45 (CT45) genes is associated with disease progression and reduced survival in epithelial ovarian cancer.
    7. CT45A1 functions as a novel proto-oncogene to trigger oncogenesis and metastasis.
      Title: CT45A1 acts as a new proto-oncogene to trigger tumorigenesis and cancer metastasis.
    8. Hodgkin lymphoma has the highest CT45 expression among all malignancies tested, in diffuse large B-cell lymphomas it is similar to that seen in epithelial cancers, and not present in low-grade non-Hodgkin B-cell lymphomas.
      Title: Expression of cancer testis antigen CT45 in classical Hodgkin lymphoma and other B-cell lymphomas.
    9. Over-expression of CT45 is associated with cancer.
      Title: Cancer/testis antigen CT45: analysis of mRNA and protein expression in human cancer.
    Submit: New GeneRIF Correction

    Phenotypes

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    Review eQTL and phenotype association data in this region using PheGenI

    Variation

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    See variants in ClinVar

    See studies and variants in dbVar

    See Variation Viewer (GRCh37.p13)

    See Variation Viewer (GRCh38)

    Genotypes

    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Homology

    Gene Ontology Provided by GOA

    Function Evidence Code Pubs
    enables protein binding IPI
    Inferred from Physical Interaction
    more info
    		 PubMed 

    General protein information

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    Preferred Names
    cancer/testis antigen family 45 member A1
    Names
    cancer/testis antigen 45-1
    cancer/testis antigen 45A1
    cancer/testis antigen CT45-1

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001017417.3 → NP_001017417.1  cancer/testis antigen family 45 member A1

      See identical proteins and their annotated locations for NP_001017417.1

      Status: VALIDATED

      Source sequence(s)
      AC240442
      Consensus CDS
      CCDS48174.1
      UniProtKB/Swiss-Prot
      B9EIR8, Q5HYN5
      Related
      ENSP00000472303.1, ENST00000594565.6
      Conserved Domains (1) summary
      pfam15300
      Location:122 → 183
      INT_SG_DDX_CT_C; INTS6/SAGE1/DDX26B/CT45 C-terminus

    RefSeqs of Annotated Genomes: GCF_000001405.40-RS_2024_08

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCh38.p14 Primary Assembly

    Genomic

    1. NC_000023.11 Reference GRCh38.p14 Primary Assembly

      Range
      135708398..135723228
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_011531352.2 → XP_011529654.1  cancer/testis antigen family 45 member A1 isoform X1

      See identical proteins and their annotated locations for XP_011529654.1

      UniProtKB/Swiss-Prot
      B9EIR8, Q5HYN5
      Related
      ENSP00000470185.2, ENST00000594117.4
      Conserved Domains (1) summary
      pfam15300
      Location:122 → 183
      INT_SG_DDX_CT_C; INTS6/SAGE1/DDX26B/CT45 C-terminus

    2. XM_005278141.5 → XP_005278198.1  cancer/testis antigen family 45 member A1 isoform X1

      See identical proteins and their annotated locations for XP_005278198.1

      UniProtKB/Swiss-Prot
      B9EIR8, Q5HYN5
      Conserved Domains (1) summary
      pfam15300
      Location:122 → 183
      INT_SG_DDX_CT_C; INTS6/SAGE1/DDX26B/CT45 C-terminus

    3. XM_047442173.1 → XP_047298129.1  cancer/testis antigen family 45 member A1 isoform X1

      UniProtKB/Swiss-Prot
      B9EIR8, Q5HYN5

    Alternate T2T-CHM13v2.0

    Genomic

    1. NC_060947.1 Alternate T2T-CHM13v2.0

      Range
      134058013..134066160
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_054327220.1 → XP_054183195.1  cancer/testis antigen family 45 member A1 isoform X1

      UniProtKB/Swiss-Prot
      B9EIR8, Q5HYN5

    2. XM_054327221.1 → XP_054183196.1  cancer/testis antigen family 45 member A1 isoform X1

      UniProtKB/Swiss-Prot
      B9EIR8, Q5HYN5
    Nucleotide Protein
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    Q5HYN5.1 GenPept UniProtKB/Swiss-Prot:Q5HYN5

    Gene LinkOut

    The following LinkOut resources are supplied by external providers. These providers are responsible for maintaining the links.

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