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    LOC730101 uncharacterized LOC730101 [ Homo sapiens (human) ]

    Gene ID: 730101, updated on 22-Oct-2024

    Summary

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    Gene symbol
    LOC730101
    Gene description
    uncharacterized LOC730101
    See related
    Ensembl:ENSG00000291006
    Gene type
    ncRNA
    RefSeq status
    VALIDATED
    Organism
    Homo sapiens
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
    Expression
    Broad expression in placenta (RPKM 10.4), duodenum (RPKM 5.9) and 23 other tissues See more
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    Genomic context

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    See LOC730101 in Genome Data Viewer
    Location:
    6p12.2
    Exon count:
    2
    Annotation release Status Assembly Chr Location
    RS_2024_08 current GRCh38.p14 (GCF_000001405.40) 6 NC_000006.12 (52664401..52669153)
    RS_2024_08 current T2T-CHM13v2.0 (GCF_009914755.1) 6 NC_060930.1 (52503141..52507893)
    RS_2024_09 previous assembly GRCh37.p13 (GCF_000001405.25) 6 NC_000006.11 (52529199..52533951)

    Chromosome 6 - NC_000006.12Genomic Context describing neighboring genes Neighboring gene uncharacterized LOC124901330 Neighboring gene SH3 domain binding glutamate rich protein like 3 pseudogene Neighboring gene ATAC-STARR-seq lymphoblastoid active region 24687 Neighboring gene Sharpr-MPRA regulatory region 5928 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 24688 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr6:52535127-52535627 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 24689 Neighboring gene OCT4-NANOG hESC enhancer GRCh37_chr6:52540056-52540616 Neighboring gene transmembrane protein 14A Neighboring gene SREK1IP1 pseudogene 2 Neighboring gene glutathione S-transferase alpha 8, pseudogene

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: HPA RNA-seq normal tissues HPA RNA-seq normal tissues
    • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
    • BioProject: PRJEB4337
    • Publication: PMID 24309898
    • Analysis date: Wed Apr 4 07:08:55 2018

    Bibliography

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    Related articles in PubMed

    1. High expression of long non-coding RNA LOC730101 correlates with distant metastasis and exhibits a poor prognosis in patients with osteosarcoma. Li SW, et al. Eur Rev Med Pharmacol Sci, 2018 Jul. PMID 30024599
    2. LncRNA LOC730101 promotes osteosarcoma cell survival under energy stress. Cheng G, et al. Biochem Biophys Res Commun, 2018 Jan 29. PMID 29253564
    3. Highly expressed lncRNA LOC730101 promotes lung cancer cell growth through Wnt canonical pathway. Liu L, et al. Biochem Biophys Res Commun, 2017 Nov 18. PMID 28943432
    4. LOC730101 transmitted by exosomes facilitates laryngeal squamous cell carcinoma tumorigenesis via regulation of p38 MAPK gamma. Zang Y, et al. Cell Signal, 2024 Oct. PMID 39121975
    5. Complete sequencing and characterization of 21,243 full-length human cDNAs. Ota T, et al. Nat Genet, 2004 Jan. PMID 14702039

    See all (6) citations in PubMed

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?
    1. LOC730101 transmitted by exosomes facilitates laryngeal squamous cell carcinoma tumorigenesis via regulation of p38 MAPK gamma.
      Title: LOC730101 transmitted by exosomes facilitates laryngeal squamous cell carcinoma tumorigenesis via regulation of p38 MAPK gamma.
    2. LOC730101 was significantly upregulated in human osteosarcoma tissues compared with corresponding adjacent normal tissues; elevated LOC730101 expression was correlated with advanced clinical stage and distant metastasis
      Title: High expression of long non-coding RNA LOC730101 correlates with distant metastasis and exhibits a poor prognosis in patients with osteosarcoma.
    3. Taken together, our findings enlarged the knowledge about the roles of LOC730101 in osteosarcoma progression.
      Title: LncRNA LOC730101 promotes osteosarcoma cell survival under energy stress.
    4. Overexpression of LOC730101 prompted the proliferation of non-small-cell lung cancer both in vitro and in vivo while Silencing observed opposite phenomenon.
      Title: Highly expressed lncRNA LOC730101 promotes lung cancer cell growth through Wnt canonical pathway.
    Submit: New GeneRIF Correction

    Phenotypes

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    Review eQTL and phenotype association data in this region using PheGenI

    Variation

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    See variants in ClinVar

    See studies and variants in dbVar

    See Variation Viewer (GRCh37.p13)

    See Variation Viewer (GRCh38)

    Genotypes

    General gene information

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    Markers

    Clone Names

    • FLJ33798, FLJ38040, FLJ38488, DKFZp566E183

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    RNA

    1. NR_024403.1 RNA Sequence

      Status: VALIDATED

      Description
      Transcript Variant: This variant (1) represents the longer transcript.
      Source sequence(s)
      AL109918
      Related
      ENST00000602367.3

    2. NR_024405.1 RNA Sequence

      Status: VALIDATED

      Description
      Transcript Variant: This variant (2) lacks an internal segment compared to variant 1.
      Source sequence(s)
      AL109918
      Related
      ENST00000643631.2

    RefSeqs of Annotated Genomes: GCF_000001405.40-RS_2024_08

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCh38.p14 Primary Assembly

    Genomic

    1. NC_000006.12 Reference GRCh38.p14 Primary Assembly

      Range
      52664401..52669153
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    Alternate T2T-CHM13v2.0

    Genomic

    1. NC_060930.1 Alternate T2T-CHM13v2.0

      Range
      52503141..52507893
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)
    Nucleotide Protein
    Heading Accession and Version

    Gene LinkOut

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