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    PIMREG PICALM interacting mitotic regulator [ Homo sapiens (human) ]

    Gene ID: 54478, updated on 28-Oct-2024

    Summary

    Official Symbol
    PIMREGprovided by HGNC
    Official Full Name
    PICALM interacting mitotic regulatorprovided by HGNC
    Primary source
    HGNC:HGNC:25483
    See related
    Ensembl:ENSG00000129195 MIM:617611; AllianceGenome:HGNC:25483
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Homo sapiens
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
    Also known as
    CATS; RCS1; FAM64A
    Summary
    Predicted to be involved in cell division. Located in nucleolus and nucleoplasm. [provided by Alliance of Genome Resources, Oct 2024]
    Expression
    Broad expression in spleen (RPKM 1.3), small intestine (RPKM 0.7) and 19 other tissues See more
    Orthologs
    NEW
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    Try the new Transcript table

    Genomic context

    See PIMREG in Genome Data Viewer
    Location:
    17p13.2
    Exon count:
    7
    Annotation release Status Assembly Chr Location
    RS_2024_08 current GRCh38.p14 (GCF_000001405.40) 17 NC_000017.11 (6444455..6451469)
    RS_2024_08 current T2T-CHM13v2.0 (GCF_009914755.1) 17 NC_060941.1 (6344181..6351199)
    RS_2024_09 previous assembly GRCh37.p13 (GCF_000001405.25) 17 NC_000017.10 (6347775..6354789)

    Chromosome 17 - NC_000017.11Genomic Context describing neighboring genes Neighboring gene uncharacterized LOC105371509 Neighboring gene uncharacterized LOC107985017 Neighboring gene H3K27ac hESC enhancer GRCh37_chr17:6347155-6347733 Neighboring gene ReSE screen-validated silencer GRCh37_chr17:6347797-6348024 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr17:6350771-6351437 Neighboring gene aryl hydrocarbon receptor interacting protein like 1 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr17:6357121-6357839 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 8075 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 8076 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr17:6360909-6361690 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr17:6361691-6362472 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr17:6367015-6367566 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr17:6367567-6368118 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr17:6373134-6373634 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr17:6374667-6375190 Neighboring gene PITPNM family member 3 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr17:6377377-6377969 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr17:6377970-6378561 Neighboring gene H3K27ac hESC enhancer GRCh37_chr17:6396251-6396752 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr17:6400873-6401763 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr17:6404362-6404908 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr17:6447205-6447705 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr17:6452242-6452960 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr17:6458140-6458786 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr17:6471007-6471507 Neighboring gene KIAA0753 Neighboring gene RNA, 5S ribosomal pseudogene 435 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr17:6540081-6540863 Neighboring gene uncharacterized LOC122526780 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr17:6540864-6541645 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 11584 Neighboring gene H3K27ac hESC enhancer GRCh37_chr17:6543558-6544439

    Genomic regions, transcripts, and products

    Expression

    • Project title: HPA RNA-seq normal tissues HPA RNA-seq normal tissues
    • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
    • BioProject: PRJEB4337
    • Publication: PMID 24309898
    • Analysis date: Wed Apr 4 07:08:55 2018

    Bibliography

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?

    Interactions

    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

    Markers

    Clone Names

    • FLJ10156, FLJ10491

    Gene Ontology Provided by GOA

    Function Evidence Code Pubs
    enables protein binding IPI
    Inferred from Physical Interaction
    more info
    PubMed 
    Process Evidence Code Pubs
    involved_in cell division IEA
    Inferred from Electronic Annotation
    more info
     
    Component Evidence Code Pubs
    located_in nucleolus IDA
    Inferred from Direct Assay
    more info
     
    located_in nucleoplasm IDA
    Inferred from Direct Assay
    more info
     

    General protein information

    Preferred Names
    protein PIMREG
    Names
    CALM interacting protein expressed in thymus and spleen
    CALM-interactor expressed in thymus and spleen
    family with sequence similarity 64 member A
    protein FAM64A
    regulator of chromosome segregation 1
    regulator of chromosome segregation protein 1

    NCBI Reference Sequences (RefSeq)

    NEW Try the new Transcript table

    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001195228.2NP_001182157.1  protein PIMREG isoform 2

      See identical proteins and their annotated locations for NP_001182157.1

      Status: VALIDATED

      Description
      Transcript Variant: This variant (2) lacks an exon in the 3' coding region, which results in a frameshift, compared to variant A. The resulting protein (isoform 2) is longer and has a distinct C-terminus, compared to isoform 1.
      Source sequence(s)
      AC055872, BC005004
      Consensus CDS
      CCDS56016.1
      UniProtKB/Swiss-Prot
      Q96CT4, Q9BSJ6, Q9NVV1, Q9NWB5
      UniProtKB/TrEMBL
      A0A0S2Z5F0, I3L156
      Related
      ENSP00000250056.8, ENST00000250056.12
      Conserved Domains (1) summary
      pfam07326
      Location:1232
      DUF1466; Protein of unknown function (DUF1466)
    2. NM_019013.3NP_061886.2  protein PIMREG isoform 1

      See identical proteins and their annotated locations for NP_061886.2

      Status: VALIDATED

      Description
      Transcript Variant: This variant (1) represents the longer transcript and encodes the shorter isoform (1).
      Source sequence(s)
      AC055872, BC013966
      Consensus CDS
      CCDS32541.1
      UniProtKB/TrEMBL
      A0A0S2Z5C7, I3L156
      Related
      ENSP00000459235.1, ENST00000572447.6
      Conserved Domains (1) summary
      pfam07326
      Location:1231
      DUF1466; Protein of unknown function (DUF1466)

    RefSeqs of Annotated Genomes: GCF_000001405.40-RS_2024_08

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCh38.p14 Primary Assembly

    Genomic

    1. NC_000017.11 Reference GRCh38.p14 Primary Assembly

      Range
      6444455..6451469
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_047436310.1XP_047292266.1  protein PIMREG isoform X1

      UniProtKB/TrEMBL
      I3L419
      Related
      ENSP00000459597.1, ENST00000571373.5
    2. XM_047436311.1XP_047292267.1  protein PIMREG isoform X2

      UniProtKB/TrEMBL
      A0A0S2Z5C7
      Related
      ENSP00000458534.1, ENST00000576056.5
    3. XM_017024778.2XP_016880267.1  protein PIMREG isoform X3

    4. XM_047436312.1XP_047292268.1  protein PIMREG isoform X4

    Alternate T2T-CHM13v2.0

    Genomic

    1. NC_060941.1 Alternate T2T-CHM13v2.0

      Range
      6344181..6351199
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_054316530.1XP_054172505.1  protein PIMREG isoform X1

      UniProtKB/TrEMBL
      I3L419
    2. XM_054316531.1XP_054172506.1  protein PIMREG isoform X2

      UniProtKB/TrEMBL
      A0A0S2Z5C7
    3. XM_054316532.1XP_054172507.1  protein PIMREG isoform X3

    4. XM_054316533.1XP_054172508.1  protein PIMREG isoform X4