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    LSB5 Lsb5p [ Saccharomyces cerevisiae S288C ]

    Gene ID: 850323, updated on 18-Sep-2024

    Summary

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    Official Symbol
    LSB5
    Official Full Name
    Lsb5p
    Primary source
    SGD:S000000539
    Locus tag
    YCL034W
    See related
    AllianceGenome:SGD:S000000539; FungiDB:YCL034W; VEuPathDB:YCL034W
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Saccharomyces cerevisiae S288C (strain: S288C)
    Lineage
    Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes; Saccharomycetales; Saccharomycetaceae; Saccharomyces
    Summary
    Involved in actin cortical patch localization; actin filament organization; and endocytosis. Located in actin cortical patch. [provided by Alliance of Genome Resources, Apr 2022]
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    Genomic context

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    See LSB5 in Genome Data Viewer
    Location:
    chromosome: III
    Exon count:
    1
    Sequence:
    Chromosome: III; NC_001135.5 (61658..62722)

    Chromosome III - NC_001135.5Genomic Context describing neighboring genes Neighboring gene Gfd2p Neighboring gene dithiol glutaredoxin GRX1 Neighboring gene peptide-methionine (R)-S-oxide reductase Neighboring gene Ste50p

    Genomic regions, transcripts, and products

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    Genomic Sequence:
    NC_001135.5

    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. Interactions between Sla1p, Lsb5p and Arf3p in yeast endocytosis. Costa R, et al. Biochem Soc Trans, 2005 Dec. PMID 16246096
    2. Novel proteins linking the actin cytoskeleton to the endocytic machinery in Saccharomyces cerevisiae. Dewar H, et al. Mol Biol Cell, 2002 Oct. PMID 12388763, Free PMC Article
    3. Multiple pathways regulate endocytic coat disassembly in Saccharomyces cerevisiae for optimal downstream trafficking. Toret CP, et al. Traffic, 2008 May. PMID 18298676
    4. Lsb5p interacts with actin regulators Sla1p and Las17p, ubiquitin and Arf3p to couple actin dynamics to membrane trafficking processes. Costa R, et al. Biochem J, 2005 May 1. PMID 15651983, Free PMC Article
    5. The Saccharomyces cerevisiae homologue of human Wiskott-Aldrich syndrome protein Las17p interacts with the Arp2/3 complex. Madania A, et al. Mol Biol Cell, 1999 Oct. PMID 10512884, Free PMC Article

    See all (23) citations in PubMed

    GeneRIFs: Gene References Into Functions

    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Homology

    Gene Ontology Provided by SGD

    Function Evidence Code Pubs
    enables molecular_function ND
    No biological Data available
    more info
    		  
    Process Evidence Code Pubs
    involved_in actin cortical patch localization IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in actin cortical patch localization IGI
    Inferred from Genetic Interaction
    more info
    		 PubMed 
    involved_in actin cytoskeleton organization IGI
    Inferred from Genetic Interaction
    more info
    		 PubMed 
    involved_in actin filament organization IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in actin filament organization IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in actin filament organization IPI
    Inferred from Physical Interaction
    more info
    		 PubMed 
    involved_in endocytosis IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in endocytosis IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in endocytosis IGI
    Inferred from Genetic Interaction
    more info
    		 PubMed 
    Component Evidence Code Pubs
    is_active_in actin cortical patch IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    located_in actin cortical patch IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    located_in cell cortex IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    located_in cell cortex IEA
    Inferred from Electronic Annotation
    more info
    		  
    located_in cytoplasm IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    located_in cytoplasm IEA
    Inferred from Electronic Annotation
    more info
    		  
    located_in cytoskeleton IEA
    Inferred from Electronic Annotation
    more info
    		  
    located_in cytosol HDA PubMed 

    General protein information

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    Preferred Names
    Lsb5p
    NP_009896.2
    • Protein involved in membrane-trafficking events at plasma membrane; interacts with actin regulators Sla1p and Las17p, ubiquitin, Arf3p to couple actin dynamics to membrane trafficking processes; similar structure to GGA family of proteins with N-terminal VHS domain and GAT domain; binds Las17p, which is homolog of human Wiskott-Aldrich Syndrome protein involved in actin patch assembly, actin polymerization; may mediate disassembly of Pan1 complex from endocytic coat

    NCBI Reference Sequences (RefSeq)

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    Genome Annotation

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference assembly

    Genomic

    1. NC_001135.5 Reference assembly

      Range
      61658..62722
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_001178679.1 → NP_009896.2  TPA: Lsb5p [Saccharomyces cerevisiae S288C]

      See identical proteins and their annotated locations for NP_009896.2

      Status: REVIEWED

      UniProtKB/Swiss-Prot
      D6VQY1, P25369, P87004, Q8NIM9
      UniProtKB/TrEMBL
      A6ZTF6, B3LU48, B5VES5, C7GSZ1, C8Z455, G2W9Z1, N1P986
      Conserved Domains (2) summary
      cd16980
      Location:12 → 158
      VHS_Lsb5; VHS (Vps27/Hrs/STAM) domain of LAS seventeen-binding protein 5
      cd14232
      Location:219 → 295
      GAT_LSB5; canonical GAT domain found in yeast LAS seventeen-binding protein 5 (Lsb5p) and similar proteins
    Nucleotide Protein
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    P25369.3

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