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    DYS1 deoxyhypusine synthase [ Saccharomyces cerevisiae S288C ]

    Gene ID: 856465, updated on 18-Sep-2024

    Summary

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    Official Symbol
    DYS1
    Official Full Name
    deoxyhypusine synthase
    Primary source
    SGD:S000001110
    Locus tag
    YHR068W
    See related
    AllianceGenome:SGD:S000001110; FungiDB:YHR068W; VEuPathDB:YHR068W
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Saccharomyces cerevisiae S288C (strain: S288C)
    Lineage
    Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes; Saccharomycetales; Saccharomycetaceae; Saccharomyces
    Summary
    Enables deoxyhypusine synthase activity. Involved in peptidyl-lysine modification to peptidyl-hypusine. Located in cytoplasm. Orthologous to human DHPS (deoxyhypusine synthase). [provided by Alliance of Genome Resources, Apr 2022]
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    Genomic context

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    See DYS1 in Genome Data Viewer
    Location:
    chromosome: VIII
    Exon count:
    1
    Sequence:
    Chromosome: VIII; NC_001140.6 (232133..233296)

    Chromosome VIII - NC_001140.6Genomic Context describing neighboring genes Neighboring gene rRNA-binding ribosome biosynthesis protein Neighboring gene hydroxyacyl-thioester dehydratase HTD2 Neighboring gene exosome non-catalytic core subunit RRP4 Neighboring gene tRNA (guanine) methyltransferase

    Genomic regions, transcripts, and products

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    Genomic Sequence:
    NC_001140.6

    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. Identification of lysine350 of yeast deoxyhypusine synthase as the site of enzyme intermediate formation. Wolff EC, et al. Yeast, 1999 Jan 15. PMID 10028184
    2. Novel features of the functional site and expression of the yeast deoxyhypusine synthase. Abid R, et al. Biol Signals, 1997 May-Jun. PMID 9285099
    3. Deoxyhypusine synthase gene is essential for cell viability in the yeast Saccharomyces cerevisiae. Sasaki K, et al. FEBS Lett, 1996 Apr 15. PMID 8612813
    4. Identification of YHR068w in Saccharomyces cerevisiae chromosome VIII as a gene for deoxyhypusine synthase. Expression and characterization of the enzyme. Kang KR, et al. J Biol Chem, 1995 Aug 4. PMID 7629166
    5. Mapping eIF5A binding sites for Dys1 and Lia1: in vivo evidence for regulation of eIF5A hypusination. Thompson GM, et al. FEBS Lett, 2003 Dec 18. PMID 14675757

    See all (30) citations in PubMed

    GeneRIFs: Gene References Into Functions

    Pathways from PubChem

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    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Homology

    Gene Ontology Provided by SGD

    Function Evidence Code Pubs
    enables deoxyhypusine synthase activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables deoxyhypusine synthase activity IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    enables deoxyhypusine synthase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables transferase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    Process Evidence Code Pubs
    involved_in peptidyl-lysine modification to peptidyl-hypusine IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    involved_in peptidyl-lysine modification to peptidyl-hypusine IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in spermidine metabolic process IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    Component Evidence Code Pubs
    located_in cytoplasm HDA PubMed 
    is_active_in cytoplasm IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  

    General protein information

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    Preferred Names
    deoxyhypusine synthase
    NP_011935.1
    • Deoxyhypusine synthase; catalyzes formation of deoxyhypusine, the first step in hypusine biosynthesis; triggers posttranslational hypusination of translation elongation factor eIF-5A and regulates its intracellular levels; tetrameric; human homolog DHPS allows growth of yeast haploid dys1 null mutant after sporulation of heterozygous diploid

    NCBI Reference Sequences (RefSeq)

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    Genome Annotation

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference assembly

    Genomic

    1. NC_001140.6 Reference assembly

      Range
      232133..233296
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_001179198.1 → NP_011935.1  TPA: deoxyhypusine synthase [Saccharomyces cerevisiae S288C]

      See identical proteins and their annotated locations for NP_011935.1

      Status: REVIEWED

      UniProtKB/Swiss-Prot
      D3DL17, P38791
      UniProtKB/TrEMBL
      A6ZSX4, B3LSI6, B5VJZ6, C7GWS9, C8Z9K6, G2WFE0, N1P2M4
      Conserved Domains (1) summary
      pfam01916
      Location:48 → 373
      DS; Deoxyhypusine synthase
    Nucleotide Protein
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    P38791.1

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