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    ROY1 Roy1p [ Saccharomyces cerevisiae S288C ]

    Gene ID: 855300, updated on 18-Sep-2024

    Summary

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    Official Symbol
    ROY1
    Official Full Name
    Roy1p
    Primary source
    SGD:S000004871
    Locus tag
    YMR258C
    See related
    AllianceGenome:SGD:S000004871; FungiDB:YMR258C; VEuPathDB:YMR258C
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Saccharomyces cerevisiae S288C (strain: S288C)
    Lineage
    Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes; Saccharomycetales; Saccharomycetaceae; Saccharomyces
    Summary
    Enables GTPase inhibitor activity. Involved in endocytosis; negative regulation of GTPase activity; and protein targeting to vacuole. Located in endoplasmic reticulum and nucleus. [provided by Alliance of Genome Resources, Apr 2022]
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    Genomic context

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    See ROY1 in Genome Data Viewer
    Location:
    chromosome: XIII
    Exon count:
    1
    Sequence:
    Chromosome: XIII; NC_001145.3 (782620..784281, complement)

    Chromosome XIII - NC_001145.3Genomic Context describing neighboring genes Neighboring gene cytochrome c oxidase subunit VII Neighboring gene Pet111p Neighboring gene tRNA methylation protein TRM732 Neighboring gene Tif11p

    Genomic regions, transcripts, and products

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    Genomic Sequence:
    NC_001145.3

    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. Overexpression of the novel F-box protein Ymr258c confers resistance to methylmercury in Saccharomyces cerevisiae. Hwang GW, et al. J Toxicol Sci, 2009 Oct. PMID 19652464
    2. Non-SCF-type F-box protein Roy1/Ymr258c interacts with a Rab5-like GTPase Ypt52 and inhibits Ypt52 function. Liu Y, et al. Mol Biol Cell, 2011 May. PMID 21389113, Free PMC Article
    3. Chemical genetics screen for enhancers of rapamycin identifies a specific inhibitor of an SCF family E3 ubiquitin ligase. Aghajan M, et al. Nat Biotechnol, 2010 Jul. PMID 20581845, Free PMC Article
    4. Signal-induced disassembly of the SCF ubiquitin ligase complex by Cdc48/p97. Yen JL, et al. Mol Cell, 2012 Oct 26. PMID 23000173, Free PMC Article
    5. PtdIns(3)P accumulation in triple lipid-phosphatase-deletion mutants triggers lethal hyperactivation of the Rho1p/Pkc1p cell-integrity MAP kinase pathway. Parrish WR, et al. J Cell Sci, 2005 Dec 1. PMID 16306222

    See all (27) citations in PubMed

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?
    1. Roy1, previously called Ymr258c, regulates cell viability and intracellular trafficking by inhibiting Ypt52, which may provide an explanation for the dormancy of Ypt52.
      Title: Non-SCF-type F-box protein Roy1/Ymr258c interacts with a Rab5-like GTPase Ypt52 and inhibits Ypt52 function.
    2. Its overexpression confers resistance to methylmercury in Saccharomyces cerevisiae.
      Title: Overexpression of the novel F-box protein Ymr258c confers resistance to methylmercury in Saccharomyces cerevisiae.
    Submit: New GeneRIF Correction

    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Homology

    Gene Ontology Provided by SGD

    Function Evidence Code Pubs
    enables GTPase inhibitor activity IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    Process Evidence Code Pubs
    involved_in endocytosis IGI
    Inferred from Genetic Interaction
    more info
    		 PubMed 
    involved_in protein targeting to vacuole IGI
    Inferred from Genetic Interaction
    more info
    		 PubMed 
    Component Evidence Code Pubs
    located_in cytoplasm HDA PubMed 
    located_in cytoplasm IEA
    Inferred from Electronic Annotation
    more info
    		  
    located_in cytoplasmic vesicle IEA
    Inferred from Electronic Annotation
    more info
    		  
    located_in cytoplasmic vesicle membrane IEA
    Inferred from Electronic Annotation
    more info
    		  
    located_in endoplasmic reticulum HDA PubMed 
    located_in membrane IEA
    Inferred from Electronic Annotation
    more info
    		  
    located_in nucleus HDA PubMed 
    located_in nucleus IEA
    Inferred from Electronic Annotation
    more info
    		  

    General protein information

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    Preferred Names
    Roy1p
    NP_013985.1
    • GTPase inhibitor with similarity to F-box proteins; inhibits Ypt52p GTPase activity by preventing Ypt52p from binding GTP; involved in regulating intracellular trafficking; physically interacts with Skp1p

    NCBI Reference Sequences (RefSeq)

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    Genome Annotation

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference assembly

    Genomic

    1. NC_001145.3 Reference assembly

      Range
      782620..784281 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_001182765.1 → NP_013985.1  TPA: Roy1p [Saccharomyces cerevisiae S288C]

      See identical proteins and their annotated locations for NP_013985.1

      Status: REVIEWED

      UniProtKB/Swiss-Prot
      D6W084, Q04847
      UniProtKB/TrEMBL
      A6ZMX3, B3LME6, B5VQ23, C7GR94, C8ZFC4, N1NYQ9
    Nucleotide Protein
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    Q04847.1

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