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    LCP5 Lcp5p [ Saccharomyces cerevisiae S288C ]

    Gene ID: 856864, updated on 18-Sep-2024

    Summary

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    Official Symbol
    LCP5
    Official Full Name
    Lcp5p
    Primary source
    SGD:S000000929
    Locus tag
    YER127W
    See related
    AllianceGenome:SGD:S000000929; FungiDB:YER127W; VEuPathDB:YER127W
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Saccharomyces cerevisiae S288C (strain: S288C)
    Lineage
    Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes; Saccharomycetales; Saccharomycetaceae; Saccharomyces
    Summary
    Involved in endonucleolytic cleavage in 5'-ETS of tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA) and endonucleolytic cleavage in ITS1 to separate SSU-rRNA from 5.8S rRNA and LSU-rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA). Located in nucleolus. Orthologous to human NGDN (neuroguidin). [provided by Alliance of Genome Resources, Apr 2022]
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    Genomic context

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    See LCP5 in Genome Data Viewer
    Location:
    chromosome: V
    Exon count:
    1
    Sequence:
    Chromosome: V; NC_001137.3 (414481..415554)

    Chromosome V - NC_001137.3Genomic Context describing neighboring genes Neighboring gene NEDD4 family E3 ubiquitin-protein ligase Neighboring gene rRNA-processing protein NSA2 Neighboring gene Vfa1p Neighboring gene serine/threonine protein kinase SAK1

    Genomic regions, transcripts, and products

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    Genomic Sequence:
    NC_001137.3

    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. Synthetic lethal interactions with conditional poly(A) polymerase alleles identify LCP5, a gene involved in 18S rRNA maturation. Wiederkehr T, et al. RNA, 1998 Nov. PMID 9814757, Free PMC Article
    2. Thermophile 90S Pre-ribosome Structures Reveal the Reverse Order of Co-transcriptional 18S rRNA Subdomain Integration. Cheng J, et al. Mol Cell, 2019 Sep 19. PMID 31378463
    3. Sgd1 is an MIF4G domain-containing cofactor of the RNA helicase Fal1 and associates with the 5' domain of the 18S rRNA sequence. Davila Gallesio J, et al. RNA Biol, 2020 Apr. PMID 31994962, Free PMC Article
    4. Rcl1p, the yeast protein similar to the RNA 3'-phosphate cyclase, associates with U3 snoRNP and is required for 18S rRNA biogenesis. Billy E, et al. EMBO J, 2000 May 2. PMID 10790377, Free PMC Article
    5. Ribosome synthesis in Saccharomyces cerevisiae. Venema J, et al. Annu Rev Genet, 1999. PMID 10690410

    See all (49) citations in PubMed

    GeneRIFs: Gene References Into Functions

    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Homology

    Gene Ontology Provided by SGD

    Function Evidence Code Pubs
    enables molecular_function ND
    No biological Data available
    more info
    		  
    Process Evidence Code Pubs
    involved_in biological_process ND
    No biological Data available
    more info
    		  
    involved_in maturation of SSU-rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA) IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in rRNA processing IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in ribosome biogenesis IEA
    Inferred from Electronic Annotation
    more info
    		  
    Component Evidence Code Pubs
    is_active_in nucleolus IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    located_in nucleolus IEA
    Inferred from Electronic Annotation
    more info
    		  
    located_in nucleus IEA
    Inferred from Electronic Annotation
    more info
    		  
    part_of ribonucleoprotein complex IEA
    Inferred from Electronic Annotation
    more info
    		  
    part_of small nuclear ribonucleoprotein complex TAS
    Traceable Author Statement
    more info
    		 PubMed 
    part_of small-subunit processome IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    part_of sno(s)RNA-containing ribonucleoprotein complex TAS
    Traceable Author Statement
    more info
    		 PubMed 

    General protein information

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    Preferred Names
    Lcp5p
    NP_011053.1
    • Essential protein involved in maturation of 18S rRNA; depletion leads to inhibited pre-rRNA processing and reduced polysome levels; localizes primarily to the nucleolus

    NCBI Reference Sequences (RefSeq)

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    Genome Annotation

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference assembly

    Genomic

    1. NC_001137.3 Reference assembly

      Range
      414481..415554
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_001179017.1 → NP_011053.1  TPA: Lcp5p [Saccharomyces cerevisiae S288C]

      See identical proteins and their annotated locations for NP_011053.1

      Status: REVIEWED

      UniProtKB/Swiss-Prot
      D3DM33, P40079
      UniProtKB/TrEMBL
      A6ZR81, B3LRP3, C7GKX4, C8Z7E4
      Conserved Domains (1) summary
      pfam04000
      Location:8 → 108
      Sas10_Utp3; Sas10/Utp3/C1D family
    Nucleotide Protein
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    P40079.1

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