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    lkh1 dual-specificity [ Schizosaccharomyces pombe (fission yeast) ]

    Gene ID: 3361532, updated on 18-Sep-2024

    Summary

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    Official Symbol
    lkh1
    Official Full Name
    dual-specificity
    Primary source
    PomBase:SPAC1D4.11c
    Locus tag
    SPOM_SPAC1D4.11C
    Gene type
    protein coding
    RefSeq status
    PROVISIONAL
    Organism
    Schizosaccharomyces pombe (strain: 972h-)
    Lineage
    Eukaryota; Fungi; Dikarya; Ascomycota; Taphrinomycotina; Schizosaccharomycetes; Schizosaccharomycetales; Schizosaccharomycetaceae; Schizosaccharomyces
    Also known as
    kic1
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    Genomic context

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    See lkh1 in Genome Data Viewer
    Location:
    chromosome: I
    Exon count:
    1
    Sequence:
    Chromosome: I; NC_003424.3 (656076..660177, complement)

    Chromosome I - NC_003424.3Genomic Context describing neighboring genes Neighboring gene ncRNA Neighboring gene ncRNA Neighboring gene DNA replication termination factor Rtf2 Neighboring gene 3' tRNA-processing endonuclease tRNAse Z L2 Trz1 Neighboring gene ncRNA Neighboring gene ncRNA Neighboring gene ncRNA Neighboring gene ncRNA Neighboring gene ncRNA Neighboring gene ncRNA Neighboring gene transcription factor TFIIH complex subunit Rad15

    Genomic regions, transcripts, and products

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    Genomic Sequence:
    NC_003424.3

    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. LAMMER kinase homolog, Lkh1, is involved in oxidative-stress response of fission yeast. Park YD, et al. Biochem Biophys Res Commun, 2003 Nov 28. PMID 14623292
    2. LAMMER Kinase Lkh1 Is an Upstream Regulator of Prk1-Mediated Non-Sexual Flocculation in Fission Yeast. Park YD, et al. Mycobiology, 2018. PMID 30294483, Free PMC Article
    3. Fission yeast LAMMER kinase Lkh1 regulates the cell cycle by phosphorylating the CDK-inhibitor Rum1. Yu EY, et al. Biochem Biophys Res Commun, 2013 Mar 1. PMID 23376070
    4. LAMMER kinase Kic1 is involved in pre-mRNA processing. Tang Z, et al. Exp Cell Res, 2011 Oct 1. PMID 21745468
    5. The kic1 kinase of schizosaccharomyces pombe is a CLK/STY orthologue that regulates cell-cell separation. Tang Z, et al. Exp Cell Res, 2003 Feb 1. PMID 12565823

    See all (19) citations in PubMed

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?
    1. this report presents for the first time a positive acting mechanism that is responsible for the CKI activity of Rum1, in which the LAMMER kinase-mediated phosphorylation of Rum1 is involved.
      Title: Fission yeast LAMMER kinase Lkh1 regulates the cell cycle by phosphorylating the CDK-inhibitor Rum1.
    2. Kic1 is not only required for efficient splicing but also affects nuclear mRNA export, providing evidence for the conserved roles of LAMMER kinases in the unicellular context of fission yeast.
      Title: LAMMER kinase Kic1 is involved in pre-mRNA processing.
    3. The LAMMER kinase homolog, Lkh1, regulates Tup11,12 transcriptional repressors through phosphorylation in Schizosaccharomyces pombe.
      Title: The LAMMER kinase homolog, Lkh1, regulates Tup transcriptional repressors through phosphorylation in Schizosaccharomyces pombe.
    Submit: New GeneRIF Correction

    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Homology

    Gene Ontology Provided by PomBase

    Function Evidence Code Pubs
    enables ATP binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables protein kinase activity IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    enables protein serine/threonine kinase activity EXP
    Inferred from Experiment
    more info
    		 PubMed 
    enables protein serine/threonine kinase activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables protein serine/threonine kinase activity IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    enables protein serine/threonine kinase activity IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    enables protein tyrosine kinase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    Process Evidence Code Pubs
    involved_in cellular response to oxidative stress IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in negative regulation of G1/S transition of mitotic cell cycle IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in negative regulation of transcription by RNA polymerase II IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in positive regulation of mRNA splicing, via spliceosome IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in regulation of RNA splicing IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in septum digestion after cytokinesis IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in signaling NAS
    Non-traceable Author Statement
    more info
    		  
    Component Evidence Code Pubs
    is_active_in nucleus HDA PubMed 
    is_active_in nucleus IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    is_active_in nucleus IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    is_active_in nucleus IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 

    General protein information

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    Preferred Names
    dual-specificity

    NCBI Reference Sequences (RefSeq)

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    Genome Annotation

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference assembly

    Genomic

    1. NC_003424.3 Reference assembly

      Range
      656076..660177 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_001018423.4 → NP_001018187.2  dual-specificity [Schizosaccharomyces pombe]

      See identical proteins and their annotated locations for NP_001018187.2

      Status: PROVISIONAL

      UniProtKB/Swiss-Prot
      Q10156, Q9C3Y9
      Conserved Domains (3) summary
      smart00220
      Location:362 → 682
      S_TKc; Serine/Threonine protein kinases, catalytic domain
      cd14134
      Location:349 → 682
      PKc_CLK; Catalytic domain of the Dual-specificity protein kinases, CDC-like kinases
      pfam06752
      Location:104 → 198
      E_Pc_C; Enhancer of Polycomb C-terminus
    Nucleotide Protein
    Heading Accession and Version

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