SRCIN1 SRC kinase signaling inhibitor 1 [Homo sapiens (human)] - Gene

Summary

Official Symbol: SRCIN1provided by HGNC
Official Full Name: SRC kinase signaling inhibitor 1provided by HGNC
Primary source: HGNC:HGNC:29506
See related: Ensembl:ENSG00000277363 MIM:610786; AllianceGenome:HGNC:29506
Gene type: protein coding
RefSeq status: VALIDATED
Organism: Homo sapiens
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Also known as: P140; SNIP
Summary: Enables protein kinase binding activity. Involved in several processes, including postsynaptic actin cytoskeleton organization; regulation of protein tyrosine kinase activity; and substrate adhesion-dependent cell spreading. Located in actin cytoskeleton and cytoplasm. Is active in glutamatergic synapse. [provided by Alliance of Genome Resources, Oct 2024]
Expression: Biased expression in brain (RPKM 9.1), salivary gland (RPKM 1.2) and 2 other tissues See more
Orthologs: mouse all
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Genomic context

Location:: 17q12

Exon count:: 26

Annotation release	Status	Assembly	Chr	Location
RS_2024_08	current	GRCh38.p14 (GCF_000001405.40)	17	NC_000017.11 (38530031..38607025, complement)
RS_2024_08	current	T2T-CHM13v2.0 (GCF_009914755.1)	17	NC_060941.1 (39393085..39470208, complement)
RS_2024_09	previous assembly	GRCh37.p13 (GCF_000001405.25)	17	NC_000017.10 (36686266..36762205, complement)

Chromosome 17 - NC_000017.11 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Go to reference sequence details

Genomic Sequence:

Go to nucleotide: Graphics FASTA GenBank

Expression

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See details

Project title: HPA RNA-seq normal tissues HPA RNA-seq normal tissues
Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
BioProject: PRJEB4337
Publication: PMID 24309898
Analysis date: Wed Apr 4 07:08:55 2018

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Hypermethylation of the Gene Body in SRCIN1 Is Involved in Breast Cancer Cell Proliferation and Is a Potential Blood-Based Biomarker for Early Detection and a Poor Prognosis.
Title: Hypermethylation of the Gene Body in SRCIN1 Is Involved in Breast Cancer Cell Proliferation and Is a Potential Blood-Based Biomarker for Early Detection and a Poor Prognosis.
p140Cap inhibits beta-Catenin in the breast cancer stem cell compartment instructing a protective anti-tumor immune response.
Title: p140Cap inhibits β-Catenin in the breast cancer stem cell compartment instructing a protective anti-tumor immune response.
FOXD3-AS1 suppresses the progression of non-small cell lung cancer by regulating miR-150/SRCIN1axis.
Title: FOXD3-AS1 suppresses the progression of non-small cell lung cancer by regulating miR-150/SRCIN1axis.
The SRCIN1/p140Cap adaptor protein negatively regulates the aggressiveness of neuroblastoma.
Title: The SRCIN1/p140Cap adaptor protein negatively regulates the aggressiveness of neuroblastoma.
SRCIN1 Regulated by circCCDC66/miR-211 Is Upregulated and Promotes Cell Proliferation in Non-Small-Cell Lung Cancer.
Title: SRCIN1 Regulated by circCCDC66/miR-211 Is Upregulated and Promotes Cell Proliferation in Non-Small-Cell Lung Cancer.
The p140Cap adaptor protein as a molecular hub to block cancer aggressiveness.
Title: The p140Cap adaptor protein as a molecular hub to block cancer aggressiveness.
lncRNA TPTEP1 competitively sponges miR3285p to inhibit the proliferation of nonsmall cell lung cancer cells.
Title: lncRNA TPTEP1 competitively sponges miR‑328‑5p to inhibit the proliferation of non‑small cell lung cancer cells.
Breast cancer cell-derived exosomal miR-20a-5p promotes the proliferation and differentiation of osteoclasts by targeting SRCIN1.
Title: Breast cancer cell-derived exosomal miR-20a-5p promotes the proliferation and differentiation of osteoclasts by targeting SRCIN1.
These findings suggest that the miR-17-5p promotes cell proliferation, and EMT in human OS by directly targeting the SRCIN1, and reveal a branch of the miR-17-5p/SRCIN1/EMT signaling pathway involved in the progression of osteosarcoma.
Title: miR-17-5p promotes proliferation and epithelial-mesenchymal transition in human osteosarcoma cells by targeting SRC kinase signaling inhibitor 1.
the present study is the first to provide evidence that miR208a exerts oncogenic functions in the carcinogenesis and progression of nonsmall cell lung cancer by directly targeting SRCIN1 and regulating the ERK pathway.
Title: MicroRNA‑208a directly targets Src kinase signaling inhibitor 1 to facilitate cell proliferation and invasion in non‑small cell lung cancer.

Submit: New GeneRIF Correction See all GeneRIFs (25)

Phenotypes

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Find tests for this gene in the NIH Genetic Testing Registry (GTR)

Review eQTL and phenotype association data in this region using PheGenI

Variation

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See variants in ClinVar

See studies and variants in dbVar

See Variation Viewer (GRCh37.p13)

See Variation Viewer (GRCh38)

Interactions

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Products	Interactant	Other Gene	Complex	Source	Pubs	Description

General gene information

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Markers

G62210 (e-PCR)
- UniSTS:146688

RH44305 (e-PCR)
- UniSTS:4472

D11S3114 (e-PCR)
- UniSTS:152207

Gene Ontology Provided by GOA

Function	Evidence Code	Pubs
enables protein binding	IPI Inferred from Physical Interaction more info	PubMed
enables protein kinase binding	IDA Inferred from Direct Assay more info	PubMed

Process	Evidence Code	Pubs
involved_in exocytosis	IEA Inferred from Electronic Annotation more info
involved_in negative regulation of protein tyrosine kinase activity	IDA Inferred from Direct Assay more info	PubMed
involved_in positive regulation of protein tyrosine kinase activity	IDA Inferred from Direct Assay more info	PubMed
involved_in postsynaptic actin cytoskeleton organization	IDA Inferred from Direct Assay more info	PubMed
involved_in postsynaptic actin cytoskeleton organization	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in regulation of cell migration	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in regulation of dendritic spine morphogenesis	IBA Inferred from Biological aspect of Ancestor more info
involved_in regulation of dendritic spine morphogenesis	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in substrate adhesion-dependent cell spreading	IMP Inferred from Mutant Phenotype more info	PubMed

Component	Evidence Code	Pubs
is_active_in actin cytoskeleton	IBA Inferred from Biological aspect of Ancestor more info
located_in actin cytoskeleton	IDA Inferred from Direct Assay more info	PubMed
located_in axon	ISS Inferred from Sequence or Structural Similarity more info
is_active_in cytoplasm	IBA Inferred from Biological aspect of Ancestor more info
located_in cytoplasm	IDA Inferred from Direct Assay more info	PubMed
located_in dendrite	ISS Inferred from Sequence or Structural Similarity more info
NOT located_in focal adhesion	IDA Inferred from Direct Assay more info	PubMed
is_active_in glutamatergic synapse	IDA Inferred from Direct Assay more info	PubMed
is_active_in glutamatergic synapse	IMP Inferred from Mutant Phenotype more info	PubMed
is_active_in postsynaptic density	IBA Inferred from Biological aspect of Ancestor more info
located_in postsynaptic density	ISS Inferred from Sequence or Structural Similarity more info
located_in presynapse	IEA Inferred from Electronic Annotation more info
located_in synapse	ISS Inferred from Sequence or Structural Similarity more info

General protein information

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Preferred Names: SRC kinase signaling inhibitor 1

Names: P130Cas-associated protein; SNAP-25-interacting protein; SNAP25-interacting protein; p140Cap

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

NM_025248.3 → NP_079524.2 SRC kinase signaling inhibitor 1

See identical proteins and their annotated locations for NP_079524.2

Status: VALIDATED

Source sequence(s)

AC006449, AC115090, AC129916

Consensus CDS

CCDS45660.1

UniProtKB/Swiss-Prot

Q75T46, Q8N4W8, Q9C0H9

UniProtKB/TrEMBL

A0A087X165

Related

ENSP00000484715.1, ENST00000617146.5

Conserved Domains (2) summary

cl25732
Location:686 → 840

SMC_N; RecF/RecN/SMC N terminal domain

cl27222
Location:184 → 263

AIP3; Actin interacting protein 3

RefSeqs of Annotated Genomes: GCF_000001405.40-RS_2024_08

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p14 Primary Assembly

Genomic

NC_000017.11 Reference GRCh38.p14 Primary Assembly

Range

38530031..38607025 complement

Download

GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

XM_017025169.2 → XP_016880658.1 SRC kinase signaling inhibitor 1 isoform X1

UniProtKB/TrEMBL

A0A087X165
XM_017025172.2 → XP_016880661.1 SRC kinase signaling inhibitor 1 isoform X5

UniProtKB/TrEMBL

A0A087X165
XM_017025171.2 → XP_016880660.1 SRC kinase signaling inhibitor 1 isoform X3

UniProtKB/TrEMBL

A0A087X165
XM_017025170.2 → XP_016880659.1 SRC kinase signaling inhibitor 1 isoform X2

UniProtKB/TrEMBL

A0A087X165
XM_047436852.1 → XP_047292808.1 SRC kinase signaling inhibitor 1 isoform X7
XM_017025173.2 → XP_016880662.1 SRC kinase signaling inhibitor 1 isoform X6

UniProtKB/TrEMBL

A0A087X165
XM_047436851.1 → XP_047292807.1 SRC kinase signaling inhibitor 1 isoform X4

Related

ENST00000621763.4