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These reference sequences exist independently of genome builds. Explain
These reference sequences are curated independently of the genome
annotation cycle, so their versions may not match the RefSeq versions in the current
genome build. Identify version mismatches by comparing the version of the RefSeq in
this section to the one reported in Genomic regions,
transcripts, and products above.
Genomic
-
NG_053158.1 RefSeqGene
- Range
-
56193..215230
- Download
- GenBank, FASTA, Sequence Viewer (Graphics)
mRNA and Protein(s)
-
NM_001256024.2 → NP_001242953.1 rho GTPase-activating protein 22 isoform 1
See identical proteins and their annotated locations for NP_001242953.1
Status: REVIEWED
- Description
- Transcript Variant: This variant (1) encodes the longest isoform (1).
- Source sequence(s)
-
AC016397, AC016399, BC126444, DB338179
- Consensus CDS
-
CCDS58080.1
- UniProtKB/TrEMBL
- A0A2X0SFC0, B3KNU1
- Related
- ENSP00000412461.2, ENST00000417912.6
- Conserved Domains (3) summary
-
- cd04390
Location:167 → 365
- RhoGAP_ARHGAP22_24_25; RhoGAP_ARHGAP22_24_25: GTPase-activator protein (GAP) domain for Rho-like GTPases found in ARHGAP22, 24 and 25-like proteins; longer isoforms of these proteins contain an additional N-terminal pleckstrin homology (PH) domain. ARHGAP25 (KIA0053) has been ...
- cd13378
Location:36 → 151
- PH_RhoGAP2; Rho GTPase activating protein 2 Pleckstrin homology (PH) domain
- cl25732
Location:606 → 694
- SMC_N; RecF/RecN/SMC N terminal domain
-
NM_001256025.3 → NP_001242954.1 rho GTPase-activating protein 22 isoform 2
See identical proteins and their annotated locations for NP_001242954.1
Status: REVIEWED
- Description
- Transcript Variant: This variant (2) uses an alternate 5' exon and thus differs in the 5' UTR and 5' coding region, and uses an alternate in-frame splice site in the 5' coding region, compared to variant 1. The resulting isoform (2) is shorter and has a distinct N-terminus, compared to isoform 1. Variants 2 and 10 both encode the same isoform (2).
- Source sequence(s)
-
AK293579, AY324801, DC391765
- Consensus CDS
-
CCDS58081.1
- UniProtKB/TrEMBL
-
B3KNU1
- Related
- ENSP00000416701.2, ENST00000435790.6
- Conserved Domains (4) summary
-
- cd04390
Location:157 → 355
- RhoGAP_ARHGAP22_24_25; RhoGAP_ARHGAP22_24_25: GTPase-activator protein (GAP) domain for Rho-like GTPases found in ARHGAP22, 24 and 25-like proteins; longer isoforms of these proteins contain an additional N-terminal pleckstrin homology (PH) domain. ARHGAP25 (KIA0053) has been ...
- cd13378
Location:42 → 157
- PH_RhoGAP2; Rho GTPase activating protein 2 Pleckstrin homology (PH) domain
- pfam00169
Location:44 → 150
- PH; PH domain
- cl05005
Location:556 → 685
- TAF4; TATA Binding Protein (TBP) Associated Factor 4 (TAF4) is one of several TAFs that bind TBP and is involved in forming Transcription Factor IID (TFIID) complex
-
NM_001256026.2 → NP_001242955.1 rho GTPase-activating protein 22 isoform 4
See identical proteins and their annotated locations for NP_001242955.1
Status: REVIEWED
- Description
- Transcript Variant: This variant (4) differs in the 5' UTR and lacks a portion of the 5' coding region, uses an alternate in-frame splice site in a 5' exon, and initiates translation at an alternate start codon compared to variant 1. The resulting protein (isoform 4) is shorter and has a distinct N-terminus compared to isoform 1.
- Source sequence(s)
-
AC016397, AK127586, DB338179
- Consensus CDS
-
CCDS58079.1
- UniProtKB/TrEMBL
-
B3KNU1
- Related
- ENSP00000410054.2, ENST00000417247.6
- Conserved Domains (4) summary
-
- cd04390
Location:61 → 259
- RhoGAP_ARHGAP22_24_25; RhoGAP_ARHGAP22_24_25: GTPase-activator protein (GAP) domain for Rho-like GTPases found in ARHGAP22, 24 and 25-like proteins; longer isoforms of these proteins contain an additional N-terminal pleckstrin homology (PH) domain. ARHGAP25 (KIA0053) has been ...
- pfam00169
Location:29 → 54
- PH; PH domain
- cl05005
Location:460 → 589
- TAF4; TATA Binding Protein (TBP) Associated Factor 4 (TAF4) is one of several TAFs that bind TBP and is involved in forming Transcription Factor IID (TFIID) complex
- cl17171
Location:18 → 61
- PH-like; Pleckstrin homology-like domain
-
NM_001347735.2 → NP_001334664.1 rho GTPase-activating protein 22 isoform 7
Status: REVIEWED
- Source sequence(s)
-
AC016397, AC016399
- UniProtKB/TrEMBL
-
B3KNU1
-
NM_001347736.2 → NP_001334665.1 rho GTPase-activating protein 22 isoform 8
Status: REVIEWED
- Source sequence(s)
-
AC016399, AC068898
- Conserved Domains (1) summary
-
- cl17171
Location:42 → 84
- PH-like; Pleckstrin homology-like domain
-
NM_001347737.2 → NP_001334666.1 rho GTPase-activating protein 22 isoform 9
Status: REVIEWED
- Source sequence(s)
-
AC016399
-
NM_001347738.2 → NP_001334667.1 rho GTPase-activating protein 22 isoform 2
Status: REVIEWED
- Description
- Transcript Variant: This variant (10), as well as variant 2, encodes isoform 2.
- Source sequence(s)
-
AC016397, AC016399, AC068898
- Consensus CDS
-
CCDS58081.1
- UniProtKB/TrEMBL
-
B3KNU1
-
NM_021226.4 → NP_067049.2 rho GTPase-activating protein 22 isoform 3
See identical proteins and their annotated locations for NP_067049.2
Status: REVIEWED
- Description
- Transcript Variant: This variant (3) uses an alternate in-frame splice site in the 5' coding region compared to variant 1. The resulting protein (isoform 3) is shorter compared with isoform 1.
- Source sequence(s)
-
AY324801
- Consensus CDS
-
CCDS7227.1
- UniProtKB/Swiss-Prot
- A0AVP7, A5YM75, B4DED8, B9EGA0, C9JDM2, O00152, Q6ZSB0, Q7Z5H3
- UniProtKB/TrEMBL
-
B3KNU1
- Related
- ENSP00000249601.4, ENST00000249601.9
- Conserved Domains (4) summary
-
- cd04390
Location:151 → 349
- RhoGAP_ARHGAP22_24_25; RhoGAP_ARHGAP22_24_25: GTPase-activator protein (GAP) domain for Rho-like GTPases found in ARHGAP22, 24 and 25-like proteins; longer isoforms of these proteins contain an additional N-terminal pleckstrin homology (PH) domain. ARHGAP25 (KIA0053) has been ...
- cd13378
Location:36 → 151
- PH_RhoGAP2; Rho GTPase activating protein 2 Pleckstrin homology (PH) domain
- pfam00169
Location:38 → 144
- PH; PH domain
- cl05005
Location:550 → 679
- TAF4; TATA Binding Protein (TBP) Associated Factor 4 (TAF4) is one of several TAFs that bind TBP and is involved in forming Transcription Factor IID (TFIID) complex
RNA
-
NR_045675.2 RNA Sequence
Status: REVIEWED
- Description
- Transcript Variant: This variant (6) contains alternate 5' exons and uses an alternate splice site in an internal exon, compared to variant 1. This variant is represented as non-coding because the use of the supported translational start codon, as used in variant 2, renders the transcript a candidate for nonsense-mediated mRNA decay (NMD).
- Source sequence(s)
-
AC016397, AK055937, DB338179
- Related
-
ENST00000460425.1
-
NR_144642.2 RNA Sequence
Status: REVIEWED
- Source sequence(s)
-
AC016397, AC016399
-
NR_144643.2 RNA Sequence
Status: REVIEWED
- Source sequence(s)
-
AC016397, AC016399
-
NR_144644.2 RNA Sequence
Status: REVIEWED
- Source sequence(s)
-
AC016397, AC016399
-
NR_144645.2 RNA Sequence
Status: REVIEWED
- Source sequence(s)
-
AC016397, AC016399
-
NR_144646.2 RNA Sequence
Status: REVIEWED
- Source sequence(s)
-
AC016397, AC016399
The following sections contain reference sequences that belong to a
specific genome build. Explain
This section includes genomic Reference
Sequences (RefSeqs) from all assemblies on which this gene is annotated, such as
RefSeqs for chromosomes and scaffolds (contigs) from both reference and alternate
assemblies. Model RNAs and proteins are also reported here.
Reference GRCh38.p14 Primary Assembly
Genomic
-
NC_000010.11 Reference GRCh38.p14 Primary Assembly
- Range
-
48429831..48656265 complement
- Download
- GenBank, FASTA, Sequence Viewer (Graphics)
mRNA and Protein(s)
-
XM_024448100.2 → XP_024303868.1 rho GTPase-activating protein 22 isoform X14
- Conserved Domains (2) summary
-
- cd04390
Location:157 → 347
- RhoGAP_ARHGAP22_24_25; RhoGAP_ARHGAP22_24_25: GTPase-activator protein (GAP) domain for Rho-like GTPases found in ARHGAP22, 24 and 25-like proteins; longer isoforms of these proteins contain an additional N-terminal pleckstrin homology (PH) domain. ARHGAP25 (KIA0053) has been ...
- cd13378
Location:42 → 157
- PH_RhoGAP2; Rho GTPase activating protein 2 Pleckstrin homology (PH) domain
-
XM_011540013.4 → XP_011538315.1 rho GTPase-activating protein 22 isoform X12
- Conserved Domains (3) summary
-
- cd04390
Location:173 → 363
- RhoGAP_ARHGAP22_24_25; RhoGAP_ARHGAP22_24_25: GTPase-activator protein (GAP) domain for Rho-like GTPases found in ARHGAP22, 24 and 25-like proteins; longer isoforms of these proteins contain an additional N-terminal pleckstrin homology (PH) domain. ARHGAP25 (KIA0053) has been ...
- cd13378
Location:42 → 157
- PH_RhoGAP2; Rho GTPase activating protein 2 Pleckstrin homology (PH) domain
- pfam00169
Location:44 → 150
- PH; PH domain
-
XM_017016476.2 → XP_016871965.1 rho GTPase-activating protein 22 isoform X16
-
XM_011540003.2 → XP_011538305.1 rho GTPase-activating protein 22 isoform X1
See identical proteins and their annotated locations for XP_011538305.1
- UniProtKB/TrEMBL
-
B3KNU1
- Conserved Domains (3) summary
-
- cd04390
Location:173 → 371
- RhoGAP_ARHGAP22_24_25; RhoGAP_ARHGAP22_24_25: GTPase-activator protein (GAP) domain for Rho-like GTPases found in ARHGAP22, 24 and 25-like proteins; longer isoforms of these proteins contain an additional N-terminal pleckstrin homology (PH) domain. ARHGAP25 (KIA0053) has been ...
- cd13378
Location:42 → 157
- PH_RhoGAP2; Rho GTPase activating protein 2 Pleckstrin homology (PH) domain
- cl25732
Location:612 → 700
- SMC_N; RecF/RecN/SMC N terminal domain
-
XM_011540006.3 → XP_011538308.1 rho GTPase-activating protein 22 isoform X5
- UniProtKB/TrEMBL
-
B3KNU1
- Conserved Domains (4) summary
-
- cd04390
Location:114 → 312
- RhoGAP_ARHGAP22_24_25; RhoGAP_ARHGAP22_24_25: GTPase-activator protein (GAP) domain for Rho-like GTPases found in ARHGAP22, 24 and 25-like proteins; longer isoforms of these proteins contain an additional N-terminal pleckstrin homology (PH) domain. ARHGAP25 (KIA0053) has been ...
- pfam00169
Location:44 → 111
- PH; PH domain
- cl05005
Location:513 → 642
- TAF4; TATA Binding Protein (TBP) Associated Factor 4 (TAF4) is one of several TAFs that bind TBP and is involved in forming Transcription Factor IID (TFIID) complex
- cl17171
Location:42 → 127
- PH-like; Pleckstrin homology-like domain
-
XM_047425586.1 → XP_047281542.1 rho GTPase-activating protein 22 isoform X2
-
XM_011540015.4 → XP_011538317.1 rho GTPase-activating protein 22 isoform X17
- Conserved Domains (3) summary
-
- cd04390
Location:173 → 351
- RhoGAP_ARHGAP22_24_25; RhoGAP_ARHGAP22_24_25: GTPase-activator protein (GAP) domain for Rho-like GTPases found in ARHGAP22, 24 and 25-like proteins; longer isoforms of these proteins contain an additional N-terminal pleckstrin homology (PH) domain. ARHGAP25 (KIA0053) has been ...
- cd13378
Location:42 → 157
- PH_RhoGAP2; Rho GTPase activating protein 2 Pleckstrin homology (PH) domain
- pfam00169
Location:44 → 150
- PH; PH domain
-
XM_011540002.3 → XP_011538304.1 rho GTPase-activating protein 22 isoform X1
See identical proteins and their annotated locations for XP_011538304.1
- UniProtKB/TrEMBL
-
B3KNU1
- Conserved Domains (3) summary
-
- cd04390
Location:173 → 371
- RhoGAP_ARHGAP22_24_25; RhoGAP_ARHGAP22_24_25: GTPase-activator protein (GAP) domain for Rho-like GTPases found in ARHGAP22, 24 and 25-like proteins; longer isoforms of these proteins contain an additional N-terminal pleckstrin homology (PH) domain. ARHGAP25 (KIA0053) has been ...
- cd13378
Location:42 → 157
- PH_RhoGAP2; Rho GTPase activating protein 2 Pleckstrin homology (PH) domain
- cl25732
Location:612 → 700
- SMC_N; RecF/RecN/SMC N terminal domain
-
XM_024448099.2 → XP_024303867.1 rho GTPase-activating protein 22 isoform X1
- UniProtKB/TrEMBL
-
B3KNU1
- Conserved Domains (3) summary
-
- cd04390
Location:173 → 371
- RhoGAP_ARHGAP22_24_25; RhoGAP_ARHGAP22_24_25: GTPase-activator protein (GAP) domain for Rho-like GTPases found in ARHGAP22, 24 and 25-like proteins; longer isoforms of these proteins contain an additional N-terminal pleckstrin homology (PH) domain. ARHGAP25 (KIA0053) has been ...
- cd13378
Location:42 → 157
- PH_RhoGAP2; Rho GTPase activating protein 2 Pleckstrin homology (PH) domain
- cl25732
Location:612 → 700
- SMC_N; RecF/RecN/SMC N terminal domain
-
XM_011540011.3 → XP_011538313.1 rho GTPase-activating protein 22 isoform X10
- UniProtKB/TrEMBL
-
B3KNU1
- Conserved Domains (2) summary
-
- cd04390
Location:18 → 216
- RhoGAP_ARHGAP22_24_25; RhoGAP_ARHGAP22_24_25: GTPase-activator protein (GAP) domain for Rho-like GTPases found in ARHGAP22, 24 and 25-like proteins; longer isoforms of these proteins contain an additional N-terminal pleckstrin homology (PH) domain. ARHGAP25 (KIA0053) has been ...
- cl05005
Location:417 → 546
- TAF4; TATA Binding Protein (TBP) Associated Factor 4 (TAF4) is one of several TAFs that bind TBP and is involved in forming Transcription Factor IID (TFIID) complex
-
XM_047425589.1 → XP_047281545.1 rho GTPase-activating protein 22 isoform X8
- Related
- ENSP00000363285.1, ENST00000374170.5
-
XM_005270014.4 → XP_005270071.1 rho GTPase-activating protein 22 isoform X6
- UniProtKB/TrEMBL
-
B3KNU1
- Conserved Domains (4) summary
-
- cd04390
Location:77 → 275
- RhoGAP_ARHGAP22_24_25; RhoGAP_ARHGAP22_24_25: GTPase-activator protein (GAP) domain for Rho-like GTPases found in ARHGAP22, 24 and 25-like proteins; longer isoforms of these proteins contain an additional N-terminal pleckstrin homology (PH) domain. ARHGAP25 (KIA0053) has been ...
- pfam00169
Location:29 → 54
- PH; PH domain
- cl05005
Location:476 → 605
- TAF4; TATA Binding Protein (TBP) Associated Factor 4 (TAF4) is one of several TAFs that bind TBP and is involved in forming Transcription Factor IID (TFIID) complex
- cl17171
Location:18 → 61
- PH-like; Pleckstrin homology-like domain
-
XM_011540005.2 → XP_011538307.1 rho GTPase-activating protein 22 isoform X4
- UniProtKB/TrEMBL
-
B3KNU1
- Related
- ENSP00000363287.1, ENST00000374172.5
- Conserved Domains (4) summary
-
- cd04390
Location:77 → 275
- RhoGAP_ARHGAP22_24_25; RhoGAP_ARHGAP22_24_25: GTPase-activator protein (GAP) domain for Rho-like GTPases found in ARHGAP22, 24 and 25-like proteins; longer isoforms of these proteins contain an additional N-terminal pleckstrin homology (PH) domain. ARHGAP25 (KIA0053) has been ...
- pfam00169
Location:29 → 54
- PH; PH domain
- cl05005
Location:476 → 605
- TAF4; TATA Binding Protein (TBP) Associated Factor 4 (TAF4) is one of several TAFs that bind TBP and is involved in forming Transcription Factor IID (TFIID) complex
- cl17171
Location:18 → 61
- PH-like; Pleckstrin homology-like domain
-
XM_047425588.1 → XP_047281544.1 rho GTPase-activating protein 22 isoform X7
-
XM_047425590.1 → XP_047281546.1 rho GTPase-activating protein 22 isoform X9
-
XM_047425591.1 → XP_047281547.1 rho GTPase-activating protein 22 isoform X9
-
XM_047425587.1 → XP_047281543.1 rho GTPase-activating protein 22 isoform X3
-
XM_017016471.3 → XP_016871960.1 rho GTPase-activating protein 22 isoform X11
- UniProtKB/TrEMBL
-
B3KNU1
- Conserved Domains (2) summary
-
- cd04390
Location:5 → 203
- RhoGAP_ARHGAP22_24_25; RhoGAP_ARHGAP22_24_25: GTPase-activator protein (GAP) domain for Rho-like GTPases found in ARHGAP22, 24 and 25-like proteins; longer isoforms of these proteins contain an additional N-terminal pleckstrin homology (PH) domain. ARHGAP25 (KIA0053) has been ...
- cl05005
Location:404 → 533
- TAF4; TATA Binding Protein (TBP) Associated Factor 4 (TAF4) is one of several TAFs that bind TBP and is involved in forming Transcription Factor IID (TFIID) complex
-
XM_047425593.1 → XP_047281549.1 rho GTPase-activating protein 22 isoform X15
-
XM_047425592.1 → XP_047281548.1 rho GTPase-activating protein 22 isoform X13
-
XM_047425594.1 → XP_047281550.1 rho GTPase-activating protein 22 isoform X18
-
XM_047425595.1 → XP_047281551.1 rho GTPase-activating protein 22 isoform X20
-
XM_024448102.2 → XP_024303870.1 rho GTPase-activating protein 22 isoform X19
- Conserved Domains (1) summary
-
- cl17171
Location:42 → 130
- PH-like; Pleckstrin homology-like domain
-
XM_024448106.2 → XP_024303874.1 rho GTPase-activating protein 22 isoform X21
- Conserved Domains (1) summary
-
- cl17171
Location:42 → 84
- PH-like; Pleckstrin homology-like domain
Alternate T2T-CHM13v2.0
Genomic
-
NC_060934.1 Alternate T2T-CHM13v2.0
- Range
-
49275552..49505563 complement
- Download
- GenBank, FASTA, Sequence Viewer (Graphics)
mRNA and Protein(s)
-
XM_054366471.1 → XP_054222446.1 rho GTPase-activating protein 22 isoform X14
-
XM_054366469.1 → XP_054222444.1 rho GTPase-activating protein 22 isoform X12
-
XM_054366473.1 → XP_054222448.1 rho GTPase-activating protein 22 isoform X16
-
XM_054366457.1 → XP_054222432.1 rho GTPase-activating protein 22 isoform X1
-
XM_054366458.1 → XP_054222433.1 rho GTPase-activating protein 22 isoform X2
-
XM_054366455.1 → XP_054222430.1 rho GTPase-activating protein 22 isoform X1
-
XM_054366461.1 → XP_054222436.1 rho GTPase-activating protein 22 isoform X5
-
XM_054366474.1 → XP_054222449.1 rho GTPase-activating protein 22 isoform X17
-
XM_054366456.1 → XP_054222431.1 rho GTPase-activating protein 22 isoform X1
-
XM_054366464.1 → XP_054222439.1 rho GTPase-activating protein 22 isoform X8
-
XM_054366462.1 → XP_054222437.1 rho GTPase-activating protein 22 isoform X6
-
XM_054366460.1 → XP_054222435.1 rho GTPase-activating protein 22 isoform X4
-
XM_054366463.1 → XP_054222438.1 rho GTPase-activating protein 22 isoform X7
-
XM_054366465.1 → XP_054222440.1 rho GTPase-activating protein 22 isoform X9
-
XM_054366468.1 → XP_054222443.1 rho GTPase-activating protein 22 isoform X22
-
XM_054366466.1 → XP_054222441.1 rho GTPase-activating protein 22 isoform X9
-
XM_054366459.1 → XP_054222434.1 rho GTPase-activating protein 22 isoform X3
-
XM_054366467.1 → XP_054222442.1 rho GTPase-activating protein 22 isoform X11
-
XM_054366472.1 → XP_054222447.1 rho GTPase-activating protein 22 isoform X15
-
XM_054366470.1 → XP_054222445.1 rho GTPase-activating protein 22 isoform X13
-
XM_054366475.1 → XP_054222450.1 rho GTPase-activating protein 22 isoform X18
-
XM_054366477.1 → XP_054222452.1 rho GTPase-activating protein 22 isoform X23
-
XM_054366479.1 → XP_054222454.1 rho GTPase-activating protein 22 isoform X20
-
XM_054366476.1 → XP_054222451.1 rho GTPase-activating protein 22 isoform X23
-
XM_054366478.1 → XP_054222453.1 rho GTPase-activating protein 22 isoform X19
The following Reference Sequences have been suppressed. Explain
These RefSeqs were suppressed for the
cited reason(s). Suppressed RefSeqs do not appear in BLAST databases, related
sequence links, or BLAST links (BLink), but may still be retrieved by clicking on
their accession.version below.
-
NM_001256027.1: Suppressed sequence
- Description
- NM_001256027.1: This RefSeq was permanently suppressed because currently there is insufficient support for the transcript and the protein.