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    Kif1c kinesin family member 1C [ Mus musculus (house mouse) ]

    Gene ID: 16562, updated on 2-Nov-2024

    Summary

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    Official Symbol
    Kif1cprovided by MGI
    Official Full Name
    kinesin family member 1Cprovided by MGI
    Primary source
    MGI:MGI:1098260
    See related
    Ensembl:ENSMUSG00000020821 AllianceGenome:MGI:1098260
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Mus musculus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
    Also known as
    Ltxs1; Orch3; D11Bwg1349e; B430105J22Rik
    Summary
    Predicted to enable ATP hydrolysis activity; microtubule binding activity; and plus-end-directed microtubule motor activity. Acts upstream of or within retrograde vesicle-mediated transport, Golgi to endoplasmic reticulum. Located in Golgi apparatus. Is expressed in alimentary system; hindbrain meninges; submandibular gland primordium; telencephalon; and vibrissa. Human ortholog(s) of this gene implicated in spastic ataxia 2. Orthologous to human KIF1C (kinesin family member 1C). [provided by Alliance of Genome Resources, Nov 2024]
    Expression
    Ubiquitous expression in heart adult (RPKM 50.0), colon adult (RPKM 41.5) and 27 other tissues See more
    Orthologs
    human all
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    Genomic context

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    See Kif1c in Genome Data Viewer
    Location:
    11 B3; 11 43.21 cM
    Exon count:
    24
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCm39 (GCF_000001635.27) 11 NC_000077.7 (70591170..70622796)
    108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 11 NC_000077.6 (70700396..70731970)

    Chromosome 11 - NC_000077.7Genomic Context describing neighboring genes Neighboring gene STARR-positive B cell enhancer ABC_E62 Neighboring gene sperm associated antigen 7 Neighboring gene calmodulin binding transcription activator 2 Neighboring gene inhibitor of CDK, cyclin A1 interacting protein 1 Neighboring gene STARR-positive B cell enhancer ABC_E7009 Neighboring gene microRNA 6925 Neighboring gene predicted gene 12320 Neighboring gene 39S ribosomal protein L42, mitochondrial pseudogene

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: Mouse ENCODE transcriptome data Mouse ENCODE transcriptome data
    • Description: RNA profiling data sets generated by the Mouse ENCODE project.
    • BioProject: PRJNA66167
    • Publication: PMID 25409824
    • Analysis date: n/a

    Bibliography

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    Related articles in PubMed

    1. M-INK, a novel tool for visualizing melanosomes and melanocores. Ishida M, et al. J Biochem, 2017 Apr 1. PMID 28096452
    2. Identification of Orch3, a locus controlling dominant resistance to autoimmune orchitis, as kinesin family member 1C. del Rio R, et al. PLoS Genet, 2012. PMID 23300462, Free PMC Article
    3. Exclusion of Kif1c as a candidate gene for anthrax toxin susceptibility. Nakajima K, et al. Microb Pathog, 2010 May. PMID 20188815
    4. Kif1C, a kinesin-like motor protein, mediates mouse macrophage resistance to anthrax lethal factor. Watters JW, et al. Curr Biol, 2001 Oct 2. PMID 11591317
    5. Ltx1, a mouse locus that influences the susceptibility of macrophages to cytolysis caused by intoxication with Bacillus anthracis lethal factor, maps to chromosome 11. Roberts JE, et al. Mol Microbiol, 1998 Jul. PMID 9720874

    See all (38) citations in PubMed

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?
    1. Kif1c regulates osteoclastic bone resorption as a downstream molecule of p130Cas.
      Title: Kif1c regulates osteoclastic bone resorption as a downstream molecule of p130Cas.
    2. Study shows that the microtubule binding surface of Kif1c motor domain interacts with its stalk and that these autoinhibitory interactions are released upon binding of protein tyrosine phosphatase Ptpn21. The FERM domain of Ptpn21 stimulates dense core vesicle transport in primary hippocampal neurons and rescues integrin trafficking in Kif1c-depleted cells.
      Title: PTPN21 and Hook3 relieve KIF1C autoinhibition and activate intracellular transport.
    3. The melanocore-interacting Kif1c-tail (M-INK) probe localize melanosomes in keratinocytes.
      Title: M-INK, a novel tool for visualizing melanosomes and melanocores.
    4. by utilizing a forward genetic approach, we identified kinesin family member 1C (Kif1c) as a positional candidate for Orch3 and, using a transgenic approach, demonstrated that Kif1c is Orch3
      Title: Identification of Orch3, a locus controlling dominant resistance to autoimmune orchitis, as kinesin family member 1C.
    5. Kif1c was excluded as a candidate anthrax susceptibility gene
      Title: Exclusion of Kif1c as a candidate gene for anthrax toxin susceptibility.
    6. More than 90% of early endocytic vesicles associated with Kifc1 also contained Kif5B, and inhibition of Kifc1 with antibody resulted in enhancement of plus-end-directed motility.
      Title: Kif5B and Kifc1 interact and are required for motility and fission of early endocytic vesicles in mouse liver.
    Submit: New GeneRIF Correction

    Phenotypes

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    Associated conditions

    Description Tests
    autoimmune orchitis resistance 3
    GeneReviews: Not available

    Variation

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    Alleles

    Alleles of this type are documented at Mouse Genome Informatics  (MGI)

    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Markers

    Homology

    Clone Names

    • MGC28766

    Gene Ontology Provided by MGI

    Function Evidence Code Pubs
    enables ATP binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables ATP hydrolysis activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables microtubule binding IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables microtubule binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables microtubule motor activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables plus-end-directed microtubule motor activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    Process Evidence Code Pubs
    involved_in anterograde neuronal dense core vesicle transport ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in microtubule-based movement IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in retrograde neuronal dense core vesicle transport IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in retrograde neuronal dense core vesicle transport ISO
    Inferred from Sequence Orthology
    more info
    		  
    acts_upstream_of_or_within retrograde vesicle-mediated transport, Golgi to endoplasmic reticulum IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    involved_in vesicle-mediated transport IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    Component Evidence Code Pubs
    located_in Golgi apparatus IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    is_active_in axon IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    is_active_in cytoplasm IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    is_active_in dendrite IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    part_of kinesin complex IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    is_active_in microtubule IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    located_in microtubule IEA
    Inferred from Electronic Annotation
    more info
    		  

    General protein information

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    Preferred Names
    kinesin-like protein KIF1C
    Names
    N-3 kinsin
    kinesin 1C
    kinesin superfamily protein 1C
    lethal factor toxin susceptibility 1

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_153103.2 → NP_694743.2  kinesin-like protein KIF1C

      See identical proteins and their annotated locations for NP_694743.2

      Status: VALIDATED

      Source sequence(s)
      AB074017, AK029250, AK046574, AL596117
      Consensus CDS
      CCDS24965.1
      UniProtKB/Swiss-Prot
      O35071, Q5SX62
      UniProtKB/TrEMBL
      Q8VI89
      Related
      ENSMUSP00000092075.5, ENSMUST00000094499.11
      Conserved Domains (3) summary
      cd00060
      Location:499 → 599
      FHA; Forkhead associated domain (FHA); found in eukaryotic and prokaryotic proteins. Putative nuclear signalling domain. FHA domains may bind phosphothreonine, phosphoserine and sometimes phosphotyrosine. In eukaryotes, many FHA domain-containing proteins ...
      cd01365
      Location:4 → 355
      KISc_KIF1A_KIF1B; Kinesin motor domain, KIF1_like proteins
      pfam16183
      Location:352 → 522
      Kinesin_assoc; Kinesin-associated

    RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCm39 C57BL/6J

    Genomic

    1. NC_000077.7 Reference GRCm39 C57BL/6J

      Range
      70591170..70622796
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_036156353.1 → XP_036012246.1  kinesin-like protein KIF1C isoform X1

      UniProtKB/TrEMBL
      E9Q9B0, Q6A011
      Conserved Domains (3) summary
      cd00060
      Location:499 → 599
      FHA; Forkhead associated domain (FHA); found in eukaryotic and prokaryotic proteins. Putative nuclear signalling domain. FHA domains may bind phosphothreonine, phosphoserine and sometimes phosphotyrosine. In eukaryotes, many FHA domain-containing proteins ...
      cd01365
      Location:4 → 355
      KISc_KIF1A_KIF1B; Kinesin motor domain, KIF1_like proteins
      pfam16183
      Location:352 → 522
      Kinesin_assoc; Kinesin-associated

    2. XM_006532321.5 → XP_006532384.1  kinesin-like protein KIF1C isoform X2

      See identical proteins and their annotated locations for XP_006532384.1

      UniProtKB/Swiss-Prot
      O35071, Q5SX62
      UniProtKB/TrEMBL
      Q8VI89
      Related
      ENSMUSP00000099614.2, ENSMUST00000102554.8
      Conserved Domains (3) summary
      cd00060
      Location:499 → 599
      FHA; Forkhead associated domain (FHA); found in eukaryotic and prokaryotic proteins. Putative nuclear signalling domain. FHA domains may bind phosphothreonine, phosphoserine and sometimes phosphotyrosine. In eukaryotes, many FHA domain-containing proteins ...
      cd01365
      Location:4 → 355
      KISc_KIF1A_KIF1B; Kinesin motor domain, KIF1_like proteins
      pfam16183
      Location:352 → 522
      Kinesin_assoc; Kinesin-associated

    3. XM_036156351.1 → XP_036012244.1  kinesin-like protein KIF1C isoform X1

      UniProtKB/TrEMBL
      E9Q9B0, Q6A011
      Conserved Domains (3) summary
      cd00060
      Location:499 → 599
      FHA; Forkhead associated domain (FHA); found in eukaryotic and prokaryotic proteins. Putative nuclear signalling domain. FHA domains may bind phosphothreonine, phosphoserine and sometimes phosphotyrosine. In eukaryotes, many FHA domain-containing proteins ...
      cd01365
      Location:4 → 355
      KISc_KIF1A_KIF1B; Kinesin motor domain, KIF1_like proteins
      pfam16183
      Location:352 → 522
      Kinesin_assoc; Kinesin-associated

    4. XM_006532323.5 → XP_006532386.1  kinesin-like protein KIF1C isoform X4

      Conserved Domains (2) summary
      cd01365
      Location:4 → 355
      KISc_KIF1A_KIF1B; Kinesin motor domain, KIF1_like proteins
      pfam16183
      Location:352 → 522
      Kinesin_assoc; Kinesin-associated

    5. XM_036156354.1 → XP_036012247.1  kinesin-like protein KIF1C isoform X1

      UniProtKB/TrEMBL
      E9Q9B0, Q6A011
      Related
      ENSMUSP00000072048.6, ENSMUST00000072187.12
      Conserved Domains (3) summary
      cd00060
      Location:499 → 599
      FHA; Forkhead associated domain (FHA); found in eukaryotic and prokaryotic proteins. Putative nuclear signalling domain. FHA domains may bind phosphothreonine, phosphoserine and sometimes phosphotyrosine. In eukaryotes, many FHA domain-containing proteins ...
      cd01365
      Location:4 → 355
      KISc_KIF1A_KIF1B; Kinesin motor domain, KIF1_like proteins
      pfam16183
      Location:352 → 522
      Kinesin_assoc; Kinesin-associated

    6. XM_006532322.5 → XP_006532385.1  kinesin-like protein KIF1C isoform X2

      See identical proteins and their annotated locations for XP_006532385.1

      UniProtKB/Swiss-Prot
      O35071, Q5SX62
      UniProtKB/TrEMBL
      Q8VI89
      Conserved Domains (3) summary
      cd00060
      Location:499 → 599
      FHA; Forkhead associated domain (FHA); found in eukaryotic and prokaryotic proteins. Putative nuclear signalling domain. FHA domains may bind phosphothreonine, phosphoserine and sometimes phosphotyrosine. In eukaryotes, many FHA domain-containing proteins ...
      cd01365
      Location:4 → 355
      KISc_KIF1A_KIF1B; Kinesin motor domain, KIF1_like proteins
      pfam16183
      Location:352 → 522
      Kinesin_assoc; Kinesin-associated

    7. XM_036156352.1 → XP_036012245.1  kinesin-like protein KIF1C isoform X1

      UniProtKB/TrEMBL
      E9Q9B0, Q6A011
      Conserved Domains (3) summary
      cd00060
      Location:499 → 599
      FHA; Forkhead associated domain (FHA); found in eukaryotic and prokaryotic proteins. Putative nuclear signalling domain. FHA domains may bind phosphothreonine, phosphoserine and sometimes phosphotyrosine. In eukaryotes, many FHA domain-containing proteins ...
      cd01365
      Location:4 → 355
      KISc_KIF1A_KIF1B; Kinesin motor domain, KIF1_like proteins
      pfam16183
      Location:352 → 522
      Kinesin_assoc; Kinesin-associated

    8. XM_036156355.1 → XP_036012248.1  kinesin-like protein KIF1C isoform X3

      Conserved Domains (2) summary
      cd00060
      Location:14 → 114
      FHA; Forkhead associated domain (FHA); found in eukaryotic and prokaryotic proteins. Putative nuclear signalling domain. FHA domains may bind phosphothreonine, phosphoserine and sometimes phosphotyrosine. In eukaryotes, many FHA domain-containing proteins ...
      pfam16183
      Location:11 → 37
      Kinesin_assoc; Kinesin-associated

    9. XM_036156356.1 → XP_036012249.1  kinesin-like protein KIF1C isoform X5

    RNA

    1. XR_003949317.2 RNA Sequence

    Nucleotide Protein Strain
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    O35071.2 GenPept UniProtKB/Swiss-Prot:O35071

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