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    Srcap Snf2-related CREBBP activator protein [ Mus musculus (house mouse) ]

    Gene ID: 100043597, updated on 2-Nov-2024

    Summary

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    Official Symbol
    Srcapprovided by MGI
    Official Full Name
    Snf2-related CREBBP activator proteinprovided by MGI
    Primary source
    MGI:MGI:2444036
    See related
    Ensembl:ENSMUSG00000053877 AllianceGenome:MGI:2444036
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Mus musculus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
    Also known as
    B930091H02Rik; D030022P06Rik; F630004O05Rik
    Summary
    Predicted to enable ATP hydrolysis activity and histone binding activity. Predicted to be involved in chromatin remodeling. Predicted to be located in Golgi apparatus; nuclear body; and perinuclear region of cytoplasm. Predicted to be part of Swr1 complex. Is expressed in cerebral cortex ventricular layer; cortical plate; early conceptus; inner cell mass; and oocyte. Human ortholog(s) of this gene implicated in Floating-Harbor syndrome. Orthologous to human SRCAP (Snf2 related CREBBP activator protein). [provided by Alliance of Genome Resources, Nov 2024]
    Expression
    Ubiquitous expression in thymus adult (RPKM 33.8), spleen adult (RPKM 21.1) and 28 other tissues See more
    Orthologs
    human all
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    Genomic context

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    See Srcap in Genome Data Viewer
    Location:
    7 F3; 7 69.56 cM
    Exon count:
    34
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCm39 (GCF_000001635.27) 7 NC_000073.7 (127111155..127160391)
    108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 7 NC_000073.6 (127511983..127561219)

    Chromosome 7 - NC_000073.7Genomic Context describing neighboring genes Neighboring gene CapStarr-seq enhancer MGSCv37_chr7:134614302-134614485 Neighboring gene STARR-positive B cell enhancer ABC_E1742 Neighboring gene CapStarr-seq enhancer MGSCv37_chr7:134621461-134621644 Neighboring gene CapStarr-seq enhancer MGSCv37_chr7:134621862-134622045 Neighboring gene CapStarr-seq enhancer MGSCv37_chr7:134623956-134624143 Neighboring gene proline rich 14 Neighboring gene fibrosin Neighboring gene microRNA 7060 Neighboring gene RIKEN cDNA 1700008J07 gene Neighboring gene STARR-seq mESC enhancer starr_20184 Neighboring gene STARR-seq mESC enhancer starr_20185 Neighboring gene small nucleolar RNA, H/ACA box 30 Neighboring gene transmembrane protein 265 Neighboring gene CapStarr-seq enhancer MGSCv37_chr7:134716729-134716937 Neighboring gene phosphorylase kinase, gamma 2 (testis)

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: Mouse ENCODE transcriptome data Mouse ENCODE transcriptome data
    • Description: RNA profiling data sets generated by the Mouse ENCODE project.
    • BioProject: PRJNA66167
    • Publication: PMID 25409824
    • Analysis date: n/a

    Bibliography

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    Related articles in PubMed

    1. The chromatin remodeler SRCAP promotes self-renewal of intestinal stem cells. Ye B, et al. EMBO J, 2020 Jul 1. PMID 32449550, Free PMC Article
    2. SRCAP mutations drive clonal hematopoiesis through epigenetic and DNA repair dysregulation. Chen CW, et al. Cell Stem Cell, 2023 Nov 2. PMID 37863054, Free PMC Article
    3. Srcap haploinsufficiency induced autistic-like behaviors in mice through disruption of Satb2 expression. Ding C, et al. Cell Rep, 2024 May 28. PMID 38733588
    4. Purification of a human SRCAP complex that remodels chromatin by incorporating the histone variant H2A.Z into nucleosomes. Ruhl DD, et al. Biochemistry, 2006 May 2. PMID 16634648
    5. CHIP as a membrane-shuttling proteostasis sensor. Kopp Y, et al. Elife, 2017 Nov 1. PMID 29091030, Free PMC Article

    See all (32) citations in PubMed

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?
    1. Srcap haploinsufficiency induced autistic-like behaviors in mice through disruption of Satb2 expression.
      Title: Srcap haploinsufficiency induced autistic-like behaviors in mice through disruption of Satb2 expression.
    2. SRCAP mutations drive clonal hematopoiesis through epigenetic and DNA repair dysregulation.
      Title: SRCAP mutations drive clonal hematopoiesis through epigenetic and DNA repair dysregulation.
    3. The chromatin remodeler SRCAP promotes self-renewal of intestinal stem cells.
      Title: The chromatin remodeler SRCAP promotes self-renewal of intestinal stem cells.
    Submit: New GeneRIF Correction

    Variation

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    Alleles

    Alleles of this type are documented at Mouse Genome Informatics  (MGI)

    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Markers

    Homology

    Gene Ontology Provided by MGI

    Function Evidence Code Pubs
    enables ATP hydrolysis activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables histone binding IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    Process Evidence Code Pubs
    involved_in chromatin remodeling IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    Component Evidence Code Pubs
    located_in Golgi apparatus ISO
    Inferred from Sequence Orthology
    more info
    		  
    part_of Swr1 complex IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    located_in nuclear body ISO
    Inferred from Sequence Orthology
    more info
    		  
    located_in nucleoplasm ISO
    Inferred from Sequence Orthology
    more info
    		  
    located_in nucleus ISO
    Inferred from Sequence Orthology
    more info
    		  
    located_in perinuclear region of cytoplasm ISO
    Inferred from Sequence Orthology
    more info
    		  
    part_of protein-containing complex ISO
    Inferred from Sequence Orthology
    more info
    		  

    General protein information

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    Preferred Names
    helicase SRCAP
    Names
    Snf2-related CBP activator protein

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001304266.1 → NP_001291195.1  helicase SRCAP

      Status: VALIDATED

      Source sequence(s)
      AC122417, AI549885, AK142089, BQ770450, BU055896, CF161846, CJ206221, CN537242, CN664718
      Consensus CDS
      CCDS80806.1
      UniProtKB/TrEMBL
      A0A087WNL7, A0A087WQ44
      Related
      ENSMUSP00000140036.2, ENSMUST00000187040.7
      Conserved Domains (6) summary
      cd00046
      Location:650 → 789
      DEXDc; DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region.
      pfam00176
      Location:633 → 919
      SNF2_N; SNF2 family N-terminal domain
      pfam00271
      Location:2042 → 2156
      Helicase_C; Helicase conserved C-terminal domain
      pfam07529
      Location:127 → 196
      HSA; HSA
      pfam15741
      Location:1500 → 1700
      LRIF1; Ligand-dependent nuclear receptor-interacting factor 1
      cl23750
      Location:2240 → 2354
      vATP-synt_E; ATP synthase (E/31 kDa) subunit

    RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCm39 C57BL/6J

    Genomic

    1. NC_000073.7 Reference GRCm39 C57BL/6J

      Range
      127111155..127160391
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    Suppressed Reference Sequence(s)

    The following Reference Sequences have been suppressed. Explain

    1. NM_001033881.1: Suppressed sequence

      Description
      NM_001033881.1: This RefSeq was permanently suppressed because currently there is insufficient support for the transcript and the protein.

    2. NM_175144.2: Suppressed sequence

      Description
      NM_175144.2: This RefSeq was permanently suppressed because currently there is insufficient support for the transcript and the protein.

    3. NM_178800.1: Suppressed sequence

      Description
      NM_178800.1: This RefSeq was permanently suppressed because currently there is insufficient support for the transcript and the protein.
    Nucleotide Protein Strain
    Heading Accession and Version

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