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    Ehf ets homologous factor [ Mus musculus (house mouse) ]

    Gene ID: 13661, updated on 2-Nov-2024

    Summary

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    Official Symbol
    Ehfprovided by MGI
    Official Full Name
    ets homologous factorprovided by MGI
    Primary source
    MGI:MGI:1270840
    See related
    Ensembl:ENSMUSG00000012350 AllianceGenome:MGI:1270840
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Mus musculus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
    Also known as
    9030625L19Rik
    Summary
    Predicted to enable DNA-binding transcription activator activity, RNA polymerase II-specific and RNA polymerase II cis-regulatory region sequence-specific DNA binding activity. Predicted to be involved in epithelial cell differentiation and positive regulation of transcription by RNA polymerase II. Predicted to be located in Golgi apparatus and nucleoplasm. Predicted to be active in nucleus. Is expressed in several structures, including central nervous system; female reproductive system; gut; salivary gland primordium; and urinary system. Orthologous to human EHF (ETS homologous factor). [provided by Alliance of Genome Resources, Nov 2024]
    Expression
    Biased expression in colon adult (RPKM 16.7), bladder adult (RPKM 11.7) and 10 other tissues See more
    Orthologs
    human all
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    Genomic context

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    See Ehf in Genome Data Viewer
    Location:
    2 E2; 2 54.43 cM
    Exon count:
    16
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCm39 (GCF_000001635.27) 2 NC_000068.8 (103093776..103133620, complement)
    108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 2 NC_000068.7 (103263431..103303275, complement)

    Chromosome 2 - NC_000068.8Genomic Context describing neighboring genes Neighboring gene STARR-positive B cell enhancer mm9_chr2:102913613-102913914 Neighboring gene STARR-seq mESC enhancer starr_05263 Neighboring gene APAF1 interacting protein Neighboring gene STARR-seq mESC enhancer starr_05264 Neighboring gene STARR-seq mESC enhancer starr_05265 Neighboring gene predicted gene 13869 Neighboring gene RIKEN cDNA A930006I01 gene Neighboring gene STARR-seq mESC enhancer starr_05269 Neighboring gene cDNA sequence BC016548

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: Mouse ENCODE transcriptome data Mouse ENCODE transcriptome data
    • Description: RNA profiling data sets generated by the Mouse ENCODE project.
    • BioProject: PRJNA66167
    • Publication: PMID 25409824
    • Analysis date: n/a

    Bibliography

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    Related articles in PubMed

    1. Molecular cloning and expression of Ehf, a new member of the ets transcription factor/oncoprotein gene family. Bochert MA, et al. Biochem Biophys Res Commun, 1998 May 8. PMID 9600089
    2. The Ets transcription factor EHF as a regulator of cornea epithelial cell identity. Stephens DN, et al. J Biol Chem, 2013 Nov 29. PMID 24142692, Free PMC Article
    3. Ehf controls mammary alveolar lineage differentiation and is a putative suppressor of breast tumorigenesis. Nightingale R, et al. Dev Cell, 2024 Aug 5. PMID 38781975
    4. Genetic Study of Elf5 and Ehf in the Mouse Salivary Gland. Song EAC, et al. J Dent Res, 2023 Mar. PMID 36348499, Free PMC Article
    5. Human chromosomal localization, tissue/tumor expression, and regulatory function of the ets family gene EHF. Kleinbaum LA, et al. Biochem Biophys Res Commun, 1999 Oct 14. PMID 10527851

    See all (44) citations in PubMed

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?
    1. Ehf controls mammary alveolar lineage differentiation and is a putative suppressor of breast tumorigenesis.
      Title: Ehf controls mammary alveolar lineage differentiation and is a putative suppressor of breast tumorigenesis.
    2. Cpeb4-mediated Dclk2 promotes neuronal pyroptosis induced by chronic cerebral ischemia through phosphorylation of Ehf.
      Title: Cpeb4-mediated Dclk2 promotes neuronal pyroptosis induced by chronic cerebral ischemia through phosphorylation of Ehf.
    3. Genetic Study of Elf5 and Ehf in the Mouse Salivary Gland.
      Title: Genetic Study of Elf5 and Ehf in the Mouse Salivary Gland.
    4. Epithelial de-differentiation triggered by co-ordinate epigenetic inactivation of the EHF and CDX1 transcription factors drives colorectal cancer progression.
      Title: Epithelial de-differentiation triggered by co-ordinate epigenetic inactivation of the EHF and CDX1 transcription factors drives colorectal cancer progression.
    5. These data provide insights into the mechanisms underlying epithelial development and aging, identifying EHF as a regulator of cornea epithelial identity
      Title: The Ets transcription factor EHF as a regulator of cornea epithelial cell identity.
    Submit: New GeneRIF Correction

    Variation

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    Alleles

    Alleles of this type are documented at Mouse Genome Informatics  (MGI)

    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Markers

    Homology

    Gene Ontology Provided by MGI

    Function Evidence Code Pubs
    enables DNA binding ISO
    Inferred from Sequence Orthology
    more info
    		  
    enables DNA binding ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  
    enables DNA-binding transcription activator activity, RNA polymerase II-specific ISO
    Inferred from Sequence Orthology
    more info
    		  
    enables DNA-binding transcription activator activity, RNA polymerase II-specific ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  
    enables DNA-binding transcription factor activity, RNA polymerase II-specific IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables RNA polymerase II cis-regulatory region sequence-specific DNA binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables RNA polymerase II cis-regulatory region sequence-specific DNA binding ISO
    Inferred from Sequence Orthology
    more info
    		  
    Process Evidence Code Pubs
    involved_in cell differentiation IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in epithelial cell differentiation ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  
    involved_in positive regulation of transcription by RNA polymerase II ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in positive regulation of transcription by RNA polymerase II ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  
    involved_in regulation of transcription by RNA polymerase II IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    Component Evidence Code Pubs
    located_in Golgi apparatus IEA
    Inferred from Electronic Annotation
    more info
    		  
    located_in Golgi apparatus ISO
    Inferred from Sequence Orthology
    more info
    		  
    located_in nucleoplasm IEA
    Inferred from Electronic Annotation
    more info
    		  
    located_in nucleoplasm ISO
    Inferred from Sequence Orthology
    more info
    		  
    is_active_in nucleus IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  

    General protein information

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    Preferred Names
    ETS homologous factor
    Names
    ETS domain-containing transcription factor

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_007914.3 → NP_031940.1  ETS homologous factor

      See identical proteins and their annotated locations for NP_031940.1

      Status: VALIDATED

      Source sequence(s)
      AF035527, AK028651, BE134913, BX901906
      Consensus CDS
      CCDS16475.1
      UniProtKB/Swiss-Prot
      O70273, Q922E8, Q922T6, Q99K12
      UniProtKB/TrEMBL
      A2BIB5
      Related
      ENSMUSP00000087961.4, ENSMUST00000090475.10
      Conserved Domains (2) summary
      cd08539
      Location:39 → 116
      SAM_PNT-ESE-3-like; Sterile alpha motif (SAM)/Pointed domain of ESE-3 like ETS transcriptional regulators
      smart00413
      Location:206 → 293
      ETS; erythroblast transformation specific domain

    RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCm39 C57BL/6J

    Genomic

    1. NC_000068.8 Reference GRCm39 C57BL/6J

      Range
      103093776..103133620 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_006498703.1 → XP_006498766.1  ETS homologous factor isoform X3

      See identical proteins and their annotated locations for XP_006498766.1

      UniProtKB/TrEMBL
      A2BIB5
      Conserved Domains (2) summary
      smart00413
      Location:205 → 292
      ETS; erythroblast transformation specific domain
      cl15755
      Location:39 → 116
      SAM_superfamily; SAM (Sterile alpha motif )

    2. XM_006498699.1 → XP_006498762.1  ETS homologous factor isoform X2

      See identical proteins and their annotated locations for XP_006498762.1

      UniProtKB/Swiss-Prot
      O70273, Q922E8, Q922T6, Q99K12
      UniProtKB/TrEMBL
      A2BIB5
      Conserved Domains (2) summary
      cd08539
      Location:39 → 116
      SAM_PNT-ESE-3-like; Sterile alpha motif (SAM)/Pointed domain of ESE-3 like ETS transcriptional regulators
      smart00413
      Location:206 → 293
      ETS; erythroblast transformation specific domain

    3. XM_006498697.3 → XP_006498760.1  ETS homologous factor isoform X2

      See identical proteins and their annotated locations for XP_006498760.1

      UniProtKB/Swiss-Prot
      O70273, Q922E8, Q922T6, Q99K12
      UniProtKB/TrEMBL
      A2BIB5
      Related
      ENSMUSP00000106805.2, ENSMUST00000111174.8
      Conserved Domains (2) summary
      cd08539
      Location:39 → 116
      SAM_PNT-ESE-3-like; Sterile alpha motif (SAM)/Pointed domain of ESE-3 like ETS transcriptional regulators
      smart00413
      Location:206 → 293
      ETS; erythroblast transformation specific domain

    4. XM_006498698.4 → XP_006498761.1  ETS homologous factor isoform X2

      See identical proteins and their annotated locations for XP_006498761.1

      UniProtKB/Swiss-Prot
      O70273, Q922E8, Q922T6, Q99K12
      UniProtKB/TrEMBL
      A2BIB5
      Conserved Domains (2) summary
      cd08539
      Location:39 → 116
      SAM_PNT-ESE-3-like; Sterile alpha motif (SAM)/Pointed domain of ESE-3 like ETS transcriptional regulators
      smart00413
      Location:206 → 293
      ETS; erythroblast transformation specific domain

    5. XM_006498695.3 → XP_006498758.1  ETS homologous factor isoform X1

      See identical proteins and their annotated locations for XP_006498758.1

      UniProtKB/TrEMBL
      A2BIB5
      Conserved Domains (2) summary
      cd08539
      Location:50 → 127
      SAM_PNT-ESE-3-like; Sterile alpha motif (SAM)/Pointed domain of ESE-3 like ETS transcriptional regulators
      smart00413
      Location:217 → 304
      ETS; erythroblast transformation specific domain

    6. XM_006498702.4 → XP_006498765.1  ETS homologous factor isoform X2

      See identical proteins and their annotated locations for XP_006498765.1

      UniProtKB/Swiss-Prot
      O70273, Q922E8, Q922T6, Q99K12
      UniProtKB/TrEMBL
      A2BIB5
      Conserved Domains (2) summary
      cd08539
      Location:39 → 116
      SAM_PNT-ESE-3-like; Sterile alpha motif (SAM)/Pointed domain of ESE-3 like ETS transcriptional regulators
      smart00413
      Location:206 → 293
      ETS; erythroblast transformation specific domain

    7. XM_006498701.4 → XP_006498764.1  ETS homologous factor isoform X2

      See identical proteins and their annotated locations for XP_006498764.1

      UniProtKB/Swiss-Prot
      O70273, Q922E8, Q922T6, Q99K12
      UniProtKB/TrEMBL
      A2BIB5
      Conserved Domains (2) summary
      cd08539
      Location:39 → 116
      SAM_PNT-ESE-3-like; Sterile alpha motif (SAM)/Pointed domain of ESE-3 like ETS transcriptional regulators
      smart00413
      Location:206 → 293
      ETS; erythroblast transformation specific domain

    8. XM_006498700.4 → XP_006498763.1  ETS homologous factor isoform X2

      See identical proteins and their annotated locations for XP_006498763.1

      UniProtKB/Swiss-Prot
      O70273, Q922E8, Q922T6, Q99K12
      UniProtKB/TrEMBL
      A2BIB5
      Conserved Domains (2) summary
      cd08539
      Location:39 → 116
      SAM_PNT-ESE-3-like; Sterile alpha motif (SAM)/Pointed domain of ESE-3 like ETS transcriptional regulators
      smart00413
      Location:206 → 293
      ETS; erythroblast transformation specific domain
    Nucleotide Protein Strain
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    O70273.1 GenPept UniProtKB/Swiss-Prot:O70273

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