Rnase10 ribonuclease, RNase A family, 10 (non-active) [Mus musculus (house mouse)] - Gene

Summary

Official Symbol: Rnase10provided by MGI
Official Full Name: ribonuclease, RNase A family, 10 (non-active)provided by MGI
Primary source: MGI:MGI:1922269
See related: Ensembl:ENSMUSG00000021872 AllianceGenome:MGI:1922269
Gene type: protein coding
RefSeq status: VALIDATED
Organism: Mus musculus
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as: Rah1; 4930474F22Rik
Summary: Predicted to enable nucleic acid binding activity. Involved in several processes, including heterotypic cell-cell adhesion; positive regulation of flagellated sperm motility; and regulation of fertilization. Acts upstream of or within epithelial cell morphogenesis; seminiferous tubule development; and single fertilization. Predicted to be located in extracellular region. Orthologous to human RNASE10 (ribonuclease A family member 10 (inactive)). [provided by Alliance of Genome Resources, Nov 2024]
Expression: Restricted expression toward genital fat pad adult (RPKM 393.6) See more
Orthologs: human all
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Genomic context

Location:: 14 C1; 14 26.34 cM

Exon count:: 4

Annotation release	Status	Assembly	Chr	Location
RS_2024_02	current	GRCm39 (GCF_000001635.27)	14	NC_000080.7 (51245208..51248218)
108.20200622	previous assembly	GRCm38.p6 (GCF_000001635.26)	14	NC_000080.6 (51007751..51010761)

Chromosome 14 - NC_000080.7 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Go to reference sequence details

Genomic Sequence:

Go to nucleotide: Graphics FASTA GenBank

Expression

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See details

Project title: Mouse ENCODE transcriptome data Mouse ENCODE transcriptome data
Description: RNA profiling data sets generated by the Mouse ENCODE project.
BioProject: PRJNA66167
Publication: PMID 25409824
Analysis date: n/a

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Epididymal protein Rnase10 is required for post-testicular sperm maturation and male fertility.
Title: Epididymal protein Rnase10 is required for post-testicular sperm maturation and male fertility.

Submit: New GeneRIF Correction

Variation

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Alleles

Alleles of this type are documented at Mouse Genome Informatics (MGI)

Endonuclease-mediated (1)
Targeted (3) 1 citation

General gene information

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Gene Ontology Provided by MGI

Function	Evidence Code	Pubs
NOT enables RNA nuclease activity	IKR Inferred from Key Residues more info	PubMed
enables nucleic acid binding	IEA Inferred from Electronic Annotation more info

Process	Evidence Code	Pubs
involved_in defense response to Gram-positive bacterium	IBA Inferred from Biological aspect of Ancestor more info
acts_upstream_of_or_within epithelial cell morphogenesis	IGI Inferred from Genetic Interaction more info	PubMed
involved_in heterotypic cell-cell adhesion	IMP Inferred from Mutant Phenotype more info	PubMed
acts_upstream_of_or_within male gonad development	IGI Inferred from Genetic Interaction more info	PubMed
involved_in positive regulation of cell-cell adhesion	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in positive regulation of flagellated sperm motility	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in regulation of fertilization	IMP Inferred from Mutant Phenotype more info	PubMed
acts_upstream_of_or_within seminiferous tubule development	IGI Inferred from Genetic Interaction more info	PubMed
acts_upstream_of_or_within single fertilization	IGI Inferred from Genetic Interaction more info	PubMed

Component	Evidence Code	Pubs
is_active_in cellular_component	ND No biological Data available more info
located_in extracellular region	IEA Inferred from Electronic Annotation more info

General protein information

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Preferred Names: inactive ribonuclease-like protein 10

Names: RNase 10; protein train A; ribonuclease A family, member 10; ribonuclease A h1; ribonuclease-like protein 10

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

NM_001162863.1 → NP_001156335.1 inactive ribonuclease-like protein 10 isoform 2 precursor

See identical proteins and their annotated locations for NP_001156335.1

Status: VALIDATED

Description

Transcript Variant: This variant (2) differs in the 5' UTR, lacks a portion of the 5' coding region, and initiates translation at a downstream start codon, compared to variant 1. The encoded isoform (2) is shorter than isoform 1.

Source sequence(s)

AC136376, AK015573

Consensus CDS

CCDS49480.1

UniProtKB/Swiss-Prot

Q6XL64, Q9D5A9

UniProtKB/TrEMBL

G3UWD1

Related

ENSMUSP00000131065.2, ENSMUST00000164632.2

Conserved Domains (1) summary

cd00163
Location:93 → 204

RNase_A; RNase A family, or Pancreatic RNases family; includes vertebrate RNase homologs to the bovine pancreatic ribonuclease A (RNase A). Many of these enzymes have special biological activities; for example, some stimulate the development of vascular ...
NM_029145.3 → NP_083421.2 inactive ribonuclease-like protein 10 isoform 1

Status: VALIDATED

Description

Transcript Variant: This variant (1) represents the longer transcript and encodes the longer isoform (1).

Source sequence(s)

AC136376

Consensus CDS

CCDS27030.1

UniProtKB/TrEMBL

B2RUF3, E9QPU5

Related

ENSMUSP00000022424.7, ENSMUST00000022424.8

Conserved Domains (1) summary

cd00163
Location:130 → 241

RNase_A; RNase A family, or Pancreatic RNases family; includes vertebrate RNase homologs to the bovine pancreatic ribonuclease A (RNase A). Many of these enzymes have special biological activities; for example, some stimulate the development of vascular ...

RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm39 C57BL/6J

Genomic

NC_000080.7 Reference GRCm39 C57BL/6J

Range

51245208..51248218

Download

GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

XM_006519639.2 → XP_006519702.1 inactive ribonuclease-like protein 10 isoform X1

See identical proteins and their annotated locations for XP_006519702.1

UniProtKB/Swiss-Prot

Q6XL64, Q9D5A9

UniProtKB/TrEMBL

G3UWD1

Conserved Domains (1) summary

cd00163
Location:93 → 204

RNase_A; RNase A family, or Pancreatic RNases family; includes vertebrate RNase homologs to the bovine pancreatic ribonuclease A (RNase A). Many of these enzymes have special biological activities; for example, some stimulate the development of vascular ...
XM_036158886.1 → XP_036014779.1 inactive ribonuclease-like protein 10 isoform X1

UniProtKB/Swiss-Prot

Q6XL64, Q9D5A9

UniProtKB/TrEMBL

G3UWD1

Conserved Domains (1) summary

cd00163
Location:93 → 204

RNase_A; RNase A family, or Pancreatic RNases family; includes vertebrate RNase homologs to the bovine pancreatic ribonuclease A (RNase A). Many of these enzymes have special biological activities; for example, some stimulate the development of vascular ...