MIR297 microRNA 297 [Homo sapiens (human)] - Gene

Summary

Official Symbol: MIR297provided by HGNC
Official Full Name: microRNA 297provided by HGNC
Primary source: HGNC:HGNC:33691
See related: Ensembl:ENSG00000215961 MIM:615520; miRBase:MI0005775; AllianceGenome:HGNC:33691
Gene type: ncRNA
RefSeq status: PROVISIONAL
Organism: Homo sapiens
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Also known as: MIRN297; hsa-mir-297
Summary: microRNAs (miRNAs) are short (20-24 nt) non-coding RNAs that are involved in post-transcriptional regulation of gene expression in multicellular organisms by affecting both the stability and translation of mRNAs. miRNAs are transcribed by RNA polymerase II as part of capped and polyadenylated primary transcripts (pri-miRNAs) that can be either protein-coding or non-coding. The primary transcript is cleaved by the Drosha ribonuclease III enzyme to produce an approximately 70-nt stem-loop precursor miRNA (pre-miRNA), which is further cleaved by the cytoplasmic Dicer ribonuclease to generate the mature miRNA and antisense miRNA star (miRNA*) products. The mature miRNA is incorporated into a RNA-induced silencing complex (RISC), which recognizes target mRNAs through imperfect base pairing with the miRNA and most commonly results in translational inhibition or destabilization of the target mRNA. The RefSeq represents the predicted microRNA stem-loop. [provided by RefSeq, Sep 2009]
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Genomic context

Location:: 4q25

Exon count:: 1

Annotation release	Status	Assembly	Chr	Location
RS_2023_10	current	GRCh38.p14 (GCF_000001405.40)	4	NC_000004.12 (110860582..110860647, complement)
RS_2023_10	current	T2T-CHM13v2.0 (GCF_009914755.1)	4	NC_060928.1 (114162497..114162562, complement)
105.20220307	previous assembly	GRCh37.p13 (GCF_000001405.25)	4	NC_000004.11 (111781738..111781803, complement)

Chromosome 4 - NC_000004.12 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Genomic Sequence:

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Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

MiR-297 inhibits tumour progression of liver cancer by targeting PTBP3.
Title: MiR-297 inhibits tumour progression of liver cancer by targeting PTBP3.
miR-297 inhibits expression of progesterone receptor and decidualization in eutopic endometria of endometriosis.
Title: miR-297 inhibits expression of progesterone receptor and decidualization in eutopic endometria of endometriosis.
Inhibition of microRNA-297 alleviates THLE-2 cell injury induced by hypoxia/reoxygenation by inhibiting NLRP3 inflammasome activation via sirtuin 3.
Title: Inhibition of microRNA-297 alleviates THLE-2 cell injury induced by hypoxia/reoxygenation by inhibiting NLRP3 inflammasome activation via sirtuin 3.
MiR-297 alleviates LPS-induced A549 cell and mice lung injury via targeting cyclin dependent kinase 8.
Title: MiR-297 alleviates LPS-induced A549 cell and mice lung injury via targeting cyclin dependent kinase 8.
The circular RNA hsa_circ_0007623 acts as a sponge of microRNA-297 and promotes cardiac repair.
Title: The circular RNA hsa_circ_0007623 acts as a sponge of microRNA-297 and promotes cardiac repair.
The miR-297 inhibited LPS-induced inflammatory response and apoptosis of HUVECs by regulating STAT3 signaling pathway.
Title: miR-297 Protects Human Umbilical Vein Endothelial Cells against LPS-Induced Inflammatory Response and Apoptosis.
The greatest levels of circulating miR-297 and miR-19b-3p with its common target CFL2 are associated with metastatic prostate cancer.
Title: Changes in the Level of Circulating hsa-miR-297 and hsa-miR-19b-3p miRNA Are Associated with Generalization of Prostate Cancer.
These results suggest that miR-297 acted as an oncogenic miRNA, partly by targeting GPC5, adenocarcinoma of the lung.
Title: miR-297 acts as an oncogene by targeting GPC5 in lung adenocarcinoma.
Loss of Mir-297 is associated with glioblastoma.
Title: A miR-297/hypoxia/DGK-α axis regulating glioblastoma survival.
Data suggest that expression of MIRN297 is negatively correlated with MRP2 (multidrug resistance-associated protein 2) expression in colorectal carcinoma cells; response of colorectal adenocarcinoma cells to MIRN297 involves down-regulation of MRP2.
Title: miR-297 modulates multidrug resistance in human colorectal carcinoma by down-regulating MRP-2.

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Phenotypes

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Review eQTL and phenotype association data in this region using PheGenI

Variation

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NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.