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    C16orf96 chromosome 16 open reading frame 96 [ Homo sapiens (human) ]

    Gene ID: 342346, updated on 17-Sep-2024

    Summary

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    Official Symbol
    C16orf96provided by HGNC
    Official Full Name
    chromosome 16 open reading frame 96provided by HGNC
    Primary source
    HGNC:HGNC:40031
    See related
    Ensembl:ENSG00000205832 AllianceGenome:HGNC:40031
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Homo sapiens
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
    Expression
    Biased expression in testis (RPKM 4.7), brain (RPKM 0.3) and 1 other tissue See more
    Orthologs
    mouse all
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    Genomic context

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    See C16orf96 in Genome Data Viewer
    Location:
    16p13.3
    Exon count:
    18
    Annotation release Status Assembly Chr Location
    RS_2024_08 current GRCh38.p14 (GCF_000001405.40) 16 NC_000016.10 (4538601..4600758)
    RS_2024_08 current T2T-CHM13v2.0 (GCF_009914755.1) 16 NC_060940.1 (4568062..4630216)
    RS_2024_09 previous assembly GRCh37.p13 (GCF_000001405.25) 16 NC_000016.9 (4588602..4650759)

    Chromosome 16 - NC_000016.10Genomic Context describing neighboring genes Neighboring gene H3K4me1 hESC enhancer GRCh37_chr16:4516031-4516532 Neighboring gene H3K27ac hESC enhancer GRCh37_chr16:4526195-4526696 Neighboring gene uncharacterized LOC124903636 Neighboring gene NmrA like redox sensor 1 Neighboring gene ReSE screen-validated silencer GRCh37_chr16:4543888-4544077 Neighboring gene heme oxygenase 2 Neighboring gene Sharpr-MPRA regulatory region 9698 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr16:4563218-4563745 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr16:4563746-4564272 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr16:4564273-4564800 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr16:4571909-4572773 Neighboring gene NANOG-H3K27ac-H3K4me1 hESC enhancer GRCh37_chr16:4579080-4579732 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr16:4579733-4580384 Neighboring gene cell death inducing p53 target 1 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 10340 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 7152 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 7153 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr16:4604203-4604813 Neighboring gene SUB1 pseudogene 3 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr16:4635152-4635652 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr16:4642470-4643270 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr16:4644073-4644872 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr16:4661103-4661738 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 7154 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 7155 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 7156 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 7157 Neighboring gene NANOG-H3K27ac-H3K4me1 hESC enhancer GRCh37_chr16:4665101-4665673 Neighboring gene NANOG-H3K27ac-H3K4me1 hESC enhancer GRCh37_chr16:4665674-4666245 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 7158 Neighboring gene H3K27ac hESC enhancer GRCh37_chr16:4674556-4675086 Neighboring gene NANOG-H3K27ac hESC enhancer GRCh37_chr16:4675087-4675616 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr16:4676147-4676675 Neighboring gene UBA like domain containing 1 Neighboring gene RNA, 7SL, cytoplasmic 850, pseudogene Neighboring gene mahogunin ring finger 1

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: HPA RNA-seq normal tissues HPA RNA-seq normal tissues
    • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
    • BioProject: PRJEB4337
    • Publication: PMID 24309898
    • Analysis date: Wed Apr 4 07:08:55 2018

    Bibliography

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    Related articles in PubMed

    1. The ubiquitin E3 ligase ARIH1 regulates hnRNP E1 protein stability, EMT and breast cancer progression. Howley BV, et al. Oncogene, 2022 Mar. PMID 35102251, Free PMC Article
    2. The sequence and analysis of duplication-rich human chromosome 16. Martin J, et al. Nature, 2004 Dec 23. PMID 15616553
    3. ABCE1 is a highly conserved RNA silencing suppressor. Kärblane K, et al. PLoS One, 2015. PMID 25659154, Free PMC Article
    4. Genome-wide CRISPR screens using isogenic cells reveal vulnerabilities conferred by loss of tumor suppressors. Feng X, et al. Sci Adv, 2022 May 13. PMID 35559673, Free PMC Article
    5. Systematic Analysis of Human Protein Phosphatase Interactions and Dynamics. Yadav L, et al. Cell Syst, 2017 Apr 26. PMID 28330616

    See all (8) citations in PubMed

    GeneRIFs: Gene References Into Functions

    Phenotypes

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    Find tests for this gene in the NIH Genetic Testing Registry (GTR)

    Review eQTL and phenotype association data in this region using PheGenI

    EBI GWAS Catalog

    Description
    Novel genetic loci identified for the pathophysiology of childhood obesity in the Hispanic population.
    EBI GWAS Catalog

    Variation

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    See variants in ClinVar

    See studies and variants in dbVar

    See Variation Viewer (GRCh37.p13)

    See Variation Viewer (GRCh38)

    Genotypes

    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Markers

    Homology

    General protein information

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    Preferred Names
    uncharacterized protein C16orf96

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001145011.2 → NP_001138483.1  uncharacterized protein C16orf96

      See identical proteins and their annotated locations for NP_001138483.1

      Status: VALIDATED

      Source sequence(s)
      AC023830
      Consensus CDS
      CCDS53986.1
      UniProtKB/Swiss-Prot
      A6NNT2, C9JH24
      Related
      ENSP00000415027.3, ENST00000444310.5
      Conserved Domains (4) summary
      PHA03247
      Location:286 → 436
      PHA03247; large tegument protein UL36; Provisional
      NF033178
      Location:476 → 543
      auto_BigA; autotransporter adhesin BigA
      pfam16043
      Location:744 → 919
      DUF4795; Domain of unknown function (DUF4795)
      cl17169
      Location:248 → 284
      RRM_SF; RNA recognition motif (RRM) superfamily

    2. NM_001387219.1 → NP_001374148.1  uncharacterized protein C16orf96

      Status: VALIDATED

      Source sequence(s)
      AC023830
      Consensus CDS
      CCDS53986.1
      UniProtKB/Swiss-Prot
      A6NNT2, C9JH24
      Conserved Domains (4) summary
      PHA03247
      Location:286 → 436
      PHA03247; large tegument protein UL36; Provisional
      NF033178
      Location:476 → 543
      auto_BigA; autotransporter adhesin BigA
      pfam16043
      Location:744 → 919
      DUF4795; Domain of unknown function (DUF4795)
      cl17169
      Location:248 → 284
      RRM_SF; RNA recognition motif (RRM) superfamily

    RefSeqs of Annotated Genomes: GCF_000001405.40-RS_2024_08

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCh38.p14 Primary Assembly

    Genomic

    1. NC_000016.10 Reference GRCh38.p14 Primary Assembly

      Range
      4538601..4600758
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_047434053.1 → XP_047290009.1  uncharacterized protein C16orf96 isoform X3

    2. XM_005255301.4 → XP_005255358.1  uncharacterized protein C16orf96 isoform X2

      Conserved Domains (4) summary
      TIGR02953
      Location:501 → 552
      penta_MxKDx; pentapeptide MXKDX repeat protein
      pfam10630
      Location:285 → 440
      DUF2476; Protein of unknown function (DUF2476)
      pfam16043
      Location:730 → 864
      DUF4795; Domain of unknown function (DUF4795)
      cl17169
      Location:248 → 284
      RRM_SF; RNA recognition motif (RRM) superfamily

    3. XM_005255298.4 → XP_005255355.1  uncharacterized protein C16orf96 isoform X1

      Conserved Domains (4) summary
      TIGR02953
      Location:481 → 532
      penta_MxKDx; pentapeptide MXKDX repeat protein
      pfam10630
      Location:285 → 440
      DUF2476; Protein of unknown function (DUF2476)
      pfam16043
      Location:710 → 899
      DUF4795; Domain of unknown function (DUF4795)
      cl17169
      Location:248 → 284
      RRM_SF; RNA recognition motif (RRM) superfamily

    Alternate T2T-CHM13v2.0

    Genomic

    1. NC_060940.1 Alternate T2T-CHM13v2.0

      Range
      4568062..4630216
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_054380217.1 → XP_054236192.1  uncharacterized protein C16orf96 isoform X4

    2. XM_054380218.1 → XP_054236193.1  uncharacterized protein C16orf96 isoform X4

    3. XM_054380221.1 → XP_054236196.1  uncharacterized protein C16orf96 isoform X3

    4. XM_054380220.1 → XP_054236195.1  uncharacterized protein C16orf96 isoform X2

    5. XM_054380219.1 → XP_054236194.1  uncharacterized protein C16orf96 isoform X1

    Nucleotide Protein
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    A6NNT2.3 GenPept UniProtKB/Swiss-Prot:A6NNT2

    Gene LinkOut

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