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    addB ATP-dependent deoxyribonuclease (subunit B) [ Bacillus subtilis subsp. subtilis str. 168 ]

    Gene ID: 936341, updated on 6-Oct-2023

    Summary

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    Gene symbol
    addB
    Gene description
    ATP-dependent deoxyribonuclease (subunit B)
    Locus tag
    BSU_10620
    Gene type
    protein coding
    RefSeq status
    PROVISIONAL
    Organism
    Bacillus subtilis subsp. subtilis str. 168 (strain: 168, sub-species: subtilis, type-material: type strain of Bacillus subtilis)
    Lineage
    Bacteria; Firmicutes; Bacilli; Bacillales; Bacillaceae; Bacillus
    Old locus tag
    BSU10620
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    Genomic context

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    Sequence:
    NC_000964.3 (1136320..1139820)

    NC_000964.3Genomic Context describing neighboring genes Neighboring gene putative metal-chelating cysteine-rich protein of unknown function Neighboring gene putative electron carrier protein (putative sporulation gene) Neighboring gene ATP-dependent deoxyribonuclease (subunit A) Neighboring gene DNA repair exonuclease Neighboring gene DNA ATP-dependent repair enzyme Neighboring gene HNH nuclease-like essential for DNA repair

    Genomic regions, transcripts, and products

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    Genomic Sequence:
    NC_000964.3

    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. Chi hotspots trigger a conformational change in the helicase-like domain of AddAB to activate homologous recombination. Gilhooly NS, et al. Nucleic Acids Res, 2016 Apr 7. PMID 26762979, Free PMC Article
    2. A dual-nuclease mechanism for DNA break processing by AddAB-type helicase-nucleases. Yeeles JT, et al. J Mol Biol, 2007 Aug 3. PMID 17570399
    3. The AddAB helicase/nuclease forms a stable complex with its cognate chi sequence during translocation. Chédin F, et al. J Biol Chem, 2006 Jul 7. PMID 16632468
    4. Bacillus subtilis, the model Gram-positive bacterium: 20 years of annotation refinement. Borriss R, et al. Microb Biotechnol, 2018 Jan. PMID 29280348, Free PMC Article
    5. An updated metabolic view of the Bacillus subtilis 168 genome. Belda E, et al. Microbiology (Reading), 2013 Apr. PMID 23429746

    See all (7) citations in PubMed

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?
    1. Chi hotspots trigger a conformational change in the helicase-like domain of AddAB to activate homologous recombination.
      Title: Chi hotspots trigger a conformational change in the helicase-like domain of AddAB to activate homologous recombination.
    2. Results show that the AddAB enzyme complex contains two active nuclease domains, each of which is dedicated to cleavage of one specific DNA strand.
      Title: A dual-nuclease mechanism for DNA break processing by AddAB-type helicase-nucleases.
    3. transient binding of AddAB to chi(Bs) is an integral part of the AddAB-chi(Bs) interaction and propose that this molecular event underlies a general mechanism for regulating the biochemical activities and biological functions of RecBCD-like enzymes
      Title: The AddAB helicase/nuclease forms a stable complex with its cognate chi sequence during translocation.
    Submit: New GeneRIF Correction

    General gene information

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    Homology

    General protein information

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    Preferred Names
    ATP-dependent deoxyribonuclease (subunit B)
    NP_388943.2
    • Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 7746142, 8387145, 8510642, 8752323, 11544244, 16385024, 16780573, 19542287, 21071401, 22307084, 24670664, 26762979; Product type e : enzyme

    NCBI Reference Sequences (RefSeq)

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    Genome Annotation

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference assembly

    Genomic

    1. NC_000964.3 Reference assembly

      Range
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NP_388943.2 ATP-dependent deoxyribonuclease (subunit B) [Bacillus subtilis subsp. subtilis str. 168]

      See identical proteins and their annotated locations for NP_388943.2

      Status: PROVISIONAL

      UniProtKB/TrEMBL
      A0A0D1IRJ9
      Conserved Domains (1) summary
      TIGR02773
      Location:1 → 1163
      addB_Gpos; helicase-exonuclease AddAB, AddB subunit
    Nucleotide Protein
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    P23477.2

    Gene LinkOut

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    Other Literature Sources
    Molecular Biology Databases