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    ezrA negative regulator of FtsZ ring formation [ Bacillus subtilis subsp. subtilis str. 168 ]

    Gene ID: 937337, updated on 4-Feb-2024

    Summary

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    Gene symbol
    ezrA
    Gene description
    negative regulator of FtsZ ring formation
    Locus tag
    BSU_29610
    Gene type
    protein coding
    RefSeq status
    PROVISIONAL
    Organism
    Bacillus subtilis subsp. subtilis str. 168 (strain: 168, sub-species: subtilis, type-material: type strain of Bacillus subtilis)
    Lineage
    Bacteria; Firmicutes; Bacilli; Bacillales; Bacillaceae; Bacillus
    Old locus tag
    BSU29610
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    Genomic context

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    Sequence:
    NC_000964.3 (3029729..3031417, complement)

    NC_000964.3Genomic Context describing neighboring genes Neighboring gene cysteine desulfurase Neighboring gene branched-chain amino acid-Na+ symporter Neighboring gene histidinol phosphate phosphatase Neighboring gene regulator of FtsZ defining the chromosome region captured in the forespore Neighboring gene free methionine-(R)-sulfoxide reductase

    Genomic regions, transcripts, and products

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    Genomic Sequence:
    NC_000964.3

    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. Structure and function of a spectrin-like regulator of bacterial cytokinesis. Cleverley RM, et al. Nat Commun, 2014 Nov 18. PMID 25403286, Free PMC Article
    2. Functional domain analysis of the cell division inhibitor EzrA. Land AD, et al. PLoS One, 2014. PMID 25068683, Free PMC Article
    3. A membrane protein, EzrA, regulates assembly dynamics of FtsZ by interacting with the C-terminal tail of FtsZ. Singh JK, et al. Biochemistry, 2007 Sep 25. PMID 17718511
    4. Control of the cell elongation-division cycle by shuttling of PBP1 protein in Bacillus subtilis. Claessen D, et al. Mol Microbiol, 2008 May. PMID 18363795
    5. Bacillus subtilis, the model Gram-positive bacterium: 20 years of annotation refinement. Borriss R, et al. Microb Biotechnol, 2018 Jan. PMID 29280348, Free PMC Article

    See all (8) citations in PubMed

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?
    1. The EzrA structure is bent into a semicircle, providing the protein with the potential to interact at both N- and C-termini with adjacent membrane-bound divisome components.
      Title: Structure and function of a spectrin-like regulator of bacterial cytokinesis.
    2. chimeric analysis indicates that EzrA's transmembrane anchor plays a generic role: concentrating EzrA at the plasma membrane where presumably it can most effectively modulate FtsZ assembly
      Title: Functional domain analysis of the cell division inhibitor EzrA.
    3. EzrA mainly promotes the recruitment of PBP1 to division sites.
      Title: Control of the cell elongation-division cycle by shuttling of PBP1 protein in Bacillus subtilis.
    4. The data together showed that EzrA binds to the C-terminal tail of FtsZ. FtsA, a positive regulator of FtsZ assembly, is also known to interact with the C-terminal tail of FtsZ.
      Title: A membrane protein, EzrA, regulates assembly dynamics of FtsZ by interacting with the C-terminal tail of FtsZ.
    Submit: New GeneRIF Correction

    General gene information

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    Homology

    General protein information

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    Preferred Names
    negative regulator of FtsZ ring formation
    NP_390839.1
    • Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 10449747, 15101985, 15317798, 16549676, 17718511, 17873055, 18363795, 19429628, 21401734, 24218584, 25954268, 28357277; Product type r: regulator

    NCBI Reference Sequences (RefSeq)

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    Genome Annotation

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference assembly

    Genomic

    1. NC_000964.3 Reference assembly

      Range
      3029729..3031417 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NP_390839.1 negative regulator of FtsZ ring formation [Bacillus subtilis subsp. subtilis str. 168]

      See identical proteins and their annotated locations for NP_390839.1

      Status: PROVISIONAL

      UniProtKB/TrEMBL
      A0AA34VMK9
      Conserved Domains (1) summary
      COG4477
      Location:1 → 562
      EzrA; Septation ring formation regulator EzrA [Cell cycle control, cell division, chromosome partitioning]
    Nucleotide Protein
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    O34894.1

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