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    ezrA negative regulator of FtsZ ring formation [ Bacillus subtilis subsp. subtilis str. 168 ]

    Gene ID: 937337, updated on 12-Feb-2021

    Summary

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    Gene symbol
    ezrA
    Gene description
    negative regulator of FtsZ ring formation
    Locus tag
    BSU_29610
    Gene type
    protein coding
    RefSeq status
    PROVISIONAL
    Organism
    Bacillus subtilis subsp. subtilis str. 168 (strain: 168, sub-species: subtilis, type-material: type strain of Bacillus subtilis)
    Lineage
    Bacteria; Firmicutes; Bacilli; Bacillales; Bacillaceae; Bacillus
    Old locus tag
    BSU29610
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    Genomic context

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    Sequence:
    NC_000964.3 (3029729..3031417, complement)

    NC_000964.3Genomic Context describing neighboring genes Neighboring gene cysteine desulfurase Neighboring gene branched-chain amino acid-Na+ symporter Neighboring gene histidinol phosphate phosphatase Neighboring gene regulator of FtsZ defining the chromosome region captured in the forespore Neighboring gene free methionine-(R)-sulfoxide reductase

    Genomic regions, transcripts, and products

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    Genomic Sequence:
    NC_000964.3

    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. Functional domain analysis of the cell division inhibitor EzrA. Land AD, et al. PLoS One, 2014. PMID 25068683, Free PMC Article
    2. A membrane protein, EzrA, regulates assembly dynamics of FtsZ by interacting with the C-terminal tail of FtsZ. Singh JK, et al. Biochemistry, 2007 Sep 25. PMID 17718511
    3. Structure and function of a spectrin-like regulator of bacterial cytokinesis. Cleverley RM, et al. Nat Commun, 2014 Nov 18. PMID 25403286, Free PMC Article
    4. Control of the cell elongation-division cycle by shuttling of PBP1 protein in Bacillus subtilis. Claessen D, et al. Mol Microbiol, 2008 May. PMID 18363795
    5. Bacillus subtilis, the model Gram-positive bacterium: 20 years of annotation refinement. Borriss R, et al. Microb Biotechnol, 2018 Jan. PMID 29280348, Free PMC Article

    See all (8) citations in PubMed

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?
    1. The EzrA structure is bent into a semicircle, providing the protein with the potential to interact at both N- and C-termini with adjacent membrane-bound divisome components.
      Title: Structure and function of a spectrin-like regulator of bacterial cytokinesis.
    2. chimeric analysis indicates that EzrA's transmembrane anchor plays a generic role: concentrating EzrA at the plasma membrane where presumably it can most effectively modulate FtsZ assembly
      Title: Functional domain analysis of the cell division inhibitor EzrA.
    3. EzrA mainly promotes the recruitment of PBP1 to division sites.
      Title: Control of the cell elongation-division cycle by shuttling of PBP1 protein in Bacillus subtilis.
    4. The data together showed that EzrA binds to the C-terminal tail of FtsZ. FtsA, a positive regulator of FtsZ assembly, is also known to interact with the C-terminal tail of FtsZ.
      Title: A membrane protein, EzrA, regulates assembly dynamics of FtsZ by interacting with the C-terminal tail of FtsZ.
    Submit: New GeneRIF Correction

    General gene information

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    Homology

    General protein information

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    Preferred Names
    negative regulator of FtsZ ring formation
    NP_390839.1
    • Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 10449747, 15101985, 15317798, 16549676, 17718511, 17873055, 18363795, 19429628, 21401734, 24218584, 25954268, 28357277; Product type r: regulator

    NCBI Reference Sequences (RefSeq)

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    Genome Annotation

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference assembly

    Genomic

    1. NC_000964.3 Reference assembly

      Range
      3029729..3031417 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NP_390839.1 negative regulator of FtsZ ring formation [Bacillus subtilis subsp. subtilis str. 168]

      See identical proteins and their annotated locations for NP_390839.1

      Status: PROVISIONAL

      Conserved Domains (1) summary
      COG4477
      Location:1 → 562
      EzrA; Septation ring formation regulator EzrA [Cell cycle control, cell division, chromosome partitioning]
    Nucleotide Protein
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    O34894.1

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    Other Literature Sources
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