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    iolA methylmalonate-semialdehyde dehydrogenase [ Bacillus subtilis subsp. subtilis str. 168 ]

    Gene ID: 937575, updated on 6-Jun-2024

    Summary

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    Gene symbol
    iolA
    Gene description
    methylmalonate-semialdehyde dehydrogenase
    Locus tag
    BSU_39760
    Gene type
    protein coding
    RefSeq status
    PROVISIONAL
    Organism
    Bacillus subtilis subsp. subtilis str. 168 (strain: 168, sub-species: subtilis, type-material: type strain of Bacillus subtilis)
    Lineage
    Bacteria; Firmicutes; Bacilli; Bacillales; Bacillaceae; Bacillus
    Old locus tag
    BSU39760
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    Genomic context

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    Sequence:
    NC_000964.3 (4082920..4084383, complement)

    NC_000964.3Genomic Context describing neighboring genes Neighboring gene 2-deoxy-5-keto-D-gluconic acid kinase Neighboring gene 5-deoxy-D-glucuronic acid isomerase Neighboring gene transcriptional regulator of the iol operon (DeoR family) Neighboring gene putative aldo-keto reductase

    Genomic regions, transcripts, and products

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    Genomic Sequence:
    NC_000964.3

    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. Mechanistic characterization of the MSDH (methylmalonate semialdehyde dehydrogenase) from Bacillus subtilis. Stines-Chaumeil C, et al. Biochem J, 2006 Apr 1. PMID 16332250, Free PMC Article
    2. Bacillus subtilis, the model Gram-positive bacterium: 20 years of annotation refinement. Borriss R, et al. Microb Biotechnol, 2018 Jan. PMID 29280348, Free PMC Article
    3. An updated metabolic view of the Bacillus subtilis 168 genome. Belda E, et al. Microbiology (Reading), 2013 Apr. PMID 23429746
    4. From a consortium sequence to a unified sequence: the Bacillus subtilis 168 reference genome a decade later. Barbe V, et al. Microbiology (Reading), 2009 Jun. PMID 19383706, Free PMC Article
    5. The complete genome sequence of the gram-positive bacterium Bacillus subtilis. Kunst F, et al. Nature, 1997 Nov 20. PMID 9384377

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?
    1. A detailed mechanistic characterization of the MSDH-catalysed reaction has been carried out.
      Title: Mechanistic characterization of the MSDH (methylmalonate semialdehyde dehydrogenase) from Bacillus subtilis.
    Submit: New GeneRIF Correction

    Pathways from PubChem

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    General gene information

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    Homology

    General protein information

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    Preferred Names
    methylmalonate-semialdehyde dehydrogenase
    NP_391855.1
    • Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 10658656, 11566986, 16332250, 18310071, 20971862, 22720735, 26832667; Product type e: enzyme

    NCBI Reference Sequences (RefSeq)

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    Genome Annotation

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference assembly

    Genomic

    1. NC_000964.3 Reference assembly

      Range
      4082920..4084383 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NP_391855.1 methylmalonate-semialdehyde dehydrogenase [Bacillus subtilis subsp. subtilis str. 168]

      See identical proteins and their annotated locations for NP_391855.1

      Status: PROVISIONAL

      UniProtKB/TrEMBL
      D4G3X1
      Conserved Domains (1) summary
      cd07085
      Location:7 → 481
      ALDH_F6_MMSDH; Methylmalonate semialdehyde dehydrogenase and ALDH family members 6A1 and 6B2
    Nucleotide Protein
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    P42412.1

    Gene LinkOut

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    Other Literature Sources
    Molecular Biology Databases