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    sigI RNA polymerase sigma factor (heat stress responsive) [ Bacillus subtilis subsp. subtilis str. 168 ]

    Gene ID: 939363, updated on 6-Oct-2023

    Summary

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    Gene symbol
    sigI
    Gene description
    RNA polymerase sigma factor (heat stress responsive)
    Locus tag
    BSU_13450
    Gene type
    protein coding
    RefSeq status
    PROVISIONAL
    Organism
    Bacillus subtilis subsp. subtilis str. 168 (strain: 168, sub-species: subtilis, type-material: type strain of Bacillus subtilis)
    Lineage
    Bacteria; Firmicutes; Bacilli; Bacillales; Bacillaceae; Bacillus
    Old locus tag
    BSU13450
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    Genomic context

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    Sequence:
    NC_000964.3 (1411892..1412647)

    NC_000964.3Genomic Context describing neighboring genes Neighboring gene putative integral membrane protein Neighboring gene miscRNA Neighboring gene putative manganese-related ion transporter Neighboring gene sigmaI modulating factor Neighboring gene small acid-soluble spore protein (alpha/beta-type SASP) Neighboring gene regulator of quality control

    Genomic regions, transcripts, and products

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    Genomic Sequence:
    NC_000964.3

    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. Genetic evidence for involvement of the alternative sigma factor SigI in controlling expression of the cell wall hydrolase gene lytE and contribution of LytE to heat survival of Bacillus subtilis. Tseng CL, et al. Arch Microbiol, 2011 Sep. PMID 21541672
    2. Glucolipids and lipoteichoic acids affect the activity of SigI, an alternative sigma factor, and WalKR, an essential two-component system, in Bacillus subtilis. Matsuoka S, et al. Genes Cells, 2022 Feb. PMID 34910349
    3. The heat-inducible essential response regulator WalR positively regulates transcription of sigI, mreBH and lytE in Bacillus subtilis under heat stress. Huang WZ, et al. Res Microbiol, 2013 Dec. PMID 24125693
    4. Genetic evidence for the actin homolog gene mreBH and the bacitracin resistance gene bcrC as targets of the alternative sigma factor SigI of Bacillus subtilis. Tseng CL, et al. J Bacteriol, 2008 Mar. PMID 18156261, Free PMC Article
    5. The cell wall regulator {sigma}I specifically suppresses the lethal phenotype of mbl mutants in Bacillus subtilis. Schirner K, et al. J Bacteriol, 2009 Mar. PMID 19114499, Free PMC Article

    See all (9) citations in PubMed

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?
    1. Glucolipids and lipoteichoic acids affect the activity of SigI, an alternative sigma factor, and WalKR, an essential two-component system, in Bacillus subtilis.
      Title: Glucolipids and lipoteichoic acids affect the activity of SigI, an alternative sigma factor, and WalKR, an essential two-component system, in Bacillus subtilis.
    2. WalR appears to coordinately and positively regulate transcription of sigI, mreBH and lytE under heat stress.
      Title: The heat-inducible essential response regulator WalR positively regulates transcription of sigI, mreBH and lytE in Bacillus subtilis under heat stress.
    3. Data strongly suggest that SigI-dependent lytE expression under heat stress is important for heat survival of B. subtilis.
      Title: Genetic evidence for involvement of the alternative sigma factor SigI in controlling expression of the cell wall hydrolase gene lytE and contribution of LytE to heat survival of Bacillus subtilis.
    4. findings show that the mbl mutant phenotype is Mg2+ dependent, and a screen for suppressor mutations revealed that activation of the sigma I regulon overcomes the requirement for Mg2+
      Title: The cell wall regulator {sigma}I specifically suppresses the lethal phenotype of mbl mutants in Bacillus subtilis.
    5. This further supports the notion that SigI can directly regulate mreBH and bcrC expression. and these results strongly suggest that mreBH and bcrC are new members of the SigI regulon.
      Title: Genetic evidence for the actin homolog gene mreBH and the bacitracin resistance gene bcrC as targets of the alternative sigma factor SigI of Bacillus subtilis.
    Submit: New GeneRIF Correction

    General gene information

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    Homology

    General protein information

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    Preferred Names
    RNA polymerase sigma factor (heat stress responsive)
    NP_389228.1
    • Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 11157964, 12682299, 17185538, 18156261, 21541672, 24125693, 28333276; Product type f: factor

    NCBI Reference Sequences (RefSeq)

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    Genome Annotation

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference assembly

    Genomic

    1. NC_000964.3 Reference assembly

      Range
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NP_389228.1 RNA polymerase sigma factor (heat stress responsive) [Bacillus subtilis subsp. subtilis str. 168]

      See identical proteins and their annotated locations for NP_389228.1

      Status: PROVISIONAL

      UniProtKB/TrEMBL
      A0A0D1ISG8
      Conserved Domains (1) summary
      PRK08311
      Location:14 → 251
      PRK08311; RNA polymerase sigma factor SigI
    Nucleotide Protein
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    O31654.1

    Gene LinkOut

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    Other Literature Sources
    Molecular Biology Databases