smc chromosome condensation and segregation SMC ATPase [Bacillus subtilis subsp. subtilis str. 168] - Gene

Summary

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Gene symbol: smc
Gene description: chromosome condensation and segregation SMC ATPase
Locus tag: BSU_15940
Gene type: protein coding
RefSeq status: PROVISIONAL
Organism: Bacillus subtilis subsp. subtilis str. 168 (strain: 168, sub-species: subtilis, type-material: type strain of Bacillus subtilis)
Lineage: Bacteria; Firmicutes; Bacilli; Bacillales; Bacillaceae; Bacillus
Old locus tag: BSU15940
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Genomic context

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Sequence:: NC_000964.3 (1666560..1670120)

NC_000964.3 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Go to reference sequence details

Genomic Sequence:: NC_000964.3

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Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Sandwiching of ATP molecules between Smc heads requires them to substantially tilt and translate relative to each other, thereby opening up the Smc arms. This mechanochemical gating reaction regulates chromosome targeting and propose a mechanism for DNA translocation based on the merging of DNA loops upon closure of Smc arms.
Title: Structure of Full-Length SMC and Rearrangements Required for Chromosome Organization.
Targeting of Smc/ScpAB to ParB/parS loading sites is strictly dependent on engagement of Smc head domains and relies on an open organization of the Smc coiled coils.
Title: Control of Smc Coiled Coil Architecture by the ATPase Heads Facilitates Targeting to Chromosomal ParB/parS and Release onto Flanking DNA.
we show that rapid inactivation of SMC or its partner protein ScpB during fast growth leads to a failure to resolve newly replicated origins and a complete block to chromosome segregation.
Title: The SMC condensin complex is required for origin segregation in Bacillus subtilis.
A mutation in SMC that affects ATPase activity and results in exaggerated DNA binding causes a strong segregation defect and affects the localization of the SMC complex, which localizes to many more sites in the cell than under normal conditions
Title: SMC condensation centers in Bacillus subtilis are dynamic structures.
An Smc dimer is bridged by a single ScpAB to generate asymmetric tripartite rings analogous to eukaryotic SMC complexes.
Title: An asymmetric SMC-kleisin bridge in prokaryotic condensin.
has a dual function, in chromosome supercoiling and in active segregation
Title: Genetic interaction of the SMC complex with topoisomerase IV in Bacillus subtilis.

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General gene information

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Homology

Orthologs from OrthoDB

General protein information

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Preferred Names: chromosome condensation and segregation SMC ATPase

NP_389476.2

Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 9701812, 12100548, 12682299, 12897137, 15987505, 16272394, 26904953, 28154080; Product type e: enzyme

NCBI Reference Sequences (RefSeq)

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Genome Annotation

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference assembly

Genomic

NC_000964.3 Reference assembly

Range

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GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

NP_389476.2 chromosome condensation and segregation SMC ATPase [Bacillus subtilis subsp. subtilis str. 168]

Status: PROVISIONAL

UniProtKB/TrEMBL

A0A0D1KV42

Conserved Domains (1) summary

TIGR02168
Location:2 → 1178

SMC_prok_B; chromosome segregation protein SMC, common bacterial type