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    Scamp1 secretory carrier membrane protein 1 [ Mus musculus (house mouse) ]

    Gene ID: 107767, updated on 28-Oct-2024

    Summary

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    Official Symbol
    Scamp1provided by MGI
    Official Full Name
    secretory carrier membrane protein 1provided by MGI
    Primary source
    MGI:MGI:1349480
    See related
    Ensembl:ENSMUSG00000021687 AllianceGenome:MGI:1349480
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Mus musculus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
    Also known as
    4930505M11Rik
    Summary
    Predicted to enable protein domain specific binding activity. Acts upstream of or within establishment of localization in cell and exocytosis. Located in synaptic vesicle membrane and zymogen granule membrane. Is expressed in neural retinal epithelium; retina inner nuclear layer; retina nuclear layer; and retina outer nuclear layer. Orthologous to human SCAMP1 (secretory carrier membrane protein 1). [provided by Alliance of Genome Resources, Oct 2024]
    Expression
    Broad expression in frontal lobe adult (RPKM 34.4), CNS E18 (RPKM 30.4) and 26 other tissues See more
    Orthologs
    human all
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    Genomic context

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    See Scamp1 in Genome Data Viewer
    Location:
    13 C3; 13 49.22 cM
    Exon count:
    13
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCm39 (GCF_000001635.27) 13 NC_000079.7 (94337818..94422339, complement)
    108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 13 NC_000079.6 (94201310..94285831, complement)

    Chromosome 13 - NC_000079.7Genomic Context describing neighboring genes Neighboring gene cytochrome c, pseudogene 3 Neighboring gene lipoma HMGIC fusion partner-like 2 Neighboring gene predicted gene, 57596 Neighboring gene STARR-seq mESC enhancer starr_35303 Neighboring gene predicted gene, 32089 Neighboring gene nucleoside diphosphate kinase B pseudogene

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: Mouse ENCODE transcriptome data Mouse ENCODE transcriptome data
    • Description: RNA profiling data sets generated by the Mouse ENCODE project.
    • BioProject: PRJNA66167
    • Publication: PMID 25409824
    • Analysis date: n/a

    Bibliography

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    Related articles in PubMed

    1. Analysis of SCAMP1 function in secretory vesicle exocytosis by means of gene targeting in mice. Fernández-Chacón R, et al. J Biol Chem, 1999 Nov 12. PMID 10551807
    2. Interaction assays in yeast and cultured cells confirm known and identify novel partners of the synaptic vesicle protein synaptophysin. Felkl M, et al. Neuroscience, 2008 Oct 2. PMID 18706977
    3. Rab3D is not required for exocrine exocytosis but for maintenance of normally sized secretory granules. Riedel D, et al. Mol Cell Biol, 2002 Sep. PMID 12192047, Free PMC Article
    4. Glucose transporter recycling in response to insulin is facilitated by myosin Myo1c. Bose A, et al. Nature, 2002 Dec 19-26. PMID 12490950
    5. Munc18-1 stabilizes syntaxin 1, but is not essential for syntaxin 1 targeting and SNARE complex formation. Toonen RF, et al. J Neurochem, 2005 Jun. PMID 15935055

    See all (27) citations in PubMed

    GeneRIFs: Gene References Into Functions

    Variation

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    Alleles

    Alleles of this type are documented at Mouse Genome Informatics  (MGI)

    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Markers

    Homology

    Gene Ontology Provided by MGI

    Function Evidence Code Pubs
    enables protein binding IPI
    Inferred from Physical Interaction
    more info
    		 PubMed 
    enables protein domain specific binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables protein domain specific binding ISO
    Inferred from Sequence Orthology
    more info
    		  
    Process Evidence Code Pubs
    involved_in endocytosis IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in endocytosis ISO
    Inferred from Sequence Orthology
    more info
    		  
    acts_upstream_of_or_within establishment of localization in cell IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    acts_upstream_of_or_within exocytosis IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in protein transport IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in protein transport ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in protein transport ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  
    Component Evidence Code Pubs
    located_in clathrin-coated vesicle IEA
    Inferred from Electronic Annotation
    more info
    		  
    located_in clathrin-coated vesicle ISO
    Inferred from Sequence Orthology
    more info
    		  
    located_in cytoplasmic vesicle membrane IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    located_in membrane ISO
    Inferred from Sequence Orthology
    more info
    		  
    located_in membrane ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  
    is_active_in recycling endosome membrane IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    located_in recycling endosome membrane ISO
    Inferred from Sequence Orthology
    more info
    		  
    located_in recycling endosome membrane ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  
    located_in synapse IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    located_in synaptic vesicle TAS
    Traceable Author Statement
    more info
    		 PubMed 
    located_in synaptic vesicle membrane IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    is_active_in synaptic vesicle membrane ISO
    Inferred from Sequence Orthology
    more info
    		  
    located_in trans-Golgi network ISO
    Inferred from Sequence Orthology
    more info
    		  
    located_in trans-Golgi network ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  
    is_active_in trans-Golgi network membrane IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    located_in zymogen granule membrane IDA
    Inferred from Direct Assay
    more info
    		 PubMed 

    General protein information

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    Preferred Names
    secretory carrier-associated membrane protein 1

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001346609.1 → NP_001333538.1  secretory carrier-associated membrane protein 1 isoform 2

      Status: VALIDATED

      Source sequence(s)
      AC148334, AK135058, AK162168
      Consensus CDS
      CCDS84049.1
      UniProtKB/TrEMBL
      Q3TSA8, Q9D577
      Related
      ENSMUSP00000123135.2, ENSMUST00000152555.8
      Conserved Domains (2) summary
      pfam04144
      Location:65 → 240
      SCAMP; SCAMP family
      cl03075
      Location:13 → 63
      GrpE; nucleotide exchange factor GrpE

    2. NM_029153.1 → NP_083429.1  secretory carrier-associated membrane protein 1 isoform 1

      See identical proteins and their annotated locations for NP_083429.1

      Status: VALIDATED

      Source sequence(s)
      BC034283
      Consensus CDS
      CCDS36750.1
      UniProtKB/Swiss-Prot
      Q8K021
      UniProtKB/TrEMBL
      Q3TD71, Q3UY11
      Related
      ENSMUSP00000022197.9, ENSMUST00000022197.15
      Conserved Domains (1) summary
      pfam04144
      Location:117 → 292
      SCAMP; SCAMP family

    RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCm39 C57BL/6J

    Genomic

    1. NC_000079.7 Reference GRCm39 C57BL/6J

      Range
      94337818..94422339 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_030247117.1 → XP_030102977.1  secretory carrier-associated membrane protein 1 isoform X1

      UniProtKB/TrEMBL
      Q3TSA8, Q9D577
      Conserved Domains (2) summary
      pfam04144
      Location:65 → 240
      SCAMP; SCAMP family
      cl03075
      Location:13 → 63
      GrpE; nucleotide exchange factor GrpE

    2. XM_030247116.1 → XP_030102976.1  secretory carrier-associated membrane protein 1 isoform X1

      UniProtKB/TrEMBL
      Q3TSA8, Q9D577
      Conserved Domains (2) summary
      pfam04144
      Location:65 → 240
      SCAMP; SCAMP family
      cl03075
      Location:13 → 63
      GrpE; nucleotide exchange factor GrpE

    3. XM_006517515.3 → XP_006517578.1  secretory carrier-associated membrane protein 1 isoform X1

      See identical proteins and their annotated locations for XP_006517578.1

      UniProtKB/TrEMBL
      Q3TSA8, Q9D577
      Related
      ENSMUSP00000120053.2, ENSMUST00000153558.8
      Conserved Domains (2) summary
      pfam04144
      Location:65 → 240
      SCAMP; SCAMP family
      cl03075
      Location:13 → 63
      GrpE; nucleotide exchange factor GrpE
    Nucleotide Protein Strain
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    Q8K021.1 GenPept UniProtKB/Swiss-Prot:Q8K021

    Gene LinkOut

    The following LinkOut resources are supplied by external providers. These providers are responsible for maintaining the links.

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