U.S. flag

An official website of the United States government

Format

Send to:

Choose Destination

Links from GEO Profiles

    • Showing Current items.

    Ap2b1 adaptor-related protein complex 2, beta 1 subunit [ Mus musculus (house mouse) ]

    Gene ID: 71770, updated on 28-Oct-2024

    Summary

    Go to the top of the page Help
    Official Symbol
    Ap2b1provided by MGI
    Official Full Name
    adaptor-related protein complex 2, beta 1 subunitprovided by MGI
    Primary source
    MGI:MGI:1919020
    See related
    Ensembl:ENSMUSG00000035152 AllianceGenome:MGI:1919020
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Mus musculus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
    Also known as
    AP105B; 1300012O03Rik
    Summary
    Predicted to enable clathrin binding activity. Involved in clathrin-dependent endocytosis and postsynaptic neurotransmitter receptor internalization. Acts upstream of or within circulatory system development and kidney development. Part of AP-2 adaptor complex. Is active in glutamatergic synapse. Is expressed in several structures, including alimentary system; genitourinary system; nervous system; respiratory system; and sensory organ. Orthologous to human AP2B1 (adaptor related protein complex 2 subunit beta 1). [provided by Alliance of Genome Resources, Oct 2024]
    Expression
    Ubiquitous expression in testis adult (RPKM 73.6), CNS E18 (RPKM 36.3) and 28 other tissues See more
    Orthologs
    human all
    NEW
    Try the new Gene table
    Try the new Transcript table

    Genomic context

    Go to the top of the page Help
    See Ap2b1 in Genome Data Viewer
    Location:
    11 C; 11 50.3 cM
    Exon count:
    23
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCm39 (GCF_000001635.27) 11 NC_000077.7 (83189545..83295861)
    108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 11 NC_000077.6 (83298719..83405035)

    Chromosome 11 - NC_000077.7Genomic Context describing neighboring genes Neighboring gene schlafen 14 Neighboring gene STARR-positive B cell enhancer ABC_E1424 Neighboring gene STARR-positive B cell enhancer ABC_E8435 Neighboring gene expressed sequence AA465934 Neighboring gene STARR-seq mESC enhancer starr_30193 Neighboring gene expressed sequence AI450353 Neighboring gene peroxisomal biogenesis factor 12 Neighboring gene small nucleolar RNA, C/D box 7 Neighboring gene STARR-seq mESC enhancer starr_30196 Neighboring gene predicted gene, 23951 Neighboring gene RAS-like, family 10, member B Neighboring gene growth arrest-specific 2 like 2

    Genomic regions, transcripts, and products

    Go to the top of the page Help

    Go to nucleotide: Graphics FASTA GenBank

    Expression

    Go to the top of the page Help
    • Project title: Mouse ENCODE transcriptome data Mouse ENCODE transcriptome data
    • Description: RNA profiling data sets generated by the Mouse ENCODE project.
    • BioProject: PRJNA66167
    • Publication: PMID 25409824
    • Analysis date: n/a

    Bibliography

    Go to the top of the pageHelp

    Related articles in PubMed

    1. The AP-2 complex is excluded from the dynamic population of plasma membrane-associated clathrin. Rappoport JZ, et al. J Biol Chem, 2003 Nov 28. PMID 14530274
    2. A proteomic screen reveals novel Fas ligand interacting proteins within nervous system Schwann cells. Thornhill PB, et al. FEBS Lett, 2007 Sep 18. PMID 17761170
    3. Eps15 is constitutively oligomerized due to homophilic interaction of its coiled-coil region. Tebar F, et al. J Biol Chem, 1997 Jun 13. PMID 9182572
    4. Disruption of the murine Ap2β1 gene causes nonsyndromic cleft palate. Li W, et al. Cleft Palate Craniofac J, 2010 Nov. PMID 20500056, Free PMC Article
    5. Role of activation of PIP5Kgamma661 by AP-2 complex in synaptic vesicle endocytosis. Nakano-Kobayashi A, et al. EMBO J, 2007 Feb 21. PMID 17290217, Free PMC Article

    See all (74) citations in PubMed

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?
    1. the AP-2 complex is not associated with the endocytosed plasma membrane-associated clathrin
      Title: The AP-2 complex is excluded from the dynamic population of plasma membrane-associated clathrin.
    Submit: New GeneRIF Correction

    Variation

    Go to the top of the page Help

    Alleles

    Alleles of this type are documented at Mouse Genome Informatics  (MGI)
    • Chemically induced (ENU) (2)  1 citation
    • Endonuclease-mediated (3) 
    • Targeted (1) 
    • Transgenic (2)  1 citation

    Pathways from PubChem

    Go to the top of the page

    Interactions

    Go to the top of the page Help
    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

    Go to the top of the page Help

    Markers

    Homology

    Gene Ontology Provided by MGI

    Function Evidence Code Pubs
    enables clathrin binding IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables clathrin binding ISO
    Inferred from Sequence Orthology
    more info
    		  
    enables protein binding IPI
    Inferred from Physical Interaction
    more info
    		 PubMed 
    enables protein-containing complex binding ISO
    Inferred from Sequence Orthology
    more info
    		  
    Process Evidence Code Pubs
    acts_upstream_of_or_within aorta development IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    acts_upstream_of_or_within cardiac septum development IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in clathrin coat assembly ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in clathrin-dependent endocytosis IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    involved_in clathrin-dependent endocytosis ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in clathrin-dependent endocytosis NAS
    Non-traceable Author Statement
    more info
    		 PubMed 
    acts_upstream_of_or_within coronary vasculature development IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    acts_upstream_of_or_within heart development IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in intracellular protein transport IEA
    Inferred from Electronic Annotation
    more info
    		  
    acts_upstream_of_or_within kidney development IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in positive regulation of endocytosis ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in positive regulation of protein localization to membrane ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in postsynaptic neurotransmitter receptor internalization IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    involved_in postsynaptic neurotransmitter receptor internalization IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in postsynaptic neurotransmitter receptor internalization ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in postsynaptic neurotransmitter receptor internalization NAS
    Non-traceable Author Statement
    more info
    		 PubMed 
    involved_in synaptic vesicle endocytosis IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in synaptic vesicle endocytosis ISO
    Inferred from Sequence Orthology
    more info
    		  
    acts_upstream_of_or_within ventricular septum development IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in vesicle-mediated transport IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in vesicle-mediated transport NAS
    Non-traceable Author Statement
    more info
    		 PubMed 
    Component Evidence Code Pubs
    part_of AP-2 adaptor complex IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    part_of AP-2 adaptor complex ISO
    Inferred from Sequence Orthology
    more info
    		  
    part_of AP-2 adaptor complex NAS
    Non-traceable Author Statement
    more info
    		 PubMed 
    part_of clathrin adaptor complex ISO
    Inferred from Sequence Orthology
    more info
    		  
    part_of clathrin coat ISO
    Inferred from Sequence Orthology
    more info
    		  
    located_in cytoplasmic side of plasma membrane NAS
    Non-traceable Author Statement
    more info
    		 PubMed 
    is_active_in extrinsic component of presynaptic endocytic zone membrane ISO
    Inferred from Sequence Orthology
    more info
    		  
    is_active_in glutamatergic synapse IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    is_active_in glutamatergic synapse IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    is_active_in glutamatergic synapse ISO
    Inferred from Sequence Orthology
    more info
    		  
    located_in postsynapse IEA
    Inferred from Electronic Annotation
    more info
    		  
    located_in presynapse IEA
    Inferred from Electronic Annotation
    more info
    		  
    is_active_in synapse EXP
    Inferred from Experiment
    more info
    		 PubMed 
    is_active_in synapse IDA
    Inferred from Direct Assay
    more info
    		 PubMed 

    General protein information

    Go to the top of the page Help
    Preferred Names
    AP-2 complex subunit beta
    Names
    adapter-related protein complex 2 beta subunit
    adapter-related protein complex 2 subunit beta
    adaptor protein complex AP-2 subunit beta
    adaptor-related protein complex 2 subunit beta
    beta-2-adaptin
    beta-adaptin
    beta2-adaptin
    clathrin assembly protein complex 2 beta large chain
    plasma membrane adaptor HA2/AP2 adaptin beta subunit

    NCBI Reference Sequences (RefSeq)

    Go to the top of the page Help

    NEW Try the new Transcript table

    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001035854.2 → NP_001030931.1  AP-2 complex subunit beta isoform a

      See identical proteins and their annotated locations for NP_001030931.1

      Status: VALIDATED

      Source sequence(s)
      AK138434, AL603711
      Consensus CDS
      CCDS25161.1
      UniProtKB/TrEMBL
      H3BIY9, Q5SWR1
      Related
      ENSMUSP00000018875.7, ENSMUST00000018875.13
      Conserved Domains (4) summary
      smart00809
      Location:731 → 831
      Alpha_adaptinC2; Adaptin C-terminal domain
      smart01020
      Location:840 → 950
      B2-adapt-app_C; Beta2-adaptin appendage, C-terminal sub-domain
      sd00044
      Location:51 → 75
      HEAT; HEAT repeat [structural motif]
      pfam01602
      Location:11 → 534
      Adaptin_N; Adaptin N terminal region

    2. NM_027915.3 → NP_082191.1  AP-2 complex subunit beta isoform b

      See identical proteins and their annotated locations for NP_082191.1

      Status: VALIDATED

      Source sequence(s)
      AK004975, AK138434, AL603711
      Consensus CDS
      CCDS25162.1
      UniProtKB/Swiss-Prot
      Q80XJ4, Q9DBG3
      UniProtKB/TrEMBL
      H3BIY9
      Related
      ENSMUSP00000070714.8, ENSMUST00000065692.14
      Conserved Domains (4) summary
      smart00809
      Location:717 → 817
      Alpha_adaptinC2; Adaptin C-terminal domain
      smart01020
      Location:826 → 936
      B2-adapt-app_C; Beta2-adaptin appendage, C-terminal sub-domain
      sd00044
      Location:51 → 75
      HEAT; HEAT repeat [structural motif]
      pfam01602
      Location:11 → 534
      Adaptin_N; Adaptin N terminal region

    RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCm39 C57BL/6J

    Genomic

    1. NC_000077.7 Reference GRCm39 C57BL/6J

      Range
      83189545..83295861
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_017314772.3 → XP_017170261.1  AP-2 complex subunit beta isoform X1

      UniProtKB/TrEMBL
      H3BIY9, Q5SWR1
      Conserved Domains (4) summary
      smart00809
      Location:731 → 831
      Alpha_adaptinC2; Adaptin C-terminal domain
      smart01020
      Location:840 → 950
      B2-adapt-app_C; Beta2-adaptin appendage, C-terminal sub-domain
      sd00044
      Location:51 → 75
      HEAT; HEAT repeat [structural motif]
      pfam01602
      Location:11 → 534
      Adaptin_N; Adaptin N terminal region

    2. XM_006534258.5 → XP_006534321.1  AP-2 complex subunit beta isoform X1

      See identical proteins and their annotated locations for XP_006534321.1

      UniProtKB/TrEMBL
      H3BIY9, Q5SWR1
      Related
      ENSMUSP00000135445.2, ENSMUST00000176523.2
      Conserved Domains (4) summary
      smart00809
      Location:731 → 831
      Alpha_adaptinC2; Adaptin C-terminal domain
      smart01020
      Location:840 → 950
      B2-adapt-app_C; Beta2-adaptin appendage, C-terminal sub-domain
      sd00044
      Location:51 → 75
      HEAT; HEAT repeat [structural motif]
      pfam01602
      Location:11 → 534
      Adaptin_N; Adaptin N terminal region

    3. XM_036156996.1 → XP_036012889.1  AP-2 complex subunit beta isoform X1

      UniProtKB/TrEMBL
      H3BIY9, Q5SWR1
      Conserved Domains (4) summary
      smart00809
      Location:731 → 831
      Alpha_adaptinC2; Adaptin C-terminal domain
      smart01020
      Location:840 → 950
      B2-adapt-app_C; Beta2-adaptin appendage, C-terminal sub-domain
      sd00044
      Location:51 → 75
      HEAT; HEAT repeat [structural motif]
      pfam01602
      Location:11 → 534
      Adaptin_N; Adaptin N terminal region
    Nucleotide Protein Strain
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    Q9DBG3.1 GenPept UniProtKB/Swiss-Prot:Q9DBG3

    Gene LinkOut

    The following LinkOut resources are supplied by external providers. These providers are responsible for maintaining the links.

    Other Literature Sources
    Chemical Information
    Molecular Biology Databases
    Research Materials
    Tools
    Miscellaneous