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    Tubgcp2 tubulin, gamma complex component 2 [ Mus musculus (house mouse) ]

    Gene ID: 74237, updated on 28-Oct-2024

    Summary

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    Official Symbol
    Tubgcp2provided by MGI
    Official Full Name
    tubulin, gamma complex component 2provided by MGI
    Primary source
    MGI:MGI:1921487
    See related
    Ensembl:ENSMUSG00000025474 AllianceGenome:MGI:1921487
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Mus musculus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
    Also known as
    1700022B05Rik
    Summary
    Predicted to enable gamma-tubulin binding activity. Predicted to contribute to microtubule minus-end binding activity. Predicted to be involved in several processes, including meiotic cell cycle; microtubule cytoskeleton organization; and nervous system development. Predicted to be located in centrosome and nucleoplasm. Predicted to be part of gamma-tubulin complex. Is expressed in cerebral cortex; cerebral cortex ventricular layer; and cortical plate. Human ortholog(s) of this gene implicated in pachygyria, microcephaly, developmental delay, and dysmorphic facies, with or without seizures. Orthologous to human TUBGCP2 (tubulin gamma complex component 2). [provided by Alliance of Genome Resources, Oct 2024]
    Expression
    Ubiquitous expression in testis adult (RPKM 22.2), limb E14.5 (RPKM 20.2) and 28 other tissues See more
    Orthologs
    human all
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    Genomic context

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    See Tubgcp2 in Genome Data Viewer
    Location:
    7 F4; 7 84.98 cM
    Exon count:
    19
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCm39 (GCF_000001635.27) 7 NC_000073.7 (139575868..139616587, complement)
    108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 7 NC_000073.6 (139995955..140036674, complement)

    Chromosome 7 - NC_000073.7Genomic Context describing neighboring genes Neighboring gene predicted gene 16201 Neighboring gene sperm flagellar 1 like Neighboring gene a disintegrin and metallopeptidase domain 8 Neighboring gene STARR-seq mESC enhancer starr_20441 Neighboring gene microRNA 7062 Neighboring gene STARR-seq mESC enhancer starr_20442 Neighboring gene STARR-positive B cell enhancer ABC_E6615 Neighboring gene STARR-positive B cell enhancer ABC_E8219 Neighboring gene zinc finger protein 511 Neighboring gene VISTA enhancer mm1489 Neighboring gene msh homeobox 3 Neighboring gene STARR-seq mESC enhancer starr_20446 Neighboring gene calcyon neuron-specific vesicular protein

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: Mouse ENCODE transcriptome data Mouse ENCODE transcriptome data
    • Description: RNA profiling data sets generated by the Mouse ENCODE project.
    • BioProject: PRJNA66167
    • Publication: PMID 25409824
    • Analysis date: n/a

    Bibliography

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    Related articles in PubMed

    1. The AP-2 complex interacts with γ-TuRC and regulates the proliferative capacity of neural progenitors. Camblor-Perujo S, et al. Life Sci Alliance, 2024 Feb. PMID 38086550, Free PMC Article
    2. The centrosome protein AKNA regulates neurogenesis via microtubule organization. Camargo Ortega G, et al. Nature, 2019 Mar. PMID 30787442
    3. Deletion in the N-terminal half of olfactomedin 1 modifies its interaction with synaptic proteins and causes brain dystrophy and abnormal behavior in mice. Nakaya N, et al. Exp Neurol, 2013 Dec. PMID 24095980, Free PMC Article
    4. Dynamin-1 co-associates with native mouse brain BKCa channels: proteomics analysis of synaptic protein complexes. Gorini G, et al. FEBS Lett, 2010 Mar 5. PMID 20114047, Free PMC Article
    5. The E3 ubiquitin ligases, HUWE1 and NEDD4-1, are involved in the post-translational regulation of the ABCG1 and ABCG4 lipid transporters. Aleidi SM, et al. J Biol Chem, 2015 Oct 2. PMID 26296893, Free PMC Article

    See all (32) citations in PubMed

    GeneRIFs: Gene References Into Functions

    Variation

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    Alleles

    Alleles of this type are documented at Mouse Genome Informatics  (MGI)
    • Endonuclease-mediated (2) 

    Pathways from PubChem

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    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Homology

    Gene Ontology Provided by MGI

    Function Evidence Code Pubs
    enables gamma-tubulin binding IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables gamma-tubulin binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    contributes_to microtubule minus-end binding IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    Process Evidence Code Pubs
    involved_in brain development ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in brain development ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  
    involved_in cytoplasmic microtubule organization IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in meiotic cell cycle IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in microtubule nucleation IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in microtubule nucleation IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in mitotic cell cycle IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in neuron migration ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in neuron migration ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  
    involved_in spindle assembly IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    Component Evidence Code Pubs
    located_in centrosome IEA
    Inferred from Electronic Annotation
    more info
    		  
    located_in centrosome ISO
    Inferred from Sequence Orthology
    more info
    		  
    located_in cytoplasm IEA
    Inferred from Electronic Annotation
    more info
    		  
    part_of gamma-tubulin complex IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    located_in microtubule IEA
    Inferred from Electronic Annotation
    more info
    		  
    located_in microtubule organizing center ISO
    Inferred from Sequence Orthology
    more info
    		  
    located_in microtubule organizing center ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  
    located_in nucleoplasm IEA
    Inferred from Electronic Annotation
    more info
    		  
    located_in nucleoplasm ISO
    Inferred from Sequence Orthology
    more info
    		  
    located_in spindle pole IEA
    Inferred from Electronic Annotation
    more info
    		  

    General protein information

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    Preferred Names
    gamma-tubulin complex component 2
    Names
    GCP-2
    tubulin, gamma complex associated protein 2

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001286007.1 → NP_001272936.1  gamma-tubulin complex component 2 isoform a

      See identical proteins and their annotated locations for NP_001272936.1

      Status: VALIDATED

      Description
      Transcript Variant: This variant (1) represents the longest transcript and encodes the longest isoform (a). Variants 1 and 2 both encode the same isoform (a).
      Source sequence(s)
      AC107822, AK006233, AK146771, BY234488
      Consensus CDS
      CCDS21960.1
      UniProtKB/Swiss-Prot
      G5E859, Q921G8
      UniProtKB/TrEMBL
      Q3UIT6
      Related
      ENSMUSP00000147329.2, ENSMUST00000211638.2
      Conserved Domains (1) summary
      pfam04130
      Location:220 → 738
      Spc97_Spc98; Spc97 / Spc98 family

    2. NM_001286009.1 → NP_001272938.1  gamma-tubulin complex component 2 isoform b

      See identical proteins and their annotated locations for NP_001272938.1

      Status: VALIDATED

      Description
      Transcript Variant: This variant (3) differs in the 3' UTR and coding region compared to variant 1. The resulting isoform (b) has a shorter and distinct C-terminus compared to isoform a.
      Source sequence(s)
      AK045084, BY234488
      UniProtKB/TrEMBL
      Q8BZZ0
      Related
      ENSMUST00000211186.2
      Conserved Domains (1) summary
      pfam04130
      Location:220 → 738
      Spc97_Spc98; Spc97 / Spc98 family

    3. NM_001286011.1 → NP_001272940.1  gamma-tubulin complex component 2 isoform c

      Status: VALIDATED

      Description
      Transcript Variant: This variant (4) lacks an alternate exon and uses a downstream start codon compared to variant 1. The resulting isoform (c) is shorter at the N-terminus compared to isoform a.
      Source sequence(s)
      AC107822, AK006233, AK146771, BY254870
      UniProtKB/TrEMBL
      Q3UIT6
      Conserved Domains (2) summary
      pfam04130
      Location:214 → 573
      Spc97_Spc98; Spc97 / Spc98 family
      pfam17681
      Location:1 → 211
      GCP_N_terminal; Gamma tubulin complex component N-terminal

    4. NM_133755.2 → NP_598516.2  gamma-tubulin complex component 2 isoform a

      See identical proteins and their annotated locations for NP_598516.2

      Status: VALIDATED

      Description
      Transcript Variant: This variant (2) differs in the 5' UTR compared to variant 1. Variants 1 and 2 both encode the same isoform (a).
      Source sequence(s)
      AK006233, AK146771, BY254870
      Consensus CDS
      CCDS21960.1
      UniProtKB/Swiss-Prot
      G5E859, Q921G8
      UniProtKB/TrEMBL
      Q3UIT6
      Related
      ENSMUSP00000026547.8, ENSMUST00000026547.9
      Conserved Domains (1) summary
      pfam04130
      Location:220 → 738
      Spc97_Spc98; Spc97 / Spc98 family

    RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCm39 C57BL/6J

    Genomic

    1. NC_000073.7 Reference GRCm39 C57BL/6J

      Range
      139575868..139616587 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_030243026.1 → XP_030098886.1  gamma-tubulin complex component 2 isoform X1

      Conserved Domains (2) summary
      pfam04130
      Location:240 → 599
      Spc97_Spc98; Spc97 / Spc98 family
      pfam17681
      Location:6 → 237
      GCP_N_terminal; Gamma tubulin complex component N-terminal

    2. XM_036153497.1 → XP_036009390.1  gamma-tubulin complex component 2 isoform X1

      Conserved Domains (2) summary
      pfam04130
      Location:240 → 599
      Spc97_Spc98; Spc97 / Spc98 family
      pfam17681
      Location:6 → 237
      GCP_N_terminal; Gamma tubulin complex component N-terminal

    3. XM_036153498.1 → XP_036009391.1  gamma-tubulin complex component 2 isoform X2

      Conserved Domains (2) summary
      pfam04130
      Location:214 → 573
      Spc97_Spc98; Spc97 / Spc98 family
      pfam17681
      Location:1 → 211
      GCP_N_terminal; Gamma tubulin complex component N-terminal

    4. XM_011249861.4 → XP_011248163.1  gamma-tubulin complex component 2 isoform X1

      Conserved Domains (2) summary
      pfam04130
      Location:240 → 599
      Spc97_Spc98; Spc97 / Spc98 family
      pfam17681
      Location:6 → 237
      GCP_N_terminal; Gamma tubulin complex component N-terminal

    5. XM_030243027.2 → XP_030098887.1  gamma-tubulin complex component 2 isoform X2

      Conserved Domains (2) summary
      pfam04130
      Location:214 → 573
      Spc97_Spc98; Spc97 / Spc98 family
      pfam17681
      Location:1 → 211
      GCP_N_terminal; Gamma tubulin complex component N-terminal
    Nucleotide Protein Strain
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    Q921G8.2 GenPept UniProtKB/Swiss-Prot:Q921G8

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