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    C1qb complement component 1, q subcomponent, beta polypeptide [ Mus musculus (house mouse) ]

    Gene ID: 12260, updated on 2-Nov-2024

    Summary

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    Official Symbol
    C1qbprovided by MGI
    Official Full Name
    complement component 1, q subcomponent, beta polypeptideprovided by MGI
    Primary source
    MGI:MGI:88224
    See related
    Ensembl:ENSMUSG00000036905 AllianceGenome:MGI:88224
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Mus musculus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
    Also known as
    Adia
    Summary
    Enables identical protein binding activity. Involved in synapse pruning. Acts upstream of or within inner ear development. Located in postsynapse. Is active in glutamatergic synapse. Is extrinsic component of postsynaptic membrane and extrinsic component of presynaptic membrane. Is expressed in several structures, including brain; genitourinary system; gut; immune system; and integumental system. Orthologous to human C1QB (complement C1q B chain). [provided by Alliance of Genome Resources, Nov 2024]
    Expression
    Ubiquitous expression in mammary gland adult (RPKM 131.9), spleen adult (RPKM 123.8) and 28 other tissues See more
    Orthologs
    human all
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    Genomic context

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    See C1qb in Genome Data Viewer
    Location:
    4 D3; 4 69.05 cM
    Exon count:
    3
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCm39 (GCF_000001635.27) 4 NC_000070.7 (136607437..136613511, complement)
    108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 4 NC_000070.6 (136880126..136886200, complement)

    Chromosome 4 - NC_000070.7Genomic Context describing neighboring genes Neighboring gene Eph receptor B2 Neighboring gene predicted gene, 52708 Neighboring gene predicted gene, 31536 Neighboring gene complement component 1, q subcomponent, C chain Neighboring gene complement component 1, q subcomponent, alpha polypeptide

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: Mouse ENCODE transcriptome data Mouse ENCODE transcriptome data
    • Description: RNA profiling data sets generated by the Mouse ENCODE project.
    • BioProject: PRJNA66167
    • Publication: PMID 25409824
    • Analysis date: n/a

    Bibliography

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    Related articles in PubMed

    1. Induction of the complement component C1qB in brain of transgenic mice with neuronal overexpression of human cyclooxygenase-2. Spielman L, et al. Acta Neuropathol, 2002 Feb. PMID 11810182
    2. Molecular cloning and characterization of the complementary DNA coding for the B-chain of murine Clq. Petry F, et al. FEBS Lett, 1989 Nov 20. PMID 2591537
    3. cDNA clones coding for the complete murine B chain of complement Clq: nucleotide and derived amino acid sequences. Wood L, et al. Immunol Lett, 1988 Jan. PMID 3258283
    4. cDNA clones coding for the complete murine B chain of complement C1q: nucleotide and derived amino acid sequences. Wood L, et al. Immunol Lett, 1988 Feb. PMID 3258843
    5. Gene expression of the A- and B-chain of mouse C1q in different tissues and the characterization of the recombinant A-chain. Petry F, et al. J Immunol, 1991 Dec 1. PMID 1940381

    See all (48) citations in PubMed

    GeneRIFs: Gene References Into Functions

    Variation

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    Alleles

    Alleles of this type are documented at Mouse Genome Informatics  (MGI)
    • Endonuclease-mediated (4) 
    • Targeted (2) 

    Pathways from PubChem

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    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Homology

    Gene Ontology Provided by MGI

    Function Evidence Code Pubs
    enables identical protein binding IPI
    Inferred from Physical Interaction
    more info
    		 PubMed 
    Process Evidence Code Pubs
    involved_in complement activation, classical pathway ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in complement activation, classical pathway NAS
    Non-traceable Author Statement
    more info
    		 PubMed 
    involved_in innate immune response IEA
    Inferred from Electronic Annotation
    more info
    		  
    acts_upstream_of_or_within inner ear development IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    involved_in synapse pruning IGI
    Inferred from Genetic Interaction
    more info
    		 PubMed 
    Component Evidence Code Pubs
    part_of collagen trimer IEA
    Inferred from Electronic Annotation
    more info
    		  
    part_of complement component C1 complex ISO
    Inferred from Sequence Orthology
    more info
    		  
    part_of complement component C1 complex NAS
    Non-traceable Author Statement
    more info
    		 PubMed 
    part_of complement component C1q complex ISO
    Inferred from Sequence Orthology
    more info
    		  
    located_in extracellular region ISO
    Inferred from Sequence Orthology
    more info
    		  
    located_in extracellular region NAS
    Non-traceable Author Statement
    more info
    		 PubMed 
    located_in extracellular space HDA PubMed 
    is_active_in extrinsic component of postsynaptic membrane IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    is_active_in extrinsic component of presynaptic membrane IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    is_active_in glutamatergic synapse IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    located_in postsynapse IGI
    Inferred from Genetic Interaction
    more info
    		 PubMed 
    located_in synapse IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    located_in synapse IGI
    Inferred from Genetic Interaction
    more info
    		 PubMed 
    located_in synapse ISO
    Inferred from Sequence Orthology
    more info
    		  

    General protein information

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    Preferred Names
    complement C1q subcomponent subunit B
    Names
    adiponectin a

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_009777.3 → NP_033907.1  complement C1q subcomponent subunit B precursor

      See identical proteins and their annotated locations for NP_033907.1

      Status: VALIDATED

      Source sequence(s)
      AL627214
      Consensus CDS
      CCDS18810.1
      UniProtKB/Swiss-Prot
      P14106, Q3U793
      UniProtKB/TrEMBL
      Q3U6I5, Q3US82
      Related
      ENSMUSP00000040246.9, ENSMUST00000046384.9
      Conserved Domains (2) summary
      pfam01391
      Location:49 → 107
      Collagen; Collagen triple helix repeat (20 copies)
      cl23878
      Location:113 → 250
      C1q; C1q domain

    RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCm39 C57BL/6J

    Genomic

    1. NC_000070.7 Reference GRCm39 C57BL/6J

      Range
      136607437..136613511 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)
    Nucleotide Protein Strain
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    P14106.2 GenPept UniProtKB/Swiss-Prot:P14106

    Gene LinkOut

    The following LinkOut resources are supplied by external providers. These providers are responsible for maintaining the links.

    Chemical Information
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