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    Rps21 ribosomal protein S21 [ Mus musculus (house mouse) ]

    Gene ID: 66481, updated on 2-Nov-2024

    Summary

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    Official Symbol
    Rps21provided by MGI
    Official Full Name
    ribosomal protein S21provided by MGI
    Primary source
    MGI:MGI:1913731
    See related
    Ensembl:ENSMUSG00000039001 AllianceGenome:MGI:1913731
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Mus musculus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
    Also known as
    1810049N11Rik; 2410030A14Rik
    Summary
    A structural constituent of ribosome. Predicted to be involved in cytoplasmic translation; endonucleolytic cleavage in ITS1 to separate SSU-rRNA from 5.8S rRNA and LSU-rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA); and endonucleolytic cleavage to generate mature 3'-end of SSU-rRNA from (SSU-rRNA, 5.8S rRNA, LSU-rRNA). Part of cytosolic small ribosomal subunit. Is active in synapse. Is expressed in 1-cell stage embryo; 2-cell stage embryo; and 4-cell stage embryo. Orthologous to human RPS21 (ribosomal protein S21). [provided by Alliance of Genome Resources, Nov 2024]
    Expression
    Ubiquitous expression in ovary adult (RPKM 1055.6), spleen adult (RPKM 751.0) and 28 other tissues See more
    Orthologs
    human all
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    Genomic context

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    See Rps21 in Genome Data Viewer
    Location:
    2 H4; 2 102.78 cM
    Exon count:
    6
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCm39 (GCF_000001635.27) 2 NC_000068.8 (179899172..179900237)
    108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 2 NC_000068.7 (180257379..180258444)

    Chromosome 2 - NC_000068.8Genomic Context describing neighboring genes Neighboring gene adhesion regulating molecule 1 26S proteasome ubiquitin receptor Neighboring gene laminin, alpha 5 Neighboring gene microRNA 7005 Neighboring gene STARR-seq mESC enhancer starr_06728 Neighboring gene STARR-seq mESC enhancer starr_06729 Neighboring gene STARR-positive B cell enhancer ABC_E6036 Neighboring gene microRNA 3091 Neighboring gene CDK5 and Abl enzyme substrate 2 Neighboring gene STARR-positive B cell enhancer ABC_E333 Neighboring gene RBBP8 N-terminal like

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: Mouse ENCODE transcriptome data Mouse ENCODE transcriptome data
    • Description: RNA profiling data sets generated by the Mouse ENCODE project.
    • BioProject: PRJNA66167
    • Publication: PMID 25409824
    • Analysis date: n/a

    Bibliography

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    Related articles in PubMed

    1. Disruption of entire Cables2 locus leads to embryonic lethality by diminished Rps21 gene expression and enhanced p53 pathway. Dinh TTH, et al. Elife, 2021 May 5. PMID 33949947, Free PMC Article
    2. Maternal DCAF13 Regulates Chromatin Tightness to Contribute to Embryonic Development. Liu Y, et al. Sci Rep, 2019 Apr 18. PMID 31000741, Free PMC Article
    3. Drp1 regulates transcription of ribosomal protein genes in embryonic hearts. Zhao Q, et al. J Cell Sci, 2022 Feb 15. PMID 35099001, Free PMC Article
    4. A novel view of the transcriptome revealed from gene trapping in mouse embryonic stem cells. Roma G, et al. Genome Res, 2007 Jul. PMID 17540781, Free PMC Article
    5. Comprehensive interactome of Otx2 in the adult mouse neural retina. Fant B, et al. Genesis, 2015 Nov. PMID 26426291

    See all (33) citations in PubMed

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?
    1. Disruption of entire Cables2 locus leads to embryonic lethality by diminished Rps21 gene expression and enhanced p53 pathway.
      Title: Disruption of entire Cables2 locus leads to embryonic lethality by diminished Rps21 gene expression and enhanced p53 pathway.
    Submit: New GeneRIF Correction

    Variation

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    Alleles

    Alleles of this type are documented at Mouse Genome Informatics  (MGI)

    Pathways from PubChem

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    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Homology

    Clone Names

    • MGC107620

    Gene Ontology Provided by MGI

    Function Evidence Code Pubs
    enables ribosome binding ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  
    enables structural constituent of ribosome IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables structural constituent of ribosome IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    enables structural constituent of ribosome ISO
    Inferred from Sequence Orthology
    more info
    		  
    Process Evidence Code Pubs
    involved_in cytoplasmic translation ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in cytoplasmic translation ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  
    involved_in cytoplasmic translation NAS
    Non-traceable Author Statement
    more info
    		 PubMed 
    involved_in endonucleolytic cleavage in ITS1 to separate SSU-rRNA from 5.8S rRNA and LSU-rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA) IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in endonucleolytic cleavage to generate mature 3'-end of SSU-rRNA from (SSU-rRNA, 5.8S rRNA, LSU-rRNA) IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    Component Evidence Code Pubs
    located_in cytoplasm NAS
    Non-traceable Author Statement
    more info
    		 PubMed 
    located_in cytosol TAS
    Traceable Author Statement
    more info
    		  
    located_in cytosolic ribosome ISO
    Inferred from Sequence Orthology
    more info
    		  
    part_of cytosolic small ribosomal subunit IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    part_of cytosolic small ribosomal subunit IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    part_of cytosolic small ribosomal subunit ISO
    Inferred from Sequence Orthology
    more info
    		  
    part_of cytosolic small ribosomal subunit ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  
    part_of cytosolic small ribosomal subunit NAS
    Non-traceable Author Statement
    more info
    		 PubMed 
    is_active_in postsynapse NAS
    Non-traceable Author Statement
    more info
    		 PubMed 
    is_active_in ribosome NAS
    Non-traceable Author Statement
    more info
    		 PubMed 
    located_in rough endoplasmic reticulum IEA
    Inferred from Electronic Annotation
    more info
    		  
    is_active_in synapse EXP
    Inferred from Experiment
    more info
    		 PubMed 
    is_active_in synapse IDA
    Inferred from Direct Assay
    more info
    		 PubMed 

    General protein information

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    Preferred Names
    small ribosomal subunit protein eS21
    Names
    40S ribosomal protein S21

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001355516.1 → NP_001342445.1  small ribosomal subunit protein eS21

      Status: VALIDATED

      Description
      Transcript Variant: This variant (1) represents the longest transcript. All six variants encode the same protein.
      Source sequence(s)
      AL663027
      Consensus CDS
      CCDS38376.1
      UniProtKB/Swiss-Prot
      Q5M9L3, Q9CQR2
      UniProtKB/TrEMBL
      Q8C1L7
      Conserved Domains (1) summary
      pfam01249
      Location:1 → 80
      Ribosomal_S21e; Ribosomal protein S21e

    2. NM_001355517.1 → NP_001342446.1  small ribosomal subunit protein eS21

      Status: VALIDATED

      Description
      Transcript Variant: This variant (3) differs in the 5' UTR compared to variant 1. All six variants encode the same protein.
      Source sequence(s)
      AI664432, AL663027
      Consensus CDS
      CCDS38376.1
      UniProtKB/Swiss-Prot
      Q5M9L3, Q9CQR2
      UniProtKB/TrEMBL
      Q8C1L7
      Conserved Domains (1) summary
      pfam01249
      Location:1 → 80
      Ribosomal_S21e; Ribosomal protein S21e

    3. NM_001355518.1 → NP_001342447.1  small ribosomal subunit protein eS21

      Status: VALIDATED

      Description
      Transcript Variant: This variant (4) differs in the 5' UTR compared to variant 1. All six variants encode the same protein.
      Source sequence(s)
      AL663027, BY707853
      Consensus CDS
      CCDS38376.1
      UniProtKB/Swiss-Prot
      Q5M9L3, Q9CQR2
      UniProtKB/TrEMBL
      Q8C1L7
      Conserved Domains (1) summary
      pfam01249
      Location:1 → 80
      Ribosomal_S21e; Ribosomal protein S21e

    4. NM_001355520.1 → NP_001342449.1  small ribosomal subunit protein eS21

      Status: VALIDATED

      Description
      Transcript Variant: This variant (5) differs in the 5' UTR compared to variant 1. All six variants encode the same protein.
      Source sequence(s)
      AL663027
      Consensus CDS
      CCDS38376.1
      UniProtKB/Swiss-Prot
      Q5M9L3, Q9CQR2
      UniProtKB/TrEMBL
      Q8C1L7
      Conserved Domains (1) summary
      pfam01249
      Location:1 → 80
      Ribosomal_S21e; Ribosomal protein S21e

    5. NM_001355521.1 → NP_001342450.1  small ribosomal subunit protein eS21

      Status: VALIDATED

      Description
      Transcript Variant: This variant (6) differs in the 5' UTR compared to variant 1. All six variants encode the same protein.
      Source sequence(s)
      AL663027
      Consensus CDS
      CCDS38376.1
      UniProtKB/Swiss-Prot
      Q5M9L3, Q9CQR2
      UniProtKB/TrEMBL
      Q8C1L7
      Conserved Domains (1) summary
      pfam01249
      Location:1 → 80
      Ribosomal_S21e; Ribosomal protein S21e

    6. NM_025587.2 → NP_079863.1  small ribosomal subunit protein eS21

      See identical proteins and their annotated locations for NP_079863.1

      Status: VALIDATED

      Description
      Transcript Variant: This variant (2) differs in the 5' UTR compared to variant 1. All six variants encode the same protein.
      Source sequence(s)
      AA049954, BU534365
      Consensus CDS
      CCDS38376.1
      UniProtKB/Swiss-Prot
      Q5M9L3, Q9CQR2
      UniProtKB/TrEMBL
      Q8C1L7
      Related
      ENSMUSP00000058432.7, ENSMUST00000059080.7
      Conserved Domains (1) summary
      pfam01249
      Location:1 → 80
      Ribosomal_S21e; Ribosomal protein S21e

    RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCm39 C57BL/6J

    Genomic

    1. NC_000068.8 Reference GRCm39 C57BL/6J

      Range
      179899172..179900237
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)
    Nucleotide Protein Strain
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    Q9CQR2.1 GenPept UniProtKB/Swiss-Prot:Q9CQR2

    Gene LinkOut

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