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    Fscn1 fascin actin-bundling protein 1 [ Mus musculus (house mouse) ]

    Gene ID: 14086, updated on 2-Nov-2024

    Summary

    Official Symbol
    Fscn1provided by MGI
    Official Full Name
    fascin actin-bundling protein 1provided by MGI
    Primary source
    MGI:MGI:1352745
    See related
    Ensembl:ENSMUSG00000029581 AllianceGenome:MGI:1352745
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Mus musculus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
    Also known as
    Fan1; fascin-1
    Summary
    Enables actin filament binding activity. Involved in cell migration and positive regulation of filopodium assembly. Acts upstream of or within actin filament bundle assembly. Located in filopodium; growth cone; and lamellipodium. Is expressed in several structures, including alimentary system; central nervous system; embryo mesenchyme; genitourinary system; and sensory organ. Orthologous to human FSCN1 (fascin actin-bundling protein 1). [provided by Alliance of Genome Resources, Nov 2024]
    Expression
    Broad expression in whole brain E14.5 (RPKM 192.6), CNS E14 (RPKM 164.7) and 21 other tissues See more
    Orthologs
    NEW
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    Genomic context

    See Fscn1 in Genome Data Viewer
    Location:
    5 G2; 5 81.84 cM
    Exon count:
    5
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCm39 (GCF_000001635.27) 5 NC_000071.7 (142946110..142958944)
    108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 5 NC_000071.6 (142960355..142973189)

    Chromosome 5 - NC_000071.7Genomic Context describing neighboring genes Neighboring gene F-box and leucine-rich repeat protein 18 Neighboring gene STARR-positive B cell enhancer ABC_E6395 Neighboring gene STARR-positive B cell enhancer ABC_E674 Neighboring gene CapStarr-seq enhancer MGSCv37_chr5:143670916-143671255 Neighboring gene predicted gene, 38733 Neighboring gene CapStarr-seq enhancer MGSCv37_chr5:143682513-143682666 Neighboring gene actin, beta Neighboring gene STARR-seq mESC enhancer starr_14775 Neighboring gene STARR-seq mESC enhancer starr_14777 Neighboring gene STARR-seq mESC enhancer starr_14779 Neighboring gene VISTA enhancer mm1619 Neighboring gene ring finger protein 216 Neighboring gene predicted gene 43380 Neighboring gene STARR-seq mESC enhancer starr_14782 Neighboring gene STARR-seq mESC enhancer starr_14783 Neighboring gene STARR-positive B cell enhancer ABC_E3631 Neighboring gene STARR-seq mESC enhancer starr_14784 Neighboring gene nonconserved acetylation island sequence M61 enhancer Neighboring gene olfactory receptor family 10 subfamily AH member 1, pseudogene 1 Neighboring gene predicted gene, 38734

    Genomic regions, transcripts, and products

    Expression

    • Project title: Mouse ENCODE transcriptome data Mouse ENCODE transcriptome data
    • Description: RNA profiling data sets generated by the Mouse ENCODE project.
    • BioProject: PRJNA66167
    • Publication: PMID 25409824
    • Analysis date: n/a

    Bibliography

    Related articles in PubMed

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?

    Variation

    Alleles

    Alleles of this type are documented at Mouse Genome Informatics  (MGI)
    • Endonuclease-mediated (3) 
    • Gene trapped (1)  1 citation
    • Targeted (2) 

    Interactions

    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

    Markers

    Gene Ontology Provided by MGI

    Function Evidence Code Pubs
    enables actin binding ISO
    Inferred from Sequence Orthology
    more info
     
    enables actin filament binding IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    enables actin filament binding IDA
    Inferred from Direct Assay
    more info
    PubMed 
    enables actin filament binding IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    enables actin filament binding ISO
    Inferred from Sequence Orthology
    more info
    PubMed 
    enables protein binding IPI
    Inferred from Physical Interaction
    more info
    PubMed 
    enables protein-macromolecule adaptor activity IEA
    Inferred from Electronic Annotation
    more info
     
    Process Evidence Code Pubs
    involved_in actin cytoskeleton organization ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in actin filament bundle assembly IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    acts_upstream_of_or_within actin filament bundle assembly IDA
    Inferred from Direct Assay
    more info
    PubMed 
    involved_in actin filament bundle assembly ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in cell migration IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    involved_in cell migration IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    involved_in cell migration ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in cell motility ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in cell motility ISS
    Inferred from Sequence or Structural Similarity
    more info
     
    involved_in cell-cell junction assembly ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in cell-cell junction assembly ISS
    Inferred from Sequence or Structural Similarity
    more info
     
    involved_in establishment of apical/basal cell polarity ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in establishment of apical/basal cell polarity ISS
    Inferred from Sequence or Structural Similarity
    more info
     
    involved_in establishment or maintenance of cell polarity IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    involved_in microspike assembly ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in microspike assembly ISS
    Inferred from Sequence or Structural Similarity
    more info
     
    involved_in parallel actin filament bundle assembly IEA
    Inferred from Electronic Annotation
    more info
     
    involved_in parallel actin filament bundle assembly ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in positive regulation of extracellular matrix disassembly ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in positive regulation of extracellular matrix disassembly ISS
    Inferred from Sequence or Structural Similarity
    more info
     
    involved_in positive regulation of filopodium assembly IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    involved_in positive regulation of filopodium assembly ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in positive regulation of filopodium assembly ISS
    Inferred from Sequence or Structural Similarity
    more info
     
    involved_in positive regulation of lamellipodium assembly ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in positive regulation of lamellipodium assembly ISS
    Inferred from Sequence or Structural Similarity
    more info
     
    involved_in positive regulation of podosome assembly ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in positive regulation of podosome assembly ISS
    Inferred from Sequence or Structural Similarity
    more info
     
    involved_in regulation of actin cytoskeleton organization ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in regulation of actin cytoskeleton organization ISS
    Inferred from Sequence or Structural Similarity
    more info
     
    involved_in regulation of microvillus assembly ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in regulation of microvillus assembly ISS
    Inferred from Sequence or Structural Similarity
    more info
     
    Component Evidence Code Pubs
    is_active_in actin cytoskeleton IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    located_in actin cytoskeleton ISO
    Inferred from Sequence Orthology
    more info
     
    located_in actin cytoskeleton ISS
    Inferred from Sequence or Structural Similarity
    more info
     
    located_in cell cortex IEA
    Inferred from Electronic Annotation
    more info
     
    is_active_in cell projection membrane IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    located_in cell projection membrane ISO
    Inferred from Sequence Orthology
    more info
     
    located_in cell projection membrane ISS
    Inferred from Sequence or Structural Similarity
    more info
     
    located_in cell-cell junction ISO
    Inferred from Sequence Orthology
    more info
     
    located_in cell-cell junction ISS
    Inferred from Sequence or Structural Similarity
    more info
     
    is_active_in cytoplasm IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    located_in cytoplasm ISO
    Inferred from Sequence Orthology
    more info
     
    located_in cytoplasm ISS
    Inferred from Sequence or Structural Similarity
    more info
     
    located_in cytoskeleton ISO
    Inferred from Sequence Orthology
    more info
     
    located_in cytoskeleton ISS
    Inferred from Sequence or Structural Similarity
    more info
     
    located_in cytosol IEA
    Inferred from Electronic Annotation
    more info
     
    located_in cytosol ISO
    Inferred from Sequence Orthology
    more info
     
    located_in dendrite ISO
    Inferred from Sequence Orthology
    more info
     
    is_active_in filopodium IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    located_in filopodium IDA
    Inferred from Direct Assay
    more info
    PubMed 
    located_in filopodium ISO
    Inferred from Sequence Orthology
    more info
     
    is_active_in growth cone IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    located_in growth cone IDA
    Inferred from Direct Assay
    more info
    PubMed 
    located_in growth cone ISO
    Inferred from Sequence Orthology
    more info
     
    is_active_in lamellipodium IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    located_in lamellipodium IDA
    Inferred from Direct Assay
    more info
    PubMed 
    located_in lamellipodium ISO
    Inferred from Sequence Orthology
    more info
     
    located_in microspike ISO
    Inferred from Sequence Orthology
    more info
     
    located_in microspike ISS
    Inferred from Sequence or Structural Similarity
    more info
     
    is_active_in microvillus IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    located_in microvillus ISO
    Inferred from Sequence Orthology
    more info
     
    located_in microvillus ISS
    Inferred from Sequence or Structural Similarity
    more info
     
    located_in myelin sheath HDA PubMed 
    located_in podosome ISO
    Inferred from Sequence Orthology
    more info
     
    located_in podosome ISS
    Inferred from Sequence or Structural Similarity
    more info
     
    is_active_in ruffle IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    located_in ruffle ISO
    Inferred from Sequence Orthology
    more info
     
    located_in ruffle ISS
    Inferred from Sequence or Structural Similarity
    more info
     
    located_in stress fiber ISO
    Inferred from Sequence Orthology
    more info
     
    located_in stress fiber ISS
    Inferred from Sequence or Structural Similarity
    more info
     

    General protein information

    Preferred Names
    fascin
    Names
    fascin 1
    singed-like protein

    NCBI Reference Sequences (RefSeq)

    NEW Try the new Transcript table

    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_007984.2NP_032010.2  fascin

      See identical proteins and their annotated locations for NP_032010.2

      Status: VALIDATED

      Source sequence(s)
      BC052408, BY311024, CJ286472
      Consensus CDS
      CCDS19834.1
      UniProtKB/Swiss-Prot
      O09099, O09156, Q05DK3, Q61553, Q7TN32, Q80V75
      Related
      ENSMUSP00000031565.9, ENSMUST00000031565.15
      Conserved Domains (2) summary
      cd00257
      Location:383493
      Fascin; Fascin-like domain; members include actin-bundling/crosslinking proteins facsin, histoactophilin and singed; identified in sea urchin, Drosophila, Xenopus, rodents, and humans; The fascin-like domain adopts a beta-trefoil topology and contains an ...
      pfam06268
      Location:268378
      Fascin; Fascin domain

    RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCm39 C57BL/6J

    Genomic

    1. NC_000071.7 Reference GRCm39 C57BL/6J

      Range
      142946110..142958944
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)