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    Nrxn3 neurexin 3 [ Rattus norvegicus (Norway rat) ]

    Gene ID: 116508, updated on 10-Jul-2024

    Summary

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    Symbol
    Nrxn3provided by RGD
    Full Name
    neurexin 3provided by RGD
    Primary source
    RGD:620212
    See related
    EnsemblRapid:ENSRNOG00000047574 AllianceGenome:RGD:620212
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Rattus norvegicus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
    Summary
    Predicted to enable calcium channel regulator activity. Predicted to be involved in several processes, including regulation of synaptic vesicle exocytosis; social behavior; and vocalization behavior. Predicted to act upstream of or within neurotransmitter secretion and synapse assembly. Predicted to be located in extracellular region; plasma membrane; and presynapse. Predicted to be integral component of membrane. Predicted to be part of protein-containing complex. Predicted to be active in GABA-ergic synapse. Orthologous to human NRXN3 (neurexin 3). [provided by Alliance of Genome Resources, Apr 2022]
    Expression
    Restricted expression toward (RPKM 214.5) See more
    Orthologs
    human mouse all
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    Genomic context

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    See Nrxn3 in Genome Data Viewer
    Location:
    6q31
    Exon count:
    31
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCr8 (GCF_036323735.1) 6 NC_086024.1 (113372667..115004073)
    RS_2023_06 previous assembly mRatBN7.2 (GCF_015227675.2) 6 NC_051341.1 (107641760..109272849)
    106 previous assembly Rnor_6.0 (GCF_000001895.5) 6 NC_005105.4 (112133204..114069589)

    Chromosome 6 - NC_086024.1Genomic Context describing neighboring genes Neighboring gene U6 spliceosomal RNA Neighboring gene ligand dependent nuclear receptor interacting factor, pseudogene 2 Neighboring gene uncharacterized LOC134479455 Neighboring gene uncharacterized LOC120093220 Neighboring gene uncharacterized LOC134479241 Neighboring gene uncharacterized LOC108351283 Neighboring gene uncharacterized LOC120093263

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
    • Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
    • BioProject: PRJNA238328
    • Publication: PMID 24510058
    • Analysis date: Mon Jun 6 17:44:12 2016

    Bibliography

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    Related articles in PubMed

    1. Developmental expression of the neuroligins and neurexins in fragile X mice. Lai JK, et al. J Comp Neurol, 2016 Mar 1. PMID 26235839
    2. Neurexin III alpha: extensive alternative splicing generates membrane-bound and soluble forms. Ushkaryov YA, et al. Proc Natl Acad Sci U S A, 1993 Jul 15. PMID 8341647, Free PMC Article
    3. Distinct circuit-dependent functions of presynaptic neurexin-3 at GABAergic and glutamatergic synapses. Aoto J, et al. Nat Neurosci, 2015 Jul. PMID 26030848, Free PMC Article
    4. Rare deletions at the neurexin 3 locus in autism spectrum disorder. Vaags AK, et al. Am J Hum Genet, 2012 Jan 13. PMID 22209245, Free PMC Article
    5. A stoichiometric complex of neurexins and dystroglycan in brain. Sugita S, et al. J Cell Biol, 2001 Jul 23. PMID 11470830, Free PMC Article

    See all (15) citations in PubMed

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?
    1. Data show beta-cell expression of the neurexin 3, and demonstrate that the neurexins are expressed outside the central nervous system and help confer an inhibitory synaptic-like phenotype onto the beta-cell surface.
      Title: Expression of neurexin, neuroligin, and their cytoplasmic binding partners in the pancreatic beta-cells and the involvement of neuroligin in insulin secretion.
    Submit: New GeneRIF Correction

    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Markers

    Homology

    Gene Ontology Provided by RGD

    Function Evidence Code Pubs
    enables calcium channel regulator activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables calcium channel regulator activity ISO
    Inferred from Sequence Orthology
    more info
    		  
    enables metal ion binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    Process Evidence Code Pubs
    involved_in adult behavior ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in biological_process ND
    No biological Data available
    more info
    		  
    involved_in cell adhesion IEA
    Inferred from Electronic Annotation
    more info
    		  
    acts_upstream_of_or_within chemical synaptic transmission ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in learning ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in neurotransmitter receptor localization to postsynaptic specialization membrane IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in neurotransmitter receptor localization to postsynaptic specialization membrane ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in neurotransmitter secretion IEA
    Inferred from Electronic Annotation
    more info
    		  
    acts_upstream_of_or_within neurotransmitter secretion ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in postsynaptic density assembly IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in postsynaptic density assembly ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in presynaptic modulation of chemical synaptic transmission IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in presynaptic modulation of chemical synaptic transmission ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in regulation of postsynaptic membrane neurotransmitter receptor levels ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in social behavior ISO
    Inferred from Sequence Orthology
    more info
    		  
    acts_upstream_of_or_within synapse assembly ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in trans-synaptic signaling ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in trans-synaptic signaling, modulating synaptic transmission ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in vocalization behavior ISO
    Inferred from Sequence Orthology
    more info
    		  
    Component Evidence Code Pubs
    located_in GABA-ergic synapse IEA
    Inferred from Electronic Annotation
    more info
    		  
    is_active_in GABA-ergic synapse ISO
    Inferred from Sequence Orthology
    more info
    		  
    located_in cell projection IEA
    Inferred from Electronic Annotation
    more info
    		  
    located_in glutamatergic synapse IEA
    Inferred from Electronic Annotation
    more info
    		  
    is_active_in glutamatergic synapse ISO
    Inferred from Sequence Orthology
    more info
    		  
    is_active_in presynaptic active zone membrane ISO
    Inferred from Sequence Orthology
    more info
    		  
    located_in presynaptic membrane IEA
    Inferred from Electronic Annotation
    more info
    		  
    part_of protein-containing complex IEA
    Inferred from Electronic Annotation
    more info
    		  
    part_of protein-containing complex ISO
    Inferred from Sequence Orthology
    more info
    		  

    General protein information

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    Preferred Names
    neurexin-3
    Names
    neurexin III

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_053817.3 → NP_446269.3  neurexin-3 precursor

      Status: VALIDATED

      Source sequence(s)
      JAXUCZ010000006
      UniProtKB/TrEMBL
      D3ZKS5
      Related
      ENSRNOP00000060600.5, ENSRNOT00000064872.5
      Conserved Domains (6) summary
      smart00282
      Location:286 → 417
      LamG; Laminin G domain
      cd00054
      Location:651 → 684
      EGF_CA; Calcium-binding EGF-like domain, present in a large number of membrane-bound and extracellular (mostly animal) proteins. Many of these proteins require calcium for their biological function and calcium-binding sites have been found to be located at the ...
      cd00110
      Location:27 → 181
      LamG; Laminin G domain; Laminin G-like domains are usually Ca++ mediated receptors that can have binding sites for steroids, beta1 integrins, heparin, sulfatides, fibulin-1, and alpha-dystroglycans. Proteins that contain LamG domains serve a variety of ...
      pfam00008
      Location:202 → 231
      EGF; EGF-like domain
      pfam01034
      Location:1504 → 1539
      Syndecan; Syndecan domain
      pfam02210
      Location:903 → 1031
      Laminin_G_2; Laminin G domain

    RefSeqs of Annotated Genomes: GCF_036323735.1-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCr8

    Genomic

    1. NC_086024.1 Reference GRCr8

      Range
      113372667..115004073
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_039111661.2 → XP_038967589.1  neurexin-3 isoform X46

      UniProtKB/TrEMBL
      A0A8I6GKC4
      Conserved Domains (6) summary
      smart00282
      Location:266 → 405
      LamG; Laminin G domain
      cd00054
      Location:639 → 672
      EGF_CA; Calcium-binding EGF-like domain, present in a large number of membrane-bound and extracellular (mostly animal) proteins. Many of these proteins require calcium for their biological function and calcium-binding sites have been found to be located at the ...
      cd00110
      Location:27 → 181
      LamG; Laminin G domain; Laminin G-like domains are usually Ca++ mediated receptors that can have binding sites for steroids, beta1 integrins, heparin, sulfatides, fibulin-1, and alpha-dystroglycans. Proteins that contain LamG domains serve a variety of ...
      pfam00008
      Location:202 → 231
      EGF; EGF-like domain
      pfam01034
      Location:1343 → 1378
      Syndecan; Syndecan domain
      pfam02210
      Location:882 → 1010
      Laminin_G_2; Laminin G domain

    2. XM_063261446.1 → XP_063117516.1  neurexin-3 isoform X27

      UniProtKB/TrEMBL
      A0A8I6GES9

    3. XM_063261447.1 → XP_063117517.1  neurexin-3 isoform X28

      UniProtKB/TrEMBL
      A0A8I6GES9
      Related
      ENSRNOP00000089493.2, ENSRNOT00000092573.3

    4. XM_063261425.1 → XP_063117495.1  neurexin-3 isoform X1

      UniProtKB/TrEMBL
      A0A8I6GKL9

    5. XM_039111627.2 → XP_038967555.1  neurexin-3 isoform X1

      UniProtKB/TrEMBL
      A0A8I6GKL9
      Conserved Domains (6) summary
      smart00282
      Location:282 → 421
      LamG; Laminin G domain
      cd00054
      Location:655 → 688
      EGF_CA; Calcium-binding EGF-like domain, present in a large number of membrane-bound and extracellular (mostly animal) proteins. Many of these proteins require calcium for their biological function and calcium-binding sites have been found to be located at the ...
      cd00110
      Location:27 → 181
      LamG; Laminin G domain; Laminin G-like domains are usually Ca++ mediated receptors that can have binding sites for steroids, beta1 integrins, heparin, sulfatides, fibulin-1, and alpha-dystroglycans. Proteins that contain LamG domains serve a variety of ...
      pfam00008
      Location:202 → 231
      EGF; EGF-like domain
      pfam01034
      Location:1618 → 1653
      Syndecan; Syndecan domain
      pfam02210
      Location:907 → 1035
      Laminin_G_2; Laminin G domain

    6. XM_063261433.1 → XP_063117503.1  neurexin-3 isoform X11

      UniProtKB/TrEMBL
      D3ZKS5

    7. XM_063261440.1 → XP_063117510.1  neurexin-3 isoform X20

      UniProtKB/TrEMBL
      D3ZKS5

    8. XM_063261427.1 → XP_063117497.1  neurexin-3 isoform X2

      UniProtKB/TrEMBL
      A0A8I6GKL9

    9. XM_063261434.1 → XP_063117504.1  neurexin-3 isoform X12

      UniProtKB/TrEMBL
      D3ZKS5

    10. XM_063261441.1 → XP_063117511.1  neurexin-3 isoform X21

      UniProtKB/TrEMBL
      D3ZKS5

    11. XM_063261431.1 → XP_063117501.1  neurexin-3 isoform X9

      UniProtKB/TrEMBL
      A0A8I6GKL9

    12. XM_063261428.1 → XP_063117498.1  neurexin-3 isoform X4

      UniProtKB/TrEMBL
      A0A8I6GKL9

    13. XM_063261442.1 → XP_063117512.1  neurexin-3 isoform X22

      UniProtKB/TrEMBL
      D3ZKS5

    14. XM_039111656.2 → XP_038967584.1  neurexin-3 isoform X36

      UniProtKB/TrEMBL
      D3ZKS5
      Conserved Domains (6) summary
      smart00282
      Location:282 → 421
      LamG; Laminin G domain
      cd00054
      Location:655 → 688
      EGF_CA; Calcium-binding EGF-like domain, present in a large number of membrane-bound and extracellular (mostly animal) proteins. Many of these proteins require calcium for their biological function and calcium-binding sites have been found to be located at the ...
      cd00110
      Location:27 → 181
      LamG; Laminin G domain; Laminin G-like domains are usually Ca++ mediated receptors that can have binding sites for steroids, beta1 integrins, heparin, sulfatides, fibulin-1, and alpha-dystroglycans. Proteins that contain LamG domains serve a variety of ...
      pfam00008
      Location:202 → 231
      EGF; EGF-like domain
      pfam01034
      Location:1398 → 1433
      Syndecan; Syndecan domain
      pfam02210
      Location:907 → 1035
      Laminin_G_2; Laminin G domain

    15. XM_063261432.1 → XP_063117502.1  neurexin-3 isoform X10

      UniProtKB/TrEMBL
      A0A8I6GKL9

    16. XM_063261445.1 → XP_063117515.1  neurexin-3 isoform X26

      UniProtKB/TrEMBL
      D3ZKS5

    17. XM_063261429.1 → XP_063117499.1  neurexin-3 isoform X5

      UniProtKB/TrEMBL
      A0A8I6GKL9

    18. XM_039111631.2 → XP_038967559.1  neurexin-3 isoform X3

      UniProtKB/TrEMBL
      A0A8I6GKL9
      Conserved Domains (6) summary
      smart00282
      Location:282 → 413
      LamG; Laminin G domain
      cd00054
      Location:647 → 680
      EGF_CA; Calcium-binding EGF-like domain, present in a large number of membrane-bound and extracellular (mostly animal) proteins. Many of these proteins require calcium for their biological function and calcium-binding sites have been found to be located at the ...
      cd00110
      Location:27 → 181
      LamG; Laminin G domain; Laminin G-like domains are usually Ca++ mediated receptors that can have binding sites for steroids, beta1 integrins, heparin, sulfatides, fibulin-1, and alpha-dystroglycans. Proteins that contain LamG domains serve a variety of ...
      pfam00008
      Location:202 → 231
      EGF; EGF-like domain
      pfam01034
      Location:1610 → 1645
      Syndecan; Syndecan domain
      pfam02210
      Location:899 → 1027
      Laminin_G_2; Laminin G domain

    19. XM_063261451.1 → XP_063117521.1  neurexin-3 isoform X34

      UniProtKB/TrEMBL
      D3ZKS5

    20. XM_063261435.1 → XP_063117505.1  neurexin-3 isoform X13

      UniProtKB/TrEMBL
      D3ZKS5

    21. XM_063261452.1 → XP_063117522.1  neurexin-3 isoform X35

      UniProtKB/TrEMBL
      D3ZKS5
      Related
      ENSRNOP00000087097.2, ENSRNOT00000097486.2

    22. XM_063261455.1 → XP_063117525.1  neurexin-3 isoform X40

      UniProtKB/TrEMBL
      D3ZKS5

    23. XM_063261439.1 → XP_063117509.1  neurexin-3 isoform X18

      UniProtKB/TrEMBL
      D3ZKS5

    24. XM_063261456.1 → XP_063117526.1  neurexin-3 isoform X41

      UniProtKB/TrEMBL
      D3ZKS5

    25. XM_063261430.1 → XP_063117500.1  neurexin-3 isoform X7

      UniProtKB/TrEMBL
      A0A8I6GKL9

    26. XM_063261436.1 → XP_063117506.1  neurexin-3 isoform X14

      UniProtKB/TrEMBL
      D3ZKS5

    27. XM_039111657.2 → XP_038967585.1  neurexin-3 isoform X23

      UniProtKB/TrEMBL
      D3ZKS5
      Conserved Domains (6) summary
      smart00282
      Location:282 → 413
      LamG; Laminin G domain
      cd00054
      Location:647 → 680
      EGF_CA; Calcium-binding EGF-like domain, present in a large number of membrane-bound and extracellular (mostly animal) proteins. Many of these proteins require calcium for their biological function and calcium-binding sites have been found to be located at the ...
      cd00110
      Location:27 → 181
      LamG; Laminin G domain; Laminin G-like domains are usually Ca++ mediated receptors that can have binding sites for steroids, beta1 integrins, heparin, sulfatides, fibulin-1, and alpha-dystroglycans. Proteins that contain LamG domains serve a variety of ...
      pfam00008
      Location:202 → 231
      EGF; EGF-like domain
      pfam01034
      Location:1393 → 1428
      Syndecan; Syndecan domain
      pfam02210
      Location:899 → 1027
      Laminin_G_2; Laminin G domain

    28. XM_039111642.2 → XP_038967570.1  neurexin-3 isoform X15

      UniProtKB/TrEMBL
      D3ZKS5
      Conserved Domains (6) summary
      smart00282
      Location:282 → 413
      LamG; Laminin G domain
      cd00054
      Location:647 → 680
      EGF_CA; Calcium-binding EGF-like domain, present in a large number of membrane-bound and extracellular (mostly animal) proteins. Many of these proteins require calcium for their biological function and calcium-binding sites have been found to be located at the ...
      cd00110
      Location:27 → 181
      LamG; Laminin G domain; Laminin G-like domains are usually Ca++ mediated receptors that can have binding sites for steroids, beta1 integrins, heparin, sulfatides, fibulin-1, and alpha-dystroglycans. Proteins that contain LamG domains serve a variety of ...
      pfam00008
      Location:202 → 231
      EGF; EGF-like domain
      pfam01034
      Location:1497 → 1532
      Syndecan; Syndecan domain
      pfam02210
      Location:899 → 1027
      Laminin_G_2; Laminin G domain

    29. XM_063261443.1 → XP_063117513.1  neurexin-3 isoform X24

      UniProtKB/TrEMBL
      D3ZKS5

    30. XM_063261457.1 → XP_063117527.1  neurexin-3 isoform X42

      UniProtKB/TrEMBL
      D3ZKS5

    31. XM_039111643.2 → XP_038967571.1  neurexin-3 isoform X19

      UniProtKB/TrEMBL
      D3ZKS5
      Conserved Domains (6) summary
      smart00282
      Location:282 → 413
      LamG; Laminin G domain
      cd00054
      Location:647 → 680
      EGF_CA; Calcium-binding EGF-like domain, present in a large number of membrane-bound and extracellular (mostly animal) proteins. Many of these proteins require calcium for their biological function and calcium-binding sites have been found to be located at the ...
      cd00110
      Location:27 → 181
      LamG; Laminin G domain; Laminin G-like domains are usually Ca++ mediated receptors that can have binding sites for steroids, beta1 integrins, heparin, sulfatides, fibulin-1, and alpha-dystroglycans. Proteins that contain LamG domains serve a variety of ...
      pfam00008
      Location:202 → 231
      EGF; EGF-like domain
      pfam01034
      Location:1467 → 1502
      Syndecan; Syndecan domain
      pfam02210
      Location:899 → 1027
      Laminin_G_2; Laminin G domain

    32. XM_063261458.1 → XP_063117528.1  neurexin-3 isoform X43

      UniProtKB/TrEMBL
      D3ZKS5

    33. XM_039111634.2 → XP_038967562.1  neurexin-3 isoform X8

      UniProtKB/TrEMBL
      A0A8I6GKL9
      Related
      ENSRNOP00000094179.1, ENSRNOT00000113245.2
      Conserved Domains (6) summary
      smart00282
      Location:282 → 413
      LamG; Laminin G domain
      cd00054
      Location:647 → 680
      EGF_CA; Calcium-binding EGF-like domain, present in a large number of membrane-bound and extracellular (mostly animal) proteins. Many of these proteins require calcium for their biological function and calcium-binding sites have been found to be located at the ...
      cd00110
      Location:27 → 181
      LamG; Laminin G domain; Laminin G-like domains are usually Ca++ mediated receptors that can have binding sites for steroids, beta1 integrins, heparin, sulfatides, fibulin-1, and alpha-dystroglycans. Proteins that contain LamG domains serve a variety of ...
      pfam00008
      Location:202 → 231
      EGF; EGF-like domain
      pfam01034
      Location:1601 → 1636
      Syndecan; Syndecan domain
      pfam02210
      Location:890 → 1018
      Laminin_G_2; Laminin G domain

    34. XM_063261437.1 → XP_063117507.1  neurexin-3 isoform X16

      UniProtKB/TrEMBL
      D3ZKS5

    35. XM_063261444.1 → XP_063117514.1  neurexin-3 isoform X25

      UniProtKB/TrEMBL
      D3ZKS5

    36. XM_063261438.1 → XP_063117508.1  neurexin-3 isoform X17

      UniProtKB/TrEMBL
      D3ZKS5

    37. XM_039111662.2 → XP_038967590.1  neurexin-3 isoform X47

      UniProtKB/TrEMBL
      D3ZKS5
      Conserved Domains (6) summary
      smart00282
      Location:282 → 413
      LamG; Laminin G domain
      cd00054
      Location:647 → 680
      EGF_CA; Calcium-binding EGF-like domain, present in a large number of membrane-bound and extracellular (mostly animal) proteins. Many of these proteins require calcium for their biological function and calcium-binding sites have been found to be located at the ...
      cd00110
      Location:27 → 181
      LamG; Laminin G domain; Laminin G-like domains are usually Ca++ mediated receptors that can have binding sites for steroids, beta1 integrins, heparin, sulfatides, fibulin-1, and alpha-dystroglycans. Proteins that contain LamG domains serve a variety of ...
      pfam00008
      Location:202 → 231
      EGF; EGF-like domain
      pfam01034
      Location:1351 → 1386
      Syndecan; Syndecan domain
      pfam02210
      Location:890 → 1018
      Laminin_G_2; Laminin G domain

    38. XM_039111633.2 → XP_038967561.1  neurexin-3 isoform X6

      UniProtKB/TrEMBL
      A0A8I6GKL9
      Conserved Domains (6) summary
      smart00282
      Location:266 → 405
      LamG; Laminin G domain
      cd00054
      Location:639 → 672
      EGF_CA; Calcium-binding EGF-like domain, present in a large number of membrane-bound and extracellular (mostly animal) proteins. Many of these proteins require calcium for their biological function and calcium-binding sites have been found to be located at the ...
      cd00110
      Location:27 → 181
      LamG; Laminin G domain; Laminin G-like domains are usually Ca++ mediated receptors that can have binding sites for steroids, beta1 integrins, heparin, sulfatides, fibulin-1, and alpha-dystroglycans. Proteins that contain LamG domains serve a variety of ...
      pfam00008
      Location:202 → 231
      EGF; EGF-like domain
      pfam01034
      Location:1602 → 1637
      Syndecan; Syndecan domain
      pfam02210
      Location:891 → 1019
      Laminin_G_2; Laminin G domain

    39. XM_039111658.2 → XP_038967586.1  neurexin-3 isoform X39

      UniProtKB/TrEMBL
      A0A8I6GKC4
      Conserved Domains (6) summary
      smart00282
      Location:266 → 405
      LamG; Laminin G domain
      cd00054
      Location:639 → 672
      EGF_CA; Calcium-binding EGF-like domain, present in a large number of membrane-bound and extracellular (mostly animal) proteins. Many of these proteins require calcium for their biological function and calcium-binding sites have been found to be located at the ...
      cd00110
      Location:27 → 181
      LamG; Laminin G domain; Laminin G-like domains are usually Ca++ mediated receptors that can have binding sites for steroids, beta1 integrins, heparin, sulfatides, fibulin-1, and alpha-dystroglycans. Proteins that contain LamG domains serve a variety of ...
      pfam00008
      Location:202 → 231
      EGF; EGF-like domain
      pfam01034
      Location:1376 → 1411
      Syndecan; Syndecan domain
      pfam02210
      Location:882 → 1010
      Laminin_G_2; Laminin G domain

    40. XM_063261449.1 → XP_063117519.1  neurexin-3 isoform X32

      UniProtKB/TrEMBL
      A0A8I6GKC4

    41. XM_063261450.1 → XP_063117520.1  neurexin-3 isoform X33

      UniProtKB/TrEMBL
      A0A8I6GKC4

    42. XM_063261453.1 → XP_063117523.1  neurexin-3 isoform X37

      UniProtKB/TrEMBL
      A0A8I6GKC4

    43. XM_063261454.1 → XP_063117524.1  neurexin-3 isoform X38

      UniProtKB/TrEMBL
      A0A8I6GKC4

    44. XM_039111659.2 → XP_038967587.1  neurexin-3 isoform X44

      UniProtKB/TrEMBL
      A0A8I6GKC4
      Conserved Domains (6) summary
      smart00282
      Location:266 → 397
      LamG; Laminin G domain
      cd00054
      Location:631 → 664
      EGF_CA; Calcium-binding EGF-like domain, present in a large number of membrane-bound and extracellular (mostly animal) proteins. Many of these proteins require calcium for their biological function and calcium-binding sites have been found to be located at the ...
      cd00110
      Location:27 → 181
      LamG; Laminin G domain; Laminin G-like domains are usually Ca++ mediated receptors that can have binding sites for steroids, beta1 integrins, heparin, sulfatides, fibulin-1, and alpha-dystroglycans. Proteins that contain LamG domains serve a variety of ...
      pfam00008
      Location:202 → 231
      EGF; EGF-like domain
      pfam01034
      Location:1338 → 1373
      Syndecan; Syndecan domain
      pfam02210
      Location:874 → 1002
      Laminin_G_2; Laminin G domain

    45. XM_039111660.2 → XP_038967588.1  neurexin-3 isoform X45

      UniProtKB/TrEMBL
      A0A8I6GKC4
      Conserved Domains (6) summary
      smart00282
      Location:266 → 397
      LamG; Laminin G domain
      cd00054
      Location:631 → 664
      EGF_CA; Calcium-binding EGF-like domain, present in a large number of membrane-bound and extracellular (mostly animal) proteins. Many of these proteins require calcium for their biological function and calcium-binding sites have been found to be located at the ...
      cd00110
      Location:27 → 181
      LamG; Laminin G domain; Laminin G-like domains are usually Ca++ mediated receptors that can have binding sites for steroids, beta1 integrins, heparin, sulfatides, fibulin-1, and alpha-dystroglycans. Proteins that contain LamG domains serve a variety of ...
      pfam00008
      Location:202 → 231
      EGF; EGF-like domain
      pfam01034
      Location:1335 → 1370
      Syndecan; Syndecan domain
      pfam02210
      Location:874 → 1002
      Laminin_G_2; Laminin G domain

    46. XM_063261424.1 → XP_063117494.1  neurexin-3 isoform X1

      UniProtKB/TrEMBL
      A0A8I6GKL9

    47. XM_063261426.1 → XP_063117496.1  neurexin-3 isoform X1

      UniProtKB/TrEMBL
      A0A8I6GKL9

    48. XM_063261448.1 → XP_063117518.1  neurexin-3 isoform X29

    49. XM_039111663.2 → XP_038967591.1  neurexin-3 isoform X31

      Conserved Domains (2) summary
      cd00110
      Location:86 → 235
      LamG; Laminin G domain; Laminin G-like domains are usually Ca++ mediated receptors that can have binding sites for steroids, beta1 integrins, heparin, sulfatides, fibulin-1, and alpha-dystroglycans. Proteins that contain LamG domains serve a variety of ...
      pfam01034
      Location:355 → 390
      Syndecan; Syndecan domain

    50. XM_008764733.4 → XP_008762955.2  neurexin-3 isoform X30

      Conserved Domains (2) summary
      cd00110
      Location:86 → 265
      LamG; Laminin G domain; Laminin G-like domains are usually Ca++ mediated receptors that can have binding sites for steroids, beta1 integrins, heparin, sulfatides, fibulin-1, and alpha-dystroglycans. Proteins that contain LamG domains serve a variety of ...
      pfam01034
      Location:385 → 420
      Syndecan; Syndecan domain
    Nucleotide Protein Strain
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    Q07310.1 GenPept UniProtKB/Swiss-Prot:Q07310

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