Cd47 Cd47 molecule [Rattus norvegicus (Norway rat)] - Gene

Summary

Official Symbol: Cd47provided by RGD
Official Full Name: Cd47 moleculeprovided by RGD
Primary source: RGD:2308
See related: EnsemblRapid:ENSRNOG00000001964 AllianceGenome:RGD:2308
Gene type: protein coding
RefSeq status: PROVISIONAL
Organism: Rattus norvegicus
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
Also known as: Itgp
Summary: Enables protein binding activity involved in heterotypic cell-cell adhesion. Involved in several processes, including cellular response to cytokine stimulus; positive regulation of monocyte extravasation; and regulation of phagocytosis. Located in cell surface. Orthologous to human CD47 (CD47 molecule). [provided by Alliance of Genome Resources, Apr 2022]
Expression: Biased expression in Spleen (RPKM 219.3), Adrenal (RPKM 160.7) and 9 other tissues See more
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Genomic context

Location:: 11q21

Exon count:: 13

Annotation release	Status	Assembly	Chr	Location
RS_2024_02	current	GRCr8 (GCF_036323735.1)	11	NC_086029.1 (64374816..64438763, complement)
RS_2023_06	previous assembly	mRatBN7.2 (GCF_015227675.2)	11	NC_051346.1 (50906052..50970000, complement)
106	previous assembly	Rnor_6.0 (GCF_000001895.5)	11	NC_005110.4 (53511485..53575754, complement)

Chromosome 11 - NC_086029.1 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Go to reference sequence details

Genomic Sequence:

Go to nucleotide: Graphics FASTA GenBank

Expression

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See details

Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
BioProject: PRJNA238328
Publication: PMID 24510058
Analysis date: Mon Jun 6 17:44:12 2016

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Anti-tumor effect of PTEN and its effect on inhibition of the bone tumor through the CD47-SIRPalpha signaling pathway.
Title: Anti-tumor effect of PTEN and its effect on inhibition of the bone tumor through the CD47-SIRPα signaling pathway.
Upregulated TSP1 and CD47 expression in the lung in nitrofen-induced congenital diaphragmatic hernia.
Title: Upregulated TSP1 and CD47 expression in the lung in nitrofen-induced congenital diaphragmatic hernia.
CD47 blocking antibody accelerates hematoma clearance and alleviates hydrocephalus after experimental intraventricular hemorrhage.
Title: CD47 blocking antibody accelerates hematoma clearance and alleviates hydrocephalus after experimental intraventricular hemorrhage.
For the quantification of an anti-CD47 monoclonal antibody.
Title: Two validated liquid chromatography-mass spectrometry methods with different pretreatments for the quantification of an anti-CD47 monoclonal antibody in rat and cynomolgus monkey serum compared with an electrochemiluminescence method.
The CD47 antibody or SiCD47 can protect cardiomyocytes against H/R injury through increasing autophagic flux and autophagic clearance. CD47 deficiency may offer a potential therapeutic approach for preventing myocardial I/R injury.
Title: CD47 deficiency protects cardiomyocytes against hypoxia/reoxygenation injury by rescuing autophagic clearance.
Evidence linking the overexpression of TSP1-CD47 signaling in diabetes to a number of parameters associated with endothelial dysfunction including impaired angiogenesis, cellular senescence and a heightened state of oxidative stress was found.
Title: Diabetes Impairs Angiogenesis and Induces Endothelial Cell Senescence by Up-Regulating Thrombospondin-CD47-Dependent Signaling.
down-regulation of CD47 exerts a protective effect against myocardial I/R injury, which may be attributable to attenuation of oxidative stress via activation of the eNOS/nitric oxide signaling pathway.
Title: RNAi-Mediated Down-Regulation of CD47 Protects against Ischemia/Reperfusion-Induced Myocardial Damage via Activation of eNOS in a Rat Model.
Bone marrow mesenchymal stromal cells expression CD47/STAT1/STAT3 prevent isoproterenol induced myocardial fibrosis.
Title: Bone marrow mesenchymal stromal cells with CD47 high expression via the signal transducer and activators of transcription signaling pathway preventing myocardial fibrosis.
CD47 blockade with CD47mAb400 administered both to the donor and the recipient reduced liver graft ischemia reperfusion injury in a rat liver transplantation model.
Title: CD47 blockade reduces ischemia/reperfusion injury and improves survival in a rat liver transplantation model.
IAP2 overexpression in neural stem cells induced neuronal differentiation.
Title: Integrin-associated protein promotes neuronal differentiation of neural stem/progenitor cells.

Submit: New GeneRIF Correction See all GeneRIFs (21)

Interactions

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Products	Interactant	Other Gene	Complex	Source	Pubs	Description

General gene information

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Markers

RH138892 (e-PCR)
- UniSTS:220979

AI071341 (e-PCR)
- UniSTS:244366

AW108519 (e-PCR)
- UniSTS:180910

Z25524 (e-PCR)
- UniSTS:125922

AB012693 (e-PCR)
- UniSTS:163575

Gene Ontology Provided by RGD

Function	Evidence Code	Pubs
enables cell-cell adhesion mediator activity	ISO Inferred from Sequence Orthology more info
enables protein binding involved in heterotypic cell-cell adhesion	IPI Inferred from Physical Interaction more info	PubMed
enables thrombospondin receptor activity	IBA Inferred from Biological aspect of Ancestor more info
enables thrombospondin receptor activity	IEA Inferred from Electronic Annotation more info
enables thrombospondin receptor activity	ISO Inferred from Sequence Orthology more info

Process	Evidence Code	Pubs
acts_upstream_of_or_within ATP export	ISO Inferred from Sequence Orthology more info
involved_in cell adhesion	IEA Inferred from Electronic Annotation more info
involved_in cell migration	IDA Inferred from Direct Assay more info	PubMed
involved_in cellular response to interleukin-1	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in cellular response to interleukin-12	ISO Inferred from Sequence Orthology more info
involved_in cellular response to type II interferon	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in heterotypic cell-cell adhesion	IEA Inferred from Electronic Annotation more info
acts_upstream_of_or_within inflammatory response	ISO Inferred from Sequence Orthology more info
involved_in integrin-mediated signaling pathway	IEA Inferred from Electronic Annotation more info
acts_upstream_of_or_within monocyte aggregation	ISO Inferred from Sequence Orthology more info
involved_in negative regulation of phagocytosis	IMP Inferred from Mutant Phenotype more info	PubMed
acts_upstream_of_or_within opsonization	ISO Inferred from Sequence Orthology more info
involved_in positive regulation of T cell activation	ISO Inferred from Sequence Orthology more info
involved_in positive regulation of cell population proliferation	ISO Inferred from Sequence Orthology more info
involved_in positive regulation of cell-cell adhesion	IBA Inferred from Biological aspect of Ancestor more info
involved_in positive regulation of cell-cell adhesion	IEA Inferred from Electronic Annotation more info
involved_in positive regulation of cell-cell adhesion	ISO Inferred from Sequence Orthology more info
involved_in positive regulation of inflammatory response	IBA Inferred from Biological aspect of Ancestor more info
involved_in positive regulation of inflammatory response	IEA Inferred from Electronic Annotation more info
acts_upstream_of_or_within positive regulation of inflammatory response	ISO Inferred from Sequence Orthology more info
involved_in positive regulation of monocyte extravasation	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in positive regulation of phagocytosis	IBA Inferred from Biological aspect of Ancestor more info
involved_in positive regulation of phagocytosis	IEA Inferred from Electronic Annotation more info
involved_in positive regulation of phagocytosis	IMP Inferred from Mutant Phenotype more info	PubMed
acts_upstream_of_or_within positive regulation of phagocytosis	ISO Inferred from Sequence Orthology more info
involved_in positive regulation of stress fiber assembly	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in regulation of Fc receptor mediated stimulatory signaling pathway	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in regulation of interleukin-10 production	ISO Inferred from Sequence Orthology more info
involved_in regulation of interleukin-12 production	ISO Inferred from Sequence Orthology more info
involved_in regulation of interleukin-6 production	ISO Inferred from Sequence Orthology more info
involved_in regulation of nitric oxide biosynthetic process	ISO Inferred from Sequence Orthology more info
involved_in regulation of synapse pruning	ISO Inferred from Sequence Orthology more info
involved_in regulation of tumor necrosis factor production	ISO Inferred from Sequence Orthology more info
involved_in regulation of type II interferon production	ISO Inferred from Sequence Orthology more info
acts_upstream_of_or_within response to bacterium	ISO Inferred from Sequence Orthology more info

Component	Evidence Code	Pubs
located_in cell surface	IDA Inferred from Direct Assay more info	PubMed
located_in cell surface	ISO Inferred from Sequence Orthology more info
is_active_in extracellular exosome	IBA Inferred from Biological aspect of Ancestor more info
located_in extracellular exosome	ISO Inferred from Sequence Orthology more info
is_active_in glutamatergic synapse	ISO Inferred from Sequence Orthology more info
is_active_in plasma membrane	IBA Inferred from Biological aspect of Ancestor more info
located_in plasma membrane	IEA Inferred from Electronic Annotation more info
located_in plasma membrane	ISO Inferred from Sequence Orthology more info
is_active_in presynapse	ISO Inferred from Sequence Orthology more info

General protein information

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Preferred Names: leukocyte surface antigen CD47

Names: CD47 antigen (Rh-related antigen, integrin-associated signal transducer); IAP; integrin-associated protein

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

NM_019195.2 → NP_062068.1 leukocyte surface antigen CD47 precursor

See identical proteins and their annotated locations for NP_062068.1

Status: PROVISIONAL

Source sequence(s)

BC085740

UniProtKB/Swiss-Prot

O35294, P97829

UniProtKB/TrEMBL

A0A8I6AR93, A6IQT9

Related

ENSRNOP00000100420.1, ENSRNOT00000168684.1

Conserved Domains (2) summary

pfam04549
Location:142 → 290

CD47; CD47 transmembrane region

pfam08204
Location:20 → 128

V-set_CD47; CD47 immunoglobulin-like domain

RefSeqs of Annotated Genomes: GCF_036323735.1-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCr8

Genomic

NC_086029.1 Reference GRCr8

Range

64374816..64438763 complement

Download

GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

XM_006248267.4 → XP_006248329.1 leukocyte surface antigen CD47 isoform X6

UniProtKB/TrEMBL

A0A0G2JTH4

Conserved Domains (2) summary

pfam04549
Location:142 → 290

CD47; CD47 transmembrane region

pfam08204
Location:20 → 128

V-set_CD47; CD47 immunoglobulin-like domain
XM_006248266.5 → XP_006248328.1 leukocyte surface antigen CD47 isoform X5

See identical proteins and their annotated locations for XP_006248328.1

UniProtKB/TrEMBL

A0A0G2JTH4, A6IQU0

Conserved Domains (2) summary

pfam04549
Location:142 → 290

CD47; CD47 transmembrane region

pfam08204
Location:20 → 128

V-set_CD47; CD47 immunoglobulin-like domain
XM_063270440.1 → XP_063126510.1 leukocyte surface antigen CD47 isoform X7

UniProtKB/TrEMBL

A0A8I6AR93, A0A8L2QRJ3, A6IQU2

Related

ENSRNOP00000082971.2, ENSRNOT00000098840.2
XM_006248264.3 → XP_006248326.1 leukocyte surface antigen CD47 isoform X3

UniProtKB/TrEMBL

A0A0G2JTH4

Conserved Domains (2) summary

pfam04549
Location:180 → 328

CD47; CD47 transmembrane region

pfam08204
Location:20 → 128

V-set_CD47; CD47 immunoglobulin-like domain
XM_006248263.4 → XP_006248325.1 leukocyte surface antigen CD47 isoform X2

UniProtKB/TrEMBL

A0A0G2JTH4

Related

ENSRNOP00000071430.3, ENSRNOT00000078434.3

Conserved Domains (2) summary

pfam04549
Location:180 → 328

CD47; CD47 transmembrane region

pfam08204
Location:20 → 128

V-set_CD47; CD47 immunoglobulin-like domain
XM_006248262.4 → XP_006248324.1 leukocyte surface antigen CD47 isoform X1

UniProtKB/TrEMBL

A0A0G2JTH4

Related

ENSRNOP00000068714.2, ENSRNOT00000078221.3

Conserved Domains (2) summary

pfam04549
Location:180 → 328

CD47; CD47 transmembrane region

pfam08204
Location:20 → 128

V-set_CD47; CD47 immunoglobulin-like domain
XM_063270439.1 → XP_063126509.1 leukocyte surface antigen CD47 isoform X4

UniProtKB/TrEMBL

A0A0G2JTH4