Wwox WW domain-containing oxidoreductase [Rattus norvegicus (Norway rat)] - Gene

Summary

Official Symbol: Wwoxprovided by RGD
Official Full Name: WW domain-containing oxidoreductaseprovided by RGD
Primary source: RGD:1309927
See related: EnsemblRapid:ENSRNOG00000012030 AllianceGenome:RGD:1309927
Gene type: protein coding
RefSeq status: VALIDATED
Organism: Rattus norvegicus
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
Summary: Predicted to enable enzyme binding activity and identical protein binding activity. Predicted to contribute to transcription coactivator activity. Predicted to be involved in cellular response to transforming growth factor beta stimulus; positive regulation of transcription by RNA polymerase II; and regulation of signal transduction. Predicted to act upstream of or within several processes, including apoptotic signaling pathway; osteoblast differentiation; and positive regulation of extrinsic apoptotic signaling pathway in absence of ligand. Predicted to be located in several cellular components, including Golgi apparatus; mitochondrion; and nucleoplasm. Predicted to be part of RNA polymerase II transcription regulator complex. Predicted to colocalize with microvillus and plasma membrane. Used to study epilepsy. Human ortholog(s) of this gene implicated in autosomal recessive spinocerebellar ataxia 12; developmental and epileptic encephalopathy 28; esophageal cancer; esophagus squamous cell carcinoma; and squamous cell carcinoma. Orthologous to human WWOX (WW domain containing oxidoreductase). [provided by Alliance of Genome Resources, Apr 2022]
Expression: Biased expression in Kidney (RPKM 58.8), Thymus (RPKM 43.6) and 9 other tissues See more
Orthologs: human mouse all
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Genomic context

Location:: 19q12

Exon count:: 16

Annotation release	Status	Assembly	Chr	Location
RS_2024_02	current	GRCr8 (GCF_036323735.1)	19	NC_086037.1 (59338402..60269323)
RS_2023_06	previous assembly	mRatBN7.2 (GCF_015227675.2)	19	NC_051354.1 (42432141..43360278)
106	previous assembly	Rnor_6.0 (GCF_000001895.5)	19	NC_005118.4 (46761353..47695247)

Chromosome 19 - NC_086037.1 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Go to reference sequence details

Genomic Sequence:

Go to nucleotide: Graphics FASTA GenBank

Expression

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See details

Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
BioProject: PRJNA238328
Publication: PMID 24510058
Analysis date: Mon Jun 6 17:44:12 2016

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

WWOX inhibition by Zfra1-31 restores mitochondrial homeostasis and viability of neuronal cells exposed to high glucose.
Title: WWOX inhibition by Zfra1-31 restores mitochondrial homeostasis and viability of neuronal cells exposed to high glucose.
Cellular Expression and Subcellular Localization of Wwox Protein During Testicular Development and Spermatogenesis in Rats.
Title: Cellular Expression and Subcellular Localization of Wwox Protein During Testicular Development and Spermatogenesis in Rats.
Wwox localizes in cis-Golgi compartment in testicular germ cells during spermatogenesis and might regulate the spermatogenesis process via interacting with Golgi associated proteins.
Title: Cellular Expression and Subcellular Localization of Wwox Protein During Testicular Development and Spermatogenesis in Rats.
The results indicate that Wwox is essential for normal development of neurons and glial cells in the cerebral cortex.
Title: Loss of Wwox Causes Defective Development of Cerebral Cortex with Hypomyelination in a Rat Model of Lethal Dwarfism with Epilepsy.
WWOX plays a critical role in normal central nervous system development and disease.
Title: The fragile site WWOX gene and the developing brain.
WWOX/WOX1 is coactivated with CREB and NF-kappaB in delayed loss of small dorsal root ganglion neurons upon sciatic nerve transection in rats
Title: Dramatic co-activation of WWOX/WOX1 with CREB and NF-kappaB in delayed loss of small dorsal root ganglion neurons upon sciatic nerve transection in rats.
The Wwox protein is expressed in the central nervous system (CNS), indicating that abnormal neuronal excitability in lde/lde rats may be because of a lack of Wwox function.
Title: A spontaneous mutation of the Wwox gene and audiogenic seizures in rats with lethal dwarfism and epilepsy.

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Interactions

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Products	Interactant	Other Gene	Complex	Source	Pubs	Description

General gene information

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Markers

RH132785 (e-PCR)
- UniSTS:216068

BE101986 (e-PCR)
- UniSTS:260882

RH142718 (e-PCR)
- UniSTS:231965

RH135382 (e-PCR)
- UniSTS:218659

D19Mit7 (e-PCR), detects polymorphism
- UniSTS:119348

BE120591 (e-PCR)
- UniSTS:247365

d19rat66 (e-PCR)
- UniSTS:121413

RH141830 (e-PCR)
- UniSTS:223822

BE101992 (e-PCR)
- UniSTS:243792

AW530821 (e-PCR)
- UniSTS:244562

D19Got59 (e-PCR)
- UniSTS:114260

D19Got43 (e-PCR)
- UniSTS:114777

D19Got40 (e-PCR)
- UniSTS:113499

AU049580 (e-PCR)
- UniSTS:146026

D19Got45 (e-PCR)
- UniSTS:113032

D19Got37 (e-PCR)
- UniSTS:111756

D19Got41 (e-PCR)
- UniSTS:114343

BQ195504 (e-PCR)
- UniSTS:260519

BE119764 (e-PCR)
- UniSTS:249262

AI548764 (e-PCR)
- UniSTS:226252

D19Got60 (e-PCR)
- UniSTS:114647

D19Got47 (e-PCR)
- UniSTS:113377

BG373585 (e-PCR)
- UniSTS:249326

D19Got39 (e-PCR)
- UniSTS:114175

Gene Ontology Provided by RGD

Function	Evidence Code	Pubs
enables enzyme binding	ISO Inferred from Sequence Orthology more info
enables identical protein binding	ISO Inferred from Sequence Orthology more info
enables oxidoreductase activity	IEA Inferred from Electronic Annotation more info
contributes_to transcription coactivator activity	ISO Inferred from Sequence Orthology more info

Process	Evidence Code	Pubs
involved_in Wnt signaling pathway	IEA Inferred from Electronic Annotation more info
involved_in biological_process	ND No biological Data available more info
involved_in cellular response to transforming growth factor beta stimulus	ISO Inferred from Sequence Orthology more info
acts_upstream_of_or_within extrinsic apoptotic signaling pathway	ISO Inferred from Sequence Orthology more info
acts_upstream_of_or_within intrinsic apoptotic signaling pathway by p53 class mediator	ISO Inferred from Sequence Orthology more info
involved_in negative regulation of Wnt signaling pathway	ISO Inferred from Sequence Orthology more info
acts_upstream_of_or_within osteoblast differentiation	ISO Inferred from Sequence Orthology more info
involved_in positive regulation of extrinsic apoptotic signaling pathway	ISO Inferred from Sequence Orthology more info
acts_upstream_of_or_within positive regulation of extrinsic apoptotic signaling pathway in absence of ligand	ISO Inferred from Sequence Orthology more info
involved_in positive regulation of transcription by RNA polymerase II	ISO Inferred from Sequence Orthology more info
acts_upstream_of_or_within skeletal system morphogenesis	ISO Inferred from Sequence Orthology more info

Component	Evidence Code	Pubs
located_in Golgi apparatus	ISO Inferred from Sequence Orthology more info
part_of RNA polymerase II transcription regulator complex	ISO Inferred from Sequence Orthology more info
located_in cytoplasm	ISO Inferred from Sequence Orthology more info
located_in cytosol	ISO Inferred from Sequence Orthology more info
located_in lysosome	IEA Inferred from Electronic Annotation more info
located_in microvillus	ISO Inferred from Sequence Orthology more info
located_in mitochondrion	ISO Inferred from Sequence Orthology more info
located_in nucleus	ISO Inferred from Sequence Orthology more info
located_in plasma membrane	ISO Inferred from Sequence Orthology more info

General protein information

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Preferred Names: WW domain-containing oxidoreductase

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

NM_001106188.2 → NP_001099658.1 WW domain-containing oxidoreductase isoform 2

See identical proteins and their annotated locations for NP_001099658.1

Status: VALIDATED

Source sequence(s)

JAXUCZ010000019

UniProtKB/TrEMBL

A0A8I5ZV28, A0A8I5ZV74, A6IZE7

Related

ENSRNOP00000082048.1, ENSRNOT00000106285.2

Conserved Domains (4) summary

cd00201
Location:60 → 90

WW; Two conserved tryptophans domain; also known as the WWP or rsp5 domain; around 40 amino acids; functions as an interaction module in a diverse set of signalling proteins; binds specific proline-rich sequences but at low affinities compared to other ...

pfam00106
Location:125 → 326

adh_short; short chain dehydrogenase

pfam00397
Location:18 → 47

WW; WW domain

cl21454
Location:124 → 352

NADB_Rossmann; Rossmann-fold NAD(P)(+)-binding proteins
NM_001415106.1 → NP_001402035.1 WW domain-containing oxidoreductase isoform 1

Status: VALIDATED

Source sequence(s)

JAXUCZ010000019

UniProtKB/TrEMBL

A0A8I5ZV28, A0A8I6AEI3

Related

ENSRNOP00000106917.1, ENSRNOT00000157023.1

RefSeqs of Annotated Genomes: GCF_036323735.1-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCr8

Genomic

NC_086037.1 Reference GRCr8

Range

59338402..60269323

Download

GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

XM_063277944.1 → XP_063134014.1 WW domain-containing oxidoreductase isoform X1

UniProtKB/TrEMBL

A0A8I5ZV28, A0A8I6AEI3
XM_039097635.2 → XP_038953563.1 WW domain-containing oxidoreductase isoform X6

Conserved Domains (1) summary

cd09809
Location:11 → 294

human_WWOX_like_SDR_c-like; human WWOX (WW domain-containing oxidoreductase)-like, classical (c)-like SDRs
XM_006255671.5 → XP_006255733.1 WW domain-containing oxidoreductase isoform X4

UniProtKB/TrEMBL

A0A8I5ZV28

Conserved Domains (4) summary

cd00201
Location:60 → 90

WW; Two conserved tryptophans domain; also known as the WWP or rsp5 domain; around 40 amino acids; functions as an interaction module in a diverse set of signalling proteins; binds specific proline-rich sequences but at low affinities compared to other ...

pfam00106
Location:125 → 326

adh_short; short chain dehydrogenase

pfam00397
Location:18 → 47

WW; WW domain

cl21454
Location:124 → 352

NADB_Rossmann; Rossmann-fold NAD(P)(+)-binding proteins
XM_006255670.5 → XP_006255732.1 WW domain-containing oxidoreductase isoform X3

UniProtKB/TrEMBL

A0A8I6GB09

Conserved Domains (4) summary

cd00201
Location:60 → 90

WW; Two conserved tryptophans domain; also known as the WWP or rsp5 domain; around 40 amino acids; functions as an interaction module in a diverse set of signalling proteins; binds specific proline-rich sequences but at low affinities compared to other ...

pfam00106
Location:125 → 326

adh_short; short chain dehydrogenase

pfam00397
Location:18 → 47

WW; WW domain

cl21454
Location:124 → 354

NADB_Rossmann; Rossmann-fold NAD(P)(+)-binding proteins
XM_039097634.2 → XP_038953562.1 WW domain-containing oxidoreductase isoform X5

UniProtKB/TrEMBL

A0A8I5ZV28

Conserved Domains (3) summary

cd00201
Location:60 → 90

WW; Two conserved tryptophans domain; also known as the WWP or rsp5 domain; around 40 amino acids; functions as an interaction module in a diverse set of signalling proteins; binds specific proline-rich sequences but at low affinities compared to other ...

pfam00397
Location:18 → 47

WW; WW domain

cl21454
Location:124 → 352

NADB_Rossmann; Rossmann-fold NAD(P)(+)-binding proteins
XM_008772491.4 → XP_008770713.1 WW domain-containing oxidoreductase isoform X2

UniProtKB/TrEMBL

A0A8I5ZLQ3, A0A8I6GB09

Conserved Domains (4) summary

cd00201
Location:60 → 90

WW; Two conserved tryptophans domain; also known as the WWP or rsp5 domain; around 40 amino acids; functions as an interaction module in a diverse set of signalling proteins; binds specific proline-rich sequences but at low affinities compared to other ...

pfam00106
Location:125 → 326

adh_short; short chain dehydrogenase

pfam00397
Location:18 → 47

WW; WW domain

cl21454
Location:124 → 352

NADB_Rossmann; Rossmann-fold NAD(P)(+)-binding proteins
XM_039097637.2 → XP_038953565.1 WW domain-containing oxidoreductase isoform X7

Conserved Domains (3) summary

cd00201
Location:60 → 90

WW; Two conserved tryptophans domain; also known as the WWP or rsp5 domain; around 40 amino acids; functions as an interaction module in a diverse set of signalling proteins; binds specific proline-rich sequences but at low affinities compared to other ...

pfam00397
Location:18 → 47

WW; WW domain

cl21454
Location:124 → 172

NADB_Rossmann; Rossmann-fold NAD(P)(+)-binding proteins