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    Mcm7 minichromosome maintenance complex component 7 [ Mus musculus (house mouse) ]

    Gene ID: 17220, updated on 28-Oct-2024

    Summary

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    Official Symbol
    Mcm7provided by MGI
    Official Full Name
    minichromosome maintenance complex component 7provided by MGI
    Primary source
    MGI:MGI:1298398
    See related
    Ensembl:ENSMUSG00000029730 AllianceGenome:MGI:1298398
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Mus musculus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
    Also known as
    Mcmd7; mCDC47
    Summary
    Enables single-stranded DNA binding activity. Contributes to DNA helicase activity. Acts upstream of or within DNA unwinding involved in DNA replication; cell population proliferation; and cellular response to xenobiotic stimulus. Located in nucleus. Part of MCM complex. Is expressed in several structures, including alimentary system; brain; genitourinary system; respiratory system; and sensory organ. Human ortholog(s) of this gene implicated in hepatocellular carcinoma. Orthologous to human MCM7 (minichromosome maintenance complex component 7). [provided by Alliance of Genome Resources, Oct 2024]
    Expression
    Broad expression in liver E14 (RPKM 73.1), liver E14.5 (RPKM 66.9) and 24 other tissues See more
    Orthologs
    human all
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    Genomic context

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    See Mcm7 in Genome Data Viewer
    Location:
    5 G2; 5 76.97 cM
    Exon count:
    16
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCm39 (GCF_000001635.27) 5 NC_000071.7 (138162845..138170675, complement)
    108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 5 NC_000071.6 (138164583..138172111, complement)

    Chromosome 5 - NC_000071.7Genomic Context describing neighboring genes Neighboring gene zinc finger protein 113 Neighboring gene STARR-positive B cell enhancer ABC_E4799 Neighboring gene STARR-positive B cell enhancer ABC_E9656 Neighboring gene COP9 signalosome subunit 6 Neighboring gene microRNA 106b Neighboring gene microRNA 25 Neighboring gene microRNA 93 Neighboring gene CapStarr-seq enhancer MGSCv37_chr5:138612151-138612338 Neighboring gene STARR-positive B cell enhancer ABC_E1693 Neighboring gene STARR-positive B cell enhancer ABC_E1694 Neighboring gene adaptor-related protein complex AP-4, mu 1 Neighboring gene STARR-seq mESC enhancer starr_14665 Neighboring gene TATA-box binding protein associated factor 6 Neighboring gene canopy FGF signaling regulator 4

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: Mouse ENCODE transcriptome data Mouse ENCODE transcriptome data
    • Description: RNA profiling data sets generated by the Mouse ENCODE project.
    • BioProject: PRJNA66167
    • Publication: PMID 25409824
    • Analysis date: n/a

    Bibliography

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    Related articles in PubMed

    1. Deregulated minichromosomal maintenance protein MCM7 contributes to oncogene driven tumorigenesis. Honeycutt KA, et al. Oncogene, 2006 Jul 6. PMID 16518415
    2. Green tea catechins suppress the DNA synthesis marker MCM7 in the TRAMP model of prostate cancer. McCarthy S, et al. Mol Oncol, 2007 Sep. PMID 18521193, Free PMC Article
    3. Sequence of mouse CDC47, a member of the minichromosome maintenance (Mcm) family involved in the DNA replication licensing system. Takizawa N, et al. Gene, 1995 Dec 29. PMID 8566808
    4. Comparative analysis of cervical cancer in women and in a human papillomavirus-transgenic mouse model: identification of minichromosome maintenance protein 7 as an informative biomarker for human cervical cancer. Brake T, et al. Cancer Res, 2003 Dec 1. PMID 14678972
    5. Unique pattern of ORC2 and MCM7 localization during DNA replication licensing in the mouse zygote. Ortega MA, et al. Biol Reprod, 2012 Sep. PMID 22674395, Free PMC Article

    See all (70) citations in PubMed

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?
    1. Unique pattern of ORC2 and MCM7 localization during DNA replication licensing in the mouse zygote.
      Title: Unique pattern of ORC2 and MCM7 localization during DNA replication licensing in the mouse zygote.
    2. cellular DNA replication factor MCM7 is involved in prostate cancer (CaP) and MCM7 gene expression was reduced by green tea catechins
      Title: Green tea catechins suppress the DNA synthesis marker MCM7 in the TRAMP model of prostate cancer.
    3. DNA binding and helicase activities of Mcm4/6/7 are significantly stimulated by Cdt1
      Title: Cdt1 forms a complex with the minichromosome maintenance protein (MCM) and activates its helicase activity.
    4. Accumulation and dynamics of Mcm7 are described during oogenesis and the first embryonic cell cycle.
      Title: Accumulation and dynamics of proteins of the MCM family during mouse oogenesis and the first embryonic cell cycle.
    5. Substrate preference and helicase actions of mouse MCM4/6/7 helicase complexes.
      Title: DNA binding and helicase actions of mouse MCM4/6/7 helicase.
    6. role of subunits in DNA helicases activity
      Title: Roles of Mcm7 and Mcm4 subunits in the DNA helicase activity of the mouse Mcm4/6/7 complex.
    7. cyclin D1/CDK4 complexes play a direct role in altering an inhibitory RB.MCM7 complex possibly allowing for setting of the origin in preparation for DNA replication
      Title: The cyclin D1-dependent kinase associates with the pre-replication complex and modulates RB.MCM7 binding.
    8. MCM7 may be a highly informative biomarker for cervical cancer.
      Title: Comparative analysis of cervical cancer in women and in a human papillomavirus-transgenic mouse model: identification of minichromosome maintenance protein 7 as an informative biomarker for human cervical cancer.
    Submit: New GeneRIF Correction

    Variation

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    Alleles

    Alleles of this type are documented at Mouse Genome Informatics  (MGI)
    • Gene trapped (1) 
    • Targeted (1) 

    Pathways from PubChem

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    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Markers

    Homology

    Gene Ontology Provided by MGI

    Function Evidence Code Pubs
    enables ATP binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables ATP hydrolysis activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    contributes_to DNA helicase activity IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    contributes_to DNA helicase activity IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    contributes_to DNA helicase activity ISO
    Inferred from Sequence Orthology
    more info
    		  
    contributes_to DNA helicase activity ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  
    enables protein binding IPI
    Inferred from Physical Interaction
    more info
    		 PubMed 
    enables single-stranded DNA binding IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    contributes_to single-stranded DNA binding IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    enables single-stranded DNA binding IPI
    Inferred from Physical Interaction
    more info
    		 PubMed 
    contributes_to single-stranded DNA binding ISO
    Inferred from Sequence Orthology
    more info
    		  
    contributes_to single-stranded DNA helicase activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    Process Evidence Code Pubs
    involved_in DNA damage response IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in DNA damage response ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in DNA replication initiation IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in DNA replication initiation IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in DNA strand elongation involved in DNA replication IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in DNA unwinding involved in DNA replication IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    acts_upstream_of_or_within DNA unwinding involved in DNA replication IPI
    Inferred from Physical Interaction
    more info
    		 PubMed 
    involved_in DNA unwinding involved in DNA replication ISO
    Inferred from Sequence Orthology
    more info
    		  
    acts_upstream_of_or_within cell population proliferation IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    acts_upstream_of_or_within cellular response to xenobiotic stimulus IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    involved_in double-strand break repair via break-induced replication IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in premeiotic DNA replication NAS
    Non-traceable Author Statement
    more info
    		 PubMed 
    involved_in regulation of phosphorylation IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in regulation of phosphorylation ISO
    Inferred from Sequence Orthology
    more info
    		  
    Component Evidence Code Pubs
    part_of CMG complex ISO
    Inferred from Sequence Orthology
    more info
    		  
    part_of CMG complex ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  
    part_of MCM complex IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    part_of MCM complex IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    part_of MCM complex ISO
    Inferred from Sequence Orthology
    more info
    		  
    part_of MCM complex ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  
    located_in cytosol IEA
    Inferred from Electronic Annotation
    more info
    		  
    located_in cytosol ISO
    Inferred from Sequence Orthology
    more info
    		  
    located_in nucleoplasm ISO
    Inferred from Sequence Orthology
    more info
    		  
    is_active_in nucleus IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    located_in nucleus IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    located_in nucleus ISO
    Inferred from Sequence Orthology
    more info
    		  
    located_in nucleus NAS
    Non-traceable Author Statement
    more info
    		 PubMed 

    General protein information

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    Preferred Names
    DNA replication licensing factor MCM7
    Names
    CDC47 homolog
    mini chromosome maintenance deficient 7
    minichromosome maintenance deficient 7
    NP_001343505.1
    NP_001343506.1
    NP_032594.1

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001356576.1 → NP_001343505.1  DNA replication licensing factor MCM7 isoform b

      Status: VALIDATED

      Description
      Transcript Variant: This variant (2) differs in the 5' UTR and coding sequence compared to variant 1. The resulting isoform (b) is shorter at the N-terminus compared to isoform a. Variants 2 and 3 both encode the same isoform (b).
      Source sequence(s)
      AC151719
      UniProtKB/TrEMBL
      Q3V122
      Conserved Domains (1) summary
      smart00350
      Location:38 → 534
      MCM; minichromosome maintenance proteins

    2. NM_001356577.1 → NP_001343506.1  DNA replication licensing factor MCM7 isoform b

      Status: VALIDATED

      Description
      Transcript Variant: This variant (3) differs in the 5' UTR and coding sequence compared to variant 1. The resulting isoform (b) is shorter at the N-terminus compared to isoform a. Variants 2 and 3 both encode the same isoform (b).
      Source sequence(s)
      AC151719
      UniProtKB/TrEMBL
      Q3V122
      Conserved Domains (1) summary
      smart00350
      Location:38 → 534
      MCM; minichromosome maintenance proteins

    3. NM_008568.3 → NP_032594.1  DNA replication licensing factor MCM7 isoform a

      See identical proteins and their annotated locations for NP_032594.1

      Status: VALIDATED

      Description
      Transcript Variant: This variant (1) encodes the longer isoform (a).
      Source sequence(s)
      AC151719, AK133091
      Consensus CDS
      CCDS19793.1
      UniProtKB/Swiss-Prot
      Q61881
      UniProtKB/TrEMBL
      Q3U4T8, Q3UDI8, Q3V122
      Related
      ENSMUSP00000000505.10, ENSMUST00000000505.16
      Conserved Domains (3) summary
      smart00350
      Location:145 → 641
      MCM; minichromosome maintenance proteins
      pfam14551
      Location:12 → 165
      MCM_N; MCM N-terminal domain
      cl21455
      Location:376 → 515
      P-loop_NTPase; P-loop containing Nucleoside Triphosphate Hydrolases

    RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCm39 C57BL/6J

    Genomic

    1. NC_000071.7 Reference GRCm39 C57BL/6J

      Range
      138162845..138170675 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    RNA

    1. XR_001784632.3 RNA Sequence

    Nucleotide Protein Strain
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    Q61881.1 GenPept UniProtKB/Swiss-Prot:Q61881

    Gene LinkOut

    The following LinkOut resources are supplied by external providers. These providers are responsible for maintaining the links.

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