U.S. flag

An official website of the United States government

Format

Send to:

Choose Destination

Links from GEO Profiles

    • Showing Current items.

    Tyrobp TYRO protein tyrosine kinase binding protein [ Mus musculus (house mouse) ]

    Gene ID: 22177, updated on 28-Oct-2024

    Summary

    Official Symbol
    Tyrobpprovided by MGI
    Official Full Name
    TYRO protein tyrosine kinase binding proteinprovided by MGI
    Primary source
    MGI:MGI:1277211
    See related
    Ensembl:ENSMUSG00000030579 AllianceGenome:MGI:1277211
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Mus musculus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
    Also known as
    Ly83; DAP12; KARAP
    Summary
    Enables signaling receptor binding activity. Involved in several processes, including myeloid cell activation involved in immune response; regulation of cytokine production; and regulation of lymphocyte activation. Acts upstream of or within osteoclast differentiation and regulation of osteoclast development. Located in cell surface. Is expressed in blood vessel; brain; central nervous system; corpus callosum; and embryo. Used to study Nasu-Hakola disease. Human ortholog(s) of this gene implicated in Nasu-Hakola disease. Orthologous to human TYROBP (transmembrane immune signaling adaptor TYROBP). [provided by Alliance of Genome Resources, Oct 2024]
    Expression
    Broad expression in spleen adult (RPKM 223.3), lung adult (RPKM 120.3) and 21 other tissues See more
    Orthologs
    NEW
    Try the new Gene table
    Try the new Transcript table

    Genomic context

    See Tyrobp in Genome Data Viewer
    Location:
    7 B1; 7 17.45 cM
    Exon count:
    5
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCm39 (GCF_000001635.27) 7 NC_000073.7 (30113207..30117007)
    108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 7 NC_000073.6 (30413782..30417582)

    Chromosome 7 - NC_000073.7Genomic Context describing neighboring genes Neighboring gene predicted gene, 42376 Neighboring gene predicted gene, 32029 Neighboring gene CapStarr-seq enhancer MGSCv37_chr7:31204808-31204961 Neighboring gene STARR-positive B cell enhancer ABC_E8837 Neighboring gene hematopoietic cell signal transducer Neighboring gene STARR-positive B cell enhancer ABC_E4916 Neighboring gene nuclear factor of kappa light polypeptide gene enhancer in B cells inhibitor, delta

    Genomic regions, transcripts, and products

    Expression

    • Project title: Mouse ENCODE transcriptome data Mouse ENCODE transcriptome data
    • Description: RNA profiling data sets generated by the Mouse ENCODE project.
    • BioProject: PRJNA66167
    • Publication: PMID 25409824
    • Analysis date: n/a

    Bibliography

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?

    Variation

    Alleles

    Alleles of this type are documented at Mouse Genome Informatics  (MGI)
    • Endonuclease-mediated (3) 
    • Targeted (4)  1 citation

    Pathways from PubChem

    Interactions

    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

    Gene Ontology Provided by MGI

    Function Evidence Code Pubs
    enables identical protein binding ISO
    Inferred from Sequence Orthology
    more info
     
    enables metal ion binding IEA
    Inferred from Electronic Annotation
    more info
     
    enables molecular adaptor activity ISO
    Inferred from Sequence Orthology
    more info
     
    enables protein binding IPI
    Inferred from Physical Interaction
    more info
    PubMed 
    enables protein homodimerization activity ISO
    Inferred from Sequence Orthology
    more info
     
    enables protein homodimerization activity ISS
    Inferred from Sequence or Structural Similarity
    more info
     
    enables signaling receptor binding IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    enables signaling receptor binding IPI
    Inferred from Physical Interaction
    more info
    PubMed 
    enables signaling receptor binding ISO
    Inferred from Sequence Orthology
    more info
     
    Process Evidence Code Pubs
    involved_in T cell activation via T cell receptor contact with antigen bound to MHC molecule on antigen presenting cell IDA
    Inferred from Direct Assay
    more info
    PubMed 
    involved_in actin cytoskeleton organization IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    involved_in apoptotic cell clearance IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    involved_in forebrain development IDA
    Inferred from Direct Assay
    more info
    PubMed 
    involved_in integrin-mediated signaling pathway IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    involved_in macrophage activation involved in immune response IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    involved_in microglial cell activation involved in immune response IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    involved_in microglial cell activation involved in immune response IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    involved_in myeloid leukocyte activation ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in negative regulation of B cell proliferation IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    involved_in negative regulation of B cell proliferation IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    involved_in negative regulation of B cell proliferation ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in negative regulation of interleukin-10 production IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    involved_in negative regulation of long-term synaptic potentiation IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    involved_in negative regulation of transforming growth factor beta1 production IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    involved_in negative regulation of transforming growth factor beta1 production IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    involved_in negative regulation of type I interferon production ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in neutrophil activation involved in immune response IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    involved_in neutrophil activation involved in immune response IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    acts_upstream_of_or_within osteoclast differentiation IDA
    Inferred from Direct Assay
    more info
    PubMed 
    acts_upstream_of_or_within osteoclast differentiation IGI
    Inferred from Genetic Interaction
    more info
    PubMed 
    acts_upstream_of_or_within osteoclast differentiation IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    acts_upstream_of_or_within osteoclast differentiation ISO
    Inferred from Sequence Orthology
    more info
    PubMed 
    involved_in positive regulation of gene expression IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    involved_in positive regulation of interleukin-1 beta production IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    involved_in positive regulation of interleukin-6 production IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    involved_in positive regulation of macrophage fusion IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    involved_in positive regulation of macrophage fusion IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    involved_in positive regulation of macrophage fusion ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in positive regulation of microglial cell mediated cytotoxicity IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    involved_in positive regulation of microglial cell mediated cytotoxicity IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    involved_in positive regulation of natural killer cell activation IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    involved_in positive regulation of natural killer cell activation IDA
    Inferred from Direct Assay
    more info
    PubMed 
    involved_in positive regulation of osteoclast development IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    involved_in positive regulation of protein localization to cell surface ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in positive regulation of receptor localization to synapse IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    involved_in positive regulation of superoxide anion generation IDA
    Inferred from Direct Assay
    more info
    PubMed 
    involved_in positive regulation of tumor necrosis factor production IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    involved_in protein stabilization ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in protein stabilization ISS
    Inferred from Sequence or Structural Similarity
    more info
     
    acts_upstream_of_or_within regulation of osteoclast development IGI
    Inferred from Genetic Interaction
    more info
    PubMed 
    involved_in response to axon injury IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    involved_in semaphorin-plexin signaling pathway IDA
    Inferred from Direct Assay
    more info
    PubMed 
    involved_in stimulatory C-type lectin receptor signaling pathway ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in stimulatory C-type lectin receptor signaling pathway ISS
    Inferred from Sequence or Structural Similarity
    more info
     
    involved_in stimulatory killer cell immunoglobulin-like receptor signaling pathway ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in stimulatory killer cell immunoglobulin-like receptor signaling pathway ISS
    Inferred from Sequence or Structural Similarity
    more info
     
    Component Evidence Code Pubs
    is_active_in cell surface IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    located_in cell surface IDA
    Inferred from Direct Assay
    more info
    PubMed 
    is_active_in cell surface ISO
    Inferred from Sequence Orthology
    more info
     
    located_in cell surface ISO
    Inferred from Sequence Orthology
    more info
     
    located_in cell surface ISS
    Inferred from Sequence or Structural Similarity
    more info
     
    located_in plasma membrane ISO
    Inferred from Sequence Orthology
    more info
     
    located_in plasma membrane ISS
    Inferred from Sequence or Structural Similarity
    more info
     
    located_in plasma membrane TAS
    Traceable Author Statement
    more info
     

    General protein information

    Preferred Names
    TYRO protein tyrosine kinase-binding protein
    Names
    DNAX-activation protein 12
    KAR-associated protein
    killer cell activating receptor associated protein
    killer-activating receptor-associated protein

    NCBI Reference Sequences (RefSeq)

    NEW Try the new Transcript table

    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_011662.3NP_035792.1  TYRO protein tyrosine kinase-binding protein precursor

      See identical proteins and their annotated locations for NP_035792.1

      Status: VALIDATED

      Source sequence(s)
      AA242315, BC056450
      Consensus CDS
      CCDS21089.1
      UniProtKB/Swiss-Prot
      O54885, O88603
      UniProtKB/TrEMBL
      A0A140LHP7, Q3U419
      Related
      ENSMUSP00000032800.10, ENSMUST00000032800.10
      Conserved Domains (1) summary
      pfam07213
      Location:2272
      DAP10; DAP10 membrane protein

    RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCm39 C57BL/6J

    Genomic

    1. NC_000073.7 Reference GRCm39 C57BL/6J

      Range
      30113207..30117007
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)