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These reference sequences exist independently of genome builds. Explain
These reference sequences are curated independently of the genome
annotation cycle, so their versions may not match the RefSeq versions in the current
genome build. Identify version mismatches by comparing the version of the RefSeq in
this section to the one reported in Genomic regions,
transcripts, and products above.
Genomic
-
NG_021272.2 RefSeqGene
- Range
-
25778..41732
- Download
- GenBank, FASTA, Sequence Viewer (Graphics), LRG_1369
mRNA and Protein(s)
-
NM_001178078.2 → NP_001171549.1 signal transducer and activator of transcription 6 isoform 1
See identical proteins and their annotated locations for NP_001171549.1
Status: REVIEWED
- Description
- Transcript Variant: This variant (1) represents the longest transcript and encodes the longest isoform (1). Variants 1, 2 and 3 encode the same protein (isoform 1).
- Source sequence(s)
-
AC023237, AI082533, AK290431
- Consensus CDS
-
CCDS8931.1
- UniProtKB/Swiss-Prot
- A8K316, B7ZA27, F5GXI9, P42226, Q5FBW5, Q71UP4
- UniProtKB/TrEMBL
- A8K4S9, B2R680
- Related
- ENSP00000401486.3, ENST00000454075.7
- Conserved Domains (5) summary
-
- cd10377
Location:517 → 646
- SH2_STAT6; Src homology 2 (SH2) domain found in signal transducer and activator of transcription (STAT) 6 proteins
- smart00964
Location:2 → 115
- STAT_int; STAT protein, protein interaction domain
- pfam14596
Location:655 → 847
- STAT6_C; STAT6 C-terminal
- pfam01017
Location:124 → 271
- STAT_alpha; STAT protein, all-alpha domain
- pfam02864
Location:273 → 526
- STAT_bind; STAT protein, DNA binding domain
-
NM_001178079.2 → NP_001171550.1 signal transducer and activator of transcription 6 isoform 1
See identical proteins and their annotated locations for NP_001171550.1
Status: REVIEWED
- Description
- Transcript Variant: This variant (3) differs in the 5' UTR compared to variant 1. Variants 1, 2 and 3 encode the same protein (isoform 1).
- Source sequence(s)
-
AC023237, AI082533, AK291044
- Consensus CDS
-
CCDS8931.1
- UniProtKB/Swiss-Prot
- A8K316, B7ZA27, F5GXI9, P42226, Q5FBW5, Q71UP4
- UniProtKB/TrEMBL
- A8K4S9, B2R680
- Related
- ENSP00000438451.2, ENST00000543873.6
- Conserved Domains (5) summary
-
- cd10377
Location:517 → 646
- SH2_STAT6; Src homology 2 (SH2) domain found in signal transducer and activator of transcription (STAT) 6 proteins
- smart00964
Location:2 → 115
- STAT_int; STAT protein, protein interaction domain
- pfam14596
Location:655 → 847
- STAT6_C; STAT6 C-terminal
- pfam01017
Location:124 → 271
- STAT_alpha; STAT protein, all-alpha domain
- pfam02864
Location:273 → 526
- STAT_bind; STAT protein, DNA binding domain
-
NM_001178080.2 → NP_001171551.1 signal transducer and activator of transcription 6 isoform 2
See identical proteins and their annotated locations for NP_001171551.1
Status: REVIEWED
- Description
- Transcript Variant: This variant (4) uses an alternate splice site in the 5' UTR, lacks an alternate in-frame exon in the 5' coding region and uses a downstream start codon compared to variant 1. The resulting protein (isoform 2 )has a shorter N-terminus compared to isoform 1. Variants 4 and 5 encode the same protein.
- Source sequence(s)
-
AC023237, AK316142
- Consensus CDS
-
CCDS53804.1
- UniProtKB/TrEMBL
-
B7ZAC1
- Related
- ENSP00000444530.2, ENST00000537215.6
- Conserved Domains (4) summary
-
- cd10377
Location:407 → 536
- SH2_STAT6; Src homology 2 (SH2) domain found in signal transducer and activator of transcription (STAT) 6 proteins
- pfam01017
Location:14 → 161
- STAT_alpha; STAT protein, all-alpha domain
- pfam02864
Location:163 → 416
- STAT_bind; STAT protein, DNA binding domain
- pfam14596
Location:545 → 737
- STAT6_C; STAT6 C-terminal
-
NM_001178081.2 → NP_001171552.1 signal transducer and activator of transcription 6 isoform 2
See identical proteins and their annotated locations for NP_001171552.1
Status: REVIEWED
- Description
- Transcript Variant: This variant (5) uses an alternate splice site in the 5' UTR, lacks two alternate in-frame exons in the 5' coding region and uses a downstream start codon compared to variant 1. The resulting protein (isoform 2) has a shorter N-terminus compared to isoform 1. Variants 4 and 5 encode the same protein.
- Source sequence(s)
-
AC023237, AI082533, AK298721
- Consensus CDS
-
CCDS53804.1
- UniProtKB/TrEMBL
-
B7ZAC1
- Related
- ENSP00000445409.2, ENST00000538913.6
- Conserved Domains (4) summary
-
- cd10377
Location:407 → 536
- SH2_STAT6; Src homology 2 (SH2) domain found in signal transducer and activator of transcription (STAT) 6 proteins
- pfam01017
Location:14 → 161
- STAT_alpha; STAT protein, all-alpha domain
- pfam02864
Location:163 → 416
- STAT_bind; STAT protein, DNA binding domain
- pfam14596
Location:545 → 737
- STAT6_C; STAT6 C-terminal
-
NM_003153.5 → NP_003144.3 signal transducer and activator of transcription 6 isoform 1
See identical proteins and their annotated locations for NP_003144.3
Status: REVIEWED
- Description
- Transcript Variant: This variant (2) uses an alternate splice site in the 5' UTR compared to variant 1. Variants 1, 2 and 3 encode the same protein (isoform 1).
- Source sequence(s)
-
AC023237, AI082533, BC005823
- Consensus CDS
-
CCDS8931.1
- UniProtKB/Swiss-Prot
- A8K316, B7ZA27, F5GXI9, P42226, Q5FBW5, Q71UP4
- UniProtKB/TrEMBL
- A8K4S9, B2R680
- Related
- ENSP00000300134.3, ENST00000300134.8
- Conserved Domains (5) summary
-
- cd10377
Location:517 → 646
- SH2_STAT6; Src homology 2 (SH2) domain found in signal transducer and activator of transcription (STAT) 6 proteins
- smart00964
Location:2 → 115
- STAT_int; STAT protein, protein interaction domain
- pfam14596
Location:655 → 847
- STAT6_C; STAT6 C-terminal
- pfam01017
Location:124 → 271
- STAT_alpha; STAT protein, all-alpha domain
- pfam02864
Location:273 → 526
- STAT_bind; STAT protein, DNA binding domain
RNA
-
NR_033659.2 RNA Sequence
Status: REVIEWED
- Description
- Transcript Variant: This variant (6) lacks an alternate 5' exon compared to variant 1. This variant is represented as non-coding because use of the 5'-most supported translation start codon, as used in variant #, renders the transcript a candidate for nonsense-mediated mRNA decay (NMD).
- Source sequence(s)
-
AC023237, AI082533, AK299094
- Related
-
ENST00000554764.6
The following sections contain reference sequences that belong to a
specific genome build. Explain
This section includes genomic Reference
Sequences (RefSeqs) from all assemblies on which this gene is annotated, such as
RefSeqs for chromosomes and scaffolds (contigs) from both reference and alternate
assemblies. Model RNAs and proteins are also reported here.
Reference GRCh38.p14 Primary Assembly
Genomic
-
NC_000012.12 Reference GRCh38.p14 Primary Assembly
- Range
-
57095408..57111362 complement
- Download
- GenBank, FASTA, Sequence Viewer (Graphics)
mRNA and Protein(s)
-
XM_047429473.1 → XP_047285429.1 signal transducer and activator of transcription 6 isoform X1
- UniProtKB/Swiss-Prot
- A8K316, B7ZA27, F5GXI9, P42226, Q5FBW5, Q71UP4
- Related
- ENSP00000452203.2, ENST00000553397.6
-
XM_047429475.1 → XP_047285431.1 signal transducer and activator of transcription 6 isoform X1
- UniProtKB/Swiss-Prot
- A8K316, B7ZA27, F5GXI9, P42226, Q5FBW5, Q71UP4
- Related
- ENSP00000491116.2, ENST00000640254.2
-
XM_047429474.1 → XP_047285430.1 signal transducer and activator of transcription 6 isoform X1
- UniProtKB/Swiss-Prot
- A8K316, B7ZA27, F5GXI9, P42226, Q5FBW5, Q71UP4
- Related
- ENSP00000450732.2, ENST00000553275.2
-
XM_047429477.1 → XP_047285433.1 signal transducer and activator of transcription 6 isoform X3
-
XM_047429476.1 → XP_047285432.1 signal transducer and activator of transcription 6 isoform X2
Alternate T2T-CHM13v2.0
Genomic
-
NC_060936.1 Alternate T2T-CHM13v2.0
- Range
-
57063280..57079195 complement
- Download
- GenBank, FASTA, Sequence Viewer (Graphics)
mRNA and Protein(s)
-
XM_054373093.1 → XP_054229068.1 signal transducer and activator of transcription 6 isoform X1
- UniProtKB/Swiss-Prot
- A8K316, B7ZA27, F5GXI9, P42226, Q5FBW5, Q71UP4
-
XM_054373095.1 → XP_054229070.1 signal transducer and activator of transcription 6 isoform X1
- UniProtKB/Swiss-Prot
- A8K316, B7ZA27, F5GXI9, P42226, Q5FBW5, Q71UP4
-
XM_054373094.1 → XP_054229069.1 signal transducer and activator of transcription 6 isoform X1
- UniProtKB/Swiss-Prot
- A8K316, B7ZA27, F5GXI9, P42226, Q5FBW5, Q71UP4
-
XM_054373097.1 → XP_054229072.1 signal transducer and activator of transcription 6 isoform X3
-
XM_054373096.1 → XP_054229071.1 signal transducer and activator of transcription 6 isoform X2