Ugcg UDP-glucose ceramide glucosyltransferase [Rattus norvegicus (Norway rat)] - Gene

Summary

Official Symbol: Ugcgprovided by RGD
Official Full Name: UDP-glucose ceramide glucosyltransferaseprovided by RGD
Primary source: RGD:621870
See related: EnsemblRapid:ENSRNOG00000015644 AllianceGenome:RGD:621870
Gene type: protein coding
RefSeq status: VALIDATED
Organism: Rattus norvegicus
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
Summary: Enables ceramide glucosyltransferase activity. Predicted to be involved in several processes, including cornified envelope assembly; establishment of skin barrier; and glucosylceramide biosynthetic process. Located in Golgi membrane. Biomarker of hypertension. Orthologous to human UGCG (UDP-glucose ceramide glucosyltransferase). [provided by Alliance of Genome Resources, Nov 2024]
Expression: Biased expression in Adrenal (RPKM 107.6), Spleen (RPKM 95.4) and 9 other tissues See more
Orthologs: human mouse all
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Genomic context

Location:: 5q24

Exon count:: 9

Annotation release	Status	Assembly	Chr	Location
RS_2024_02	current	GRCr8 (GCF_036323735.1)	5	NC_086023.1 (78828006..78860725)
RS_2023_06	previous assembly	mRatBN7.2 (GCF_015227675.2)	5	NC_051340.1 (74032978..74065701)
106	previous assembly	Rnor_6.0 (GCF_000001895.5)	5	NC_005104.4 (76376722..76419564)

Chromosome 5 - NC_086023.1 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Genomic Sequence:

Go to nucleotide: Graphics FASTA GenBank

Expression

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See details

Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
BioProject: PRJNA238328
Publication: PMID 24510058
Analysis date: Mon Jun 6 17:44:12 2016

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

A glucosylceramide synthase inhibitor protects rats against the cytotoxic effects of shiga toxin 2.
Title: A glucosylceramide synthase inhibitor protects rats against the cytotoxic effects of shiga toxin 2.
Data suggest that during ischemic tolerance, glucosylceramide synthase (GCS) appears to modulate otherwise high levels of brain ceramide.
Title: Glucosylceramide synthase activity and ceramide levels are modulated during cerebral ischemia after ischemic preconditioning.

Submit: New GeneRIF Correction

General gene information

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Markers

D5Wox42 (e-PCR)
- UniSTS:518928

RH133596 (e-PCR)
- UniSTS:216879

d5rat75 (e-PCR)
- UniSTS:122163

D5Uwm68 (e-PCR)
- UniSTS:517965

Ugcg (e-PCR), detects polymorphism
- UniSTS:508026

RH135237 (e-PCR)
- UniSTS:218514

Gene Ontology Provided by RGD

Function	Evidence Code	Pubs
enables ceramide glucosyltransferase activity	IBA Inferred from Biological aspect of Ancestor more info
enables ceramide glucosyltransferase activity	IDA Inferred from Direct Assay more info	PubMed
enables ceramide glucosyltransferase activity	IEA Inferred from Electronic Annotation more info
enables ceramide glucosyltransferase activity	ISO Inferred from Sequence Orthology more info

Process	Evidence Code	Pubs
involved_in cell differentiation	ISO Inferred from Sequence Orthology more info
involved_in cell differentiation	ISS Inferred from Sequence or Structural Similarity more info
involved_in cornified envelope assembly	ISO Inferred from Sequence Orthology more info
involved_in cornified envelope assembly	ISS Inferred from Sequence or Structural Similarity more info
involved_in establishment of skin barrier	ISO Inferred from Sequence Orthology more info
involved_in establishment of skin barrier	ISS Inferred from Sequence or Structural Similarity more info
involved_in glucosylceramide biosynthetic process	IBA Inferred from Biological aspect of Ancestor more info
involved_in glucosylceramide biosynthetic process	ISO Inferred from Sequence Orthology more info
involved_in glucosylceramide biosynthetic process	ISS Inferred from Sequence or Structural Similarity more info
involved_in intestinal lipid absorption	ISO Inferred from Sequence Orthology more info
involved_in intestinal lipid absorption	ISS Inferred from Sequence or Structural Similarity more info
involved_in keratinocyte differentiation	ISO Inferred from Sequence Orthology more info
involved_in keratinocyte differentiation	ISS Inferred from Sequence or Structural Similarity more info
involved_in leptin-mediated signaling pathway	ISO Inferred from Sequence Orthology more info
involved_in leptin-mediated signaling pathway	ISS Inferred from Sequence or Structural Similarity more info
involved_in neuron development	ISO Inferred from Sequence Orthology more info
involved_in neuron development	ISS Inferred from Sequence or Structural Similarity more info
involved_in protein lipidation	ISO Inferred from Sequence Orthology more info
involved_in protein lipidation	ISS Inferred from Sequence or Structural Similarity more info
involved_in regulation of signal transduction	ISO Inferred from Sequence Orthology more info
involved_in regulation of signal transduction	ISS Inferred from Sequence or Structural Similarity more info

Component	Evidence Code	Pubs
located_in Golgi membrane	IDA Inferred from Direct Assay more info	PubMed
located_in Golgi membrane	ISO Inferred from Sequence Orthology more info
is_active_in membrane	IBA Inferred from Biological aspect of Ancestor more info
located_in membrane	IDA Inferred from Direct Assay more info	PubMed

General protein information

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Preferred Names: ceramide glucosyltransferase

Names: GCS; GLCT-1; UDP-glucose:N-acylsphingosine D-glucosyltransferase; UDP-glucose:ceramide glycosyltransferase; glucosylceramide synthase; glycosylceramide synthase

NP_113983.1

EC 2.4.1.80

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

NM_031795.2 → NP_113983.1 ceramide glucosyltransferase

See identical proteins and their annotated locations for NP_113983.1

Status: VALIDATED

Source sequence(s)

JAXUCZ010000005

UniProtKB/Swiss-Prot

O55149, Q9R0E0

UniProtKB/TrEMBL

A6KDW2

Related

ENSRNOP00000075148.1, ENSRNOT00000088872.3

Conserved Domains (2) summary

cd02520
Location:51 → 280

Glucosylceramide_synthase; Glucosylceramide synthase catalyzes the first glycosylation step of glycosphingolipid synthesis

pfam13641
Location:51 → 276

Glyco_tranf_2_3; Glycosyltransferase like family 2