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    OXSR1 oxidative stress responsive kinase 1 [ Homo sapiens (human) ]

    Gene ID: 9943, updated on 2-Nov-2024

    Summary

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    Official Symbol
    OXSR1provided by HGNC
    Official Full Name
    oxidative stress responsive kinase 1provided by HGNC
    Primary source
    HGNC:HGNC:8508
    See related
    Ensembl:ENSG00000172939 MIM:604046; AllianceGenome:HGNC:8508
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Homo sapiens
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
    Also known as
    OSR1
    Summary
    The product of this gene belongs to the Ser/Thr protein kinase family of proteins. It regulates downstream kinases in response to environmental stress, and may play a role in regulating the actin cytoskeleton. [provided by RefSeq, Jul 2008]
    Annotation information
    Note: OSR1 (Gene ID: 130497) and OXSR1 (Gene ID: 9943) share the OSR1 symbol/alias in common. OSR1 is a widely used alternative name for oxidative stress responsive 1 (OXSR1). [29 Jun 2018]
    Expression
    Ubiquitous expression in esophagus (RPKM 13.6), bone marrow (RPKM 11.2) and 25 other tissues See more
    Orthologs
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    Genomic context

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    See OXSR1 in Genome Data Viewer
    Location:
    3p22.2
    Exon count:
    23
    Annotation release Status Assembly Chr Location
    RS_2024_08 current GRCh38.p14 (GCF_000001405.40) 3 NC_000003.12 (38164063..38255484)
    RS_2024_08 current T2T-CHM13v2.0 (GCF_009914755.1) 3 NC_060927.1 (38170735..38261199)
    RS_2024_09 previous assembly GRCh37.p13 (GCF_000001405.25) 3 NC_000003.11 (38207028..38296975)

    Chromosome 3 - NC_000003.12Genomic Context describing neighboring genes Neighboring gene DLEC1 cilia and flagella associated protein Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr3:38179733-38180676 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 19680 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 19681 Neighboring gene acetyl-CoA acyltransferase 1 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr3:38196601-38197102 Neighboring gene uncharacterized LOC101928234 Neighboring gene CDK7 strongly-dependent group 2 enhancer GRCh37_chr3:38205703-38206902 Neighboring gene NANOG-H3K27ac-H3K4me1 hESC enhancer GRCh37_chr3:38207186-38207801 Neighboring gene MYD88 innate immune signal transduction adaptor Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 14207 Neighboring gene Sharpr-MPRA regulatory region 12810 Neighboring gene Sharpr-MPRA regulatory region 5010 Neighboring gene solute carrier family 22 member 13 Neighboring gene CDC42 pseudogene 7 Neighboring gene solute carrier family 22 member 14 Neighboring gene RNA, U6 small nuclear 235, pseudogene

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: HPA RNA-seq normal tissues HPA RNA-seq normal tissues
    • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
    • BioProject: PRJEB4337
    • Publication: PMID 24309898
    • Analysis date: Wed Apr 4 07:08:55 2018

    Bibliography

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    Related articles in PubMed

    1. Isolation and characterization of a novel serine threonine kinase gene on chromosome 3p22-21.3. Tamari M, et al. J Hum Genet, 1999. PMID 10083736
    2. Sequence specific assignment and determination of OSR1 C-terminal domain structure by NMR. AlAmri MA, et al. Biochem Biophys Res Commun, 2019 Apr 30. PMID 30894278
    3. Association of OSR-1 With Vascular Dysfunction and Hypertension in Polycystic Kidney Disease. Kocyigit I, et al. Ther Apher Dial, 2020 Feb. PMID 31020807
    4. Crystal structure of domain-swapped STE20 OSR1 kinase domain. Lee SJ, et al. Protein Sci, 2009 Feb. PMID 19177573, Free PMC Article
    5. Structure of the OSR1 kinase, a hypertension drug target. Villa F, et al. Proteins, 2008 Dec. PMID 18831043

    See all (110) citations in PubMed

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?
    1. Association of genetic variants of oxidative stress responsive kinase 1 (OXSR1) with asthma exacerbations in non-smoking asthmatics.
      Title: Association of genetic variants of oxidative stress responsive kinase 1 (OXSR1) with asthma exacerbations in non-smoking asthmatics.
    2. Structures of the Human SPAK and OSR1 Conserved C-Terminal (CCT) Domains.
      Title: Structures of the Human SPAK and OSR1 Conserved C-Terminal (CCT) Domains.
    3. The Cul4-DDB1-WDR3/WDR6 Complex Binds SPAK and OSR1 Kinases in a Phosphorylation-Dependent Manner.
      Title: The Cul4-DDB1-WDR3/WDR6 Complex Binds SPAK and OSR1 Kinases in a Phosphorylation-Dependent Manner.
    4. SPAK and OSR1 kinases bind and phosphorylate the beta2-Adrenergic receptor.
      Title: SPAK and OSR1 kinases bind and phosphorylate the β(2)-Adrenergic receptor.
    5. High expression of OSR1 as a predictive biomarker for poor prognosis and lymph node metastasis in breast cancer.
      Title: High expression of OSR1 as a predictive biomarker for poor prognosis and lymph node metastasis in breast cancer.
    6. Regulation of ClC-2 activity by SPAK and OSR1.
      Title: Regulation of ClC-2 activity by SPAK and OSR1.
    7. WNK1 and OSR1 regulate the Na+, K+, 2Cl- cotransporter in HeLa cells.
      Title: WNK1 and OSR1 regulate the Na+, K+, 2Cl- cotransporter in HeLa cells.
    8. SPAK and OSR1 Sensitive Cell Membrane Protein Abundance and Activity of KCNQ1/E1 K+ Channels.
      Title: SPAK and OSR1 Sensitive Cell Membrane Protein Abundance and Activity of KCNQ1/E1 K+ Channels.
    9. Negative regulation of the creatine transporter SLC6A8 by SPAK and OSR1.
      Title: Negative regulation of the creatine transporter SLC6A8 by SPAK and OSR1.
    10. Downregulation of peptide transporters PEPT1 and PEPT2 by oxidative stress responsive kinase OSR1.
      Title: Downregulation of peptide transporters PEPT1 and PEPT2 by oxidative stress responsive kinase OSR1.
    Submit: New GeneRIF Correction See all GeneRIFs (38)

    Phenotypes

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    Find tests for this gene in the NIH Genetic Testing Registry (GTR)

    Review eQTL and phenotype association data in this region using PheGenI

    Variation

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    See variants in ClinVar

    See studies and variants in dbVar

    See Variation Viewer (GRCh37.p13)

    See Variation Viewer (GRCh38)

    Genotypes

    Pathways from PubChem

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    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Markers

    Homology

    Clone Names

    • KIAA1101

    Gene Ontology Provided by GOA

    Function Evidence Code Pubs
    enables ATP binding IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    enables histone H2AS1 kinase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables identical protein binding IPI
    Inferred from Physical Interaction
    more info
    		 PubMed 
    enables magnesium ion binding IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    enables protein binding IPI
    Inferred from Physical Interaction
    more info
    		 PubMed 
    enables protein kinase binding IPI
    Inferred from Physical Interaction
    more info
    		 PubMed 
    enables protein serine kinase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables protein serine/threonine kinase activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables protein serine/threonine kinase activity IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    enables protein serine/threonine kinase activity IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    Process Evidence Code Pubs
    involved_in cell volume homeostasis IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    involved_in cellular hyperosmotic response IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in cellular hyperosmotic response IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    involved_in cellular hypotonic response IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in cellular response to chemokine IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in chemokine (C-C motif) ligand 21 signaling pathway ISS
    Inferred from Sequence or Structural Similarity
    more info
    		 PubMed 
    involved_in chemokine (C-X-C motif) ligand 12 signaling pathway IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in chromatin remodeling IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in intracellular signal transduction IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in intracellular signal transduction IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    involved_in negative regulation of potassium ion transmembrane transporter activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in osmosensory signaling pathway IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in peptidyl-threonine phosphorylation IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    involved_in peptidyl-threonine phosphorylation IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in positive regulation of T cell chemotaxis IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in positive regulation of T cell chemotaxis IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in protein autophosphorylation IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    involved_in protein phosphorylation IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    involved_in renal sodium ion absorption IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    involved_in response to oxidative stress IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in response to xenobiotic stimulus IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in signal transduction IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    Component Evidence Code Pubs
    is_active_in cytoplasm IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    is_active_in cytoplasm IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    is_active_in cytosol IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    located_in cytosol IDA
    Inferred from Direct Assay
    more info
    		  
    located_in extracellular exosome HDA PubMed 

    General protein information

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    Preferred Names
    serine/threonine-protein kinase OSR1
    Names
    oxidative stress responsive 1
    oxidative stress-responsive 1 protein
    NP_005100.1
    XP_011532633.1
    XP_016863090.1
    XP_024309619.1
    XP_024309620.1
    XP_047305342.1
    XP_047305343.1
    XP_047305344.1
    XP_054204650.1
    XP_054204651.1
    XP_054204652.1
    XP_054204653.1
    XP_054204654.1
    XP_054204655.1

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_005109.3 → NP_005100.1  serine/threonine-protein kinase OSR1

      See identical proteins and their annotated locations for NP_005100.1

      Status: REVIEWED

      Source sequence(s)
      AB017642, BC008726
      Consensus CDS
      CCDS2675.1
      UniProtKB/Swiss-Prot
      O95747, Q3LR53, Q7Z501, Q9UPQ1
      UniProtKB/TrEMBL
      C9JIG9
      Related
      ENSP00000311713.3, ENST00000311806.8
      Conserved Domains (2) summary
      smart00220
      Location:17 → 291
      S_TKc; Serine/Threonine protein kinases, catalytic domain
      cd06610
      Location:15 → 291
      STKc_OSR1_SPAK; Catalytic domain of the Serine/Threonine Kinases, Oxidative stress response kinase and Ste20-related proline alanine-rich kinase

    RefSeqs of Annotated Genomes: GCF_000001405.40-RS_2024_08

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCh38.p14 Primary Assembly

    Genomic

    1. NC_000003.12 Reference GRCh38.p14 Primary Assembly

      Range
      38164063..38255484
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_011534331.3 → XP_011532633.1  serine/threonine-protein kinase OSR1 isoform X1

      Conserved Domains (2) summary
      smart00220
      Location:77 → 344
      S_TKc; Serine/Threonine protein kinases, catalytic domain
      cd06610
      Location:77 → 344
      STKc_OSR1_SPAK; Catalytic domain of the Serine/Threonine Kinases, Oxidative stress response kinase and Ste20-related proline alanine-rich kinase

    2. XM_017007601.2 → XP_016863090.1  serine/threonine-protein kinase OSR1 isoform X2

    3. XM_024453851.2 → XP_024309619.1  serine/threonine-protein kinase OSR1 isoform X6

      Conserved Domains (1) summary
      cd06610
      Location:77 → 344
      STKc_OSR1_SPAK; Catalytic domain of the Serine/Threonine Kinases, Oxidative stress response kinase and Ste20-related proline alanine-rich kinase

    4. XM_047449386.1 → XP_047305342.1  serine/threonine-protein kinase OSR1 isoform X3

    5. XM_047449387.1 → XP_047305343.1  serine/threonine-protein kinase OSR1 isoform X4

    6. XM_047449388.1 → XP_047305344.1  serine/threonine-protein kinase OSR1 isoform X5

    7. XM_024453852.2 → XP_024309620.1  serine/threonine-protein kinase OSR1 isoform X7

      Conserved Domains (3) summary
      COG0515
      Location:1 → 204
      SPS1; Serine/threonine protein kinase [Signal transduction mechanisms]
      pfam12202
      Location:242 → 273
      OSR1_C; Oxidative-stress-responsive kinase 1 C terminal
      cl21453
      Location:1 → 99
      PKc_like; Protein Kinases, catalytic domain

    RNA

    1. XR_007095781.1 RNA Sequence

    Alternate T2T-CHM13v2.0

    Genomic

    1. NC_060927.1 Alternate T2T-CHM13v2.0

      Range
      38170735..38261199
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_054348675.1 → XP_054204650.1  serine/threonine-protein kinase OSR1 isoform X1

    2. XM_054348676.1 → XP_054204651.1  serine/threonine-protein kinase OSR1 isoform X2

    3. XM_054348677.1 → XP_054204652.1  serine/threonine-protein kinase OSR1 isoform X3

    4. XM_054348678.1 → XP_054204653.1  serine/threonine-protein kinase OSR1 isoform X4

    5. XM_054348679.1 → XP_054204654.1  serine/threonine-protein kinase OSR1 isoform X5

    6. XM_054348680.1 → XP_054204655.1  serine/threonine-protein kinase OSR1 isoform X7

    RNA

    1. XR_008486879.1 RNA Sequence

    Nucleotide Protein
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    O95747.1 GenPept UniProtKB/Swiss-Prot:O95747

    Gene LinkOut

    The following LinkOut resources are supplied by external providers. These providers are responsible for maintaining the links.

    Chemical Information
    Molecular Biology Databases
    Research Materials
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