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    SSX3 SSX family member 3 [ Homo sapiens (human) ]

    Gene ID: 10214, updated on 2-Nov-2024

    Summary

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    Official Symbol
    SSX3provided by HGNC
    Official Full Name
    SSX family member 3provided by HGNC
    Primary source
    HGNC:HGNC:11337
    See related
    Ensembl:ENSG00000165584 MIM:300325; AllianceGenome:HGNC:11337
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Homo sapiens
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
    Also known as
    CT5.3
    Summary
    The product of this gene belongs to the family of highly homologous synovial sarcoma X (SSX) breakpoint proteins. These proteins may function as transcriptional repressors. They are also capable of eliciting spontaneous humoral and cellular immune responses in cancer patients, and are potentially useful targets in cancer vaccine-based immunotherapy. While some of the related SSX genes are involved in t(X;18)(p11.2;q11.2) translocations that are characteristically found in all synovial sarcomas, this gene does not appear to be involved in such translocations. [provided by RefSeq, Jul 2013]
    Expression
    Restricted expression toward testis (RPKM 5.8) See more
    Orthologs
    all
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    Genomic context

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    See SSX3 in Genome Data Viewer
    Location:
    Xp11.23
    Exon count:
    9
    Annotation release Status Assembly Chr Location
    RS_2024_08 current GRCh38.p14 (GCF_000001405.40) X NC_000023.11 (48346427..48356703, complement)
    RS_2024_08 current T2T-CHM13v2.0 (GCF_009914755.1) X NC_060947.1 (47755403..47765669, complement)
    RS_2024_09 previous assembly GRCh37.p13 (GCF_000001405.25) X NC_000023.10 (48205862..48216138, complement)

    Chromosome X - NC_000023.11Genomic Context describing neighboring genes Neighboring gene SSX family member 19, pseudogene Neighboring gene ReSE screen-validated silencer GRCh37_chrX:48186958-48187217 Neighboring gene S100A11 pseudogene 9 Neighboring gene ornithine aminotransferase pseudogene Neighboring gene ornithine aminotransferase, mitochondrial-like

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: HPA RNA-seq normal tissues HPA RNA-seq normal tissues
    • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
    • BioProject: PRJEB4337
    • Publication: PMID 24309898
    • Analysis date: Wed Apr 4 07:08:55 2018

    Bibliography

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    Related articles in PubMed

    1. A novel Krüppel-associated box containing the SSX gene (SSX3) on the human X chromosome is not implicated in t(X;18)-positive synovial sarcomas. de Leeuw B, et al. Cytogenet Cell Genet, 1996. PMID 8697803
    2. A multigene predictor of metastatic outcome in early stage hormone receptor-negative and triple-negative breast cancer. Yau C, et al. Breast Cancer Res, 2010. PMID 20946665, Free PMC Article
    3. SSX2-4 expression in early-stage non-small cell lung cancer. Greve KB, et al. Tissue Antigens, 2014 May. PMID 24645645
    4. Heterogeneous expression of the SSX cancer/testis antigens in human melanoma lesions and cell lines. dos Santos NR, et al. Cancer Res, 2000 Mar 15. PMID 10749136
    5. SSX: a multigene family with several members transcribed in normal testis and human cancer. Gure AO, et al. Int J Cancer, 1997 Sep 17. PMID 9378559

    See all (18) citations in PubMed

    GeneRIFs: Gene References Into Functions

    Phenotypes

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    Find tests for this gene in the NIH Genetic Testing Registry (GTR)

    Review eQTL and phenotype association data in this region using PheGenI

    Variation

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    See variants in ClinVar

    See studies and variants in dbVar

    See Variation Viewer (GRCh37.p13)

    See Variation Viewer (GRCh38)

    Genotypes

    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Markers

    Homology

    Clone Names

    • MGC14495, MGC119054

    Gene Ontology Provided by GOA

    Function Evidence Code Pubs
    enables protein binding IPI
    Inferred from Physical Interaction
    more info
    		 PubMed 
    Process Evidence Code Pubs
    involved_in regulation of DNA-templated transcription IEA
    Inferred from Electronic Annotation
    more info
    		  
    Component Evidence Code Pubs
    is_active_in nucleus IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  

    General protein information

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    Preferred Names
    protein SSX3
    Names
    Kruppel-associated box containing gene product SSX3
    cancer/testis antigen 5.3
    synovial sarcoma, X breakpoint 3

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    Genomic

    1. NG_012561.1 RefSeqGene

      Range
      5005..15281
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_021014.4 → NP_066294.1  protein SSX3

      See identical proteins and their annotated locations for NP_066294.1

      Status: REVIEWED

      Source sequence(s)
      AA609599, AL606490, BC103862, U90840
      Consensus CDS
      CCDS14291.1
      UniProtKB/Swiss-Prot
      O60223, Q5JQZ3, Q99909, Q9BRW7
      Related
      ENSP00000298396.2, ENST00000298396.7
      Conserved Domains (2) summary
      smart00349
      Location:23 → 82
      KRAB; krueppel associated box
      pfam09514
      Location:156 → 187
      SSXRD; SSXRD motif

    RNA

    1. NR_176964.1 RNA Sequence

      Status: REVIEWED

      Source sequence(s)
      AL606490

    RefSeqs of Annotated Genomes: GCF_000001405.40-RS_2024_08

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCh38.p14 Primary Assembly

    Genomic

    1. NC_000023.11 Reference GRCh38.p14 Primary Assembly

      Range
      48346427..48356703 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_011543885.3 → XP_011542187.1  protein SSX3 isoform X1

      See identical proteins and their annotated locations for XP_011542187.1

      Related
      ENSP00000366090.3, ENST00000376893.7
      Conserved Domains (1) summary
      smart00349
      Location:23 → 82
      KRAB; krueppel associated box

    Alternate T2T-CHM13v2.0

    Genomic

    1. NC_060947.1 Alternate T2T-CHM13v2.0

      Range
      47755403..47765669 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_054326359.1 → XP_054182334.1  protein SSX3 isoform X1

    Suppressed Reference Sequence(s)

    The following Reference Sequences have been suppressed. Explain

    1. NM_175711.1: Suppressed sequence

      Description
      NM_175711.1: This RefSeq was permanently suppressed because currently there is insufficient support for the transcript and the protein.
    Nucleotide Protein
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    Q99909.2 GenPept UniProtKB/Swiss-Prot:Q99909

    Gene LinkOut

    The following LinkOut resources are supplied by external providers. These providers are responsible for maintaining the links.

    Chemical Information
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