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    DRD2 dopamine receptor D2 [ Sus scrofa (pig) ]

    Gene ID: 100624857, updated on 17-Aug-2024

    Summary

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    Official Symbol
    DRD2provided by VGNC
    Official Full Name
    dopamine receptor D2provided by VGNC
    Primary source
    VGNC:VGNC:87444
    See related
    Ensembl:ENSSSCG00000015048
    Gene type
    protein coding
    RefSeq status
    PROVISIONAL
    Organism
    Sus scrofa
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Laurasiatheria; Artiodactyla; Suina; Suidae; Sus
    Expression
    Broad expression in ovary (RPKM 2.0), psoas major muscle (RPKM 0.4) and 6 other tissues See more
    Orthologs
    human mouse all
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    Genomic context

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    See DRD2 in Genome Data Viewer
    Location:
    chromosome: 9
    Exon count:
    8
    Annotation release Status Assembly Chr Location
    106 current Sscrofa11.1 (GCF_000003025.6) 9 NC_010451.4 (41068618..41135262, complement)
    105 previous assembly Sscrofa10.2 (GCF_000003025.5) 9 NC_010451.3 (45883054..45897704)

    Chromosome 9 - NC_010451.4Genomic Context describing neighboring genes Neighboring gene neural cell adhesion molecule 1 Neighboring gene tetratricopeptide repeat domain 12 Neighboring gene transmembrane serine protease 5 Neighboring gene zw10 kinetochore protein

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: Transcriptome data used for gene annotation Transcriptome data used for gene annotation
    • Description: Nine kinds of tissues and a mixture of multiple tissues were sequenced for genome annotation
    • BioProject: PRJNA311523
    • Publication: PMID 27646534
    • Analysis date: Thu Dec 14 17:10:49 2017

    Bibliography

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    Related articles in PubMed

    1. Molecular cloning, expression and variation analyses of the dopamine D2 receptor gene in pig breeds in China. Xu HP, et al. Genet Mol Res, 2011 Dec 5. PMID 22180074
    2. Dopamine D2-receptor-mediated increase in vascular and endothelial NOS activity ameliorates cerebral vasospasm after subarachnoid hemorrhage in vitro. Pyne-Geithman GJ, et al. Neurocrit Care, 2009. PMID 18807216, Free PMC Article
    3. Manual GO annotation of predictive protein signatures: the InterPro approach to GO curation. Burge S, et al. Database (Oxford), 2012. PMID 22301074, Free PMC Article
    4. TreeGrafter: phylogenetic tree-based annotation of proteins with Gene Ontology terms and other annotations. Tang H, et al. Bioinformatics, 2019 Feb 1. PMID 30032202, Free PMC Article

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?
    1. The pig DRD2 gene was cloned, investigated its distribution in tissues and polymorphisms were identified.
      Title: Molecular cloning, expression and variation analyses of the dopamine D2 receptor gene in pig breeds in China.
    2. The increase in NOS protein seen in both the endothelium and vascular smooth muscle in response to cerebral vasospasm is enhanced by dopamine in a D(2)R-dependent mechanism.
      Title: Dopamine D2-receptor-mediated increase in vascular and endothelial NOS activity ameliorates cerebral vasospasm after subarachnoid hemorrhage in vitro.
    Submit: New GeneRIF Correction

    General gene information

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    Markers

    Homology

    Gene Ontology Provided by RefSeq

    Function Evidence Code Pubs
    enables G protein-coupled receptor activity IEA
    Inferred from Electronic Annotation
    more info
    		 PubMed 
    enables dopamine neurotransmitter receptor activity, coupled via Gi/Go IEA
    Inferred from Electronic Annotation
    more info
    		 PubMed 
    Process Evidence Code Pubs
    involved_in adenylate cyclase-activating adrenergic receptor signaling pathway IEA
    Inferred from Electronic Annotation
    more info
    		 PubMed 
    involved_in adenylate cyclase-inhibiting dopamine receptor signaling pathway IEA
    Inferred from Electronic Annotation
    more info
    		 PubMed 
    Component Evidence Code Pubs
    located_in glutamatergic synapse IEA
    Inferred from Electronic Annotation
    more info
    		 PubMed 
    located_in presynaptic membrane IEA
    Inferred from Electronic Annotation
    more info
    		 PubMed 

    General protein information

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    Preferred Names
    D(2) dopamine receptor

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001244253.1 → NP_001231182.1  D(2) dopamine receptor

      See identical proteins and their annotated locations for NP_001231182.1

      Status: PROVISIONAL

      Source sequence(s)
      JF412702
      UniProtKB/TrEMBL
      A0A4X1T900, A0A8D0IXN2, F1SM69, G3ETR0
      Related
      ENSSSCP00000015973.2, ENSSSCT00000016414.4
      Conserved Domains (1) summary
      cd15309
      Location:35 → 437
      7tmA_D2_dopamine_R; D2 subtype of the D2-like family of dopamine receptors, member of the class A family of seven-transmembrane G protein-coupled receptors

    RefSeqs of Annotated Genomes: Sus scrofa Annotation Release 106 details...Open this link in a new tab

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference Sscrofa11.1 Primary Assembly

    Genomic

    1. NC_010451.4 Reference Sscrofa11.1 Primary Assembly

      Range
      41068618..41135262 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_021102112.1 → XP_020957771.1  D(2) dopamine receptor isoform X2

      UniProtKB/TrEMBL
      A0A8D0IXN2, A0A8D0YUQ4, G3ETR1
      Related
      ENSSSCP00000053203.1, ENSSSCT00000050179.2
      Conserved Domains (1) summary
      cd15309
      Location:35 → 408
      7tmA_D2_dopamine_R; D2 subtype of the D2-like family of dopamine receptors, member of the class A family of seven-transmembrane G protein-coupled receptors

    2. XM_021102111.1 → XP_020957770.1  D(2) dopamine receptor isoform X1

      UniProtKB/TrEMBL
      A0A4X1T900, A0A8D0IXN2, F1SM69, G3ETR0
      Conserved Domains (1) summary
      cd15309
      Location:35 → 437
      7tmA_D2_dopamine_R; D2 subtype of the D2-like family of dopamine receptors, member of the class A family of seven-transmembrane G protein-coupled receptors
    Nucleotide Protein
    Heading Accession and Version

    Gene LinkOut

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