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    SLC47A2 solute carrier family 47 member 2 [ Homo sapiens (human) ]

    Gene ID: 146802, updated on 28-Oct-2024

    Summary

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    Official Symbol
    SLC47A2provided by HGNC
    Official Full Name
    solute carrier family 47 member 2provided by HGNC
    Primary source
    HGNC:HGNC:26439
    See related
    Ensembl:ENSG00000180638 MIM:609833; AllianceGenome:HGNC:26439
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Homo sapiens
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
    Also known as
    MATE2; MATE2K; MATE2-B; MATE2-K
    Summary
    This gene encodes a protein belonging to a family of transporters involved in excretion of toxic electrolytes, both endogenous and exogenous, through urine and bile. This transporter family shares homology with the bacterial MATE (multidrug and toxin extrusion) protein family responsible for drug resistance. This gene is one of two members of the MATE transporter family located near each other on chromosome 17. Alternatively spliced transcript variants encoding different isoforms have been identified for this gene. [provided by RefSeq, Jul 2008]
    Expression
    Restricted expression toward kidney (RPKM 17.1) See more
    Orthologs
    all
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    Genomic context

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    See SLC47A2 in Genome Data Viewer
    Location:
    17p11.2
    Exon count:
    22
    Annotation release Status Assembly Chr Location
    RS_2024_08 current GRCh38.p14 (GCF_000001405.40) 17 NC_000017.11 (19678317..19718979, complement)
    RS_2024_08 current T2T-CHM13v2.0 (GCF_009914755.1) 17 NC_060941.1 (19626936..19667598, complement)
    RS_2024_09 previous assembly GRCh37.p13 (GCF_000001405.25) 17 NC_000017.10 (19581630..19622292, complement)

    Chromosome 17 - NC_000017.11Genomic Context describing neighboring genes Neighboring gene SLC47A1 pseudogene 2 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 11859 Neighboring gene OCT4-NANOG-H3K27ac hESC enhancer GRCh37_chr17:19550219-19550869 Neighboring gene OCT4-NANOG-H3K27ac hESC enhancer GRCh37_chr17:19550870-19551519 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 8297 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 11860 Neighboring gene aldehyde dehydrogenase 3 family member A2 Neighboring gene uncharacterized LOC124900397 Neighboring gene NANOG hESC enhancer GRCh37_chr17:19567261-19567762 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr17:19584163-19584664 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr17:19609675-19610312 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr17:19610313-19610950 Neighboring gene uncharacterized LOC124903948 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr17:19619375-19620224 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr17:19620225-19621072 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 8298 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr17:19648320-19649287 Neighboring gene aldehyde dehydrogenase 3 family member A1 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 11861 Neighboring gene MED14-independent group 3 enhancer GRCh37_chr17:19656044-19657243 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 8299 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 11862 Neighboring gene TBC1 domain family member 25 pseudogene

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: HPA RNA-seq normal tissues HPA RNA-seq normal tissues
    • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
    • BioProject: PRJEB4337
    • Publication: PMID 24309898
    • Analysis date: Wed Apr 4 07:08:55 2018

    Bibliography

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    Related articles in PubMed

    1. Population diversity of three variants of the SLC47A2 gene (MATE2-K transporter) in Mexican Mestizos and Native Americans. Favela-Mendoza AF, et al. Mol Biol Rep, 2021 Sep. PMID 34383246
    2. Identification and functional characterization of novel nonsynonymous variants in the human multidrug and toxin extrusion 2-K. Nishimura K, et al. Drug Metab Dispos, 2014 Sep. PMID 24985703
    3. Histone H3 Lysine 4 Trimethylation, Lysine 27 Trimethylation, and Lysine 27 Acetylation Contribute to the Transcriptional Repression of Solute Carrier Family 47 Member 2 in Renal Cell Carcinoma. Yu Q, et al. Drug Metab Dispos, 2017 Jan. PMID 27821436
    4. MATE2 Expression Is Associated with Cancer Cell Response to Metformin. Chowdhury S, et al. PLoS One, 2016. PMID 27959931, Free PMC Article
    5. A novel human lncRNA SANT1 cis-regulates the expression of SLC47A2 by altering SFPQ/E2F1/HDAC1 binding to the promoter region in renal cell carcinoma. Gao Z, et al. RNA Biol, 2019 Jul. PMID 30951404, Free PMC Article

    See all (32) citations in PubMed

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?
    1. Population diversity of three variants of the SLC47A2 gene (MATE2-K transporter) in Mexican Mestizos and Native Americans.
      Title: Population diversity of three variants of the SLC47A2 gene (MATE2-K transporter) in Mexican Mestizos and Native Americans.
    2. Rapid Regulation of Human Multidrug and Extrusion Transporters hMATE1 and hMATE2K.
      Title: Rapid Regulation of Human Multidrug and Extrusion Transporters hMATE1 and hMATE2K.
    3. the SLC47A2 locus highly expresses SANT1, which can remove the regulatory SFPQ/E2F1/HDAC1 suppressor complex from the promoter region.
      Title: A novel human lncRNA SANT1 cis-regulates the expression of SLC47A2 by altering SFPQ/E2F1/HDAC1 binding to the promoter region in renal cell carcinoma.
    4. The studied SLC47A1 and SLC47A2 SNPs had no influence on the dose requirement or adverse effects of metformin.
      Title: Lack of effect of the SLC47A1 and SLC47A2 gene polymorphisms on the glycemic response to metformin in type 2 diabetes mellitus patients.
    5. SLC47A2 transcriptional repression in Renal Cell Carcinoma tissues.
      Title: Histone H3 Lysine 4 Trimethylation, Lysine 27 Trimethylation, and Lysine 27 Acetylation Contribute to the Transcriptional Repression of Solute Carrier Family 47 Member 2 in Renal Cell Carcinoma.
    6. The impact of assay conditions on IC50 determination is negligible, kinetic characteristics differ among used test substrates, and substrate-dependent inhibition exists for MATE1 and MATE2-K, giving valuable insight into the assessment of clinically relevant MATE-mediated drug interactions in vitro.
      Title: Impact of Experimental Conditions on the Evaluation of Interactions between Multidrug and Toxin Extrusion Proteins and Candidate Drugs.
    7. Pazopanib inhibits OCT2, MATE1 and MATE2-K, which are involved in cisplatin secretion into urine, potentiating cisplatin toxicity.
      Title: Inhibition of OCT2, MATE1 and MATE2-K as a possible mechanism of drug interaction between pazopanib and cisplatin.
    8. Network and cell biological analysis additionally showed that expression of MATE2-K is regulated by Nrf2 signaling
      Title: Fluid shear stress stimulates MATE2-K expression via Nrf2 pathway activation.
    9. There were statistically significant association between resistance to metformin and MATE2 expression in cancer cells.
      Title: MATE2 Expression Is Associated with Cancer Cell Response to Metformin.
    10. These were associated with markedly reduced or increased MATE2-K function.
      Title: Identification and functional characterization of novel nonsynonymous variants in the human multidrug and toxin extrusion 2-K.
    Submit: New GeneRIF Correction See all GeneRIFs (20)

    Phenotypes

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    Find tests for this gene in the NIH Genetic Testing Registry (GTR)

    Review eQTL and phenotype association data in this region using PheGenI

    Variation

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    See variants in ClinVar

    See studies and variants in dbVar

    See Variation Viewer (GRCh37.p13)

    See Variation Viewer (GRCh38)

    Genotypes

    Pathways from PubChem

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    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Homology

    Clone Names

    • FLJ31196

    Gene Ontology Provided by GOA

    Function Evidence Code Pubs
    enables antiporter activity IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    enables organic cation transmembrane transporter activity IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    enables polyspecific organic cation:proton antiporter activity IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    enables transmembrane transporter activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables transmembrane transporter activity TAS
    Traceable Author Statement
    more info
    		  
    enables xenobiotic transmembrane transporter activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    Process Evidence Code Pubs
    involved_in organic cation transport IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    involved_in proton transmembrane transport IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in transmembrane transport TAS
    Traceable Author Statement
    more info
    		  
    involved_in xenobiotic detoxification by transmembrane export across the plasma membrane IEA
    Inferred from Electronic Annotation
    more info
    		  
    Component Evidence Code Pubs
    located_in apical plasma membrane IEA
    Inferred from Electronic Annotation
    more info
    		  
    is_active_in membrane IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    located_in plasma membrane IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    located_in plasma membrane TAS
    Traceable Author Statement
    more info
    		  

    General protein information

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    Preferred Names
    multidrug and toxin extrusion protein 2
    Names
    kidney-specific H(+)/organic cation antiporter
    solute carrier family 47 (multidrug and toxin extrusion), member 2

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    Genomic

    1. NG_052805.1 RefSeqGene

      Range
      7396..45663
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_001099646.3 → NP_001093116.1  multidrug and toxin extrusion protein 2 isoform 2

      See identical proteins and their annotated locations for NP_001093116.1

      Status: REVIEWED

      Description
      Transcript Variant: This variant (2) uses an alternate in-frame splice site in the 5' coding region, compared to variant 1. This results in a shorter protein (isoform 2, also known as MATE2-K), compared to isoform 1.
      Source sequence(s)
      AB250364, AC005722
      Consensus CDS
      CCDS92273.1
      UniProtKB/Swiss-Prot
      Q86VL8
      Related
      ENSP00000391848.3, ENST00000433844.4
      Conserved Domains (2) summary
      COG0534
      Location:33 → 467
      NorM; Na+-driven multidrug efflux pump [Defense mechanisms]
      cd13132
      Location:30 → 464
      MATE_eukaryotic; Eukaryotic members of the multidrug and toxic compound extrusion (MATE) family

    2. NM_001256663.3 → NP_001243592.1  multidrug and toxin extrusion protein 2 isoform 3

      See identical proteins and their annotated locations for NP_001243592.1

      Status: REVIEWED

      Description
      Transcript Variant: This variant (3) uses an alternate in-frame splice site and contains an alternate in-frame exon in the coding region, compared to variant 1. This results in a shorter protein (isoform 3), compared to isoform 1.
      Source sequence(s)
      AB250364, BC035288, DA312379
      Consensus CDS
      CCDS58530.1
      UniProtKB/Swiss-Prot
      Q86VL8
      Related
      ENSP00000338084.6, ENST00000350657.9
      Conserved Domains (2) summary
      COG0534
      Location:33 → 481
      NorM; Na+-driven multidrug efflux pump [Defense mechanisms]
      cd13132
      Location:30 → 478
      MATE_eukaryotic; Eukaryotic members of the multidrug and toxic compound extrusion (MATE) family

    3. NM_152908.5 → NP_690872.2  multidrug and toxin extrusion protein 2 isoform 1

      See identical proteins and their annotated locations for NP_690872.2

      Status: REVIEWED

      Description
      Transcript Variant: This variant (1) encodes the longest isoform (1), also known as MATE2.
      Source sequence(s)
      AC005722, BC050578
      Consensus CDS
      CCDS11211.1
      UniProtKB/Swiss-Prot
      A0JBX9, A0P8Z7, Q63HJ9, Q86VL8, Q8IV44, Q96NA1
      Related
      ENSP00000326671.5, ENST00000325411.9
      Conserved Domains (2) summary
      COG0534
      Location:33 → 503
      NorM; Na+-driven multidrug efflux pump [Defense mechanisms]
      cd13132
      Location:30 → 500
      MATE_eukaryotic; Eukaryotic members of the multidrug and toxic compound extrusion (MATE) family

    RNA

    1. NR_135624.2 RNA Sequence

      Status: REVIEWED

      Source sequence(s)
      AB250364, BC035288, BX648861
      Related
      ENST00000463318.5

    2. NR_135625.3 RNA Sequence

      Status: REVIEWED

      Source sequence(s)
      AB250701, AK307647, BC035288
      Related
      ENST00000574239.5

    RefSeqs of Annotated Genomes: GCF_000001405.40-RS_2024_08

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCh38.p14 Primary Assembly

    Genomic

    1. NC_000017.11 Reference GRCh38.p14 Primary Assembly

      Range
      19678317..19718979 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_017024222.3 → XP_016879711.1  multidrug and toxin extrusion protein 2 isoform X2

    2. XM_017024221.2 → XP_016879710.1  multidrug and toxin extrusion protein 2 isoform X1

    3. XM_047435435.1 → XP_047291391.1  multidrug and toxin extrusion protein 2 isoform X6

    4. XM_047435434.1 → XP_047291390.1  multidrug and toxin extrusion protein 2 isoform X4

    5. XM_017024223.2 → XP_016879712.1  multidrug and toxin extrusion protein 2 isoform X3

      UniProtKB/TrEMBL
      C9JAE6

    6. XM_017024224.2 → XP_016879713.1  multidrug and toxin extrusion protein 2 isoform X5

      UniProtKB/TrEMBL
      C9JAE6

    7. XM_017024226.2 → XP_016879715.1  multidrug and toxin extrusion protein 2 isoform X8

      UniProtKB/TrEMBL
      C9JAE6

    8. XM_017024225.2 → XP_016879714.1  multidrug and toxin extrusion protein 2 isoform X7

    RNA

    1. XR_001752432.2 RNA Sequence

    2. XR_001752433.2 RNA Sequence

    Alternate T2T-CHM13v2.0

    Genomic

    1. NC_060941.1 Alternate T2T-CHM13v2.0

      Range
      19626936..19667598 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_054315164.1 → XP_054171139.1  multidrug and toxin extrusion protein 2 isoform X2

    2. XM_054315163.1 → XP_054171138.1  multidrug and toxin extrusion protein 2 isoform X1

    3. XM_054315168.1 → XP_054171143.1  multidrug and toxin extrusion protein 2 isoform X6

    4. XM_054315166.1 → XP_054171141.1  multidrug and toxin extrusion protein 2 isoform X4

    5. XM_054315165.1 → XP_054171140.1  multidrug and toxin extrusion protein 2 isoform X3

    6. XM_054315167.1 → XP_054171142.1  multidrug and toxin extrusion protein 2 isoform X5

    7. XM_054315170.1 → XP_054171145.1  multidrug and toxin extrusion protein 2 isoform X8

    8. XM_054315169.1 → XP_054171144.1  multidrug and toxin extrusion protein 2 isoform X7

    RNA

    1. XR_008484786.1 RNA Sequence

    2. XR_008484787.1 RNA Sequence

    Nucleotide Protein
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    Q86VL8.1 GenPept UniProtKB/Swiss-Prot:Q86VL8

    Gene LinkOut

    The following LinkOut resources are supplied by external providers. These providers are responsible for maintaining the links.

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